{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T12:48:43Z","timestamp":1770900523091,"version":"3.50.1"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2007,5,18]],"date-time":"2007-05-18T00:00:00Z","timestamp":1179446400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2008,1]]},"DOI":"10.1007\/s10620-007-9837-x","type":"journal-article","created":{"date-parts":[[2007,5,18]],"date-time":"2007-05-18T05:54:54Z","timestamp":1179467694000},"page":"155-162","source":"Crossref","is-referenced-by-count":6,"title":["Effects of Sibutramine on Gastric Emptying, Intestinal Motility and Rectal Tone in Dogs"],"prefix":"10.1007","volume":"53","author":[{"given":"Junying","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiande","family":"DZ Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2007,5,18]]},"reference":[{"key":"9837_CR1","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/35007508","volume":"404","author":"PG Kopelman","year":"2000","unstructured":"Kopelman PG (2000) Obesity as a medical problem. Nature 404:635\u2013643","journal-title":"Nature"},{"key":"9837_CR2","first-page":"50","volume":"20","author":"C McLoughlin","year":"2005","unstructured":"McLoughlin C (2005) Pharmacological treatments for obesity. Prof Nurse 20:50\u201351","journal-title":"Prof Nurse"},{"key":"9837_CR3","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1038\/sj.ijo.0802475","volume":"27","author":"R Padwal","year":"2003","unstructured":"Padwal R, Li SK, Lau DC (2003) Long-term pharmacotherapy for overweight and obesity: a systematic review and meta-analysis of randomized controlled trials. Int J Obes 27:1437\u20131446","journal-title":"Int J Obes"},{"key":"9837_CR4","doi-asserted-by":"crossref","first-page":"553S","DOI":"10.1002\/j.1550-8528.1995.tb00227.x","volume":"4","author":"DH Ryan","year":"1995","unstructured":"Ryan DH, Kaiser P, Bray GA (1995) Sibutramine: a novel new agent for obesity treatment. Obes Res 4:553S\u2013559S","journal-title":"Obes Res"},{"key":"9837_CR5","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1038\/sj.bjp.0704030","volume":"132","author":"M Brown","year":"2001","unstructured":"Brown M, Bing C, King P, Pickavance L, Heal D, Wilding J (2001) Sibutramine reduces feeding, body fat and improves insulin resistance in dietary-obese male Wister rats. Independently of hypothalamic neuropptid Y. Br J Pharmacol 132:1898\u20131940","journal-title":"Br J Pharmacol"},{"key":"9837_CR6","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/sj.ijo.0802298","volume":"27","author":"B Barkeling","year":"2003","unstructured":"Barkeling B, Elfhag K, Rooth P, Rossner S (2003) Short-term effects of sibutramine (Reductil) on appetite and eating behaviour and the long-term therapeutic outcome. Int J Obes 27:693\u2013700","journal-title":"Int J Obes"},{"key":"9837_CR7","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1080\/1028415031000094264","volume":"6","author":"A Casado","year":"2003","unstructured":"Casado A, Rodriguez M, Portillo MP et al (2003) Sibutramine decreases body weight gain and increases energy expenditure in obese Zucker rats without change in NPY and orexins. Nutr Neurosci 6:103\u2013111","journal-title":"Nutr Neurosci"},{"key":"9837_CR8","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1038\/sj.ijo.0801931","volume":"25","author":"ME Lean","year":"2001","unstructured":"Lean ME (2001) How does sibutramine work?. Int J Obes Suppl 25:S8\u2013S11","journal-title":"Int J Obes Suppl"},{"key":"9837_CR9","doi-asserted-by":"crossref","first-page":"201","DOI":"10.2174\/1389450053174550","volume":"6","author":"JC Halford","year":"2005","unstructured":"Halford JC, Harrold JA, Lawton CL, Blundell JE (2005) Serotonin (5-HT) drugs: effects on appetite expression and use for the treatment of obesity. Curr Drug Targets 6:201\u2013213","journal-title":"Curr Drug Targets"},{"key":"9837_CR10","first-page":"437","volume":"48","author":"GK Pal","year":"2004","unstructured":"Pal GK, Kannan N, Pal P (2004) Effects of injection of serotonin into nucleus caudatus on food and water intake and body weight in albino rats. Indian J Physiol Pharmacol 48:437\u2013445","journal-title":"Indian J Physiol Pharmacol"},{"key":"9837_CR11","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.physbeh.2004.02.012","volume":"81","author":"RC Ritter","year":"2004","unstructured":"Ritter RC (2004) Gastrointestinal mechanisms of satiation for food. Physiol Behav 81:249\u2013273","journal-title":"Physiol Behav"},{"key":"9837_CR12","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1111\/j.1365-2982.2004.00573.x","volume":"16","author":"D Grundy","year":"2004","unstructured":"Grundy D, Schumann M (2004) Serotonin in the gut: pretty when it gets down to the nitty gritty. Neurogastroenterol Motil 16:507\u2013509","journal-title":"Neurogastroenterol Motil"},{"key":"9837_CR13","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1038\/oby.2006.154","volume":"14","author":"JY Xu","year":"2006","unstructured":"Xu JY, Chen JDZ (2006) Peripheral mechanisms of sibutramine involving proximal gastric motility in dogs. Obes Res 14:1363\u20131370","journal-title":"Obes Res"},{"key":"9837_CR14","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1023\/A:1013726223531","volume":"47","author":"XH Xu","year":"2002","unstructured":"Xu XH, Wang ZS, Hayes J, Chen JDZ (2002) Is there a one-to-one correlation between gastric emptying of liquids and gastric myoelectrical or motor activity in dogs?. Dig Dis Sci 47:365\u2013372","journal-title":"Dig Dis Sci"},{"key":"9837_CR15","first-page":"345","volume":"7","author":"Z Abolfathi","year":"2004","unstructured":"Abolfathi Z, Conture J, Vallee F, LeBel M, Tanguay M, Masson E (2004) A pilot study to evaluate the pharmacokinetics of sibutramine in healthy subjects under fasting and fed conditions. J Pharm Pharmaceut Sci 7:345\u2013349","journal-title":"J Pharm Pharmaceut Sci"},{"key":"9837_CR16","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1038\/sj.bjp.0701311","volume":"121","author":"HC Jackson","year":"1997","unstructured":"Jackson HC, Bearham HC, Hutchins LJ, Mazurkiewicz SE, Needham AM, Heal DJ (1997) Investigation of the mechanisms underlying the hypophagic effects of the 5-HT and noradrenalin reuptake inhibitor, sibutramine, in the rat. Br J Pharmacol 121:1613\u20131618","journal-title":"Br J Pharmacol"},{"key":"9837_CR17","unstructured":"Chen JDZ, McCallum RW (1994) Electrogastrographic parameters and their clinical significance. In: Chen JDZ, McCallum RW (eds) The electrogastrography: principles and clinical applications. New York, Raven, pp 45\u201373"},{"key":"9837_CR18","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1023\/A:1013726223531","volume":"47","author":"XH Xu","year":"2002","unstructured":"Xu XH, Wang ZS, Hayes J, Chen JDZ (2002) Is there a one-to-one correlation between gastric emptying of liquids and gastric myoelectrical or motor activity in dogs?. Dig Dis Sci 47:365\u2013372","journal-title":"Dig Dis Sci"},{"key":"9837_CR19","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1023\/A:1005466904380","volume":"45","author":"X Lin","year":"2000","unstructured":"Lin X, Peters LJ, Hayes J, Chen JD (2000) Entrainment of segmental small intestinal slow waves with electrical stimulation in dogs. Dig Dis Sci 45:652\u2013656","journal-title":"Dig Dis Sci"},{"key":"9837_CR20","doi-asserted-by":"crossref","first-page":"G1195","DOI":"10.1152\/ajpgi.00554.2004","volume":"288","author":"S Liu","year":"2005","unstructured":"Liu S, Wang L, Chen JD (2005) Cross-talk along gastrointestinal tract during electrical stimulation: effects and mechanisms of gastric\/colonic stimulation on rectal tone in dogs. Am J Physiol Gastrointest Liver Physiol 288:G1195\u2013G1198","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"9837_CR21","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1023\/A:1018885028501","volume":"42","author":"WE Whitehead","year":"1997","unstructured":"Whitehead WE, Delvaux M (1997) Standardization of barostat procedures for testing smooth muscle tone and sensory thresholds in the gastrointestinal. Dig Dis Sci 42:223\u2013241","journal-title":"Dig Dis Sci"},{"key":"9837_CR22","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/S0095-4543(03)00005-8","volume":"30","author":"DH Ryan","year":"2003","unstructured":"Ryan DH (2003) Use of sibutramine to treat obesity. Prim Care 30:405\u2013426","journal-title":"Prim Care"},{"key":"9837_CR23","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/oby.2003.85","volume":"11","author":"JE Mitchell","year":"2003","unstructured":"Mitchell JE, Gosnell BA, Roerig JL et al (2003) Effects of sibutramine on binge eating, hunger, and fullness in a laboratory human feeding paradigm. Obes Res 11:599\u2013602","journal-title":"Obes Res"},{"key":"9837_CR24","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0031-9384(99)00176-6","volume":"68","author":"D Chapelot","year":"2000","unstructured":"Chapelot D, Marmonier C, Thomas T, Hanotin C (2000) Modalities of the food intake-reducing effect of sibutramine in humans. Physiol Behav 68:299\u2013308","journal-title":"Physiol Behav"},{"key":"9837_CR25","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1038\/oby.2004.213","volume":"12","author":"JH Xing","year":"2004","unstructured":"Xing JH, Chen JDZ (2004) Alteration of gastrointestinal motility in obesity. Obes Res 12:1723\u20131732","journal-title":"Obes Res"},{"key":"9837_CR26","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1006\/appe.2001.0397","volume":"36","author":"JE Cecil","year":"2001","unstructured":"Cecil JE (2001) Oral, gastric and intestinal influences on the control of appetite and feeding in human. Appetite 36:235\u2013236","journal-title":"Appetite"},{"key":"9837_CR27","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.physbeh.2004.07.031","volume":"83","author":"C Beglinger","year":"2004","unstructured":"Beglinger C, Degen L (2004) Fat in the intestine as a regulator of appetite\u2014role of CCK. Physiol Behav 83:617\u2013621","journal-title":"Physiol Behav"},{"key":"9837_CR28","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1053\/j.gastro.2004.10.043","volume":"128","author":"AD Strader","year":"2005","unstructured":"Strader AD, Woods SC (2005) Gastrointestinal hormones and food intake. Gastroenterology 128:175\u2013191","journal-title":"Gastroenterology"},{"key":"9837_CR29","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1053\/j.gastro.2004.09.006","volume":"127","author":"S Delgado-aros","year":"2004","unstructured":"Delgado-aros S, Camilleri M, Cremonini F, Ferber I, Stephens D, Burton DD (2004) Contributions of gastric volumes and gastric emptying to meal size and postmeal symptom in functional dyspepsia. Gastroenterology 127:1685\u20131694","journal-title":"Gastroenterology"},{"key":"9837_CR30","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/0016-5085(88)90428-3","volume":"94","author":"IM Welch","year":"1988","unstructured":"Welch IM, Cunningham KM, Read NW (1988) Regulation of gastric emptying by ileal nutrients in humans. Gastroenterology 94:401\u2013404","journal-title":"Gastroenterology"},{"key":"9837_CR31","doi-asserted-by":"crossref","first-page":"689S","DOI":"10.1002\/j.1550-8528.1995.tb00487.x","volume":"3","author":"P Tso","year":"1995","unstructured":"Tso P, Chen Q, Fujimoto K, Fukagawa K, Sakata T (1995) Apolipoprotein A-IV: a circulating satiety signal produced by the small intestine. Obes Res 3:689S\u2013695S","journal-title":"Obes Res"},{"key":"9837_CR32","first-page":"R1308","volume":"275","author":"JH Meyer","year":"1998","unstructured":"Meyer JH, Tabrizi Y, DiMaso N, Hlinka M, Raybould HE (1998) Length of intestinal contact on nutrient-driven satiety. Am J Physiol 275:R1308\u2013R1319","journal-title":"Am J Physiol"},{"key":"9837_CR33","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1037\/h0082376","volume":"25","author":"GK Ehman","year":"1971","unstructured":"Ehman GK, Albert DJ, Jamiesson JL (1971) Injections into the duodenum and the induction of satiety in the rat. Can J Psychol 25:147\u2013166","journal-title":"Can J Psychol"},{"key":"9837_CR34","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1136\/gut.29.3.306","volume":"29","author":"IM Welch","year":"1988","unstructured":"Welch IM, Sepple CP, Read NW (1988) Comparisons of the effects on satiety and eating behavior of infusion of lipid into the different regions of the small intestine. Gut 29:306\u2013311","journal-title":"Gut"},{"key":"9837_CR35","first-page":"R569","volume":"255","author":"DP Yox","year":"1988","unstructured":"Yox DP, Ritter RC (1988) Capsaicin attenuates suppression of sham feeding induced by intestinal nutrients. Am J Physiol 255:R569\u2013R574","journal-title":"Am J Physiol"},{"key":"9837_CR36","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1046\/j.1365-2982.2002.00332.x","volume":"14","author":"J Steens","year":"2002","unstructured":"Steens J, Van Der Schaar PJ, Penning C, Brussee J, Masclee AA (2002) Compliance, tone and sensitivity of the rectum in different subtypes of irritable bowel syndrome. Neurogastroenterol Motil 14:241\u2013247","journal-title":"Neurogastroenterol Motil"},{"key":"9837_CR37","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1111\/j.1463-1318.2004.00632.x","volume":"6","author":"U Karlbom","year":"2004","unstructured":"Karlbom U, Lundin E, Graf W, Pahlman L (2004) Anorectal physiology in relation to clinical subgroups of patients with severe constipation. Colorectal Dis 6:343\u2013349","journal-title":"Colorectal Dis"},{"key":"9837_CR38","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/j.1365-2036.2004.01848.x","volume":"19","author":"M Fox","year":"2004","unstructured":"Fox M, Thumshirn M, Menne D, Stutz B, Fried M, Schwizer M (2004) The pathophysiology of faecal spotting in obese subjects during treatment with orlistat. Aliment Pharmacol Ther 19:311\u2013321","journal-title":"Aliment Pharmacol Ther"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-007-9837-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10620-007-9837-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-007-9837-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T19:43:44Z","timestamp":1559245424000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10620-007-9837-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5,18]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["9837"],"URL":"https:\/\/doi.org\/10.1007\/s10620-007-9837-x","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,5,18]]}}}