{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T07:07:55Z","timestamp":1777100875832,"version":"3.51.4"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T00:00:00Z","timestamp":1665964800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T00:00:00Z","timestamp":1665964800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cytotechnology"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1007\/s10616-022-00555-x","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T19:02:37Z","timestamp":1666033357000},"page":"1-16","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Selinexor assists vorinostat in inhibiting HDAC activity via promoting the accumulation of maspin in the nucleus of oral tongue squamous cell carcinoma cells"],"prefix":"10.1007","volume":"75","author":[{"given":"Fenqian","family":"Yuan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingkang","family":"Yong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueming","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yifeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,10,17]]},"reference":[{"key":"555_CR1","unstructured":"Bethesda (2021) LiverTox: clinical and research information on drug-induced liver injury [Internet]. LiverTox,\u00a02012"},{"key":"555_CR2","doi-asserted-by":"publisher","first-page":"2378","DOI":"10.1002\/jcp.22574","volume":"226","author":"F Bruzzese","year":"2011","unstructured":"Bruzzese F, Leone A, Rocco M, Carbone C, Piro G, Caraglia M, Gennaro ED, Budillon A (2011) HDAC inhibitor vorinostat enhances the antitumor effect of gefitinib in squamous cell carcinoma of head and neck by modulating ErbB receptor expression and reverting EMT. J Cell Physiol 226:2378\u20132390","journal-title":"J Cell Physiol"},{"key":"555_CR3","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1016\/j.oraloncology.2008.08.011","volume":"45","author":"H-H Chang","year":"2009","unstructured":"Chang H-H, Chiang C-P, Hung H-C, Lin C-Y, Deng Y-T, Kuo MY-P (2009) Histone deacetylase 2 expression predicts poorer prognosis in oral cancer patients. Oral Oncol 45:610\u2013614","journal-title":"Oral Oncol"},{"key":"555_CR4","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1111\/j.1600-0714.2011.01009.x","volume":"40","author":"C-C Chang","year":"2011","unstructured":"Chang C-C, Lin B-R, Chen S-T, Hsieh T-H, Li Y-J, Kuo MYP (2011) HDAC2 promotes cell migration\/invasion abilities through HIF-1\u03b1 stabilization in human oral squamous cell carcinoma. J Oral Pathol Med 40:567\u2013575","journal-title":"J Oral Pathol Med"},{"key":"555_CR5","doi-asserted-by":"publisher","first-page":"401","DOI":"10.3322\/caac.21293","volume":"65","author":"AC Chi","year":"2015","unstructured":"Chi AC, Day TA, Neville BW (2015) Oral cavity and oropharyngeal squamous cell carcinoma\u2014an update. CA Cancer J Clin 65:401\u2013421","journal-title":"CA Cancer J Clin"},{"key":"555_CR6","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1111\/j.1365-2559.2009.03260.x","volume":"54","author":"A Frey","year":"2010","unstructured":"Frey A, Soubani AO, Adam AK, Sheng S, Pass HI, Lonardo F (2010) Nuclear, compared with combined nuclear and cytoplasmic expression of maspin, is linked in lung adenocarcinoma to reduced VEGF-A levels and in stage I, improved survival. Histopathology 54:590\u2013597","journal-title":"Histopathology"},{"key":"555_CR7","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1038\/labinvest.2011.66","volume":"91","author":"B Goulet","year":"2011","unstructured":"Goulet B, Kennette W, Ablack A, Postenka CO, Hague MN, Mymryk JS, Tuck AB, Gigu\u00e8re V, Chambers AF, Lewis JD (2011) Nuclear localization of maspin is essential for its inhibition of tumor growth and metastasis. Lab Investig 91:1181\u20131187","journal-title":"Lab Investig"},{"key":"555_CR8","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1002\/onco.13859","volume":"26","author":"YL Kasamon","year":"2021","unstructured":"Kasamon YL, Price LSL, Okusanya OO, Richardson NC, Li R-J, Ma L, Wu Y-T, Theoret M, Pazdur R, Gormley NJ (2021) FDA approval summary: selinexor for relapsed or refractory diffuse large B-cell lymphoma. Oncologist 26:879\u2013886","journal-title":"Oncologist"},{"key":"555_CR9","doi-asserted-by":"publisher","first-page":"169","DOI":"10.18632\/genesandcancer.54","volume":"6","author":"B Kumar","year":"2015","unstructured":"Kumar B, Yadav A, Lang JC, Teknos TN, Kumar P (2015) Suberoylanilide hydroxamic acid (SAHA) reverses chemoresistance in head and neck cancer cells by targeting cancer stem cells via the downregulation of nanog. Genes Cancer 6:169\u2013181","journal-title":"Genes Cancer"},{"key":"555_CR10","doi-asserted-by":"publisher","first-page":"9323","DOI":"10.1158\/0008-5472.CAN-06-1578","volume":"66","author":"X Li","year":"2006","unstructured":"Li X, Yin S, Meng Y, Sakr W, Sheng S (2006) Endogenous inhibition of histone deacetylase 1 by tumor-suppressive maspin. Cancer Res 66:9323\u20139329","journal-title":"Cancer Res"},{"key":"555_CR11","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1186\/s12964-021-00758-3","volume":"19","author":"MT Longhi","year":"2021","unstructured":"Longhi MT, Silva LE, Pereira M, Magalh\u00e3es M, Reina J, Vitorino FN, Gumbiner BM, Da Cunha JP, Cella N (2021) PI3K-AKT, JAK2-STAT3 pathways and cell\u2013cell contact regulate maspin subcellular localization. Cell Commun Signal 19:86","journal-title":"Cell Commun Signal"},{"key":"555_CR12","first-page":"211","volume":"44","author":"FIIC M\u0103r\u0103\u015fescu","year":"2018","unstructured":"M\u0103r\u0103\u015fescu FIIC, Marasescu PC, Matei M, Florescu AM, Margaritescu C, Petrescu SMS, Dumitrescu CI (2018) Epidemiological and histopathological aspects of tongue squamous cell carcinomas-retrospective study. Curr Health Sci J 44:211\u2013224","journal-title":"Curr Health Sci J"},{"key":"555_CR13","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1111\/j.1365-2559.2005.02141.x","volume":"46","author":"G Marioni","year":"2010","unstructured":"Marioni G, Blandamura S, Giacomelli L, Calgaro N, Segato P, Leo G, Fischetto D, Staffieri A, De Filippis C (2010) Nuclear expression of maspin is associated with a lower recurrence rate and a longer disease-free interval after surgery for squamous cell carcinoma of the larynx. Histopathology 46:576\u2013582","journal-title":"Histopathology"},{"key":"555_CR14","doi-asserted-by":"publisher","first-page":"84","DOI":"10.14639\/0392-100X-2336","volume":"39","author":"A Marra","year":"2019","unstructured":"Marra A, Violati M, Broggio F, Codec\u00e0 C, Blasi M, Luciani A, Zonato S, Rabbiosi D, Moneghini L, Saibene A, Maccari A, Felisati G, Ferrari D (2019) Long-term disease-free survival in surgically-resected oral tongue cancer: a 10-year retrospective study. Acta Otorhinolaryngologica Italica 39:84\u201391","journal-title":"Acta Otorhinolaryngologica Italica"},{"key":"555_CR15","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/bs.acr.2018.02.006","volume":"138","author":"JJ McClure","year":"2018","unstructured":"McClure JJ, Li X, Chou CJ (2018) Advances and challenges of HDAC inhibitors in cancer therapeutics. Adv Cancer Res 138:183\u2013211","journal-title":"Adv Cancer Res"},{"key":"555_CR16","first-page":"1790","volume":"52","author":"H Nakajima","year":"2007","unstructured":"Nakajima H (2007) A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. Tanpakushitsu Kakusan Koso 52:1790\u20131791","journal-title":"Tanpakushitsu Kakusan Koso"},{"key":"555_CR17","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1002\/hed.24589","volume":"39","author":"JH Ng","year":"2017","unstructured":"Ng JH, Iyer NG, Tan M-H, Edgren G (2017) Changing epidemiology of oral squamous cell carcinoma of the tongue: a global study. Head Neck 39:297\u2013304","journal-title":"Head Neck"},{"key":"555_CR18","first-page":"151","volume":"58","author":"K Nosaka","year":"2015","unstructured":"Nosaka K, Horie Y, Shiomi T, Itamochi H, Oishi T, Shimada M, Sato S, Sakabe T, Harada T, Umekita Y (2015) Cytoplasmic maspin expression correlates with poor prognosis of patients with adenocarcinoma of the uterine cervix. Yonago Acta Med 58:151\u2013156","journal-title":"Yonago Acta Med"},{"key":"555_CR19","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/s40259-021-00514-6","volume":"36","author":"S Richard","year":"2022","unstructured":"Richard S, Jagannath S (2022) Targeting nuclear export proteins in multiple myeloma therapy. BioDrugs 36:13\u201325","journal-title":"BioDrugs"},{"key":"555_CR20","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1158\/1078-0432.CCR-19-2214","volume":"26","author":"CP Rodriguez","year":"2019","unstructured":"Rodriguez CP, Wu QV, Voutsinas J, Fromm JR, Jiang X, Pillarisetty VG, Lee SM, Santana-Davila R, Goulart B, Baik CS, Chow LQM, Eaton K, Martins R (2019) A phase II trial of pembrolizumab and vorinostat in recurrent metastatic head and neck squamous cell carcinomas and salivary gland cancer. Clin Cancer Res 26:837\u2013845","journal-title":"Clin Cancer Res"},{"key":"555_CR21","doi-asserted-by":"publisher","first-page":"eaar7223","DOI":"10.1126\/scitranslmed.aar7223","volume":"10","author":"N Saenz-Ponce","year":"2019","unstructured":"Saenz-Ponce N, Pillay R, Long LM, d., Kashyap T, Argueta C, Landesman Y, Hazar-Rethinam M, Boros S, Panizza B, Jacquemyn M, Daelemans D, Gannon OM, Saunders NA (2019) Targeting the XPO1-dependent nuclear export of E2F7 reverses anthracycline resistance in head and neck squamous cell carcinomas. Sci Transl Med 10:eaar7223","journal-title":"Sci Transl Med"},{"key":"555_CR22","doi-asserted-by":"publisher","first-page":"176","DOI":"10.4068\/cmj.2021.57.3.176","volume":"57","author":"AK Sajnani","year":"2021","unstructured":"Sajnani AK, Shah SG, Rashid M, Natu A, Gera PB, Gupta S (2021) In-silico analysis of chromatin modifiers and profiling of histone deacetylases (HDAC\u2019s) in human oral cancer. Chonnam Med J 57:176\u2013184","journal-title":"Chonnam Med J"},{"key":"555_CR23","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1002\/mc.23214","volume":"59","author":"E Shankar","year":"2020","unstructured":"Shankar E, Pandey M, Verma S, Abbas A, Candamo M, Kanwal R, Shukla S, MacLennan GT, Gupta S (2020) Role of class I histone deacetylases in the regulation of maspin expression in prostate cancer. Mol Carcinog 59:955\u2013966","journal-title":"Mol Carcinog"},{"key":"555_CR24","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1111\/his.12586","volume":"66","author":"Y Takagi","year":"2014","unstructured":"Takagi Y, Matsuoka Y, Shiomi T, Nosaka K, Takeda C, Haruki T, Araki K, Taniguchi Y, Nakamura H, Umekita Y (2014) Cytoplasmic maspin expression is a predictor of poor prognosis in patients with lung adenocarcinoma measuring less than 3\u00a0cm. Histopathology 66:732\u2013739","journal-title":"Histopathology"},{"key":"555_CR25","doi-asserted-by":"publisher","first-page":"573820","DOI":"10.3389\/fcell.2020.573820","volume":"8","author":"S Tang","year":"2020","unstructured":"Tang S, Lian X, Jiang J, Cheng H, Guo J, Huang C, Meng H, Li X (2020) Tumor suppressive maspin-sensitized prostate cancer to drug treatment through negative regulating androgen receptor expression. Front Cell Dev Biol 8:573820","journal-title":"Front Cell Dev Biol"},{"key":"555_CR26","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1126\/science.272.5260.408","volume":"272","author":"J Taunton","year":"1996","unstructured":"Taunton J, Hassig CA, Schreiber SL (1996) A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. Science 272:408\u2013411","journal-title":"Science"},{"key":"555_CR27","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1007\/s10637-018-0696-4","volume":"37","author":"TN Teknos","year":"2016","unstructured":"Teknos TN, Grecula J, Agrawal A, Old MO, Ozer E, Carrau R, Kang S, Rocco J, Blakaj D, Diavolitsis V, Kumar B, Kumar P, Pan Q, Palettas M, Wei L, Baiocchi R, Savvides P (2016) A phase 1 trial of vorinostat in combination with concurrent chemoradiation therapy in the treatment of advanced staged head and neck squamous cell carcinoma. Investig New Drugs 37:702\u2013710","journal-title":"Investig New Drugs"},{"key":"555_CR28","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1111\/j.1600-0714.2011.01031.x","volume":"40","author":"S Theocharis","year":"2011","unstructured":"Theocharis S, Klijanienko J, Giaginis C, Rodriguez J, Jouffroy T, Girod A, Alexandrou P, Sastre-Garau X (2011) Histone deacetylase-1 and -2 expression in mobile tongue squamous cell carcinoma: associations with clinicopathological parameters and patients survival. J Oral Pathol Med 40:706\u2013714","journal-title":"J Oral Pathol Med"},{"key":"555_CR29","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1002\/hed.1139","volume":"23","author":"R Yasumatsu","year":"2001","unstructured":"Yasumatsu R, Nakashima T, Hirakawa N, Kumamoto Y, Kuratomi Y, Tomita K, Komiyama S (2001) Maspin expression in stage I and II oral tongue squamous cell carcinoma. Head Neck 23:962\u2013966","journal-title":"Head Neck"}],"container-title":["Cytotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10616-022-00555-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10616-022-00555-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10616-022-00555-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T05:25:26Z","timestamp":1674797126000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10616-022-00555-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,17]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["555"],"URL":"https:\/\/doi.org\/10.1007\/s10616-022-00555-x","relation":{},"ISSN":["0920-9069","1573-0778"],"issn-type":[{"value":"0920-9069","type":"print"},{"value":"1573-0778","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,17]]},"assertion":[{"value":"11 June 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 October 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 October 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}