{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:41:18Z","timestamp":1777614078399,"version":"3.51.4"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2007,12,14]],"date-time":"2007-12-14T00:00:00Z","timestamp":1197590400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2008,7]]},"DOI":"10.1007\/s10620-007-0099-4","type":"journal-article","created":{"date-parts":[[2007,12,12]],"date-time":"2007-12-12T18:14:07Z","timestamp":1197483247000},"page":"1994-1999","source":"Crossref","is-referenced-by-count":29,"title":["Liver Transplantation in the Setting of Hepatocellular Carcinoma and Portal Vein Thrombosis: A Challenging Dilemma?"],"prefix":"10.1007","volume":"53","author":[{"given":"Georgios C.","family":"Sotiropoulos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnold","family":"Radtke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus J.","family":"Schmitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernesto P.","family":"Molmenti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Schroeder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuat H.","family":"Saner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideo A.","family":"Baba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioannis","family":"Fouzas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph E.","family":"Broelsch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Malag\u00f3","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hauke","family":"Lang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2007,12,14]]},"reference":[{"key":"99_CR1","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1056\/NEJM199603143341104","volume":"334","author":"V Mazzaferro","year":"1996","unstructured":"Mazzaferro V, Regalia E, Doci R et\u00a0al (1996) Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis. N Engl J Med 334:693\u2013699","journal-title":"N Engl J Med"},{"key":"99_CR2","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1002\/hep.510270616","volume":"27","author":"JM Llovet","year":"1998","unstructured":"Llovet JM, Bruix J, Fuster J et\u00a0al (1998) Liver transplantation for small hepatocellular carcinoma: the tumor-node-metastasis classification does not have prognostic power. Hepatology 27:1572\u20131577","journal-title":"Hepatology"},{"key":"99_CR3","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1055\/s-2007-1007120","volume":"19","author":"H Bismuth","year":"1999","unstructured":"Bismuth H, Majno PE, Adam R (1999) Liver transplantation for hepatocellular carcinoma. Semin Liver Dis 19:311\u2013322","journal-title":"Semin Liver Dis"},{"key":"99_CR4","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/j.1432-2277.2003.tb00272.x","volume":"16","author":"L Carlis De","year":"2003","unstructured":"De Carlis L, Giacomoni A, Lauterio A et\u00a0al (2003) Liver transplantation for hepatocellular cancer: should the current indication criteria be changed? Transpl Int 16:115\u2013122","journal-title":"Transpl Int"},{"key":"99_CR5","doi-asserted-by":"crossref","first-page":"S37","DOI":"10.1097\/01.TP.0000047029.02806.16","volume":"75","author":"S Kaihara","year":"2003","unstructured":"Kaihara S, Kiuchi T, Ueda M et\u00a0al (2003) Living-donor liver transplantation for hepatocellular carcinoma. Transplantation 75:S37\u2013S40","journal-title":"Transplantation"},{"key":"99_CR6","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1002\/lt.20677","volume":"12","author":"M Malago","year":"2006","unstructured":"Malago M, Sotiropoulos GC, Nadalin S et\u00a0al (2006) Living donor liver transplantation for hepatocellular carcinoma: a single-center preliminary report. Liver Transpl 12:934\u2013940","journal-title":"Liver Transpl"},{"key":"99_CR7","doi-asserted-by":"crossref","first-page":"S57","DOI":"10.1148\/rg.25si055505","volume":"25","author":"M Akahane","year":"2005","unstructured":"Akahane M, Koga H, Kato N et\u00a0al (2005) Complications of percutaneous radiofrequency ablation for hepatocellular carcinoma: imaging spectrum and management. Radiographics 25:S57\u2013S68","journal-title":"Radiographics"},{"key":"99_CR8","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/hep.510310213","volume":"31","author":"L Amitrano","year":"2000","unstructured":"Amitrano L, Brancaccio V, Guardascione MA et\u00a0al (2000) Inherited coagulation disorders in cirrhotic patients with portal vein thrombosis. Hepatology 31:345\u2013348","journal-title":"Hepatology"},{"key":"99_CR9","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1097\/01.TP.0000152801.82734.74","volume":"79","author":"GC Sotiropoulos","year":"2005","unstructured":"Sotiropoulos GC, Malago M, Molmenti E et\u00a0al (2005) Liver transplantation for hepatocellular carcinoma in cirrhosis: is clinical tumor classification before transplantation realistic? Transplantation 79:483\u2013487","journal-title":"Transplantation"},{"key":"99_CR10","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1097\/01.TP.0000173644.63692.DC","volume":"80","author":"GC Sotiropoulos","year":"2005","unstructured":"Sotiropoulos GC, Paul A, Molmenti E et\u00a0al (2005) Liver transplantation for hepatocellular carcinoma in cirrhosis within the Eurotransplant area: an additional option with \u201clivers that nobody wants\u201d. Transplantation 80:897\u2013902","journal-title":"Transplantation"},{"key":"99_CR11","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1097\/01.tp.0000229447.37333.ed","volume":"82","author":"GC Sotiropoulos","year":"2006","unstructured":"Sotiropoulos GC, Paul A, Gerling T et\u00a0al (2006) Liver transplantation with \u201crescue organ offers\u201d within the eurotransplant area: a 2-year report from the University Hospital Essen. Transplantation 82:304\u2013309","journal-title":"Transplantation"},{"key":"99_CR12","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/978-1-4757-3656-4","volume-title":"AJCC cancer staging manual","author":"FL Greene","year":"2002","unstructured":"Greene FL, Page DL, Fleming ID et\u00a0al (2002) AJCC cancer staging manual, 6th edn. Springer, New York, p 131","edition":"6th"},{"key":"99_CR13","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0168-8278(01)00130-1","volume":"35","author":"J Bruix","year":"2001","unstructured":"Bruix J, Sherman M, Llovet JM et\u00a0al (2001) Clinical management of hepatocellular carcinoma. Conclusions of the Barcelona-2000 EASL conference. European Association for the Study of the Liver. J Hepatol 35:421\u2013430","journal-title":"J Hepatol"},{"key":"99_CR14","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1002\/hep.1840160515","volume":"16","author":"T Nonami","year":"1992","unstructured":"Nonami T, Yokoyama I, Iwatsuki S, Starzl TE (1992) The incidence of portal vein thrombosis at liver transplantation. Hepatology 16:1195\u20131198","journal-title":"Hepatology"},{"key":"99_CR15","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1016\/S0041-1345(03)00599-2","volume":"35","author":"R Robles","year":"2003","unstructured":"Robles R, Fernandez JA, Hernandez Q et\u00a0al (2003) Eversion thromboendovenectomy for organized portal vein thrombosis encountered during liver transplantation. Transplant Proc 35:1915\u20131917","journal-title":"Transplant Proc"},{"key":"99_CR16","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S1072-7515(99)00299-9","volume":"190","author":"D Azoulay","year":"2000","unstructured":"Azoulay D, Hargreaves GM, Castaing D, Bismuth H (2000) Caval inflow to the graft: a successful way to overcome diffuse portal system thrombosis in liver transplantation. J Am Coll Surg 190:493\u2013496","journal-title":"J Am Coll Surg"},{"key":"99_CR17","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1016\/S0041-1345(01)02075-9","volume":"33","author":"J Norrby","year":"2001","unstructured":"Norrby J, Mjornstedt L, Liden H et\u00a0al (2001) Liver transplantation using cavoportal hemitransposition: a possibility in the presence of extensive portal vein thrombosis. Transplant Proc 33:2495\u20132496","journal-title":"Transplant Proc"},{"key":"99_CR18","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1111\/j.1399-0012.2006.00560.x","volume":"20","author":"M Paskonis","year":"2006","unstructured":"Paskonis M, Jurgaitis J, Mehrabi A et\u00a0al (2006) Surgical strategies for liver transplantation in the case of portal vein thrombosis\u2014current role of cavoportal hemitransposition and renoportal anastomosis. Clin Transplant 20:551\u2013562","journal-title":"Clin Transplant"},{"key":"99_CR19","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1007\/BF01659140","volume":"17","author":"D Cherqui","year":"1993","unstructured":"Cherqui D, Duvoux C, Rahmouni A et\u00a0al (1993) Orthotopic liver transplantation in the presence of partial or total portal vein thrombosis: problems in diagnosis and management. World J Surg 17:669\u2013674","journal-title":"World J Surg"},{"key":"99_CR20","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1034\/j.1600-6143.2002.21009.x","volume":"2","author":"J Dumortier","year":"2002","unstructured":"Dumortier J, Czyglik O, Poncet G et\u00a0al (2002) Eversion thrombectomy for portal vein thrombosis during liver transplantation. Am J Transplant 2:934\u2013938","journal-title":"Am J Transplant"},{"key":"99_CR21","first-page":"341","volume":"3","author":"X Xu","year":"2004","unstructured":"Xu X, Zheng SS, Liang TB et\u00a0al (2004) Orthotopic liver transplantation for patients with hepatocellular carcinoma complicated by portal vein tumor thrombi. Hepatobiliary Pancreat Dis Int 3:341\u2013344","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"99_CR22","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s00423-005-0552-9","volume":"390","author":"XP Chen","year":"2005","unstructured":"Chen XP, Huang ZY (2005) Surgical treatment of hepatocellular carcinoma in China: surgical techniques, indications, and outcomes. Langenbecks Arch Surg 390:259\u2013265","journal-title":"Langenbecks Arch Surg"},{"key":"99_CR23","first-page":"379","volume":"4","author":"FS Wu","year":"2005","unstructured":"Wu FS, Zhao WH, Liang TB et\u00a0al (2005) Survival factors after resection of small hepatocellular carcinoma. Hepatobiliary Pancreat Dis Int 4:379\u2013384","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"99_CR24","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3748\/wjg.v7.i1.28","volume":"7","author":"J Fan","year":"2001","unstructured":"Fan J, Wu ZQ, Tang ZY et\u00a0al (2001) Multimodality treatment in hepatocellular carcinoma patients with tumor thrombi in portal vein. World J Gastroenterol 7:28\u201332","journal-title":"World J Gastroenterol"},{"key":"99_CR25","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1001\/archsurg.135.11.1273","volume":"135","author":"CC Wu","year":"2000","unstructured":"Wu CC, Hsieh SR, Chen JT et\u00a0al (2000) An appraisal of liver and portal vein resection for hepatocellular carcinoma with tumor thrombi extending to portal bifurcation. Arch Surg 135:1273\u20131279","journal-title":"Arch Surg"},{"key":"99_CR26","doi-asserted-by":"crossref","first-page":"S64","DOI":"10.1002\/lt.20035","volume":"10","author":"L Capussotti","year":"2004","unstructured":"Capussotti L, Muratore A, Massucco P et\u00a0al (2004) Major liver resections for hepatocellular carcinoma on cirrhosis: early and long-term outcomes. Liver Transpl 10:S64\u2013S68","journal-title":"Liver Transpl"},{"key":"99_CR27","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1245\/ASO.2006.08.007","volume":"13","author":"XP Chen","year":"2006","unstructured":"Chen XP, Qiu FZ, Wu ZD et\u00a0al (2006) Effects of location and extension of portal vein tumor thrombus on long-term outcomes of surgical treatment for hepatocellular carcinoma. Ann Surg Oncol 13:940\u2013946","journal-title":"Ann Surg Oncol"},{"key":"99_CR28","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.jamcollsurg.2005.11.012","volume":"202","author":"I Ikai","year":"2006","unstructured":"Ikai I, Hatano E, Hasegawa S et\u00a0al (2006) Prognostic index for patients with hepatocellular carcinoma combined with tumor thrombosis in the major portal vein. J Am Coll Surg 202:431\u2013438","journal-title":"J Am Coll Surg"},{"key":"99_CR29","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.3748\/wjg.v11.i8.1215","volume":"11","author":"J Fan","year":"2005","unstructured":"Fan J, Zhou J, Wu ZQ et\u00a0al (2005) Efficacy of different treatment strategies for hepatocellular carcinoma with portal vein tumor thrombosis. World J Gastroenterol 11:1215\u20131219","journal-title":"World J Gastroenterol"},{"key":"99_CR30","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1002\/cncr.21237","volume":"104","author":"M Hata","year":"2005","unstructured":"Hata M, Tokuuye K, Sugahara S et\u00a0al (2005) Proton beam therapy for hepatocellular carcinoma with portal vein tumor thrombus. Cancer 104:794\u2013801","journal-title":"Cancer"},{"key":"99_CR31","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1002\/cncr.10694","volume":"95","author":"E Ando","year":"2002","unstructured":"Ando E, Tanaka M, Yamashita F et\u00a0al (2002) Hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma with portal vein tumor thrombosis: analysis of 48 cases. Cancer 95:588\u2013595","journal-title":"Cancer"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-007-0099-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10620-007-0099-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-007-0099-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T15:43:39Z","timestamp":1559231019000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10620-007-0099-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12,14]]},"references-count":31,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2008,7]]}},"alternative-id":["99"],"URL":"https:\/\/doi.org\/10.1007\/s10620-007-0099-4","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,12,14]]}}}