{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:09:04Z","timestamp":1790791744023,"version":"4.1.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2009,1,22]],"date-time":"2009-01-22T00:00:00Z","timestamp":1232582400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2009,12]]},"DOI":"10.1007\/s10620-008-0685-0","type":"journal-article","created":{"date-parts":[[2009,1,21]],"date-time":"2009-01-21T22:04:03Z","timestamp":1232575443000},"page":"2588-2597","source":"Crossref","is-referenced-by-count":14,"title":["Ileal Mucosal and Fecal Pancreatitis Associated Protein Levels Reflect Severity of Salmonella Infection in Rats"],"prefix":"10.1007","volume":"54","author":[{"given":"Marleen T. J.","family":"van Ampting","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Rodenburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolien","family":"Vink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelien","family":"Kramer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjan J.","family":"Schonewille","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaap","family":"Keijer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roelof","family":"van der Meer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingeborg M. J.","family":"Bovee-Oudenhoven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,1,22]]},"reference":[{"key":"685_CR1","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1136\/gut.52.3.439","volume":"52","author":"J Berkes","year":"2003","unstructured":"Berkes J, Viswanathan VK, Savkovic SD, Hecht G. Intestinal epithelial responses to enteric pathogens: effects on the tight junction barrier, ion transport, and inflammation. Gut. 2003;52:439\u2013451. doi: 10.1136\/gut.52.3.439 .","journal-title":"Gut"},{"key":"685_CR2","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1136\/gut.40.4.497","volume":"40","author":"IM Bovee-Oudenhoven","year":"1997","unstructured":"Bovee-Oudenhoven IM, Termont DS, Heidt PJ, Van der Meer R. Increasing the intestinal resistance of rats to the invasive pathogen Salmonella enteritidis: additive effects of dietary lactulose and calcium. Gut. 1997;40:497\u2013504.","journal-title":"Gut"},{"key":"685_CR3","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1053\/gast.1997.v113.pm9247475","volume":"113","author":"IM Bovee-Oudenhoven","year":"1997","unstructured":"Bovee-Oudenhoven IM, Termont DS, Weerkamp AH, Faassen-Peters MA, Van der Meer R. Dietary calcium inhibits the intestinal colonization and translocation of Salmonella in rats. Gastroenterology. 1997;113:550\u2013557. doi: 10.1053\/gast.1997.v113.pm9247475 .","journal-title":"Gastroenterology"},{"key":"685_CR4","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1093\/jn\/129.3.607","volume":"129","author":"IM Bovee-Oudenhoven","year":"1999","unstructured":"Bovee-Oudenhoven IM, Wissink ML, Wouters JT, Van der Meer R. Dietary calcium phosphate stimulates intestinal lactobacilli and decreases the severity of a salmonella infection in rats. J Nutr. 1999;129:607\u2013612.","journal-title":"J Nutr"},{"key":"685_CR5","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S0016-5085(03)00884-9","volume":"125","author":"IM Bovee-Oudenhoven","year":"2003","unstructured":"Bovee-Oudenhoven IM, Lettink-Wissink ML, Van Doesburg W, Witteman BJ, Van Der Meer R. Diarrhea caused by enterotoxigenic Escherichia coli infection of humans is inhibited by dietary calcium. Gastroenterology. 2003;125:469\u2013476. doi: 10.1016\/S0016-5085(03)00884-9 .","journal-title":"Gastroenterology"},{"key":"685_CR6","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1136\/gut.52.11.1572","volume":"52","author":"IM Bovee-Oudenhoven","year":"2003","unstructured":"Bovee-Oudenhoven IM, ten Bruggencate SJ, Lettink-Wissink ML, van der Meer R. Dietary fructo-oligosaccharides and lactulose inhibit intestinal colonisation but stimulate translocation of salmonella in rats. Gut. 2003;52:1572\u20131578. doi: 10.1136\/gut.52.11.1572 .","journal-title":"Gut"},{"key":"685_CR7","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1159\/000201430","volume":"58","author":"A Carroccio","year":"1997","unstructured":"Carroccio A, Iovanna JL, Iacono G, et al. Pancreatitis-associated protein in patients with celiac disease: serum levels and immunocytochemical localization in small intestine. Digestion. 1997;58:98\u2013103.","journal-title":"Digestion"},{"key":"685_CR8","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1126\/science.1127119","volume":"313","author":"HL Cash","year":"2006","unstructured":"Cash HL, Whitham CV, Behrendt CL, Hooper LV. Symbiotic bacteria direct expression of an intestinal bactericidal lectin. Science. 2006;313:1126\u20131130. doi: 10.1126\/science.1127119 .","journal-title":"Science"},{"key":"685_CR9","first-page":"G993","volume":"271","author":"L Christa","year":"1996","unstructured":"Christa L, Carnot F, Simon MT, et al. HIP\/PAP is an adhesive protein expressed in hepatocarcinoma, normal Paneth, and pancreatic cells. Am J Physiol. 1996;271:G993\u2013G1002.","journal-title":"Am J Physiol"},{"key":"685_CR10","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1126\/science.1090124","volume":"304","author":"P Cossart","year":"2004","unstructured":"Cossart P, Sansonetti PJ. Bacterial invasion: the paradigms of enteroinvasive pathogens. Science. 2004;304:242\u2013248. doi: 10.1126\/science.1090124 .","journal-title":"Science"},{"key":"685_CR11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/physiolgenomics.2000.4.1.1","volume":"4","author":"BK Dieckgraefe","year":"2000","unstructured":"Dieckgraefe BK, Stenson WF, Korzenik JR, Swanson PE, Harrington CA. Analysis of mucosal gene expression in inflammatory bowel disease by parallel oligonucleotide arrays. Physiol Genomics. 2000;4:1\u201311.","journal-title":"Physiol Genomics"},{"key":"685_CR12","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1097\/00000658-199306000-00006","volume":"217","author":"L Gianotti","year":"1993","unstructured":"Gianotti L, Alexander JW, Pyles T, Fukushima R. Arginine-supplemented diets improve survival in gut-derived sepsis and peritonitis by modulating bacterial clearance. The role of nitric oxide. Ann Surg. 1993;217:644\u2013653. doi: 10.1097\/00000658-199306000-00006 . discussion 653\u2013654.","journal-title":"Ann Surg"},{"key":"685_CR13","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1136\/gut.2004.056309","volume":"54","author":"M Gironella","year":"2005","unstructured":"Gironella M, Iovanna JL, Sans M, et al. Anti-inflammatory effects of pancreatitis associated protein in inflammatory bowel disease. Gut. 2005;54:1244\u20131253. doi: 10.1136\/gut.2004.056309 .","journal-title":"Gut"},{"key":"685_CR14","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1136\/gut.2006.116087","volume":"56","author":"M Gironella","year":"2007","unstructured":"Gironella M, Folch-Puy E, LeGoffic A, et al. Experimental acute pancreatitis in PAP\/HIP knock-out mice. Gut. 2007;56:1091\u20131097. doi: 10.1136\/gut.2006.116087 .","journal-title":"Gut"},{"key":"685_CR15","doi-asserted-by":"crossref","first-page":"21028","DOI":"10.1074\/jbc.M010717200","volume":"276","author":"R Graf","year":"2001","unstructured":"Graf R, Schiesser M, Scheele GA, et al. A family of 16-kDa pancreatic secretory stress proteins form highly organized fibrillar structures upon tryptic activation. J Biol Chem. 2001;276:21028\u201321038. doi: 10.1074\/jbc.M010717200 .","journal-title":"J Biol Chem"},{"key":"685_CR16","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.jss.2005.09.030","volume":"133","author":"R Graf","year":"2006","unstructured":"Graf R, Schiesser M, Reding T, et al. Exocrine meets endocrine: pancreatic stone protein and regenerating protein\u2014two sides of the same coin. J Surg Res. 2006;133:113\u2013120. doi: 10.1016\/j.jss.2005.09.030 .","journal-title":"J Surg Res"},{"key":"685_CR17","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1046\/j.1365-2672.2001.01399.x","volume":"91","author":"AH Havelaar","year":"2001","unstructured":"Havelaar AH, Garssen J, Takumi K, et al. A rat model for dose\u2013response relationships of Salmonella enteritidis infection. J Appl Microbiol. 2001;91:442\u2013452. doi: 10.1046\/j.1365-2672.2001.01399.x .","journal-title":"J Appl Microbiol"},{"key":"685_CR18","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/j.gastro.2003.07.009","volume":"125","author":"W He","year":"2003","unstructured":"He W, Wang ML, Jiang HQ, et al. Bacterial colonization leads to the colonic secretion of RELMbeta\/FIZZ2, a novel goblet cell-specific protein. Gastroenterology. 2003;125:1388\u20131397. doi: 10.1016\/j.gastro.2003.07.009 .","journal-title":"Gastroenterology"},{"key":"685_CR19","doi-asserted-by":"crossref","first-page":"24664","DOI":"10.1016\/S0021-9258(18)54281-2","volume":"266","author":"J Iovanna","year":"1991","unstructured":"Iovanna J, Orelle B, Keim V, Dagorn JC. Messenger RNA sequence and expression of rat pancreatitis-associated protein, a lectin-related protein overexpressed during acute experimental pancreatitis. J Biol Chem. 1991;266:24664\u201324669.","journal-title":"J Biol Chem"},{"key":"685_CR20","first-page":"G611","volume":"265","author":"JL Iovanna","year":"1993","unstructured":"Iovanna JL, Keim V, Bosshard A, et al. PAP, a pancreatic secretory protein induced during acute pancreatitis, is expressed in rat intestine. Am J Physiol. 1993;265:G611\u2013G618.","journal-title":"Am J Physiol"},{"key":"685_CR21","first-page":"136","volume":"4","author":"V Keim","year":"1986","unstructured":"Keim V, Loffler HG. Pancreatitis-associated protein in bile acid-induced pancreatitis of the rat. Clin Physiol Biochem. 1986;4:136\u2013142.","journal-title":"Clin Physiol Biochem"},{"key":"685_CR22","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1080\/003655202320378220","volume":"37","author":"B Kleessen","year":"2002","unstructured":"Kleessen B, Kroesen AJ, Buhr HJ, Blaut M. Mucosal and invading bacteria in patients with inflammatory bowel disease compared with controls. Scand J Gastroenterol. 2002;37:1034\u20131041. doi: 10.1080\/003655202320378220 .","journal-title":"Scand J Gastroenterol"},{"key":"685_CR23","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.vetimm.2005.02.010","volume":"105","author":"TA Niewold","year":"2005","unstructured":"Niewold TA, Kerstens HH, van der Mulen J, Smits MA, Hulst MM. Development of a porcine small intestinal cDNA micro-array: characterization and functional analysis of the response to enterotoxigenic E. coli. Vet Immunol Immunopathol. 2005;105:317\u2013329. doi: 10.1016\/j.vetimm.2005.02.010 .","journal-title":"Vet Immunol Immunopathol"},{"key":"685_CR24","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1016\/j.molimm.2006.05.013","volume":"44","author":"TA Niewold","year":"2007","unstructured":"Niewold TA, Veldhuizen EJ, van der Meulen J, et al. The early transcriptional response of pig small intestinal mucosa to invasion by Salmonella enterica serovar typhimurium DT104. Mol Immunol. 2007;44:1316\u20131322. doi: 10.1016\/j.molimm.2006.05.013 .","journal-title":"Mol Immunol"},{"key":"685_CR25","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1097\/00054725-200305000-00003","volume":"9","author":"H Ogawa","year":"2003","unstructured":"Ogawa H, Fukushima K, Naito H, et al. Increased expression of HIP\/PAP and regenerating gene III in human inflammatory bowel disease and a murine bacterial reconstitution model. Inflamm Bowel Dis. 2003;9:162\u2013170. doi: 10.1097\/00054725-200305000-00003 .","journal-title":"Inflamm Bowel Dis"},{"key":"685_CR26","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0016-5085(94)90059-0","volume":"107","author":"IM Oudenhoven","year":"1994","unstructured":"Oudenhoven IM, Klaasen HL, Lapre JA, Weerkamp AH, Van der Meer R. Nitric oxide-derived urinary nitrate as a marker of intestinal bacterial translocation in rats. Gastroenterology. 1994;107:47\u201353.","journal-title":"Gastroenterology"},{"key":"685_CR27","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1007\/s005350070017","volume":"35","author":"RS Pitman","year":"2000","unstructured":"Pitman RS, Blumberg RS. First line of defense: the role of the intestinal epithelium as an active component of the mucosal immune system. J Gastroenterol. 2000;35:805\u2013814. doi: 10.1007\/s005350070017 .","journal-title":"J Gastroenterol"},{"key":"685_CR28","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.cell.2006.02.012","volume":"124","author":"J Pizarro-Cerda","year":"2006","unstructured":"Pizarro-Cerda J, Cossart P. Bacterial adhesion and entry into host cells. Cell. 2006;124:715\u2013727. doi: 10.1016\/j.cell.2006.02.012 .","journal-title":"Cell"},{"key":"685_CR29","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1093\/jn\/123.11.1939","volume":"123","author":"PG Reeves","year":"1993","unstructured":"Reeves PG, Nielsen FH, Fahey GC Jr. AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr. 1993;123:1939\u20131951.","journal-title":"J Nutr"},{"key":"685_CR30","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1152\/physiolgenomics.00190.2006","volume":"30","author":"W Rodenburg","year":"2007","unstructured":"Rodenburg W, Bovee-Oudenhoven IM, Kramer E, van der Meer R, Keijer J. Gene expression response of the rat small intestine following oral Salmonella infection. Physiol Genomics. 2007;30:123\u2013133. doi: 10.1152\/physiolgenomics.00190.2006 .","journal-title":"Physiol Genomics"},{"key":"685_CR31","doi-asserted-by":"crossref","unstructured":"Rodenburg W, Keijer J, Kramer E, Roosing S, Vink C, Katan MB, van der Meer R, Bovee-Oudenhoven IM. Salmonella induces prominent gene expression in the rat colon. BMC Microbiol. 2007;7:84. doi: 10.1186\/1471-2180-7-84 .","DOI":"10.1186\/1471-2180-7-84"},{"key":"685_CR32","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1155\/2004\/690421","volume":"18","author":"HN Shi","year":"2004","unstructured":"Shi HN, Walker A. Bacterial colonization and the development of intestinal defences. Can J Gastroenterol. 2004;18:493\u2013500.","journal-title":"Can J Gastroenterol"},{"key":"685_CR33","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1053\/gast.2002.30294","volume":"122","author":"A Swidsinski","year":"2002","unstructured":"Swidsinski A, Ladhoff A, Pernthaler A, et al. Mucosal flora in inflammatory bowel disease. Gastroenterology. 2002;122:44\u201354. doi: 10.1053\/gast.2002.30294 .","journal-title":"Gastroenterology"},{"key":"685_CR34","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1136\/gut.2006.098160","volume":"56","author":"A Swidsinski","year":"2007","unstructured":"Swidsinski A, Loening-Baucke V, Theissig F, et al. Comparative study of the intestinal mucus barrier in normal and inflamed colon. Gut. 2007;56:343\u2013350. doi: 10.1136\/gut.2006.098160 .","journal-title":"Gut"},{"key":"685_CR35","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1093\/intimm\/14.2.111","volume":"14","author":"K Takumi","year":"2002","unstructured":"Takumi K, Garssen J, Havelaar A. A quantitative model for neutrophil response and delayed-type hypersensitivity reaction in rats orally inoculated with various doses of Salmonella enteritidis. Int Immunol. 2002;14:111\u2013119. doi: 10.1093\/intimm\/14.2.111 .","journal-title":"Int Immunol"},{"key":"685_CR36","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1002\/ibd.20079","volume":"13","author":"AA te Velde","year":"2007","unstructured":"te Velde AA, de Kort F, Sterrenburg E, et al. Comparative analysis of colonic gene expression of three experimental colitis models mimicking inflammatory bowel disease. Inflamm Bowel Dis. 2007;13:325\u2013330. doi: 10.1002\/ibd.20079 .","journal-title":"Inflamm Bowel Dis"},{"key":"685_CR37","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1093\/jn\/133.7.2313","volume":"133","author":"SJ Ten Bruggencate","year":"2003","unstructured":"Ten Bruggencate SJ, Bovee-Oudenhoven IM, Lettink-Wissink ML, Van der Meer R. Dietary fructo-oligosaccharides dose-dependently increase translocation of salmonella in rats. J Nutr. 2003;133:2313\u20132318.","journal-title":"J Nutr"},{"key":"685_CR38","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1136\/gut.2003.023499","volume":"53","author":"SJ Ten Bruggencate","year":"2004","unstructured":"Ten Bruggencate SJ, Bovee-Oudenhoven IM, Lettink-Wissink ML, Katan MB, Van Der Meer R. Dietary fructo-oligosaccharides and inulin decrease resistance of rats to salmonella: protective role of calcium. Gut. 2004;53:530\u2013535. doi: 10.1136\/gut.2003.023499 .","journal-title":"Gut"},{"key":"685_CR39","doi-asserted-by":"crossref","first-page":"15974","DOI":"10.1016\/S0021-9258(18)82347-X","volume":"268","author":"M Unno","year":"1993","unstructured":"Unno M, Yonekura H, Nakagawara K, et al. Structure, chromosomal localization, and expression of mouse reg genes, reg I and reg II. A novel type of reg gene, reg II, exists in the mouse genome. J Biol Chem. 1993;268:15974\u201315982.","journal-title":"J Biol Chem"},{"key":"685_CR40","doi-asserted-by":"crossref","first-page":"7432","DOI":"10.1016\/S0021-9258(19)39132-X","volume":"265","author":"T Watanabe","year":"1990","unstructured":"Watanabe T, Yonekura H, Terazono K, Yamamoto H, Okamoto H. Complete nucleotide sequence of human reg gene and its expression in normal and tumoral tissues. The reg protein, pancreatic stone protein, and pancreatic thread protein are one and the same product of the gene. J Biol Chem. 1990;265:7432\u20137439.","journal-title":"J Biol Chem"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-008-0685-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10620-008-0685-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-008-0685-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T08:56:21Z","timestamp":1632992181000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10620-008-0685-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1,22]]},"references-count":40,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["685"],"URL":"https:\/\/doi.org\/10.1007\/s10620-008-0685-0","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,1,22]]}}}