{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:23:43Z","timestamp":1791393823832,"version":"4.3.3"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2006,8]]},"DOI":"10.1007\/s10620-006-9104-6","type":"journal-article","created":{"date-parts":[[2006,7,10]],"date-time":"2006-07-10T20:57:45Z","timestamp":1152565065000},"page":"1297-1301","source":"Crossref","is-referenced-by-count":125,"title":["Neomycin Improves Constipation-Predominant Irritable Bowel Syndrome in a Fashion That Is Dependent on the Presence of Methane Gas: Subanalysis of a Double-Blind Randomized Controlled Study"],"prefix":"10.1007","volume":"51","author":[{"given":"Mark","family":"Pimentel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soumya","family":"Chatterjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyn J.","family":"Chow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandy","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuthana","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"9104_CR1","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1136\/gut.42.1.42","volume":"42","author":"CP Bearcroft","year":"1998","unstructured":"Bearcroft CP, Perrett D, Farthing MJ (1998) Postprandial plasma 5-hydroxytryptamine in diarrhoea predominant irritable bowel syndrome: a pilot study. Gut 42:42\u201346.","journal-title":"Gut"},{"key":"9104_CR2","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1001\/archinte.161.14.1733","volume":"161","author":"M Camilleri","year":"2001","unstructured":"Camilleri M, Chey WY, Mayer EA, Northcutt AR, Heath A, Dukes GE, McSorley D, Mangel AM (2001) A randomized controlled clinical trial of the serotonin type 3 receptor antagonist alosetron in women with diarrhea-predominant irritable bowel syndrome. Arch Intern Med 161:1733\u20131740.","journal-title":"Arch Intern Med"},{"key":"9104_CR3","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/S0140-6736(00)02033-X","volume":"355","author":"M Camilleri","year":"2000","unstructured":"Camilleri M, Northcutt AR, Kong S, Dukes GE, McSorley D, Mangel AW (2000) Efficacy and safety of alosetron in women with irritable bowel syndrome: a randomised, placebo-controlled trial. Lancet 355:1035\u20131040.","journal-title":"Lancet"},{"key":"9104_CR4","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1046\/j.1365-2036.2001.01094.x","volume":"15","author":"SA Muller-Lissner","year":"2001","unstructured":"Muller-Lissner SA, Fumagalli I, Bardhan KD, Pace F, Pecher E, Nault B, Ruegg P (2001) Tegaserod, a 5-HT(4) receptor partial agonist, relieves symptoms in irritable bowel syndrome patients with abdominal pain, bloating and constipation. Aliment Pharm Therap 15:1655\u20131666.","journal-title":"Aliment Pharm Therap"},{"key":"9104_CR5","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1136\/bmj.314.7083.779","volume":"314","author":"KR Neal","year":"1997","unstructured":"Neal KR, Hebden J, Spiller R (1997) Prevalence of gastrointestinal symptoms six months after bacterial gastroenteritis and risk factors for development of the irritable bowel syndrome: postal survey of patients. Br Med J 314:779\u2013782.","journal-title":"Br Med J"},{"key":"9104_CR6","doi-asserted-by":"crossref","first-page":"3503","DOI":"10.1111\/j.1572-0241.2000.03368.x","volume":"95","author":"M Pimentel","year":"2000","unstructured":"Pimentel M, Chow EJ, Lin HC (2000) Eradication of small intestinal bacterial overgrowth reduces symptoms of irritable bowel syndrome. Am J Gastroenterol 95:3503\u20133506.","journal-title":"Am J Gastroenterol"},{"key":"9104_CR7","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1111\/j.1572-0241.2003.07946.x","volume":"98","author":"M Pimentel","year":"2003","unstructured":"Pimentel M, Chow EJ, Lin HC (2003) Normalization of lactulose breath testing correlates with symptom improvement in irritable bowel syndrome: A double-blind, randomized, placebo controlled study. Am J Gastroenterol 98:412\u2013419.","journal-title":"Am J Gastroenterol"},{"key":"9104_CR8","doi-asserted-by":"crossref","first-page":"A163","DOI":"10.1016\/S0016-5085(03)80815-6","volume":"124","author":"M Simren","year":"2003","unstructured":"Simren M, Ringstorm G, Agerforz P, et\u00a0al (2003) Small intestinal bacterial overgrowth is not of major importance in irritable bowel syndrome. Gastroenterol 124:A163","journal-title":"Gastroenterol"},{"key":"9104_CR9","doi-asserted-by":"crossref","first-page":"S271","DOI":"10.1111\/j.1572-0241.2003.08553.x","volume":"98","author":"KM Robson","year":"2003","unstructured":"Robson KM, Kakullavarapu J, Lembo T (2003) Bacterial overgrowth and irritable bowel syndrome: a look at prevalence, symptoms and quality of life. Am J Gastroenterol 98:S271","journal-title":"Am J Gastroenterol"},{"key":"9104_CR10","first-page":"II43","volume":"45","author":"WG Thompson","year":"1999","unstructured":"Thompson WG, Longstreth GF, Drossman DA, Heaton KW, Irvine EJ, Muller-Lissner SA (1999) Functional bowel disorders and functional abdominal pain. Gut 45:II43\u2013II47.","journal-title":"Gut"},{"key":"9104_CR11","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1136\/gut.31.3.300","volume":"31","author":"D Cloarec","year":"1990","unstructured":"Cloarec D, Bornet F, Gouilloud S, Barry JL, Salim B, Galmiche JP (1990) Breath hydrogen response to lactulose in healthy subjects: relationship to methane producing status. Gut 31:300\u2013304.","journal-title":"Gut"},{"key":"9104_CR12","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1023\/A:1021738515885","volume":"48","author":"M Pimentel","year":"2003","unstructured":"Pimentel M, Mayer AG, Park S, Chow EJ, Hasan A, Kong Y (2003) Methane production during lactulose breath test is associated with gastrointestinal disease presentation. Dig Dis Sci 48:86\u201392.","journal-title":"Dig Dis Sci"},{"key":"9104_CR13","first-page":"437","volume":"4","author":"HC Lin","year":"2002","unstructured":"Lin HC, Pimentel M, Chen JH (2002) Intestinal transit is slowed by luminal methane. Neurogastroenterol Motil 4:437.","journal-title":"Neurogastroenterol Motil"},{"key":"9104_CR14","volume-title":"Functional gastrointestinal disorders: Diagnosis, pathophysiology and treatment: A multinational consensus","author":"DA Drossman","year":"1994","unstructured":"Drossman DA, Richter JE, Talley NJ, et\u00a0al (eds) (1994) Functional gastrointestinal disorders: Diagnosis, pathophysiology and treatment: A multinational consensus. Little, Brown, Boston."},{"key":"9104_CR15","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1053\/j.gastro.2003.10.026","volume":"125","author":"M Pimentel","year":"2003","unstructured":"Pimentel M (2003) Lactulose breath testing, bacterial overgrowth and IBS: Just a lot of hot air? Gastroenterology 125:1898\u20131900.","journal-title":"Gastroenterology"},{"key":"9104_CR16","first-page":"II43","volume":"45","author":"WG Thompson","year":"1999","unstructured":"Thompson WG, Longstreth GF, Drossman DA, Heaton KW, Irvine EJ, Muller-Lissner SA (1999) Functional bowel disorders and functional abdominal pain. Gut 45:II43\u2013II47.","journal-title":"Gut"},{"key":"9104_CR17","volume-title":"Textbook of gastroenterology","author":"E Li","year":"1995","unstructured":"Li E (1995) Bacterial overgrowth. In: Yamada T, Alpers DH, Owyang C, Powell DW, Silverstein FE (eds) Textbook of gastroenterology. Lippincott, Philadelphia."},{"key":"9104_CR18","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1079\/BJN19860116","volume":"56","author":"AM Stephen","year":"1986","unstructured":"Stephen AM, Wiggins HS, Englyst HN, Cole TJ, Wayman BJ, Cummings JH (1986) The effect of age, sex and level of intake of dietary fibre from wheat on large-bowel function in thirty healthy subjects. Br J Nutr 56:349\u2013361.","journal-title":"Br J Nutr"},{"key":"9104_CR19","first-page":"A165","volume":"126","author":"M Pimentel","year":"2004","unstructured":"Pimentel M, Lee H-R, Zaidel O, van der Burg B, Park S, Conklin JL (2004) Methane gas induces prolonged duration and high amplitude contractile activity in the guinea pig ileum. Gastroenterol 126:A165.","journal-title":"Gastroenterol"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-006-9104-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10620-006-9104-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-006-9104-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T19:35:47Z","timestamp":1559244947000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10620-006-9104-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7,11]]},"references-count":19,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["9104"],"URL":"https:\/\/doi.org\/10.1007\/s10620-006-9104-6","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,7,11]]}}}