{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:22:33Z","timestamp":1762100553529},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2006,8,22]],"date-time":"2006-08-22T00:00:00Z","timestamp":1156204800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2006,9]]},"DOI":"10.1007\/s10620-005-9064-2","type":"journal-article","created":{"date-parts":[[2006,8,23]],"date-time":"2006-08-23T09:47:56Z","timestamp":1156326476000},"page":"1650-1657","source":"Crossref","is-referenced-by-count":9,"title":["A Ligand for Peroxisome Proliferator-Activated Receptor \u03b3 Inhibits Human Cholangiocarcinoma Cell Growth: Potential Molecular Targeting Strategy for Cholangioma"],"prefix":"10.1007","volume":"51","author":[{"given":"T.","family":"Kobuke","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Tazuma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Hyogo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Chayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2006,8,22]]},"reference":[{"key":"9064_CR1","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/0092-8674(94)90006-X","volume":"79","author":"P Tontonoz","year":"1994","unstructured":"Tontonoz P, Hu E, Spiegelman BM (1994) Stimulation of adipogenesis by PPAR\u03b32, a lipid-activated transcription factor. Cell 79:1147\u20131156","journal-title":"Cell"},{"key":"9064_CR2","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/0092-8674(95)90194-9","volume":"83","author":"SA Kliwer","year":"1995","unstructured":"Kliwer SA, Lenhard JM, Wilson TM, Patel I, Morris DC, Lehmann JM (1995) A prostaglandin J2 metabolite binds peroxisome proliferators-activated receptor \u03b3 and promotes adipocyte differentiation. Cell 83:813\u2013819","journal-title":"Cell"},{"key":"9064_CR3","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/0092-8674(95)90193-0","volume":"813","author":"BM Forman","year":"1995","unstructured":"Forman BM, Tontonoz P, Chen J (1995) 15-Deoxy-delta 12,14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma. Cell 813:803\u2013812","journal-title":"Cell"},{"key":"9064_CR4","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1006\/bbrc.1996.0832","volume":"222","author":"A Mansen","year":"1996","unstructured":"Mansen A, Guardiola-Diaz H, Rafter J, et\u00a0al. (1996) Expression of the peroxisome proliferators-activated receptor (PPAR) in the mouse colonic mucosa. Biochem Biophys Res Commun 222:844\u2013851","journal-title":"Biochem Biophys Res Commun"},{"key":"9064_CR5","doi-asserted-by":"crossref","first-page":"18779","DOI":"10.1074\/jbc.272.30.18779","volume":"272","author":"L Fajas","year":"1997","unstructured":"Fajas L, Auboef D, Raspe E, et\u00a0al. (1997) The organization, promoter analysis, and expression of the human PPARgamma gene. J Biol Chem 272:18779\u201318789","journal-title":"J Biol Chem"},{"key":"9064_CR6","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1016\/S0140-6736(02)11395-X","volume":"360","author":"L Dubuquoy","year":"2002","unstructured":"Dubuquoy L, Dharancy S, Nutten S, et\u00a0al. (2002) Role of peroxisome proliferators-activated receptor \u03b3 and retinoid X receptor heterodimer in hepatogastroenterological disease. Lancet 360:1410\u20131418","journal-title":"Lancet"},{"key":"9064_CR7","first-page":"3344","volume":"58","author":"T Kubota","year":"1998","unstructured":"Kubota T, Koshizuka K, Williamson EA, et\u00a0al. (1998) Ligand for peroxisome proliferators-activated receptor \u03b3 (troglitazone) has potent antitumor effect against human prostatic cancer both in vitro and in vivo. Cancer Res 58:3344\u20133352","journal-title":"Cancer Res"},{"key":"9064_CR8","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1002\/cncr.10906","volume":"95","author":"K Yoshizawa","year":"2002","unstructured":"Yoshizawa K, Cioca DP, Kawa S, Tanaka E, Kiyosawa K (2002) Peroxisome proliferators-activated receptor \u03b3 induces cell cycle arrest and apoptosis of hepatocellular carcinoma cell lines. Cancer 95:2243\u20132251","journal-title":"Cancer"},{"key":"9064_CR9","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1038\/2030","volume":"4","author":"P Sarraf","year":"1998","unstructured":"Sarraf P, Mueller E, Jones D, et\u00a0al. (1998) Differentiation and reversal of malignant changes in colon cancer through PPAR\u03b3. Nat Med 4:1046\u20131052","journal-title":"Nat Med"},{"key":"9064_CR10","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1016\/S0024-3205(01)01524-7","volume":"70","author":"M Toyota","year":"2002","unstructured":"Toyota M, Miyazaki Y, Kitamura S, et\u00a0al. (2002) Peroxisome proliferator-activated receptor gamma reduces the growth rate of pancreatic cancer cells through the reduction of cyclin D1. Life Sci 70:1565\u20131575","journal-title":"Life Sci"},{"key":"9064_CR11","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1006\/bbrc.2001.5619","volume":"287","author":"G Eibl","year":"2001","unstructured":"Eibl G, Wente MN, Reber HA, et\u00a0al. (2001) Peroxisome proliferators-activated receptor \u03b3 induces pancreatic cancer cell apoptosis. Biochem Biophys Res Commun 287:522\u2013529","journal-title":"Biochem Biophys Res Commun"},{"key":"9064_CR12","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1038\/sj.bjc.6601306","volume":"89","author":"G Debrock","year":"2003","unstructured":"Debrock G, Vanhentenrijk V, Sciot R, Debiec\u2013Rychter M, Oyen R, Van Oosterom A (2003) A phase II trial with rosiglitazone in liposarcoma patients. Br J Cancer 89:1409\u20131412","journal-title":"Br J Cancer"},{"key":"9064_CR13","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/j.1349-7006.1999.tb00668.x","volume":"90","author":"S Kitamura","year":"1999","unstructured":"Kitamura S, Miyazaki Y, Shimomura Y, et\u00a0al. (1999) Peroxisome proliferators-activated receptor \u03b3 induces growth arrest and differentiation of human colon cancer cells. Jpn J Cancer Res 90:75\u201380","journal-title":"Jpn J Cancer Res"},{"key":"9064_CR14","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1111\/j.1365-2443.2004.00793.x","volume":"11","author":"MA Rumi","year":"2004","unstructured":"Rumi MA, Ishihara S, Kadowaki Y, et\u00a0al. (2004) Peroxisome proliferators-activated receptor gamma\u2013dependent and \u2013independent growth inhibition of gastrointestinal tumor cells. Genes Cells 11:1113\u20131123","journal-title":"Genes Cells"},{"key":"9064_CR15","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/0092-8674(95)90385-2","volume":"81","author":"RA Weinberg","year":"1995","unstructured":"Weinberg RA (1995) The retinoblastoma protein and cell cycle control. Cell 81:323\u2013330","journal-title":"Cell"},{"key":"9064_CR16","doi-asserted-by":"crossref","first-page":"8022","DOI":"10.1073\/pnas.91.17.8022","volume":"91","author":"EA Musgrove","year":"1994","unstructured":"Musgrove EA, Lee CS, Buckley MF, Suthurland RL (1994) Cyclin D1 induction in breast cancer cells shortens G1 and is sufficient for cells arrested in G1 to complete the cell cycle. Proc Natl Acad Sci USA 91:8022\u20138026","journal-title":"Proc Natl Acad Sci USA"},{"key":"9064_CR17","doi-asserted-by":"crossref","first-page":"17088","DOI":"10.1074\/jbc.274.24.17088","volume":"274","author":"RF Morrison","year":"1999","unstructured":"Morrison RF, Farmer SR (1999) Role of PPARg in regulating a cascade expression of cyclin-dependent kinase inhibitors, p18 (INC4c) and p21 (Waf1\/Cip1), during adipogenesis. J Biol Chem 274:17088\u201317097","journal-title":"J Biol Chem"},{"key":"9064_CR18","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1002\/hep.510380503","volume":"38","author":"H Koga","year":"2003","unstructured":"Koga H, Sakisaka S, Harada M, et\u00a0al. (2003) Involvement of p21WAF\/Cip1, p27Kip1, and p18INC4c in troglitazone-induced cell-cycle arrest in human hepatoma cell lines. Hepatology 38:1087\u20131096","journal-title":"Hepatology"},{"key":"9064_CR19","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1053\/jhep.2003.50296","volume":"38","author":"C Han","year":"2003","unstructured":"Han C, Demetris AJ, Michalopoulus GK, et\u00a0al. (2003) PPAR\u03b3 ligands inhibit cholangiocarcinoma cell growth through p-53 dependent GADD45 and p21WAF\/Cip1 pathway. Hepatology 38:167\u2013177","journal-title":"Hepatology"},{"key":"9064_CR20","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1002\/cncr.10906","volume":"95","author":"K Yoshizawa","year":"2002","unstructured":"Yoshizawa K, Cioca DP, Kawa S, et\u00a0al. (2002) Peroxisome proliferator-activated receptor \u03b3 ligand troglitazone induces cell cycle arrest and apoptosis of hepatocellular carcinoma cell lines. Cancer 95:2243\u20132251","journal-title":"Cancer"},{"key":"9064_CR21","doi-asserted-by":"crossref","first-page":"8806","DOI":"10.1073\/pnas.95.15.8806","volume":"95","author":"E Elsmer","year":"1998","unstructured":"Elsmer E, Muller C, Koshizuka K, et\u00a0al. (1998) Ligands for peroxisome proliferator-activated receptor \u03b3 and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX mice. Proc Natl Acad Sci USA 95:8806\u20138811","journal-title":"Proc Natl Acad Sci USA"},{"key":"9064_CR22","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0014-5793(99)00871-6","volume":"16","author":"N Takahashi","year":"1999","unstructured":"Takahashi N, Okumura T, Motomura W, et\u00a0al. (1999) Activation of PPAR gamma inhibits cell growth and induces apoptosis in human gastric cancer cells. FEBS Lett 16:135\u2013139","journal-title":"FEBS Lett"},{"key":"9064_CR23","first-page":"465","volume":"19","author":"T Takahashi","year":"2001","unstructured":"Takahashi T, Fujiwara Y, Higuchi K, et\u00a0al. (2001) PPAR-gamma ligands inhibit growth of human esophageal adenocarcinoma cells through induction of apoptosis, cell cycle arrest and reduction of ornithine decarboxylase activity. Int J Oncol 19:465\u2013471","journal-title":"Int J Oncol"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-005-9064-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10620-005-9064-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-005-9064-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T19:35:42Z","timestamp":1559244942000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10620-005-9064-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8,22]]},"references-count":23,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["9064"],"URL":"https:\/\/doi.org\/10.1007\/s10620-005-9064-2","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,8,22]]}}}