{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T09:07:06Z","timestamp":1697447226342},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"S1","license":[{"start":{"date-parts":[[2005,10,1]],"date-time":"2005-10-01T00:00:00Z","timestamp":1128124800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2005,10]]},"DOI":"10.1007\/s10620-005-2808-1","type":"journal-article","created":{"date-parts":[[2005,9,24]],"date-time":"2005-09-24T00:35:27Z","timestamp":1127522127000},"page":"S63-S69","source":"Crossref","is-referenced-by-count":16,"title":["Rebamipide Reduces Delay in Gastric Ulcer Healing in Cyclooxygenase-2-Deficient Mice"],"prefix":"10.1007","volume":"50","author":[{"given":"Toshio","family":"Watanabe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhide","family":"Higuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Taira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiji","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatsugu","family":"Shiba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunari","family":"Tominaga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Fujiwara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuhide","family":"Oshitani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuo","family":"Arakawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"2808_CR1","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0889-8553(21)00052-2","volume":"21","author":"JL Wallace","year":"1992","unstructured":"Wallace JL: Prostaglandins, NSAIDs, cytoprotection. Gastroenterol Clin N Am 21:631\u2013641, 1992","journal-title":"Gastroenterol Clin N Am"},{"key":"2808_CR2","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1016\/S0016-5085(99)70496-8","volume":"116","author":"S Fu","year":"1999","unstructured":"Fu S, Ramanujam KS, Wong A, Fantry GT, Drachenberg CB, James SP, Meltzer SJ, Wilson KT: Increased expression and cellular localization of inducible nitric oxide synthase and cyclooxygenase 2 in Helicobacter pylori gastritis. Gastroenterology 116:1319\u20131329, 1999","journal-title":"Gastroenterology"},{"key":"2808_CR3","doi-asserted-by":"crossref","first-page":"G148","DOI":"10.1152\/ajpgi.00137.2003","volume":"286","author":"T Tanigawa","year":"2004","unstructured":"Tanigawa T, Watanabe T, Hamaguchi M, Sasaki E, Tominaga K, Fujiwara Y, Oshitani N, Matsumoto T, Higuchi K, Arakawa T: Anti-inflammatory effect of two isoforms of COX in H. pylori-induced gastritis in mice: possible involvement of PGE2. Am J Physiol Gastrointest Liver Physiol 286:G148\u2013G156, 2004","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"2808_CR4","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1053\/gast.1997.v112.pm9024292","volume":"112","author":"H Mizuno","year":"1997","unstructured":"Mizuno H, Sakamoto C, Matsuda K, Wada K, Uchida T, Noguchi H, Akamatsu T, Kasuga M: Induction of cyclooxygenase 2 in gastric mucosal lesions and its inhibition by the specific antagonist delays healing in mice. Gastroenterology 112:387\u2013397, 1997","journal-title":"Gastroenterology"},{"key":"2808_CR5","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/S0002-9440(10)64918-8","volume":"160","author":"D Baatar","year":"2002","unstructured":"Baatar D, Jones MK, Pai R, Kawanaka H, Szabo IL, Moon WS, Kitano S, Tarnawski AS: Selective cyclooxygenase-2 blocker delays healing of esophageal ulcers in rats and inhibits ulceration-triggered c-Met\/hepatocyte growth factor receptor induction and extracellular signal-regulated kinase 2 activation. Am J Pathol 160:963\u2013972, 2002","journal-title":"Am J Pathol"},{"key":"2808_CR6","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1038\/sj.bjp.0701672","volume":"12","author":"A Schmassmann","year":"1998","unstructured":"Schmassmann A, Peskar BM, Stettler C, Netzer P, Stroff T, Flogerzi B, Halter F: Effects of inhibition of prostaglandin endoperoxide synthase-2 in chronic gastrointestinal ulcer models in rats. Br J Pharmacol 12:795\u2013804, 1998","journal-title":"Br J Pharmacol"},{"key":"2808_CR7","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.ejphar.2004.10.019","volume":"28","author":"S Sanchez-Fidalgo","year":"2004","unstructured":"Sanchez-Fidalgo S, Martin-Lacave I, Illanes M, Motilva V: Angiogenesis, cell proliferation, and apoptosis in gastric ulcer healing. Effect of a selective COX-2 inhibitor. Eur J Pharmacol 28:187\u2013194, 2004","journal-title":"Eur J Pharmacol"},{"key":"2808_CR8","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0014-2999(91)90370-6","volume":"197","author":"S Oka","year":"1991","unstructured":"Oka S, Ogino K, Hobara T, Yoshimura S, Okazaki Y, Takemoto T, Iida Y: Effects of various mucosal protective drugs on diethyldithiocarbamate-induced antral ulcer in rats. Eur J Pharmacol 197:99\u2013102, 1991","journal-title":"Eur J Pharmacol"},{"key":"2808_CR9","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1254\/jjp.64.229","volume":"64","author":"K Sakurai","year":"1994","unstructured":"Sakurai K, Yamasaki K: Protective effect of rebamipide against hydrogen peroxide-induced hemorrhagic mucosal lesions in rat stomach. Jpn J Pharmacol 64:229\u2013234, 1994","journal-title":"Jpn J Pharmacol"},{"key":"2808_CR10","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1023\/A:1018861818023","volume":"42","author":"K Murakami","year":"1997","unstructured":"Murakami K, Okajima K, Uchiba M, Harada N, Johno M, Okabe H, Takatsuki K: Rebamipide attenuates indomethacin-induced gastric mucosal lesion formation by inhibiting activation of leukocytes in rats. Dig Dis Sci 42:319\u2013325, 1997","journal-title":"Dig Dis Sci"},{"key":"2808_CR11","doi-asserted-by":"crossref","first-page":"2566","DOI":"10.1023\/A:1018829032175","volume":"42","author":"S Kokura","year":"1997","unstructured":"Kokura S, Yoshikawa T, Naito Y, Ichikawa H, Takano H, Takahashi S, Tomii T, Yoshida N, Kondo M: Effects of rebamipide, a novel antiulcer agent, on gastric mucosal injury induced by platelet-activating factor in rats. Dig Dis Sci 42:2566\u20132571, 1997","journal-title":"Dig Dis Sci"},{"key":"2808_CR12","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1254\/jjp.49.441","volume":"49","author":"K Yamasaki","year":"1989","unstructured":"Yamasaki K, Ishikawa H, Imaizumi T, Kanbe T, Yabuuchi Y: Effect of OPC-12759, a novel antiulcer agent, on chronic and acute experimental gastric ulcer and gastric acid secretion in rats. Jpn J Pharmacol 49:441\u2013448, 1989","journal-title":"Jpn J Pharmacol"},{"key":"2808_CR13","doi-asserted-by":"crossref","first-page":"2469","DOI":"10.1007\/BF02063257","volume":"40","author":"T Arakawa","year":"1995","unstructured":"Arakawa T, Watanabe T, Fukuda T, Yamasaki K, Kobayashi K: Rebamipide, a novel prostaglandin-inducer, accelerates healing and reduces relapse of acetic acid-induced rat gastric ulcer: comparison with cimetidine. Dig Dis Sci 40:2469\u20132472, 1995","journal-title":"Dig Dis Sci"},{"key":"2808_CR14","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1023\/A:1015879421739","volume":"47","author":"T Watanabe","year":"2002","unstructured":"Watanabe T, Higuchi K, Hamaguchi M, Tanigawa T, Wada R, Tominaga K, Fujiwara Y, Arakawa T: Rebamipide prevents delay of acetic acid-induced gastric ulcer healing caused by Helicobacter pylori infection in Mongolian gerbils. Dig Dis Sci 47:1582\u20131589, 2002","journal-title":"Dig Dis Sci"},{"key":"2808_CR15","first-page":"340","volume":"275","author":"CD Kim","year":"1995","unstructured":"Kim CD, Hong KW: Preventive effect of rebamipide on gastric lesions induced by ischemia-reperfusion in the rat. J Pharmacol Exp Ther 275:340\u2013344, 1995","journal-title":"J Pharmacol Exp Ther"},{"key":"2808_CR16","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0891-5849(94)00110-6","volume":"18","author":"Y Naito","year":"1995","unstructured":"Naito Y, Yoshikawa T, Tanigawa T, Sakurai K, Yamasaki K, Uchida M, Kondo M: Hydroxylradical scavenging by rebamipide and related compounds: electron paramagnetic resonance study. Free Radic Res Commun 18:117\u2013123, 1995","journal-title":"Free Radic Res Commun"},{"key":"2808_CR17","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1007\/BF01308601","volume":"38","author":"A Kleine","year":"1993","unstructured":"Kleine A, Kluge S, Peskar BM: Stimulation of prostaglandin biosynthesis mediates gastroprotective effect of rebamipide in rats. Dig Dis Sci 38:1441\u20131449, 1993","journal-title":"Dig Dis Sci"},{"key":"2808_CR18","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1080\/00365520310000609","volume":"38","author":"A Udagawa","year":"2003","unstructured":"Udagawa A, Shiota G, Ichiba M, Murawaki Y: Effect of rebamipide on acetic acid-induced gastric ulcer in rats: involvement of hepatocyte growth factor. Scand J Gastroenterol 38:141\u2013146, 2003","journal-title":"Scand J Gastroenterol"},{"key":"2808_CR19","first-page":"447","volume":"295","author":"WH Sun","year":"2000","unstructured":"Sun WH, Tsuji S, Tsujii M, Gunawan ES, Kawai N, Kimura A, Kakiuchi Y, Yasumaru M, Iijima H, Okuda Y, Sasaki Y, Hori M, Kawano S: Induction of cyclooxygenase-2 in rat gastric mucosa by rebamipide, a mucoprotective agent. J Pharmacol Exp Ther 295:447\u2013452, 2000","journal-title":"J Pharmacol Exp Ther"},{"key":"2808_CR20","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/BF02235252","volume":"16","author":"S Okabe","year":"1971","unstructured":"Okabe S, Roth JL, Pfeiffer CJ: A method for experimental, penetrating gastric and duodenal ulcers in rats. Observation on normal healing. Am J Dig Dis 16:277\u2013284, 1971","journal-title":"Am J Dig Dis"},{"key":"2808_CR21","first-page":"802","volume":"295","author":"AK Ghosh","year":"2000","unstructured":"Ghosh AK, Hirasawa N, Niki H, Ohuchi K: Cyclooxygenase-2-mediated angiogenesis in carrageenin-induced granulation tissue in rats. J Pharmacol Exp Ther 295:802\u2013809, 2000","journal-title":"J Pharmacol Exp Ther"},{"key":"2808_CR22","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1006\/bbrc.2001.5494","volume":"286","author":"R Pai","year":"2001","unstructured":"Pai R, Szabo IL, Soreghan BA, Atay S, Kawanaka H, Tarnawski AS: PGE(2) stimulates VEGF expression in endothelial cells via ERK2\/JNK1 signaling pathways. Biochem Biophys Res Commun 286:923\u2013928, 2001","journal-title":"Biochem Biophys Res Commun"},{"key":"2808_CR23","doi-asserted-by":"crossref","first-page":"3504","DOI":"10.1210\/jcem.87.7.8796","volume":"87","author":"M Tamura","year":"2002","unstructured":"Tamura M, Sebastian S, Gurates B, Yang S, Fang Z, Bulun SE: Vascular endothelial growth factor upregulates cyclooxygenase-2 expression in human endothelial cells. J Clin Endocrinol Metab 87:3504\u20133507, 2002","journal-title":"J Clin Endocrinol Metab"},{"key":"2808_CR24","doi-asserted-by":"crossref","unstructured":"Sasaki E, Pai R, Halter F, Komurasaki T, Arakawa T, Kobayashi K, Kuroki T, Tarnawski AS: Induction of cyclooxygenase-2 in a rat gastric epithelial cell line by epiregulin and basic fibroblast growth factor. J Clin Gastroenterol (Suppl 1):S21\u2013S27, 1998","DOI":"10.1097\/00004836-199800001-00005"},{"key":"2808_CR25","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1023\/B:DDAS.0000017439.60943.5c","volume":"49","author":"AS Tarnawski","year":"2004","unstructured":"Tarnawski AS, Chai J, Pai R, Chiou SK: Rebamipide activates genes encoding angiogenic growth factors and COX2 and stimulates angiogenesis: a key to its ulcer healing action? Dig Dis Sci 49:202\u2013209, 2004","journal-title":"Dig Dis Sci"},{"key":"2808_CR26","first-page":"741","volume":"6","author":"WL Lowe","year":"1992","unstructured":"Lowe WL Jr, Yorek MA, Karpen CW, Teasdale RM, Hovis JG, Albrecht B, Prokopiou C: Activation of protein kinase-C differentially regulates insulin-like growth factor-I and basic fibroblast growth factor messenger RNA levels. Mol Endocrinol 6:741\u2013752, 1992","journal-title":"Mol Endocrinol"},{"key":"2808_CR27","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1159\/000007752","volume":"61","author":"N Shimizu","year":"2000","unstructured":"Shimizu N, Watanabe T, Arakawa T, Fujiwara Y, Higuchi K, Kuroki T: Pentoxifylline accelerates gastric ulcer healing in rats: roles of tumor necrosis factor-\u03b1 and neutrophils during the early phase of ulcer healing. Digestion 61:157\u2013164, 2000","journal-title":"Digestion"},{"key":"2808_CR28","first-page":"160S","volume":"43","author":"M Aihara","year":"1998","unstructured":"Aihara M, Imagawa K, Funakoshi Y, Ohmoto Y, Kikuchi M: Effects of rebamipide on production of several cytokines by human peripheral blood mononuclear cells. Dig Dis Sci 43:160S\u2013166S, 1998","journal-title":"Dig Dis Sci"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-005-2808-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10620-005-2808-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-005-2808-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,18]],"date-time":"2021-07-18T02:20:02Z","timestamp":1626574802000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10620-005-2808-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,10]]},"references-count":28,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2005,10]]}},"alternative-id":["2808"],"URL":"https:\/\/doi.org\/10.1007\/s10620-005-2808-1","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,10]]}}}