{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T22:23:36Z","timestamp":1770503016963,"version":"3.49.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2008,4,26]],"date-time":"2008-04-26T00:00:00Z","timestamp":1209168000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2008,12]]},"DOI":"10.1007\/s10620-008-0270-6","type":"journal-article","created":{"date-parts":[[2008,4,25]],"date-time":"2008-04-25T14:03:24Z","timestamp":1209132204000},"page":"3076-3081","source":"Crossref","is-referenced-by-count":39,"title":["NERD, GERD, and Barrett\u2019s Esophagus: Role of Acid and Non-acid Reflux Revisited with Combined pH-Impedance Monitoring"],"prefix":"10.1007","volume":"53","author":[{"given":"Christian A.","family":"Gutschow","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Bludau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Vallb\u00f6hmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Schr\u00f6der","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elfriede","family":"Bollschweiler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnulf H.","family":"H\u00f6lscher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2008,4,26]]},"reference":[{"key":"270_CR1","first-page":"764","volume":"106","author":"SEA Attwood","year":"1989","unstructured":"Attwood SEA, DeMeester TR, Bremner CG, Barlow AP, Hinder RA (1989) Alkaline gastroesophageal reflux: implications in the development of complications in Barrett\u2019s columnar-lined lower esophagus. Surgery 106:764\u2013776","journal-title":"Surgery"},{"key":"270_CR2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1136\/gut.34.1.11","volume":"34","author":"SEA Attwood","year":"1993","unstructured":"Attwood SEA, Ball CS, Barlow AP, Jenkinson L, Norris TL, Watson A (1993) Role of intragastric and intraesophageal alkalinization in the genesis of complications in Barrett\u2019s columnar lined lower oesophagus. Gut 34:11\u201315. doi: 10.1136\/gut.34.1.11","journal-title":"Gut"},{"key":"270_CR3","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1136\/gut.34.3.309","volume":"34","author":"S Singh","year":"1993","unstructured":"Singh S, Bradley LA, Richter JE (1993) Determinants of oesophageal \u201calkaline\u201d pH environment in controls and patients with gastro-oesophageal reflux disease. Gut 34:309\u2013316. doi: 10.1136\/gut.34.3.309","journal-title":"Gut"},{"key":"270_CR4","first-page":"1040","volume":"88","author":"KR Devault","year":"1993","unstructured":"Devault KR, Georgeson S, Castell DO (1993) Salivary stimulation mimics esophageal exposure to refluxed duodenal contents. Am J Gastroenterol 88:1040\u20131043","journal-title":"Am J Gastroenterol"},{"key":"270_CR5","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1007\/BF01296082","volume":"38","author":"P Bechi","year":"1993","unstructured":"Bechi P, Pucciani F, Baldini F, Cosi F, Falciai R, Mazzanti R, Castagnoli A, Passeri A, Boscherini S (1993) Long-term ambulatory enterogastric reflux monitoring. Validation of a new fiberoptic technique. Dig Dis Sci 38:1297\u20131306. doi: 10.1007\/BF01296082","journal-title":"Dig Dis Sci"},{"key":"270_CR6","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1097\/00000658-199522240-00010","volume":"222","author":"WKH Kauer","year":"1995","unstructured":"Kauer WKH, Peters JH, DeMeester TR, Ireland AP, Bremner CG, Hagen JA (1995) Mixed reflux of gastric and duodenal juice is more harmful to the esophagus than gastric juice alone. The need for surgical therapy re-emphazised. Ann Surg 222:525\u2013531","journal-title":"Ann Surg"},{"key":"270_CR7","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s11605-006-0006-x","volume":"1","author":"M Fein","year":"1997","unstructured":"Fein M, Ireland AP, Ritter MP, Peters JH, Hagen JA, Bremner CG, DeMeester TR (1997) Duodenogastric reflux potentiates the injurious effects of gastroesophageal reflux. J Gastrointest Surg 1:27\u201333","journal-title":"J Gastrointest Surg"},{"key":"270_CR8","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.1572-0241.2006.00966.x","volume":"102","author":"AJ Bredenoord","year":"2007","unstructured":"Bredenoord AJ, Tutuian R, Smout AJ, Castell DO (2007) Technology review: Esophageal impedance monitoring. Am J Gastroenterol 102:187\u2013194. doi: 10.1111\/j.1572-0241.2006.00966.x","journal-title":"Am J Gastroenterol"},{"key":"270_CR9","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/978-3-642-60372-3_2","volume-title":"Gastrointestinale Funktionsst\u00f6rungen","author":"SM Freys","year":"1997","unstructured":"Freys SM (1997) Station\u00e4re \u00d6sophagusmanometrie. In: Fuchs K, Stein HJ, Thiede A (eds) Gastrointestinale Funktionsst\u00f6rungen. Springer, Berlin, pp 24\u201346"},{"key":"270_CR10","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.cgh.2007.10.006","volume":"6","author":"JA Abrams","year":"2008","unstructured":"Abrams JA, Fields S, Lightdale CJ, Neugut AI (2008) Racial and ethnic disparities in the prevalence of Barrett\u2019s esophagus among patients who undergo upper endoscopy. Clin Gastroenterol Hepatol 6:30\u201334. doi: 10.1016\/j.cgh.2007.10.006","journal-title":"Clin Gastroenterol Hepatol"},{"key":"270_CR11","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1053\/j.gastro.2007.05.026","volume":"133","author":"ZR Edelstein","year":"2007","unstructured":"Edelstein ZR, Farrow DC, Bronner MP, Rosen SN, Vaughan TL (2007) Central adiposity and risk of Barrett\u2019s esophagus. Gastroenterology 133:403\u2013411. doi: 10.1053\/j.gastro.2007.05.026","journal-title":"Gastroenterology"},{"key":"270_CR12","first-page":"1","volume-title":"Barrett\u2019s esophagus","author":"A Watson","year":"2003","unstructured":"Watson A, Sampliner RE, Appelman HD, Spechler SJ, Shepherd NA (2003) Consensus of a panel at the end of the 6th OESO World Congress. In: Siewert JR, Couturier D, Scarpignato C (eds) Barrett\u2019s esophagus. John Libbey, Paris, pp 1\u20134"},{"key":"270_CR13","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1159\/000171554","volume":"14","author":"GW Clark","year":"1996","unstructured":"Clark GW, Ireland AP, DeMeester TR (1996) Dysplasia in Barrett\u2019s esophagus: diagnosis, surveillance and treatment [review]. Dig Dis 14:213\u2013227","journal-title":"Dig Dis"},{"key":"270_CR14","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0022-5223(19)33854-1","volume":"105","author":"HJ Stein","year":"1993","unstructured":"Stein HJ, Hoeft S, DeMeester TR (1993) Functional foregut abnormalities in Barrett\u2019s esophagus. J Thorac Cardiovasc Surg 105:107\u2013111","journal-title":"J Thorac Cardiovasc Surg"},{"key":"270_CR15","first-page":"349","volume":"89","author":"P Singh","year":"1994","unstructured":"Singh P, Taylor RH, Colin-Jones DG (1994) Esophageal motor dysfunction and acid exposure in reflux esophagitis are more severe if Barrett\u2019s metaplasia is present. Am J Gastroenterol 89:349\u2013356","journal-title":"Am J Gastroenterol"},{"key":"270_CR16","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/S0022-5223(99)70337-5","volume":"117","author":"S \u00d6berg","year":"1999","unstructured":"\u00d6berg S, DeMeester TR, Peters JH, Hagen JA, Nigro JJ, DeMeester SR, Theisen J, Campos GM, Crookes GF (1999) The extent of Barrett\u2019s esophagus depends on the status of the lower esophageal sphincter and the degree of esophageal acid exposure. J Thorac Cardiovasc Surg 117:572\u2013580. doi: 10.1016\/S0022-5223(99)70337-5","journal-title":"J Thorac Cardiovasc Surg"},{"key":"270_CR17","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1111\/j.1572-0241.1998.00331.x","volume":"93","author":"M Coenraad","year":"1998","unstructured":"Coenraad M, Masclee AA, Straathof JW, Ganesh S, Griffioen G, Lamers CB (1998) Is Barrett\u2019s esophagus characterized by more pronounced acid reflux than esophagitis? Am J Gastroenterol 93:1068\u20131072. doi: 10.1111\/j.1572-0241.1998.00331.x","journal-title":"Am J Gastroenterol"},{"key":"270_CR18","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1097\/00000658-199010000-00015","volume":"212","author":"TR DeMeester","year":"1990","unstructured":"DeMeester TR, Attwood SEA, Smyrk TC, Therkildsen DH, Hinder RA (1990) Surgical therapy in Barrett\u2019s esophagus. Ann Surg 212:528\u2013542. doi: 10.1097\/00000658-199010000-00015","journal-title":"Ann Surg"},{"key":"270_CR19","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1053\/gast.1996.v111.pm8898632","volume":"111","author":"MF Vaezi","year":"1996","unstructured":"Vaezi MF, Richter JE (1996) Role of acid and duodenogastric reflux in gastroesophageal reflux disease. Gastroenterology 111:1192\u20131199. doi: 10.1053\/gast.1996.v111.pm8898632","journal-title":"Gastroenterology"},{"key":"270_CR20","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1097\/00000658-200003000-00003","volume":"231","author":"SR DeMeester","year":"2000","unstructured":"DeMeester SR, DeMeester TR (2000) Columnar mucosa and intestinal metaplasia of the esophagus: fifty years of controversy. Ann Surg 231:303\u2013321. doi: 10.1097\/00000658-200003000-00003","journal-title":"Ann Surg"},{"key":"270_CR21","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/0016-5085(94)90123-6","volume":"107","author":"G Champion","year":"1994","unstructured":"Champion G, Richter JE, Vaezi MF, Singh S, Alexander R (1994) Duodenogastric reflux: relationship to pH and importance in Barrett\u2019s esophagus. Gastroenterology 107:747\u2013754","journal-title":"Gastroenterology"},{"key":"270_CR22","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/S0039-6060(95)80015-8","volume":"117","author":"MF Vaezi","year":"1995","unstructured":"Vaezi MF, Richter JE (1995) Synergism of acid and duodenogastroesophageal reflux in complicated Barrett\u2019s esophagus. Surgery 117:699\u2013704. doi: 10.1016\/S0039-6060(95)80015-8","journal-title":"Surgery"},{"key":"270_CR23","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1002\/bjs.1800820528","volume":"82","author":"MTP Caldwell","year":"1995","unstructured":"Caldwell MTP, Lawlor P, Byrne PJ, Walsh TN, Hennessy TP (1995) Ambulatory oesophageal bile reflux monitoring in Barrett\u2019s esophagus. Br J Surg 82:657\u2013660. doi: 10.1002\/bjs.1800820528","journal-title":"Br J Surg"},{"key":"270_CR24","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1097\/00004836-199201000-00002","volume":"14","author":"DC Gotley","year":"1992","unstructured":"Gotley DC, Appleton GVN, Cooper MJ (1992) Bile acids and trypsin are unimportant in alkaline esophageal reflux. J Clin Gastroenterol 14:2\u20137. doi: 10.1097\/00004836-199201000-00002","journal-title":"J Clin Gastroenterol"},{"key":"270_CR25","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1007\/BF01537239","volume":"35","author":"S Mattioli","year":"1990","unstructured":"Mattioli S, Pilotti V, Felice V, Lazzari A, Zannoli R, Bacchi ML, Loria P, Tripodi A, Gozzetti G (1990) Ambulatory 24\u00a0hour pH monitoring of the esophagus, fundus and antrum. Dig Dis Sci 35:929\u2013938. doi: 10.1007\/BF01537239","journal-title":"Dig Dis Sci"},{"key":"270_CR26","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1046\/j.1442-2050.2002.00218.x","volume":"15","author":"CA Gutschow","year":"2002","unstructured":"Gutschow CA, Schr\u00f6der W, H\u00f6lscher AH (2002) Barrett\u2019s esophagus: what is the poison\u2014alkaline, biliary or acidic reflux? Dis Esophagus 15:5\u20139. doi: 10.1046\/j.1442-2050.2002.00218.x","journal-title":"Dis Esophagus"},{"key":"270_CR27","doi-asserted-by":"crossref","unstructured":"van Herwaarden MA, Samsom M, Smout AJ (1999) 24-h recording of intragastric pH: technical aspects and clinical relevance. Scand J Gastroenterol Suppl 230:9\u201316","DOI":"10.1080\/003655299750025480"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-008-0270-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10620-008-0270-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-008-0270-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,4]],"date-time":"2020-05-04T19:44:58Z","timestamp":1588621498000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10620-008-0270-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4,26]]},"references-count":27,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["270"],"URL":"https:\/\/doi.org\/10.1007\/s10620-008-0270-6","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,4,26]]}}}