{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T17:35:08Z","timestamp":1770744908553,"version":"3.49.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2007,10,13]],"date-time":"2007-10-13T00:00:00Z","timestamp":1192233600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2008,5]]},"DOI":"10.1007\/s10620-007-0021-0","type":"journal-article","created":{"date-parts":[[2007,10,12]],"date-time":"2007-10-12T19:09:11Z","timestamp":1192216151000},"page":"1252-1256","source":"Crossref","is-referenced-by-count":45,"title":["Restless Legs Syndrome in Patients with Irritable Bowel Syndrome: Response to Small Intestinal Bacterial Overgrowth Therapy"],"prefix":"10.1007","volume":"53","author":[{"given":"Leonard B.","family":"Weinstock","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steve E.","family":"Fern","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen P.","family":"Duntley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2007,10,13]]},"reference":[{"key":"21_CR1","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1001\/archinte.165.11.1286","volume":"165","author":"RP Allen","year":"2005","unstructured":"Allen RP, Walters AS, Montplaisir J, Hening W, Myers A, Bell TJ, Ferini-Strambi L (2005) Restless legs syndrome prevalence and impact: REST general population study. Arch Intern Med 165:1286\u20131292","journal-title":"Arch Intern Med"},{"key":"21_CR2","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1001\/archinte.164.2.196","volume":"164","author":"K Berger","year":"2004","unstructured":"Berger K, Luedemann J, Trenkwalder C, John U, Kessler C (2004) Sex and the risk of restless legs syndrome in the general population. Arch Intern Med 164:196\u2013202","journal-title":"Arch Intern Med"},{"key":"21_CR3","first-page":"739","volume":"17","author":"GJ Lavigne","year":"1994","unstructured":"Lavigne GJ, Montplaisir JY (1994) Restless legs syndrome and sleep bruxism: prevalence and association among Canadians. Sleep 17:739\u2013743","journal-title":"Sleep"},{"key":"21_CR4","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.sleep.2004.01.012","volume":"5","author":"R Allen","year":"2004","unstructured":"Allen R (2004) Dopamine and iron in the pathophysiology of restless legs syndrome (RLS). Sleep Med 5:385\u2013391","journal-title":"Sleep Med"},{"key":"21_CR5","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.sleep.2004.01.014","volume":"5","author":"GL Gigli","year":"2004","unstructured":"Gigli GL, Adorati M, Dolso P, Piani A, Valente M, Brotini S, Budai R (2004) Restless legs syndrome in end-stage renal disease. Sleep Med 5:309\u2013315","journal-title":"Sleep Med"},{"key":"21_CR6","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1212\/WNL.47.6.1435","volume":"47","author":"W Ondo","year":"1996","unstructured":"Ondo W, Jankovic W (1996) Restless legs syndrome: clinicoetiologic correlates. Neurology 47:1435\u20131441","journal-title":"Neurology"},{"key":"21_CR7","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1212\/WNL.54.4.1013-a","volume":"54","author":"S Iannaccone","year":"2000","unstructured":"Iannaccone S, Quattrini A, Sferrazza B, Ferini-Strambi L (2000) Charcot\u2013Marie\u2013Tooth disease type 2 with restless legs syndrome. Neurology 54:1013\u20131014","journal-title":"Neurology"},{"key":"21_CR8","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1136\/bmj.312.7042.1339","volume":"312","author":"MB Yunus","year":"1996","unstructured":"Yunus MB, Aldag JC (1996) Restless legs syndrome and leg cramps in fibromyalgia syndrome: a controlled study. BMJ 312:1339","journal-title":"BMJ"},{"key":"21_CR9","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S1389-9457(02)00013-8","volume":"3","author":"GF Prado","year":"2002","unstructured":"Prado GF, Allen RP, Trevisani VMF, Toscano VG, Earley CJ (2002) Sleep disruption in systemic sclerosis (scleroderma) patients: clinical and polysomnographic findings. Sleep Med 3:341\u2013345","journal-title":"Sleep Med"},{"key":"21_CR10","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1093\/rheumatology\/30.3.220","volume":"30","author":"D Veale","year":"1991","unstructured":"Veale D, Kavanagh G, Fielding JF, Fitzgerald O (1991) Primary fibromyalgia and the irritable bowel syndrome: different expressions of a common pathogenetic process. Br J Rheumatol 30:220\u2013222","journal-title":"Br J Rheumatol"},{"key":"21_CR11","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s003840100299","volume":"16","author":"E Lubrano","year":"2001","unstructured":"Lubrano E, Iovino P, Tremolaterra F, Parsons WJ, Ciacci C, Mazzacca G (2001) Fibromyalgia in patients with irritable bowel syndrome. An association with the severity of the intestinal disorder. Int J Colorectal Dis 16:211\u2013215","journal-title":"Int J Colorectal Dis"},{"key":"21_CR12","doi-asserted-by":"crossref","first-page":"3541","DOI":"10.1111\/j.1572-0241.1999.01643.x","volume":"94","author":"AD Sperber","year":"1999","unstructured":"Sperber AD, Atzmon Y, Neumann L, Weisberg I, Shalit Y, Abu-Shakrah M, Fich A, Buskila D (1999) Fibromyalgia in the irritable bowel syndrome: studies of prevalence and clinical implications. Am J Gastroenterol 94:3541\u20133546","journal-title":"Am J Gastroenterol"},{"key":"21_CR13","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1111\/j.1572-0241.2003.07478.x","volume":"98","author":"L Chang","year":"2003","unstructured":"Chang L, Berman S, Mayer E, Suyenobu B, Derbyshire S, Naliboff B, Vogt B, FitzGerald L, Mandelkern MA (2003) Brain responses to visceral and somatic stimuli in patients with irritable bowel syndrome with and without fibromyalgia. Am J Gastroenterol 98:1354\u20131361","journal-title":"Am J Gastroenterol"},{"key":"21_CR14","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1136\/ard.2003.011502","volume":"63","author":"M Pimentel","year":"2004","unstructured":"Pimentel M, Wallace D, Hallegua D, Chow E, Kong Y, Park S, Lin HC (2004) A link between irritable bowel syndrome and fibromyalgia may be related to findings on lactulose breath testing. Ann Rheum Dis 63:450\u2013452","journal-title":"Ann Rheum Dis"},{"key":"21_CR15","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1001\/jama.292.7.852","volume":"292","author":"HC Lin","year":"2004","unstructured":"Lin HC (2004) Small intestinal bacterial overgrowth: a framework for understanding irritable bowel syndrome. JAMA 292:852\u2013858","journal-title":"JAMA"},{"key":"21_CR16","doi-asserted-by":"crossref","first-page":"2510","DOI":"10.1111\/j.1572-0241.2005.00257.x","volume":"100","author":"PPJ Veek van der","year":"2005","unstructured":"van der Veek PPJ, van den Berg M, de Kroon YE, Verspaget HW, Masclee AA (2005) Role of tumor necrosis factor-alpha and interleukin-10 gene polymorphisms in irritable bowel syndrome. Am J Gastroenterol 100:2510\u20132516","journal-title":"Am J Gastroenterol"},{"key":"21_CR17","doi-asserted-by":"crossref","first-page":"977","DOI":"10.3109\/00365529609003117","volume":"31","author":"SM Riordan","year":"1996","unstructured":"Riordan SM, McIver CJ, Wakefield D, Duncombe VM, Bolin TD, Thomas MC (1996) Mucosal cytokine production in small-intestinal bacterial overgrowth. Scand J Gastroenterol 31:977\u2013984","journal-title":"Scand J Gastroenterol"},{"key":"21_CR18","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1053\/j.gastro.2003.11.055","volume":"126","author":"G Barbara","year":"2004","unstructured":"Barbara G, Stanghellini V, de Giorgia R, Cremon C, Cottrell GS, Santini D, Pasquinelli G, Morselli-Labate AM, Grady EF, Bunnett NW, Collins SM, Corinaldesi R (2004) Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome. Gastroenterology 126:693\u2013702","journal-title":"Gastroenterology"},{"key":"21_CR19","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1053\/gast.2002.37059","volume":"123","author":"H T\u00f6rnblom","year":"2002","unstructured":"T\u00f6rnblom H, Lindberg G, Nyberg B, Veress B (2002) Full-thickness biopsy of the jejunum reveals inflammation and enteric neuropathy in irritable bowel syndrome. Gastroenterology 123:1972\u20131979","journal-title":"Gastroenterology"},{"key":"21_CR20","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1111\/j.1572-0241.2002.05664.x","volume":"97","author":"J Romagnuolo","year":"2002","unstructured":"Romagnuolo J, Schiller D, Bailey RJ (2002) Using breath tests wisely in a gastroenterology practice: an evidence-based review of indications and pitfalls in interpretation. Am J Gastroenterol 97:1113\u20131126","journal-title":"Am J Gastroenterol"},{"key":"21_CR21","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1111\/j.1365-2036.2005.02690.x","volume":"22","author":"A Lupascu","year":"2005","unstructured":"Lupascu A, Gabrielli M, Lauritano EC, Scarpellini E, Santoliquido A, Cammarota G, Flore R, Tondi P, Pola P, Gasbarrini G, Gasbarrini A (2005) Hydrogen glucose breath test to detect small intestinal bacterial overgrowth: a prevalence case-control study in irritable bowel syndrome. Aliment Pharmacol Ther 22:1157\u20131160","journal-title":"Aliment Pharmacol Ther"},{"key":"21_CR22","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1111\/j.1572-0241.2003.07946.x","volume":"98","author":"M Pimentel","year":"2003","unstructured":"Pimentel M, Chow EJ, Lin HC (2003) Normalization of lactulose breath testing correlates with symptom improvement in irritable bowel syndrome: a double-blind, randomized, placebo-controlled study. Am J Gastroenterol 98:412\u2013419","journal-title":"Am J Gastroenterol"},{"key":"21_CR23","doi-asserted-by":"crossref","first-page":"557","DOI":"10.7326\/0003-4819-145-8-200610170-00004","volume":"145","author":"M Pimentel","year":"2006","unstructured":"Pimentel M, Park S, Mirocha J, Kane JMSV, Kong Y (2006) The Effects of a nonabsorbed oral antibiotic (rifaximin) on the symptoms of irritable bowel syndrome. Ann Intern Med 145:557\u2013563","journal-title":"Ann Intern Med"},{"issue":"Suppl 2","key":"21_CR24","first-page":"S470","volume":"101","author":"LB Weinstock","year":"2006","unstructured":"Weinstock LB, Todorczuk JR, Fern SE, Thyssen EP (2006) Comprehensive small intestinal bacterial (SIBO) therapy for irritable bowel syndrome (IBS). Am J Gastroenterol 101(Suppl 2):S470\u2013S471","journal-title":"Am J Gastroenterol"},{"key":"21_CR25","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.1023\/A:1021039032413","volume":"47","author":"M Pimentel","year":"2002","unstructured":"Pimentel M, Soffer EE, Chow EJ, Kong Y, Lin HC (2002) Lower frequency of MMC is found in IBS subjects with abnormal lactulose breath test, suggesting bacterial overgrowth. Dig Dis Sci 47:2639\u20132643","journal-title":"Dig Dis Sci"},{"key":"21_CR26","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1172\/JCI108740","volume":"59","author":"G Vantrappen","year":"1977","unstructured":"Vantrappen G, Janssens J, Hellemans J, Ghoos Y (1977) The interdigestive motor complex of normal subjects and patients with bacterial overgrowth of the small intestine. J Clin Invest 59:1158\u20131166","journal-title":"J Clin Invest"},{"key":"21_CR27","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1111\/j.1572-0241.2006.00672.x","volume":"101","author":"SP Dunlop","year":"2006","unstructured":"Dunlop SP, Hebden J, Campbell E, Naesdal J, Olbe L, Perkins AC, Spiller RC (2006) Abnormal intestinal permeability in subgroups of diarrhea-predominant irritable bowel syndromes. Am J Gastroenterol 101:1288\u20131294","journal-title":"Am J Gastroenterol"},{"key":"21_CR28","first-page":"539","volume":"2","author":"MA Plaza","year":"2001","unstructured":"Plaza MA (2001) 5-Hydroxytryptamine and the gastrointestinal migrating motor complex. Curr Opin Investig Drugs 2:539\u2013544","journal-title":"Curr Opin Investig Drugs"},{"key":"21_CR29","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1067\/mlc.2002.123624","volume":"139","author":"GC Sturniolo","year":"2002","unstructured":"Sturniolo GC, Fries W, Mazzon E, Di Leo V, Barollo M, D\u2019inca R (2002) Effect of zinc supplementation on intestinal permeability in experimental colitis. J Lab Clin Med 139:311\u2013315","journal-title":"J Lab Clin Med"},{"issue":"Suppl 1","key":"21_CR30","doi-asserted-by":"crossref","first-page":"S78","DOI":"10.1053\/j.gastro.2005.11.046","volume":"130","author":"EM Quigley","year":"2006","unstructured":"Quigley EM, Quera R. (2006) Small intestinal bacterial overgrowth: roles of antibiotics, prebiotics, and probiotics. Gastroenterology 130(Suppl 1):S78\u2013S90","journal-title":"Gastroenterology"},{"key":"21_CR31","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S1389-9457(03)00006-6","volume":"4","author":"WA Hening","year":"2003","unstructured":"Hening WA, Allen RP, Thanner S, Washburn T, Heckler D, Walters AS, Earley CJ (2003) The Johns Hopkins telephone diagnostic interview for the restless legs syndrome: preliminary investigation for validation in a multi-center patient and control population. Sleep Med 4:137\u2013141","journal-title":"Sleep Med"},{"key":"21_CR32","doi-asserted-by":"crossref","first-page":"868","DOI":"10.7326\/0003-4819-134-9_Part_2-200105011-00011","volume":"134","author":"LA Aaron","year":"2001","unstructured":"Aaron LA, Buchwald D (2001) A review of the evidence for overlap among unexplained clinical conditions. Ann Intern Med 134:868\u2013881","journal-title":"Ann Intern Med"},{"key":"21_CR33","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1007\/s11916-004-0025-9","volume":"8","author":"G Blackburn-Munro","year":"2004","unstructured":"Blackburn-Munro G (2004) Hypothalamo\u2013pituitary\u2013adrenal axis dysfunction as a contributory factor to chronic pain and depression. Curr Pain Headache Rep 8:116\u2013124","journal-title":"Curr Pain Headache Rep"},{"key":"21_CR34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10253890310001650268","volume":"7","author":"SF Bomholt","year":"2004","unstructured":"Bomholt SF, Harbuz MS, Blackburn-Munro G (2004) Involvement and role of the hypothalamo\u2013pituitary\u2013adrenal (HPA) stress axis in animal models of chronic pain and inflammation. Stress 7:1\u201314","journal-title":"Stress"},{"key":"21_CR35","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1046\/j.1365-2826.2001.00684.x","volume":"13","author":"V Grinevich","year":"2001","unstructured":"Grinevich V, Ma X-M, Herman JP, Jezova D, Akmayev I, Aguilera G (2001) Effect of repeated lipopolysaccharide administration on tissue cytokine expression and hypothalamic-pituitary-adrenal axis activity in rats. J Neuroendocrinol 13:711\u2013723","journal-title":"J Neuroendocrinol"},{"key":"21_CR36","doi-asserted-by":"crossref","unstructured":"Pimentel M, Lin HC. Response to Dr. Parisi, et al. (2003) Am J Gastroenterol 98:2573\u20132574","DOI":"10.1016\/S0002-9270(03)01718-0"},{"key":"21_CR37","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1053\/j.gastro.2005.11.061","volume":"130","author":"GF Longstreth","year":"2006","unstructured":"Longstreth GF, Thompson WG, Chey WD, Houghton LA, Mearin F, Spiller RC (2006) Functional bowel disorders. Gastroenterology 130:1480\u20131491","journal-title":"Gastroenterology"},{"key":"21_CR38","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1111\/j.1365-2141.2005.05814.x","volume":"131","author":"KB Raja","year":"2005","unstructured":"Raja KB, Latunde-Dada GO, Peters TJ, McKie AT, Simpson RJ (2005) Role of interleukin-6 in hypoxic regulation of intestinal iron absorption. Br J Haematol 131:656\u2013662","journal-title":"Br J Haematol"},{"key":"21_CR39","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.bcmd.2005.04.006","volume":"35","author":"X-B Liu","year":"2005","unstructured":"Liu X-B, Nguyen N-BH, Marquess KD, Yang F, Haile DJ (2005) Regulation of hepcidin and ferroportin expression by lipopolysaccharide in splenic macrophages. Blood Cells Mol Dis 35:47\u201356","journal-title":"Blood Cells Mol Dis"},{"key":"21_CR40","unstructured":"Alpers DH, Klein S (2003) Approach to the patient requiring nutritional supplementation. In: Yamada T, Alpers DH, Laine L, et\u00a0al (eds) Textbook of gastroenterology, 2nd edn. Lippincott, Williams, & Wilkins, Philadelphia, pp 1056\u20131084"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-007-0021-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10620-007-0021-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-007-0021-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T19:43:38Z","timestamp":1559245418000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10620-007-0021-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10,13]]},"references-count":40,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,5]]}},"alternative-id":["21"],"URL":"https:\/\/doi.org\/10.1007\/s10620-007-0021-0","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,10,13]]}}}