{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:42:51Z","timestamp":1791229371423,"version":"4.1.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2008,11,26]],"date-time":"2008-11-26T00:00:00Z","timestamp":1227657600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2009,8]]},"DOI":"10.1007\/s10620-008-0563-9","type":"journal-article","created":{"date-parts":[[2008,11,26]],"date-time":"2008-11-26T17:02:31Z","timestamp":1227718951000},"page":"1643-1650","source":"Crossref","is-referenced-by-count":45,"title":["Effect of N-acetylcysteine on the Murine Model of Colitis Induced by Dextran Sodium Sulfate Through Up-Regulating PON1 Activity"],"prefix":"10.1007","volume":"54","author":[{"given":"Yu","family":"You","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Jiang","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-Dong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Hui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,11,26]]},"reference":[{"key":"563_CR1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nri1747","volume":"6","author":"W Strober","year":"2006","unstructured":"Strober W, Murray PJ, Kitani A, et al. Signalling pathways and molecular interactions of NOD1 and NOD2. Nat Rev Immunol. 2006;6:9\u201320. doi: 10.1038\/nri1747 .","journal-title":"Nat Rev Immunol"},{"key":"563_CR2","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1002\/eji.200425229","volume":"34","author":"MG Netea","year":"2004","unstructured":"Netea MG, Kullberg BJ, de Jong DJ, et al. NOD2 mediates anti-inflammatory signals induced by TLR2 ligands: implications for Crohn\u2019s disease. Eur J Immunol. 2004;34:2052\u20132059. doi: 10.1002\/eji.200425229 .","journal-title":"Eur J Immunol"},{"issue":"6","key":"563_CR3","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1111\/j.1572-0241.2008.01845.x","volume":"103","author":"JE Mawdsley","year":"2008","unstructured":"Mawdsley JE, Jenkins DG, Macey MG, et al. The effect of hypnosis on systemic and rectal mucosal measures of inflammation in ulcerative colitis. Am J Gastroenterol. 2008;103(6):1460\u20131469. doi: 10.1111\/j.1572-0241.2008.01845.x .","journal-title":"Am J Gastroenterol"},{"issue":"4","key":"563_CR4","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.intimp.2008.01.009","volume":"8","author":"HS Lee","year":"2008","unstructured":"Lee HS, Han SY, Bae EA, et al. Lactic acid bacteria inhibit proinflammatory cytokine expression and bacterial glycosaminoglycan degradation activity in dextran sulfate sodium-induced colitic mice. Int Immunopharmacol. 2008;8(4):574\u2013580. doi: 10.1016\/j.intimp.2008.01.009 .","journal-title":"Int Immunopharmacol"},{"issue":"7","key":"563_CR5","first-page":"PI13","volume":"13","author":"R Rahimi","year":"2007","unstructured":"Rahimi R, Nikfar S, Abdollahi M. Meta-analysis technique confirms the effectiveness of anti-TNF-alpha in the management of active ulcerative colitis when administered in combination with corticosteroids. Med Sci Monit. 2007;13(7):PI13\u2013PI18.","journal-title":"Med Sci Monit"},{"issue":"1","key":"563_CR6","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.biopha.2006.06.022","volume":"61","author":"R Rahimi","year":"2007","unstructured":"Rahimi R, Nikfar S, Abdollahi Mohammad. Do anti-tumor necrosis factors induce response and remission in patients with acute refractory Crohn\u2019s disease? A systematic meta-analysis of controlled clinical trials. Biomed Pharmacother. 2007;61(1):75\u201380. doi: 10.1016\/j.biopha.2006.06.022 .","journal-title":"Biomed Pharmacother"},{"key":"563_CR7","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1016\/j.clinthera.2006.12.012","volume":"28","author":"R Rahimi","year":"2006","unstructured":"Rahimi R, Nikfar S, Rezaie A, et al. A meta-analysis of broad spectrum antibiotic therapy in patients with active Crohn\u2019s disease. Clin Ther. 2006;28:1983\u20131988. doi: 10.1016\/j.clinthera.2006.12.012 .","journal-title":"Clin Ther"},{"issue":"11","key":"563_CR8","doi-asserted-by":"crossref","first-page":"2920","DOI":"10.1007\/s10620-007-9760-1","volume":"52","author":"R Rahimi","year":"2007","unstructured":"Rahimi R, Nikfar S, Rezaie A, et al. A meta-analysis of antibiotic therapy for active ulcerative colitis. Dig Dis Sci. 2007;52(11):2920\u20132925. doi: 10.1007\/s10620-007-9760-1 .","journal-title":"Dig Dis Sci"},{"key":"563_CR9","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.jnutbio.2004.09.007","volume":"16","author":"TS Helieh Oza","year":"2005","unstructured":"Helieh Oza TS, Theresa Chenb S, Craig McClain J, et al. Antioxidants as novel therapy in a murine model of colitis. J Nutr Biochem. 2005;16:297\u2013304. doi: 10.1016\/j.jnutbio.2004.09.007 .","journal-title":"J Nutr Biochem"},{"issue":"3","key":"563_CR10","first-page":"497","volume":"17","author":"Y Isozaki","year":"2006","unstructured":"Isozaki Y, Yoshida N, Kuroda M, et al. Effect of a novel water-soluble vitamin E derivative as a cure for TNBS-induced colitis in rats. Int J Mol Med. 2006;17(3):497\u2013502.","journal-title":"Int J Mol Med"},{"issue":"1","key":"563_CR11","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1002\/path.1409","volume":"201","author":"L Kruidenier","year":"2003","unstructured":"Kruidenier L, Kuiper I, Lamers CB, et al. Intestinal oxidative damage in inflammatory bowel disease: semi-quantification, localization, and association with mucosal antioxidants. J Pathol. 2003;201(1):28\u201336. doi: 10.1002\/path.1409 .","journal-title":"J Pathol"},{"key":"563_CR12","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1073\/pnas.87.5.1715","volume":"87","author":"J Mrtensson","year":"1990","unstructured":"Mrtensson J, Jain A, Meister A. Glutathione is required for intestinal function. Proc Natl Acad Sci USA. 1990;87:1715\u20131719. doi: 10.1073\/pnas.87.5.1715 .","journal-title":"Proc Natl Acad Sci USA"},{"issue":"9","key":"563_CR13","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1177\/0960327107083452","volume":"26","author":"MS Soltan-Sharifi","year":"2007","unstructured":"Soltan-Sharifi MS, Mojtahedzadeh M, Najafi A, et al. Improvement by N-acetylcysteine of acute respiratory distress syndrome through increasing intracellular glutathione, and extracellular thiol molecules and anti-oxidant power: evidence for underlying toxicological mechanisms. Hum Exp Toxicol. 2007;26(9):697\u2013703. doi: 10.1177\/0960327107083452 .","journal-title":"Hum Exp Toxicol"},{"issue":"2","key":"563_CR14","first-page":"135","volume":"3","author":"F Ebrahimi","year":"2008","unstructured":"Ebrahimi F, Esmaily H, Baeeri M, et al. Molecular evidences on the benefit of N-acetylcysteine in experimental colitis. Cent Eur J Biol 2008;3(2):135\u2013142. doi: 10.2478\/s11535-008-0005-x .","journal-title":"Cent Eur J Biol"},{"key":"563_CR15","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1161\/01.ATV.21.4.473","volume":"21","author":"PN Durrington","year":"2001","unstructured":"Durrington PN, Mackness B, Mackness MI. Paraoxonase and atherosclerosis. Arterioscler Thromb Vasc Biol. 2001;21:473\u2013480.","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"3","key":"563_CR16","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1002\/cbf.1224","volume":"24","author":"G Baskol","year":"2006","unstructured":"Baskol G, Baskol M, Yurci A, et al. Serum paraoxonase 1 activity and malondialdehyde levels in patients with ulcerative colitis. Cell Biochem Funct. 2006;24(3):283\u2013286. doi: 10.1002\/cbf.1224 .","journal-title":"Cell Biochem Funct"},{"key":"563_CR17","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.freeradbiomed.2007.05.003","volume":"43","author":"L Rothem","year":"2007","unstructured":"Rothem L, Hartman C, Dahan A, et al. Paraoxonases are associated with intestinal inflammatory diseases and intracellularly localized to the endoplasmic reticulum. Free Radic Biol Med. 2007;43:730\u2013739. doi: 10.1016\/j.freeradbiomed.2007.05.003 .","journal-title":"Free Radic Biol Med"},{"key":"563_CR18","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s005350050067","volume":"33","author":"O Kanauchi","year":"1998","unstructured":"Kanauchi O, Nakamura T, Agata K, et al. Effects of germinated barley food stuff on dextran sulfate sodium-induced colitis in rats. J Gastroenterol. 1998;33:179\u2013188. doi: 10.1007\/s005350050067 .","journal-title":"J Gastroenterol"},{"key":"563_CR19","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.canlet.2003.12.007","volume":"208","author":"LM Sanders","year":"2004","unstructured":"Sanders LM, Henderson CE, Hong MY, et al. Pro-oxidant environment of the colon compared to the small intestine may contribute to greater cancer susceptibility. Cancer Lett. 2004;208:155\u2013161. doi: 10.1016\/j.canlet.2003.12.007 .","journal-title":"Cancer Lett"},{"key":"563_CR20","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1080\/003655201317097164","volume":"36","author":"K Suzuki","year":"2001","unstructured":"Suzuki K, Sugimura K, Hasegawa K, et al. Activated platelets in ulcerative colitis enhance the production of reactive oxygen species by polymorphonuclear leukocytes. Scand J Gastroenterol. 2001;36:1301\u20131306. doi: 10.1080\/003655201317097164 .","journal-title":"Scand J Gastroenterol"},{"issue":"4","key":"563_CR21","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1189\/jlb.1205734","volume":"80","author":"JE Qualls","year":"2006","unstructured":"Qualls JE, Kaplan AM, van Rooijen N, et al. Suppression of experimental colitis by intestinal mononuclear phagocytes. J Leukoc Biol. 2006;80(4):802\u2013815. doi: 10.1189\/jlb.1205734 .","journal-title":"J Leukoc Biol"},{"issue":"9","key":"563_CR22","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1007\/s10620-006-9622-2","volume":"52","author":"A Rezaie","year":"2007","unstructured":"Rezaie A, Parker RD, Abdollahi M. Oxidative stress and pathogenesis of inflammatory bowel disease: an epiphenomenon or the cause? Dig Dis Sci. 2007;52(9):2015\u20132021. doi: 10.1007\/s10620-006-9622-2 .","journal-title":"Dig Dis Sci"},{"issue":"5","key":"563_CR23","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/S0891-5849(00)00160-X","volume":"28","author":"A Banan","year":"2000","unstructured":"Banan A, Choudhary S, Zhang Y, et al. Oxidant-induced intestinal barrier disruption and its prevention by growth factors in a human colonic cell line: role of the microtubule cytoskeleton. Free Radic Biol Med. 2000;28(5):727\u2013738. doi: 10.1016\/S0891-5849(00)00160-X .","journal-title":"Free Radic Biol Med"},{"issue":"1","key":"563_CR24","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/path.1408","volume":"201","author":"L Kruidenier","year":"2003","unstructured":"Kruidenier L, Kuiper I, Van Duijn W, et al. Imbalanced secondary mucosal antioxidant response in inflammatory bowel disease. J Pathol. 2003;201(1):17\u201327. doi: 10.1002\/path.1408 .","journal-title":"J Pathol"},{"issue":"3","key":"563_CR25","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.taap.2004.11.016","volume":"204","author":"TY Aw","year":"2005","unstructured":"Aw TY. Intestinal glutathione: determinant of mucosal peroxide transport, metabolism, and oxidative susceptibility. Toxicol Appl Pharmacol. 2005;204(3):320\u2013328. doi: 10.1016\/j.taap.2004.11.016 .","journal-title":"Toxicol Appl Pharmacol"},{"key":"563_CR26","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1161\/01.ATV.18.10.1617","volume":"18","author":"M Aviram","year":"1998","unstructured":"Aviram M, Billecke S, Sorenson R, et al. Paraoxonase active site required for protection against LDL oxidation involves its free sulfhydryl group and is different than that required for its arylesterase\/paraoxonase activities: selective action of human paraoxonase allozymes Q and R. Arterioscler Thromb Vasc Biol. 1998;18:1617\u20131624.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"563_CR27","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/S0891-5849(98)00272-X","volume":"26","author":"M Aviram","year":"1999","unstructured":"Aviram M, Rosenblat M, Billecke S, et al. Human serum paraoxonase (PON 1) is inactivated by oxidized low density lipoprotein and preserved by antioxidants. Free Radic Biol Med. 1999;26:892\u2013904.","journal-title":"Free Radic Biol Med"},{"issue":"1","key":"563_CR28","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1097\/01.fjc.0000195306.61719.64","volume":"47","author":"Y-H Liu","year":"2006","unstructured":"Liu Y-H, Liu L-Y, Wu J-X, et al. Comparison of Captopril and Enalapril to study the role of the sulfhydryl-group in improvement of endothelial dysfunction with ACE inhibitors in high dieted methionine mice. J Cardiovasc Pharmacol. 2006;47(1):82\u201388.","journal-title":"J Cardiovasc Pharmacol"},{"issue":"2","key":"563_CR29","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0306-3623(01)00094-5","volume":"35","author":"V Nosal\u2019ova","year":"2000","unstructured":"Nosal\u2019ova V, Cerna S, Bauer V. Effect of N-acetylcysteine on colitis induced by acetic acid in rats. Gen.Pharmaco. 2000;35(2):77\u201381.","journal-title":"Gen.Pharmaco"},{"key":"563_CR30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0167-4781(02)00343-3","volume":"1576","author":"RC Scarpulla","year":"2002","unstructured":"Scarpulla RC. Nuclear activators and coactivators in mammalian mitochondrial biogenesis. Biochim Biophys Acta. 2002;1576:1\u201314.","journal-title":"Biochim Biophys Acta"},{"key":"563_CR31","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1056\/NEJM199704103361506","volume":"336","author":"PJ Barnes","year":"1997","unstructured":"Barnes PJ, Karin M. Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. N Engl J Med. 1997;336:1066\u20131071.","journal-title":"N Engl J Med"},{"key":"563_CR32","doi-asserted-by":"crossref","first-page":"160","DOI":"10.3109\/13506120209114817","volume":"9","author":"Y Kumon","year":"2002","unstructured":"Kumon Y, Nakauchi Y, Suehiro T, et al. Proinflammatory cytokines but not acute phase serum amyloid A or C-reactive protein, downregulate paraoxonase 1 (PON1) expression by Hep G2. Amyloid. 2002;9:160\u2013164.","journal-title":"Amyloid"},{"issue":"5","key":"563_CR33","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1080\/08941930701598784","volume":"20","author":"AM Chromik","year":"2007","unstructured":"Chromik AM, M\u00fcller AM, Albrecht M, et al. Oral administration of taurolidine ameliorates chronic DSS colitis in mice. J Invest Surg. 2007;20(5):273\u2013282.","journal-title":"J Invest Surg"},{"issue":"4","key":"563_CR34","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1002\/ibd.20039","volume":"13","author":"M Paganelli","year":"2007","unstructured":"Paganelli M, Albanese C, Borrelli O, et al. Inflammation is the main determinant of low bone mineral density in pediatric inflammatory bowel disease. Inflamm Bowel Dis. 2007;13(4):416\u2013423.","journal-title":"Inflamm Bowel Dis"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-008-0563-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10620-008-0563-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-008-0563-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T19:42:43Z","timestamp":1559245363000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10620-008-0563-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11,26]]},"references-count":34,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2009,8]]}},"alternative-id":["563"],"URL":"https:\/\/doi.org\/10.1007\/s10620-008-0563-9","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,11,26]]}}}