{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T07:26:16Z","timestamp":1769239576641,"version":"3.49.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2008,11,26]],"date-time":"2008-11-26T00:00:00Z","timestamp":1227657600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2009,9]]},"DOI":"10.1007\/s10620-008-0554-x","type":"journal-article","created":{"date-parts":[[2008,11,26]],"date-time":"2008-11-26T17:02:43Z","timestamp":1227718963000},"page":"1979-1984","source":"Crossref","is-referenced-by-count":23,"title":["Expression of p53, VEGF, Microvessel Density, and Cyclin-D1 in Noncancerous Tissue of Inflammatory Bowel Disease"],"prefix":"10.1007","volume":"54","author":[{"given":"Canan","family":"Alkim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berna","family":"Savas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arzu","family":"Ensari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huseyin","family":"Alkim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulku","family":"Dagli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erkan","family":"Parlak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aysel","family":"Ulker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Burhan","family":"Sahin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2008,11,26]]},"reference":[{"key":"554_CR1","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S0889-8553(05)70065-0","volume":"28","author":"JD Lewis","year":"1999","unstructured":"Lewis JD, Deren JJ, Lichtenstein GR. Cancer risk in patients with inflammatory bowel disease. Gastroenterol Clin North Am. 1999;28:459\u2013477. doi: 10.1016\/S0889-8553(05)70065-0 .","journal-title":"Gastroenterol Clin North Am"},{"key":"554_CR2","doi-asserted-by":"crossref","first-page":"S50","DOI":"10.1016\/S0016-5107(99)70526-2","volume":"49","author":"DJ Ahnen","year":"1999","unstructured":"Ahnen DJ. Tissue markers of colon cancer risk. Gastrointest Endosc. 1999;49:S50\u2013S59. doi: 10.1016\/S0016-5107(99)70526-2 .","journal-title":"Gastrointest Endosc"},{"key":"554_CR3","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1007\/s00384-003-0495-y","volume":"18","author":"A Kapsoritakis","year":"2003","unstructured":"Kapsoritakis A, Sfiridaki A, Maltezos E, et al. Vascular endothelial growth factor in inflammatory bowel disease. Int J Colorectal Dis. 2003;18:418\u2013422. doi: 10.1007\/s00384-003-0495-y .","journal-title":"Int J Colorectal Dis"},{"key":"554_CR4","first-page":"116","volume":"49","author":"T Griga","year":"2002","unstructured":"Griga T, May B, Pfisterer O, Muller KM, Brasch F. Immunohistochemical localization of vascular endothelial growth factor in colonic mucosa of patients with inflammatory bowel disease. Hepatogastroenterology. 2002;49:116\u2013123.","journal-title":"Hepatogastroenterology"},{"key":"554_CR5","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1111\/j.1572-0241.1998.538_f.x","volume":"93","author":"JB Seidelin","year":"1998","unstructured":"Seidelin JB, Vainer B, Horn T, Nielsen OH. Circulating l-selectin levels and endothelial CD34 expression in inflammatory bowel disease. Am J Gastroenterol. 1998;93:1854\u20131859. doi: 10.1111\/j.1572-0241.1998.538_f.x .","journal-title":"Am J Gastroenterol"},{"key":"554_CR6","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1046\/j.1365-2559.2000.00798.x","volume":"36","author":"P Blok","year":"2000","unstructured":"Blok P, Craanen ME, van Diest PJ, Dekker W, Tytgat GN. Lack of cyclin D1 overexpression in gastric carcinogenesis. Histopathology. 2000;36:151\u2013155. doi: 10.1046\/j.1365-2559.2000.00798.x .","journal-title":"Histopathology"},{"key":"554_CR7","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1007\/s004280050034","volume":"436","author":"IK Bukholm","year":"2000","unstructured":"Bukholm IK, Nesland JM. Protein expression of p53, p21 (WAF1\/CIP1), bcl-2, Bax, cyclin D1 and pRb in human colon carcinomas. Virchows Arch. 2000;436:224\u2013228. doi: 10.1007\/s004280050034 .","journal-title":"Virchows Arch"},{"key":"554_CR8","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/BF03032661","volume":"6","author":"D Kristt","year":"2000","unstructured":"Kristt D, Turner I, Koren R, Ramadan E, Gal R. Overexpression of cyclin D1 mRNA in colorectal carcinomas and relationship to clinicopathological features: an in\u00a0situ hybridization analysis. Pathol Oncol Res. 2000;6:65\u201370.","journal-title":"Pathol Oncol Res"},{"key":"554_CR9","doi-asserted-by":"crossref","first-page":"G7","DOI":"10.1152\/ajpgi.00079.2004","volume":"287","author":"S Itzkowitz","year":"2004","unstructured":"Itzkowitz S, Yio X. Colorectal cancer in inflammatory bowel disease: the role of inflammation. Am J Physiol Gastrointest Liver Physiol. 2004;287:G7\u2013G17. doi: 10.1152\/ajpgi.00079.2004 .","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"554_CR10","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1136\/gut.2003.028779","volume":"53","author":"S Fujii","year":"2004","unstructured":"Fujii S, Fujimori T, Kawamata H, et al. Development of colonic neoplasia in p53 deficient mice with experimental colitis induced by dextran sulphate sodium. Gut. 2004;53:710\u2013716. doi: 10.1136\/gut.2003.028779 .","journal-title":"Gut"},{"key":"554_CR11","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.1349-7006.2001.tb01073.x","volume":"92","author":"H Takaku","year":"2001","unstructured":"Takaku H, Ajioka Y, Watanabe H, et al. Mutations of p53 in morphologically non-neoplastic mocosa of long-standing ulcerative colitis. Jpn J Cancer Res. 2001;92:119\u2013126.","journal-title":"Jpn J Cancer Res"},{"key":"554_CR12","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1046\/j.1365-2559.2001.01274.x","volume":"39","author":"AE Noffsinger","year":"2001","unstructured":"Noffsinger AE, Belli JM, Miller MA, Fenoglio-Presier CM. A unique basal pattern of p53 expression in ulcerative colitis is associated with mutation in the p53 gene. Histopathology. 2001;39:482\u2013492. doi: 10.1046\/j.1365-2559.2001.01274.x .","journal-title":"Histopathology"},{"key":"554_CR13","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/S0046-8177(99)90242-3","volume":"30","author":"E Mueller","year":"1999","unstructured":"Mueller E, Vieth M, Stolte M, Mueller J. The differentiation of true adenomas from colitis-associated dysplasia in ulcerative colitis: a comparative immunohistochemical study. Hum Pathol. 1999;30:898\u2013905. doi: 10.1016\/S0046-8177(99)90242-3 .","journal-title":"Hum Pathol"},{"key":"554_CR14","first-page":"3333","volume":"60","author":"SP Hussain","year":"2000","unstructured":"Hussain SP, Amstad P, Raja K, et al. Increased p53 mutation load in noncancerous colon tissue from ulcerative colitis: a cancer-prone chronic inflammatory disease. Cancer Res. 2000;60:3333\u20133337.","journal-title":"Cancer Res"},{"key":"554_CR15","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1111\/j.1572-0241.2003.07573.x","volume":"98","author":"BA Lashner","year":"2003","unstructured":"Lashner BA, Bauer WM, Rybicki LA, Goldblum JR. Abnormal p53 immunohistochemistry is associated with an increased colorectal cancer-related mortality in patients with ulcerative colitis. Am J Gastroenterol. 2003;98:1423\u20131427.","journal-title":"Am J Gastroenterol"},{"key":"554_CR16","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1590\/S0100-879X1999000900005","volume":"32","author":"R Mattar","year":"1999","unstructured":"Mattar R, Alexandrino AM, Laudanna AA. Infrequent p53 gene alterations in ulcerative colitis. Braz J Med Biol Res. 1999;32:1083\u20131088. doi: 10.1590\/S0100-879X1999000900005 .","journal-title":"Braz J Med Biol Res"},{"key":"554_CR17","first-page":"822","volume":"96","author":"S Kanazawa","year":"2001","unstructured":"Kanazawa S, Tsunoda T, Onuma E, Majima T, Kagiyama M, Kikuchi K. VEGF, basic-FGF and TGF-beta in Crohn\u2019s disease and ulcerative colitis: a novel mechanism of chronic intestinal inflammation. Am J Gastroenterol. 2001;96:822\u2013828.","journal-title":"Am J Gastroenterol"},{"key":"554_CR18","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1471-2407-2-8","volume":"2","author":"CW Feng","year":"2002","unstructured":"Feng CW, Wang LD, Jiao LH, Liu B, Zheng S, Xie XJ. Expression of p53, inducible nitric oxide synthase and vascular endothelial growth factor in gastric precancerous and cancerous lesions: correlation with clinical features. BMC Cancer. 2002;2:8. doi: 10.1186\/1471-2407-2-8 .","journal-title":"BMC Cancer"},{"key":"554_CR19","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1097\/01.mib.0000235095.01608.10","volume":"12","author":"M Ferrante","year":"2006","unstructured":"Ferrante M, Pierik M, Henckaerts L, et al. The role of vascular endothelial growth factor (VEGF) in inflammatory bowel disease. Inflamm Bowel Dis. 2006;12:870\u2013878. doi: 10.1097\/01.mib.0000235095.01608.10 .","journal-title":"Inflamm Bowel Dis"},{"key":"554_CR20","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s00384-003-0571-3","volume":"19","author":"EE Ioachim","year":"2004","unstructured":"Ioachim EE, Katsanos KH, Michael MC, Tsianos EV, Agnantis NJ. Immunohistochemical expression of cyclin D1, cyclin E, p21\/waf1 and p27\/kip1 in inflammatory bowel disease: correlation with other cell-cycle-related proteins (Rb, p53, ki-67 and PCNA) and clinicopathological features. Int J Colorectal Dis. 2004;19:325\u2013333. doi: 10.1007\/s00384-003-0571-3 .","journal-title":"Int J Colorectal Dis"},{"key":"554_CR21","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/S0046-8177(03)00125-4","volume":"34","author":"NA Wong","year":"2003","unstructured":"Wong NA, Mayer NJ, Anderson CE, et al. Cyclin D1 and p21 in ulcerative colitis-related inflammation and epithelial neoplasia: a study of aberran expression and underlying mechanism. Hum Pathol. 2003;34:580\u2013588. doi: 10.1016\/S0046-8177(03)00125-4 .","journal-title":"Hum Pathol"},{"key":"554_CR22","first-page":"951","volume":"11","author":"KA Hill","year":"2004","unstructured":"Hill KA, Wang KL, Stryker SJ, Gupta R, Weinrach DM, Rao MS. Comparative analysis of cell adhesion molecules, cell cycle regulatory proteins, mismatch repair genes, cyclooxygenase-2 and DPC4 in carcinomas arising in inflammatory bowel disease and sporadic colon cancer. Oncol Rep. 2004;11:951\u2013956.","journal-title":"Oncol Rep"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-008-0554-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10620-008-0554-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-008-0554-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T08:24:10Z","timestamp":1632385450000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10620-008-0554-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11,26]]},"references-count":22,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2009,9]]}},"alternative-id":["554"],"URL":"https:\/\/doi.org\/10.1007\/s10620-008-0554-x","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,11,26]]}}}