{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:20:16Z","timestamp":1790806816318,"version":"4.1.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2007,10,12]],"date-time":"2007-10-12T00:00:00Z","timestamp":1192147200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2008,5]]},"DOI":"10.1007\/s10620-007-0022-z","type":"journal-article","created":{"date-parts":[[2007,10,11]],"date-time":"2007-10-11T20:59:24Z","timestamp":1192136364000},"page":"1246-1251","source":"Crossref","is-referenced-by-count":27,"title":["Small Intestinal Bacterial Overgrowth in Patients with Interstitial Cystitis and Gastrointestinal Symptoms"],"prefix":"10.1007","volume":"53","author":[{"given":"Leonard B.","family":"Weinstock","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl G.","family":"Klutke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry C.","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2007,10,12]]},"reference":[{"key":"22_CR1","doi-asserted-by":"crossref","unstructured":"Nickel JC (2004) Interstitial cystitis: a chronic pelvic pain syndrome. Med Clin North Am 88:467\u2013481","DOI":"10.1016\/S0025-7125(03)00151-2"},{"key":"22_CR2","volume-title":"Sex gender and pain","author":"M Giamberardino","year":"2000","unstructured":"Giamberardino M (2000) Sex-related and hormonal modulation of visceral pain. In: Fillingim R (ed) Sex gender and pain, vol 17. IASP Press, Seattle"},{"key":"22_CR3","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1001\/jama.292.7.852","volume":"292","author":"HC Lin","year":"2004","unstructured":"Lin HC (2004) Small intestinal bacterial overgrowth: a framework for understanding irritable bowel syndrome. JAMA 292:852\u2013858","journal-title":"JAMA"},{"key":"22_CR4","first-page":"105","volume":"6","author":"J Ritchie","year":"1973","unstructured":"Ritchie J (1973) Pain from distension of the pelvic colon by inflating a balloon in the irritable bowel syndrome. Gut 6:105\u2013112","journal-title":"Gut"},{"key":"22_CR5","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1002\/nau.20178","volume":"24","author":"MP Fitzgerald","year":"2005","unstructured":"Fitzgerald MP, Koch D, Senka J (2005) Visceral and cutaneous sensory testing in patients with painful bladder syndrome. Neurourol Urodyn 24:627\u2013632","journal-title":"Neurourol Urodyn"},{"key":"22_CR6","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1053\/gast.2002.37059","volume":"123","author":"H Tornblom","year":"2002","unstructured":"Tornblom H, Lindberg G, Nyberg B et al (2002) Full-thickness biopsy of the jejunum reveals inflammation and enteric neuropathy in irritable bowel syndrome. Gastroenterology 123:1972\u20131979","journal-title":"Gastroenterology"},{"key":"22_CR7","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1053\/j.gastro.2003.11.055","volume":"126","author":"G Barbara","year":"2004","unstructured":"Barbara G, Stanghellini V, De Giorgio R et al (2004) Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome. Gastroenterology 126:693\u2013702","journal-title":"Gastroenterology"},{"key":"22_CR8","first-page":"504","volume":"30","author":"YN Sun","year":"2005","unstructured":"Sun YN, Luo JY, Shang P et al (2005) Effects of N-methyl-d-aspartate receptor in visceral, hypersensitivity in rats with colonic inflammation. Zhong Nan Da Xue Xue Bao Yi Xue Ban 30:504\u2013509","journal-title":"Zhong Nan Da Xue Xue Bao Yi Xue Ban"},{"key":"22_CR9","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1097\/01.ju.0000146466.71311.ab","volume":"173","author":"DR Erickson","year":"2005","unstructured":"Erickson DR, Tomaszewski JE, Kunselman AR et al (2005) Do the National Institute of Diabetes and Digestive and Kidney Diseases cystoscopic criteria associate with other clinical and objective features of interstitial cystitis? J Urol 173:93\u201397","journal-title":"J Urol"},{"key":"22_CR10","first-page":"3505","volume":"95","author":"M Pimentel","year":"2000","unstructured":"Pimentel M, Chow EJ, Lin HC (2000) Eradication of small intestinal bacterial overgrowth reduces symptoms of irritable bowel syndrome. Am J Gastroenterol 95:3505\u20133506","journal-title":"Am J Gastroenterol"},{"key":"22_CR11","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1111\/j.1572-0241.2003.07946.x","volume":"98","author":"M Pimentel","year":"2003","unstructured":"Pimentel M, Chow EJ, Lin HC (2003) Normalization of lactulose breath testing correlates with symptom improvement in irritable bowel syndrome. A double-blind, randomized, placebo-controlled study. Am J Gastroenterol 98:412\u2013419","journal-title":"Am J Gastroenterol"},{"key":"22_CR12","doi-asserted-by":"crossref","first-page":"557","DOI":"10.7326\/0003-4819-145-8-200610170-00004","volume":"145","author":"M Pimentel","year":"2006","unstructured":"Pimentel M, Park S, Kane SV et al (2006) The effect of a nonabsorbed oral antibiotic (rifaximin) on the symptoms of the irritable bowel syndrome: a randomized trial. Ann Intern Med 145:557\u2013563","journal-title":"Ann Intern Med"},{"key":"22_CR13","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1111\/j.1572-0241.2006.00458.x","volume":"101","author":"AI Sharara","year":"2006","unstructured":"Sharara AI, Aoun E, Abdul-Baki H et al (2006) A randomized double-blind placebo-controlled trial of rifaximin in patients with abdominal bloating and flatulence. Am J Gastroenterol 101:326\u2013333","journal-title":"Am J Gastroenterol"},{"key":"22_CR14","first-page":"A1223","volume":"110","author":"HR Lee","year":"2006","unstructured":"Lee HR, Low K, Chatterjee S et al (2006) In the treatment of IBS, the clinical response to rifaximin is determined by the normalization of the lactulose breath test. Am J Gastroenterol 110:A1223","journal-title":"Am J Gastroenterol"},{"key":"22_CR15","doi-asserted-by":"crossref","first-page":"556","DOI":"10.3109\/00365529709025099","volume":"32","author":"SM Riordan","year":"1997","unstructured":"Riordan SM, McIver CJ, Thomas DH et al (1997) Luminal bacteria and small-intestinal permeability. Scand J Gastroenterol 32:556\u2013563","journal-title":"Scand J Gastroenterol"},{"key":"22_CR16","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1046\/j.1365-2362.1999.00364.x","volume":"29","author":"VB Nieuwenhuijs","year":"1999","unstructured":"Nieuwenhuijs VB, van Duijvenbode-Beumer H, Verheem A et al (1999) The effects of ABT-229 and octreotide on interdigestive small bowel motility, bacterial overgrowth and bacterial translocation in rats. Eur J Clin Invest 29:33\u201340","journal-title":"Eur J Clin Invest"},{"key":"22_CR17","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1136\/jcp.54.8.619","volume":"54","author":"NP Woodcock","year":"2001","unstructured":"Woodcock NP, Robertson J, Morgan DR et al (2001) Bacterial translocation and immunohistochemical measurement of gut immune function. J Clin Pathol 54:619\u2013623","journal-title":"J Clin Pathol"},{"key":"22_CR18","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0094-0143(21)00590-5","volume":"21","author":"GR Sant","year":"1994","unstructured":"Sant GR, Theoharides TC (1994) The role of the mast cell in interstitial cystitis. Urol Clin North Am 21:41\u201353","journal-title":"Urol Clin North Am"},{"key":"22_CR19","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1007\/BF01303164","volume":"38","author":"AP Weston","year":"1993","unstructured":"Weston AP, Biddle WL, Bhatia PS et al (1993) Terminal ileal mucosal mast cells in irritable bowel syndrome. Dig Dis Sci 38:1590\u20131595","journal-title":"Dig Dis Sci"},{"issue":"3","key":"22_CR20","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/S0090-4295(99)00162-4","volume":"54","author":"KM Peters","year":"1999","unstructured":"Peters KM, Diokno AC, Steinert BW (1999) Preliminary study on urinary cytokine levels in interstitial cystitis: does intravesical bacille Calmette-Guerin treat interstitial cystitis by altering the immune profile in the bladder? Urology 54(3):450\u2013453","journal-title":"Urology"},{"key":"22_CR21","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1111\/j.1572-0241.2006.00672.x","volume":"101","author":"SP Dunlap","year":"2006","unstructured":"Dunlap SP, Hebden J, Campbell E (2006) Abnormal intestinal permeability in subgroups of diarrhea-predominant irritable bowel syndromes. Am J Gastroenterol 101:1288\u20131294","journal-title":"Am J Gastroenterol"},{"key":"22_CR22","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1016\/S0022-5347(05)67520-9","volume":"163","author":"JM Warren","year":"2000","unstructured":"Warren JM, Horne LM, Hebel JR et al (2000) Pilot study of sequential oral antibiotics for the treatment of interstitial cystitis. J Urol 163:1685\u20131688","journal-title":"J Urol"},{"key":"22_CR23","first-page":"A105412","volume":"126","author":"M Stefano Di","year":"2003","unstructured":"Di Stefano M, Vos R, Janssens J et al (2003) Effect of tegaserod, a 5-HT4 receptor partial agonist, on interdigestive and postprandial gastrointestinal motility in healthy volunteers. Gastroenterology 126:A105412","journal-title":"Gastroenterology"},{"key":"22_CR24","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.1023\/A:1021039032413","volume":"47","author":"M Pimentel","year":"2002","unstructured":"Pimentel M, Soffer EE, Chow EJ, Kong Y, Lin HC (2002) Lower frequency of MMC is found in IBS subjects with abnormal lactulose breath test, suggesting bacterial overgrowth. Dig Dis Sci 47:2639\u20132643","journal-title":"Dig Dis Sci"},{"key":"22_CR25","first-page":"A1123","volume":"110","author":"LB Weinstock","year":"2006","unstructured":"Weinstock LB, Tordorczuk JT, Fern SE et al (2006) Comprehensive SIBO therapy of IBS patients. Am J Gastroenterol 110:A1123","journal-title":"Am J Gastroenterol"},{"key":"22_CR26","first-page":"A1124","volume":"110","author":"LB Weinstock","year":"2006","unstructured":"Weinstock LB, Tordorczuk JT, Fern SE et al (2006) Comprehensive SIBO therapy of functional bowel patients. Am J Gastroenterol 110:A1124","journal-title":"Am J Gastroenterol"},{"key":"22_CR27","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.jinf.2004.05.019","volume":"50","author":"DB Huang","year":"2005","unstructured":"Huang DB, DuPont HL (2005) Rifaximin \u2013 a novel antimicrobial for enteric infections. J Infect 50:97\u2013106","journal-title":"J Infect"},{"key":"22_CR28","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1023\/A:1018832117482","volume":"42","author":"A Minocha","year":"1997","unstructured":"Minocha A, Rashid S (1997) Reliability and reproducibility of breath hydrogen and methane in male diabetic subjects. Dig Dis Sci 42:672\u2013676","journal-title":"Dig Dis Sci"},{"key":"22_CR29","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1126\/science.1110591","volume":"308","author":"PB Eckburg","year":"2005","unstructured":"Eckburg PB, Bik EM, Bernstein CN et al (2005) Diversity of the human intestinal microbial flora. Science 308:1635\u20131638","journal-title":"Science"},{"key":"22_CR30","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1136\/gut.35.8.1098","volume":"35","author":"A Strocchi","year":"1994","unstructured":"Strocchi A, Furne J, Ellis C et al (1994) Methanogens outcompete sulphate reducing bacteria for H2 in the human colon. Gut 35:1098\u20131101","journal-title":"Gut"},{"key":"22_CR31","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1172\/JCI7712","volume":"104","author":"MD Levitt","year":"1999","unstructured":"Levitt MD, Furne J, Springfield J et al (1999) Detoxification of hydrogen sulfide and methanethiol in the cecal mucosa. J Clin Invest 104:1107\u20131114","journal-title":"J Clin Invest"},{"key":"22_CR32","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1158\/1541-7786.MCR-05-0126","volume":"4","author":"MS Attene-Ramos","year":"2006","unstructured":"Attene-Ramos MS, Wagner ED, Plewa MJ, Gaskins HR (2006) Evidence that hydrogen sulfide is a genotoxic agent. Mol Cancer Res 4:9\u201314","journal-title":"Mol Cancer Res"},{"key":"22_CR33","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.ejphar.2005.01.005","volume":"509","author":"R Patacchini","year":"2005","unstructured":"Patacchini R, Santicioli P, Giuliani S, Maggi CA (2005) Pharmacological investigation of hydrogen sulfide (H2S) contractile activity in rat detrusor muscle. Eur J Pharmacol 509:171\u2013177","journal-title":"Eur J Pharmacol"},{"key":"22_CR34","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/sj.bjp.0705764","volume":"142","author":"R Patacchini","year":"2004","unstructured":"Patacchini R, Santicioli P, Giuliani S, Maggi CA (2004) Hydrogen sulfide (H2S) stimulates capsaicin-sensitive primary afferent neurons in the rat urinary bladder. Br J Pharmacol 142:31\u201334","journal-title":"Br J Pharmacol"},{"key":"22_CR35","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1111\/j.1464-410X.1995.tb07840.x","volume":"76","author":"W Boucher","year":"1995","unstructured":"Boucher W, el-Mansoury M, Pang X, Sant GR, Theoharides TC (1995) Elevated mast cell tryptase in the urine of patients with interstitial cystitis. Br J Urol 76:94\u2013100","journal-title":"Br J Urol"},{"issue":"Pt B","key":"22_CR36","first-page":"713","volume":"539","author":"G Chiang","year":"2003","unstructured":"Chiang G, Patra P, Letourneau R, Jeudy S, Boucher W, Green M, Sant GR, Theoharides TC (2003) Pentosanpolysulfate (Elmiron) is a potent inhibitor of mast cell histamine secretion. Adv Exp Med Biol 539(Pt B):713\u2013729","journal-title":"Adv Exp Med Biol"},{"key":"22_CR37","doi-asserted-by":"crossref","first-page":"G781","DOI":"10.1152\/ajpgi.2000.279.4.G781","volume":"279","author":"AM Coelho","year":"2000","unstructured":"Coelho AM, Fioramonti J, Bueno L (2000) Systemic lipopolysaccharide influences rectal sensitivity in rats: role of mast cells, cytokines and vagus nerve. Am J Physiol Gastrointestinal Liver Physiol 279:G781\u2013G790","journal-title":"Am J Physiol Gastrointestinal Liver Physiol"},{"key":"22_CR38","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/j.1365-2982.2005.00685.x","volume":"18","author":"G Barbara","year":"2006","unstructured":"Barbara G, Stanghellini V, De Giorgio R et al (2006) Functional gastrointestinal disorders and mast cells: implications for therapy. Neurogastroenterol Motil 18:6\u201317","journal-title":"Neurogastroenterol Motil"},{"key":"22_CR39","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1053\/j.gastro.2005.03.008","volume":"128","author":"MA Pezzone","year":"2005","unstructured":"Pezzone MA, Liang R, Fraser MO (2005) A model of neural cross-talk and irritation in the pelvis: implications for the overlap of chronic pelvic pain disorders. Gastroenterology 128:1953\u20131954","journal-title":"Gastroenterology"},{"key":"22_CR40","first-page":"1","volume":"18","author":"TC Theoharides","year":"1996","unstructured":"Theoharides TC (1996) The mast cell: a neuroimmunoendocrine master player. Int J Tissue React 18:1\u201321","journal-title":"Int J Tissue React"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-007-0022-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10620-007-0022-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-007-0022-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T18:15:01Z","timestamp":1629915301000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10620-007-0022-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10,12]]},"references-count":40,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,5]]}},"alternative-id":["22"],"URL":"https:\/\/doi.org\/10.1007\/s10620-007-0022-z","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,10,12]]}}}