{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:22:44Z","timestamp":1791285764945,"version":"4.1.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2008,10,31]],"date-time":"2008-10-31T00:00:00Z","timestamp":1225411200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2009,7]]},"DOI":"10.1007\/s10620-008-0514-5","type":"journal-article","created":{"date-parts":[[2008,10,30]],"date-time":"2008-10-30T17:56:20Z","timestamp":1225389380000},"page":"1525-1531","source":"Crossref","is-referenced-by-count":64,"title":["Correlation of Serum-Soluble Triggering Receptor Expressed on Myeloid Cells-1 with Clinical Disease Activity in Inflammatory Bowel Disease"],"prefix":"10.1007","volume":"54","author":[{"given":"Jae Jun","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Hee","family":"Cheon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo Young","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duk Hwan","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Soo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Il","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoung Ryul","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won Ho","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,10,31]]},"reference":[{"key":"514_CR1","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1136\/gut.26.2.158","volume":"26","author":"C Hendriksen","year":"1985","unstructured":"Hendriksen C, Kreiner S, Binder V. Long term prognosis in ulcerative colitis\u2014based on results from a regional patient group from the county of Copenhagen. Gut. 1985;26:158\u2013163. doi: 10.1136\/gut.26.2.158 .","journal-title":"Gut"},{"key":"514_CR2","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1136\/gut.28.10.1261","volume":"28","author":"CM Stonnington","year":"1987","unstructured":"Stonnington CM, Phillips SF, Zinsmeister AR, Melton LJ III. Prognosis of chronic ulcerative colitis in a community. Gut. 1987;28:1261\u20131266. doi: 10.1136\/gut.28.10.1261 .","journal-title":"Gut"},{"key":"514_CR3","doi-asserted-by":"crossref","first-page":"699","DOI":"10.3109\/00365529509096316","volume":"30","author":"PLE Munkholm","year":"1995","unstructured":"Munkholm PLE, Davidsen M, Binder V. Disease activity courses in a regional cohort of Crohn\u2019s disease patients. Scand J Gastroenterol. 1995;30:699\u2013706. doi: 10.3109\/00365529509096316 .","journal-title":"Scand J Gastroenterol"},{"key":"514_CR4","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.3109\/00365529709011217","volume":"32","author":"B Moum","year":"1997","unstructured":"Moum B, Ekbom A, Vatn MH, et al. Clinical course during the 1st year after diagnosis in ulcerative colitis and Crohn\u2019s disease. Results of a large, prospective population-based study in southeastern Norway, 1990\u201393. Scand J Gastroenterol. 1997;32:1005\u20131012. doi: 10.3109\/00365529709011217 .","journal-title":"Scand J Gastroenterol"},{"key":"514_CR5","first-page":"359","volume":"95","author":"OH Nielsen","year":"2000","unstructured":"Nielsen OH, Vainer B, Madsen SM, Seidelin JB, Heegaard NH. Established and emerging biological activity markers of inflammatory bowel disease. Am J Gastroenterol. 2000;95:359\u2013367.","journal-title":"Am J Gastroenterol"},{"key":"514_CR6","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1136\/gut.2005.069476","volume":"55","author":"S Vermeire","year":"2006","unstructured":"Vermeire S, Van Assche G, Rutgeerts P. Laboratory markers in IBD: useful, magic, or unnecessary toys? Gut. 2006;55:426\u2013431. doi: 10.1136\/gut.2005.069476 .","journal-title":"Gut"},{"key":"514_CR7","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1365-2036.2006.03184.x","volume":"25","author":"D Desai","year":"2007","unstructured":"Desai D, Faubion WA, Sandborn WJ. Review article: biological activity markers in inflammatory bowel disease. Aliment Pharmacol Ther. 2007;25:247\u2013255.","journal-title":"Aliment Pharmacol Ther"},{"key":"514_CR8","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1097\/00054725-200409000-00026","volume":"10","author":"S Vermeire","year":"2004","unstructured":"Vermeire S, Van Assche G, Rutgeerts P. C-reactive protein as a marker for inflammatory bowel disease. Inflamm Bowel Dis. 2004;10:661\u2013665. doi: 10.1097\/00054725-200409000-00026 .","journal-title":"Inflamm Bowel Dis"},{"key":"514_CR9","doi-asserted-by":"crossref","first-page":"4991","DOI":"10.4049\/jimmunol.164.10.4991","volume":"164","author":"A Bouchon","year":"2000","unstructured":"Bouchon A, Dietrich J, Colonna M. Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes. J Immunol. 2000;164:4991\u20134995.","journal-title":"J Immunol"},{"key":"514_CR10","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1038\/35074114","volume":"410","author":"A Bouchon","year":"2001","unstructured":"Bouchon A, Facchetti F, Weigand MA, Colonna M. TREM-1 amplifies inflammation and is a crucial mediator of septic shock. Nature. 2001;410:1103\u20131107. doi: 10.1038\/35074114 .","journal-title":"Nature"},{"key":"514_CR11","doi-asserted-by":"crossref","first-page":"9","DOI":"10.7326\/0003-4819-141-1-200407060-00009","volume":"141","author":"S Gibot","year":"2004","unstructured":"Gibot S, Kolopp-Sarda MN, B\u00e9n\u00e9 MC, et al. Plasma level of a triggering receptor expressed on myeloid cells-1: its diagnostic accuracy in patients with suspected sepsis. Ann Intern Med. 2004;141:9\u201315.","journal-title":"Ann Intern Med"},{"key":"514_CR12","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1056\/NEJMoa031544","volume":"350","author":"S Gibot","year":"2004","unstructured":"Gibot S, Cravoisy A, Levy B, Bene MC, Faure G, Bollaert PE. Soluble triggering receptor expressed on myeloid cells and the diagnosis of pneumonia. N Engl J Med. 2004;350:451\u2013458.","journal-title":"N Engl J Med"},{"key":"514_CR13","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1097\/00042737-200604000-00010","volume":"18","author":"V Koussoulas","year":"2006","unstructured":"Koussoulas V, Vassiliou S, Demonakou M, et al. Soluble triggering receptor expressed on myeloid cells (sTREM-1): a new mediator involved in the pathogenesis of peptic ulcer disease. Eur J Gastroenterol Hepatol. 2006;18:375\u2013379. doi: 10.1097\/00042737-200604000-00010 .","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"514_CR14","doi-asserted-by":"crossref","first-page":"3097","DOI":"10.1172\/JCI30602","volume":"117","author":"M Schenk","year":"2007","unstructured":"Schenk M, Bouchon A, Seibold F, Mueller C. TREM-1\u2014expressing intestinal macrophages crucially amplify chronic inflammation in experimental colitis and inflammatory bowel diseases. J Clin Invest. 2007;117:3097\u20133106. doi: 10.1172\/JCI30602 .","journal-title":"J Clin Invest"},{"key":"514_CR15","doi-asserted-by":"crossref","first-page":"2","DOI":"10.3109\/00365528909091339","volume":"170","author":"JE Lennard-Jones","year":"1989","unstructured":"Lennard-Jones JE. Classification of inflammatory bowel disease. Scand J Gastroenterol Suppl. 1989;170:2\u20136. Discussion 16\u201319.","journal-title":"Scand J Gastroenterol Suppl"},{"key":"514_CR16","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1111\/j.1572-0241.2001.03671.x","volume":"96","author":"SB Hanauer","year":"2001","unstructured":"Hanauer SB, Sandborn W. Management of Crohn\u2019s disease in adults. Am J Gastroenterol. 2001;96:635\u2013643. doi: 10.1111\/j.1572-0241.2001.03671.x .","journal-title":"Am J Gastroenterol"},{"key":"514_CR17","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1111\/j.1572-0241.2004.40036.x","volume":"99","author":"A Kornbluth","year":"2004","unstructured":"Kornbluth A, Sachar DB. Ulcerative colitis practice guidelines in adults (update): American College of Gastroenterology, Practice Parameters Committee. Am J Gastroenterol. 2004;99:1371\u20131385. doi: 10.1111\/j.1572-0241.2004.40036.x .","journal-title":"Am J Gastroenterol"},{"key":"514_CR18","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/nri1132","volume":"3","author":"G Bouma","year":"2003","unstructured":"Bouma G, Strober W. The immunological and genetic basis of inflammatory bowel disease. Nat Rev Immunol. 2003;3:521\u2013533. doi: 10.1038\/nri1132 .","journal-title":"Nat Rev Immunol"},{"key":"514_CR19","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1126\/science.1106442","volume":"307","author":"TT Macdonald","year":"2005","unstructured":"Macdonald TT, Monteleone G. Immunity, inflammation, and allergy in the gut. Science. 2005;307:1920\u20131925. doi: 10.1126\/science.1106442 .","journal-title":"Science"},{"key":"514_CR20","doi-asserted-by":"crossref","first-page":"4956","DOI":"10.4049\/jimmunol.172.8.4956","volume":"172","author":"MP Radsak","year":"2004","unstructured":"Radsak MP, Salih HR, Rammensee HG, Schild H. Triggering receptor expressed on myeloid cells-1 in neutrophil inflammatory responses: differential regulation of activation and survival. J Immunol. 2004;172:4956\u20134963.","journal-title":"J Immunol"},{"key":"514_CR21","doi-asserted-by":"crossref","first-page":"3416","DOI":"10.3748\/wjg.v12.i21.3416","volume":"12","author":"M Tzivras","year":"2006","unstructured":"Tzivras M, Koussoulas V, Giamarellos-Bourboulis EJ, et al. Role of soluble triggering receptor expressed on myeloid cells in inflammatory bowel disease. World J Gastroenterol. 2006;12:3416\u20133419.","journal-title":"World J Gastroenterol"},{"key":"514_CR22","first-page":"2007","volume":"52040","author":"MP Radsak","year":"2007","unstructured":"Radsak MP, Taube C, Haselmayer P, et al. Soluble triggering receptor expressed on myeloid cells 1 is released in patients with stable chronic obstructive pulmonary disease. Clin Dev Immunol. 2007;52040:2007.","journal-title":"Clin Dev Immunol"},{"key":"514_CR23","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1097\/CCM.0b013e31817b8824","volume":"36","author":"T Yasuda","year":"2008","unstructured":"Yasuda T, Takeyama Y, Ueda T, et al. Increased levels of soluble triggering receptor expressed on myeloid cells-1 in patients with acute pancreatitis. Crit Care Med. 2008;36:2048\u20132053.","journal-title":"Crit Care Med"},{"key":"514_CR24","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1097\/00004836-198612000-00011","volume":"8","author":"DB Sachar","year":"1986","unstructured":"Sachar DB, Smith H, Chan S, Cohen LB, Lichtiger S, Messer J. Erythrocytic sedimentation rate as a measure of clinical activity in inflammatory bowel disease. J Clin Gastroenterol. 1986;8:647\u2013650. doi: 10.1097\/00004836-198612000-00011 .","journal-title":"J Clin Gastroenterol"},{"key":"514_CR25","doi-asserted-by":"crossref","first-page":"526","DOI":"10.7326\/0003-4819-107-4-526","volume":"107","author":"CE Cross","year":"1987","unstructured":"Cross CE, Halliwell B, Borish ET, et al. Oxygen radicals and human disease. Ann Intern Med. 1987;107:526\u2013545.","journal-title":"Ann Intern Med"},{"key":"514_CR26","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1056\/NEJM198902093200606","volume":"320","author":"SJ Weiss","year":"1989","unstructured":"Weiss SJ. Tissue destruction by neutrophils. N Engl J Med. 1989;320:365\u2013376.","journal-title":"N Engl J Med"},{"key":"514_CR27","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1097\/00054725-199712000-00003","volume":"3","author":"U Dagli","year":"1997","unstructured":"Dagli U, Balk M, Y\u00fccel D, et al. The role of reactive oxygen metabolites in ulcerative colitis. Inflamm Bowel Dis. 1997;3:260\u2013264. doi: 10.1002\/ibd.3780030404 .","journal-title":"Inflamm Bowel Dis"},{"key":"514_CR28","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1136\/gut.34.7.936","volume":"34","author":"N Oshitani","year":"1993","unstructured":"Oshitani N, Kitano A, Okabe H, Nakamura S, Matsumoto T, Kobayashi K. Location of superoxide anion generation in human colonic mucosa obtained by biopsy. Gut. 1993;34:936\u2013938. doi: 10.1136\/gut.34.7.936 .","journal-title":"Gut"},{"key":"514_CR29","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1023\/A:1018899222258","volume":"43","author":"EW Holmes","year":"1998","unstructured":"Holmes EW, Yong SL, Eiznhamer D, Keshavarzian A. Glutathione content of colonic mucosa: evidence for oxidative damage in active ulcerative colitis. Dig Dis Sci. 1998;43:1088\u20131095. doi: 10.1023\/A:1018899222258 .","journal-title":"Dig Dis Sci"},{"key":"514_CR30","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1016\/0016-5085(84)90202-6","volume":"87","author":"JE Krawisz","year":"1984","unstructured":"Krawisz JE, Sharon P, Stenson WF. Quantitative assay for acute intestinal inflammation based on myeloperoxidase activity. Assessment of inflammation in rat and hamster models. Gastroenterology. 1984;87:1344\u20131350.","journal-title":"Gastroenterology"},{"key":"514_CR31","doi-asserted-by":"crossref","first-page":"6S","DOI":"10.1007\/BF01538126","volume":"33","author":"MB Grisham","year":"1988","unstructured":"Grisham MB, Granger DN. Neutrophil-mediated mucosal injury. Role of reactive oxygen metabolites. Dig Dis Sci. 1988;33:6S\u201315S. doi: 10.1007\/BF01538126 .","journal-title":"Dig Dis Sci"},{"key":"514_CR32","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/0016-5085(92)91112-H","volume":"103","author":"NJ Simmonds","year":"1992","unstructured":"Simmonds NJ, Allen RE, Stevens TR, Van Someren RN, Blake DR, Rampton DS. Chemiluminescence assay of mucosal reactive oxygen metabolites in inflammatory bowel disease. Gastroenterology. 1992;103:186\u2013196.","journal-title":"Gastroenterology"},{"key":"514_CR33","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1136\/gut.34.9.1191","volume":"34","author":"S Sedghi","year":"1993","unstructured":"Sedghi S, Fields JZ, Klamut M, et al. Increased production of luminol enhanced chemiluminescence by the inflamed colonic mucosa in patients with ulcerative colitis. Gut. 1993;34:1191\u20131197. doi: 10.1136\/gut.34.9.1191 .","journal-title":"Gut"},{"key":"514_CR34","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1111\/j.1572-0241.2007.01343.x","volume":"102","author":"SJ Brown","year":"2007","unstructured":"Brown SJ, Mayer L. The immune response in inflammatory bowel disease. Am J Gastroenterol. 2007;102:2058\u20132069. doi: 10.1111\/j.1572-0241.2007.01343.x .","journal-title":"Am J Gastroenterol"},{"key":"514_CR35","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1136\/gut.27.7.809","volume":"27","author":"SH Saverymuttu","year":"1986","unstructured":"Saverymuttu SH, Hodgson HJ, Chadwick VS, Pepys MB. Differing acute phase responses in Crohn\u2019s disease and ulcerative colitis. Gut. 1986;27:809\u2013813. doi: 10.1136\/gut.27.7.809 .","journal-title":"Gut"},{"key":"514_CR36","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1111\/j.1365-2362.1982.tb02244.x","volume":"12","author":"EA Fagan","year":"1982","unstructured":"Fagan EA, Dyck RF, Maton PN, et al. Serum levels of C-reactive protein in Crohn\u2019s disease and ulcerative colitis. Eur J Clin Invest. 1982;12:351\u2013360. doi: 10.1111\/j.1365-2362.1982.tb02244.x .","journal-title":"Eur J Clin Invest"},{"key":"514_CR37","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1097\/01.MIB.0000173271.18319.53","volume":"11","author":"CA Solem","year":"2005","unstructured":"Solem CA, Loftus EV, Tremaine WJ, Harmsen WS, Zinsmeister AR, Sandborn WJ. Correlation of C-reactive protein with clinical, endoscopic, histologic, and radiographic activity in inflammatory bowel disease. Inflamm Bowel Dis. 2005;11:707\u2013712. doi: 10.1097\/01.MIB.0000173271.18319.53 .","journal-title":"Inflamm Bowel Dis"},{"key":"514_CR38","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1080\/00365520500217118","volume":"41","author":"TH Florin","year":"2006","unstructured":"Florin TH, Paterson EW, Fowler EV, Radford-Smith GL. Clinically active Crohn\u2019s disease in the presence of a low C-reactive protein. Scand J Gastroenterol. 2006;41:306\u2013311. doi: 10.1080\/00365520500217118 .","journal-title":"Scand J Gastroenterol"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-008-0514-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10620-008-0514-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-008-0514-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T19:42:42Z","timestamp":1559245362000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10620-008-0514-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10,31]]},"references-count":38,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2009,7]]}},"alternative-id":["514"],"URL":"https:\/\/doi.org\/10.1007\/s10620-008-0514-5","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,10,31]]}}}