{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T18:17:08Z","timestamp":1770833828022,"version":"3.50.1"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2005,11,1]],"date-time":"2005-11-01T00:00:00Z","timestamp":1130803200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2005,11]]},"DOI":"10.1007\/s10620-005-3028-4","type":"journal-article","created":{"date-parts":[[2005,10,21]],"date-time":"2005-10-21T02:02:14Z","timestamp":1129860134000},"page":"2178-2182","source":"Crossref","is-referenced-by-count":14,"title":["Inverse Dose Effect of Pretest Dietary Lactose Intake on Breath Hydrogen Results and Symptoms in Lactase Nonpersistent Subjects"],"prefix":"10.1007","volume":"50","author":[{"given":"Andrew","family":"Szilagyi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Malolepszy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samara","family":"Yesovitch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Usha","family":"Nathwani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Vinokuroff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqing","family":"Xue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"3028_CR1","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1111\/j.1651-2227.1973.tb17080.x","volume":"62","author":"D Habte","year":"1973","unstructured":"Habte D, Sterky G, Hjalmarsson B: Lactose malabsorption in Ethiopian children. Acta Paediatr Scand 62:649\u2013654, 1973","journal-title":"Acta Paediatr Scand"},{"key":"3028_CR2","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1093\/ajcn\/32.9.1948","volume":"32","author":"M Sadre","year":"1979","unstructured":"Sadre M, Karbasi K: Lactose intolerance in Iran. Am J Clin Nutr 32:1948\u20131954, 1979","journal-title":"Am J Clin Nutr"},{"key":"3028_CR3","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1093\/ajcn\/59.5.1021","volume":"59","author":"FL Suarez","year":"1994","unstructured":"Suarez FL, Savaiano DA: Lactose digestion and tolerance in adult and elderly Asian-Americans. Am J Clin Nutr 59:1021\u20131024, 1994","journal-title":"Am J Clin Nutr"},{"key":"3028_CR4","first-page":"697","volume":"71","author":"J Villar","year":"1988","unstructured":"Villar J, Kestler E, Castillo P, Juarez A, Menendez R, Solomons NW; Improved lactose digestion during pregnancy: A case of physiologic adaptation? Obstet Gynecol 71:697\u2013700, 1988","journal-title":"Obstet Gynecol"},{"key":"3028_CR5","first-page":"416","volume":"19","author":"A Szilagyi","year":"1996","unstructured":"Szilagyi A, Salomon R, Martin M, Fokeeff K, Seidman E: Lactose handling by women with lactose malabsorption is improved during pregnancy. Clin Invest Med 19:416\u2013426, 1996","journal-title":"Clin Invest Med"},{"key":"3028_CR6","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1093\/ajcn\/64.2.232","volume":"64","author":"SR Hertzler","year":"1996","unstructured":"Hertzler SR, Savaiano DA: Colonic adaptation to daily lactose feeding in lactose maldigesters reduces lactose intolerance. Am J Clin Nutr 64:232\u2013326, 1996","journal-title":"Am J Clin Nutr"},{"key":"3028_CR7","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1093\/jn\/127.8.1489","volume":"127","author":"T Jiang","year":"1997","unstructured":"Jiang T, Savaiano DA: In vitro lactose fermentation by human colonic bacteria is modified by Lactobacillus acidophilus supplementation. J Nutr 127:1489\u20131495, 1997","journal-title":"J Nutr"},{"key":"3028_CR8","first-page":"2370","volume":"42","author":"T Jiang","year":"1997","unstructured":"Jiang T, Savaiano DA: Modification of colonic fermentation by bifidobacteria and pH in vitro. Impact on lactose metabolism, short-chain fatty acid, and lactate production. Dig Dis Sci 42:2370\u20132377, 1997","journal-title":"Impact on lactose metabolism, short-chain fatty acid, and lactate production. Dig Dis Sci"},{"key":"3028_CR9","doi-asserted-by":"crossref","first-page":"73","DOI":"10.3109\/08910609309141564","volume":"6","author":"M Ito","year":"1993","unstructured":"Ito M, Kimura M: Influence of lactose on faecal microflora in lactose maldigesters. Microb Ecol Health Dis 6:73\u201376, 1993","journal-title":"Microb Ecol Health Dis"},{"key":"3028_CR10","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1093\/jn\/125.6.1401","volume":"125","author":"GR Gibson","year":"1995","unstructured":"Gibson GR, Roberfroid MB: Dietary modulation of the human colonic microbiota: Introducing the concept of prebiotics. J Nutr 125:1401\u20131412, 1995","journal-title":"J Nutr"},{"key":"3028_CR11","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1155\/2004\/350732","volume":"18","author":"A Szilagyi","year":"2004","unstructured":"Szilagyi A: Redefining lactose as a conditional prebiotic. Can J Gastroenterol 18:163\u2013167, 2004","journal-title":"Can J Gastroenterol"},{"key":"3028_CR12","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1056\/NEJM197512112932405","volume":"293","author":"AD Newcomer","year":"1975","unstructured":"Newcomer AD, McGill DB, Thomas PJ, Hofman AF: Prospective comparison of indirect methods for detecting lactase deficiency. N Engl J Med 293:1232\u20131236, 1975","journal-title":"N Engl J Med"},{"key":"3028_CR13","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1111\/j.1572-0241.2002.05664.x","volume":"97","author":"J Romagnuolo","year":"2002","unstructured":"Romagnuolo J, Schiller D, Bailey RJ: Using breath tests wisely in a gastroenterology practice: An evidence-based review of indications and pitfalls in interpretation. Am J Gastroenterol 97:1113\u20131126, 2002","journal-title":"Am J Gastroenterol"},{"key":"3028_CR14","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1023\/A:1024163327183","volume":"48","author":"F Casellas","year":"2003","unstructured":"Casellas F, Malagelada JR: Applicability of short hydrogen breath test for screening of lactose malabsorption. Dig Dis Sci 48:1333\u20131338, 2003","journal-title":"Dig Dis Sci"},{"key":"3028_CR15","first-page":"237","volume":"50","author":"G Metz","year":"1976","unstructured":"Metz G, Gassull MA, Leeds AR, Blendis LM, Jenkins DJ: A simple method of measuring breath hydrogen in carbohydrate malabsorption by end-expiratory sampling. Clin Sci Mol Med 50:237\u2013240, 1976","journal-title":"Clin Sci Mol Med"},{"key":"3028_CR16","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/BF00572764","volume":"141","author":"der Van","year":"1984","unstructured":"Van der Klei-van Moorsel JM, Douwes AC, van Oeveren JP: New principle for estimation of hydrogen in expired air. Eur J Pediatr 141:221\u2013224, 1984","journal-title":"Eur J Pediatr"},{"key":"3028_CR17","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1016\/0016-5085(93)90145-3","volume":"105","author":"A Strocchi","year":"1993","unstructured":"Strocchi A, Corazza G, Ellis CJ, Gasbarrini G, Levitt MD: Detection of malabsorption of low doses of carbohydrate: Accuracy of various breath H2 criteria. Gastroenterology 105:1404\u20131410, 1993","journal-title":"Gastroenterology"},{"key":"3028_CR18","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1542\/peds.68.4.526","volume":"68","author":"RG Barr","year":"1981","unstructured":"Barr RG, Watkins JB, Perman JA: Mucosal function and breath hydrogen excretion: Comparative studies in the clinical evaluation of children with nonspecific abdominal complaints. Pediatrics 68:526\u2013533, 1981","journal-title":"Pediatrics"},{"key":"3028_CR19","first-page":"348","volume":"42","author":"SR Hertzler","year":"1997","unstructured":"Hertzler SR, Savaiano DA, Levitt MD: Fecal hydrogen production and consumption measurements. Response to daily lactose ingestion by lactose maldigesters. Dig Dis Sci 42:348\u2013353, 1997","journal-title":"Response to daily lactose ingestion by lactose maldigesters. Dig Dis Sci"},{"key":"3028_CR20","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1093\/jn\/134.8.1881","volume":"134","author":"D Chinda","year":"2004","unstructured":"Chinda D, Nakaji S, Fukuda S, et al.: The fermentation of different dietary fibers is associated with fecal clostridia levels in men. J Nutr 134:1881\u20131886, 2004","journal-title":"J Nutr"},{"key":"3028_CR21","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/1047-2797(95)00063-1","volume":"5","author":"GS Cooper","year":"1995","unstructured":"Cooper GS, Busby MG, Fairchild AP: Measurement of lactose consumption reliability and comparison of two methods. Ann Epidemiol 5:473\u2013477, 1995","journal-title":"Ann Epidemiol"},{"key":"3028_CR22","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/scientificamerican1072-70","volume":"227","author":"N Kretchmer","year":"1972","unstructured":"Kretchmer N: Lactose and lactase. Sci Am 227:71\u201378, 1972","journal-title":"Sci Am"},{"issue":"4 Suppl","key":"3028_CR23","first-page":"1079","volume":"48","author":"NS Scrimshaw","year":"1988","unstructured":"Scrimshaw NS, Murray EB: The acceptability of milk and milk products in populations with a high prevalence of lactose intolerance. Am J Clin Nutr 48(4 Suppl):1079\u20131159, 1988","journal-title":"Am J Clin Nutr"},{"issue":"theme issue","key":"3028_CR24","first-page":"52","volume":"3","author":"DW Cramer","year":"1993","unstructured":"Cramer DW, Xu H: Lactase persistence galactose metabolism, and milk consumption as risk factors for ovarian cancer. Dyn Nutr Res 3(theme issue):52\u201360, 1993","journal-title":"Dyn Nutr Res"},{"key":"3028_CR25","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1023\/A:1010652223705","volume":"46","author":"A Szilagyi","year":"2001","unstructured":"Szilagyi A, Rivard J, Fokeeff K: Improved parameters of lactose maldigestion using lactulose. Dig Dis Sci 46:1509\u20131519, 2001","journal-title":"Dig Dis Sci"},{"key":"3028_CR26","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1023\/B:DDAS.0000011606.96795.40","volume":"49","author":"Y Zhong","year":"2004","unstructured":"Zhong Y, Priebe MG, Vonk RJ, et al.: The role of colonic microbiota in lactose intolerance. Dig Dis Sci 49:78\u201383, 2004","journal-title":"Dig Dis Sci"},{"key":"3028_CR27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1056\/NEJM199507063330101","volume":"333","author":"FL Suarez","year":"1995","unstructured":"Suarez FL, Savaiano DA, Levitt MD: A comparison of symptoms after the consumption of milk or lactose-hydrolyzed milk by people with self-reported severe lactose intolerance. N Engl J Med 333:1\u20134, 1995","journal-title":"N Engl J Med"},{"key":"3028_CR28","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/j.clnu.2003.12.005","volume":"23","author":"P Vernia","year":"2004","unstructured":"Vernia P, Marinaro V, Argnani F, Di Camillo M, Caprilli R: Self-reported milk intolerance in irritable bowel syndrome: What should we believe? Clin Nutr 23:996\u20131000, 2004","journal-title":"Clin Nutr"},{"key":"3028_CR29","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1093\/ajcn\/65.5.1502","volume":"65","author":"FL Suarez","year":"1997","unstructured":"Suarez FL, Savaiano D, Arbisi P, Levitt MD: Tolerance to the daily ingestion of two cups of milk by individuals claiming lactose intolerance. Am J Clin Nutr 65:1502\u20131506, 1997","journal-title":"Am J Clin Nutr"},{"key":"3028_CR30","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1159\/000051878","volume":"63","author":"M Simren","year":"2001","unstructured":"Simren M, Mansson A, Langkilde AM, et al.: Food-related gastrointestinal symptoms in the irritable bowel syndrome. Digestion 63:108\u2013115, 2001","journal-title":"Digestion"},{"key":"3028_CR31","first-page":"695","volume":"124","author":"GR Corazza","year":"1994","unstructured":"Corazza GR, Benati G, Strocchi A, Malservisi S, Gasbarrini G: The possible role of breath methane measurement in detecting carbohydrate malabsorption. J Lab Clin Med 124:695\u2013700, 1994","journal-title":"J Lab Clin Med"},{"key":"3028_CR32","doi-asserted-by":"crossref","first-page":"826","DOI":"10.3109\/00365529409092518","volume":"29","author":"JJ Rumessen","year":"1994","unstructured":"Rumessen JJ, Nordgaard-Andersen I, Gudmand-Hoyer E: Carbohydrate malabsorption: Quantification by methane and hydrogen breath tests. Scand J Gastroenterol 29:826\u2013832, 1994","journal-title":"Scand J Gastroenterol"},{"key":"3028_CR33","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1155\/2004\/763529","volume":"18","author":"A Szilagyi","year":"2004","unstructured":"Szilagyi A, Cohen A, Vinokuroff C, Ahmad D, Nathwani U, Yesovitch S: Deadaption and readaptation with lactose, but no cross-adaptation to lactulose: A case of occult colonic bacterial adaptation. Can J Gastroenterol 18:677\u2013680, 2004","journal-title":"Can J Gastroenterol"},{"key":"3028_CR34","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1136\/gut.41.5.632","volume":"41","author":"F Briet","year":"1997","unstructured":"Briet F, Pochart P, Marteau P, Flourie B, Arrigoni E, Rambaud JC: Improved clinical tolerance to chronic lactose ingestion in subjects with lactose intolerance: A placebo effect? Gut 41:632, 1997","journal-title":"Gut"},{"key":"3028_CR35","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1136\/gut.2004.040048","volume":"53","author":"H Rasinpera","year":"2004","unstructured":"Rasinpera H, Savilahti E, Enattah NS, et al.: A genetic test which can be used to diagnose adult-type hypolactasia in children. Gut 53:1571\u20131576, 2004","journal-title":"Gut"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-005-3028-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10620-005-3028-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-005-3028-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T05:08:36Z","timestamp":1683263316000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10620-005-3028-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,11]]},"references-count":35,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2005,11]]}},"alternative-id":["3028"],"URL":"https:\/\/doi.org\/10.1007\/s10620-005-3028-4","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,11]]}}}