{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T11:25:59Z","timestamp":1774437959755,"version":"3.50.1"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2009,1,29]],"date-time":"2009-01-29T00:00:00Z","timestamp":1233187200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2010,1]]},"DOI":"10.1007\/s10620-008-0688-x","type":"journal-article","created":{"date-parts":[[2009,1,28]],"date-time":"2009-01-28T12:26:14Z","timestamp":1233145574000},"page":"101-110","source":"Crossref","is-referenced-by-count":9,"title":["The Discrepancy Between Genetic Polymorphism of p53 Codon 72 and the Expression of p53 Protein in Helicobacter pylori-Associated Gastric Cancer in Korea"],"prefix":"10.1007","volume":"55","author":[{"given":"Nayoung","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung-Il","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hye Seung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Hyun","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jee Hyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joo Sung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun Chae","family":"Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In Sung","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2009,1,29]]},"reference":[{"key":"688_CR1","first-page":"59","volume":"12","author":"AJ Levine","year":"1992","unstructured":"Levine AJ. The p53 tumor suppressor gene and product. Cancer Surv. 1992;12:59\u201379.","journal-title":"Cancer Surv"},{"key":"688_CR2","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0092-8674(00)81871-1","volume":"88","author":"AJ Levine","year":"1997","unstructured":"Levine AJ. p53, the cellular gatekeeper for growth and division. Cell. 1997;88:323\u2013331. doi: 10.1016\/S0092-8674(00)81871-1 .","journal-title":"Cell"},{"key":"688_CR3","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/S0016-5085(00)70356-8","volume":"118","author":"T Shepherd","year":"2000","unstructured":"Shepherd T, Tolbert D, Benedetti J, et al. Alterations in exon 4 of the p53 gene in gastric carcinoma. Gastroenterology. 2000;118:1039\u20131044. doi: 10.1016\/S0016-5085(00)70356-8 .","journal-title":"Gastroenterology"},{"key":"688_CR4","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/S0959-8049(98)00369-4","volume":"35","author":"YC Wang","year":"1999","unstructured":"Wang YC, Lee HS, Chen SK, Chang YY, Chen CY. Prognostic significance of p53 codon 72 polymorphism in lung carcinomas. Eur J Cancer. 1999;35:226\u2013230. doi: 10.1016\/S0959-8049(98)00369-4 .","journal-title":"Eur J Cancer"},{"key":"688_CR5","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1159\/000154325","volume":"46","author":"R Birgander","year":"1996","unstructured":"Birgander R, Sjalander A, Zhou Z, Fan C, Beckman L, Beckman G. p53 polymorphisms and haplotypes in nasopharyngeal cancer. Hum Hered. 1996;46:49\u201354. doi: 10.1159\/000154325 .","journal-title":"Hum Hered"},{"key":"688_CR6","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1093\/carcin\/14.6.1085","volume":"14","author":"K Kawajiri","year":"1993","unstructured":"Kawajiri K, Nakachi K, Imai K, Watanabe J, Hayashi S. Germ line polymorphisms of p53 and CYP1A1 genes involved in human lung cancer. Carcinogenesis. 1993;14:1085\u20131089. doi: 10.1093\/carcin\/14.6.1085 .","journal-title":"Carcinogenesis"},{"key":"688_CR7","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1093\/carcin\/16.9.2205","volume":"16","author":"X Jin","year":"1995","unstructured":"Jin X, Wu X, Roth JA, et al. Higher lung cancer risk for younger African-Americans with the Pro\/Pro p53 genotype. Carcinogenesis. 1995;16:2205\u20132208. doi: 10.1093\/carcin\/16.9.2205 .","journal-title":"Carcinogenesis"},{"key":"688_CR8","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1006\/mcbr.2000.0241","volume":"3","author":"EN Papadakis","year":"2000","unstructured":"Papadakis EN, Dokianakis DN, Spandidos DA. p53 codon 72 polymorphism as a risk factor in the development of breast cancer. Mol Cell Biol Res Commun. 2000;3:389\u2013392. doi: 10.1006\/mcbr.2000.0241 .","journal-title":"Mol Cell Biol Res Commun"},{"key":"688_CR9","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1093\/carcin\/17.6.1313","volume":"17","author":"A Sjalander","year":"1996","unstructured":"Sjalander A, Birgander R, Hallmans G, et al. p53 polymorphisms and haplotypes in breast cancer. Carcinogenesis. 1996;17:1313\u20131316. doi: 10.1093\/carcin\/17.6.1313 .","journal-title":"Carcinogenesis"},{"key":"688_CR10","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/S0140-6736(99)01914-5","volume":"354","author":"I Zehbe","year":"1999","unstructured":"Zehbe I, Voglino G, Wilander E, Genta F, Tommasino M. Codon 72 polymorphism of p53 and its association with cervical cancer. Lancet. 1999;354:218\u2013219. doi: 10.1016\/S0140-6736(99)01914-5 .","journal-title":"Lancet"},{"key":"688_CR11","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/30400","volume":"393","author":"A Storey","year":"1998","unstructured":"Storey A, Thomas M, Kalita A, et al. Role of a p53 polymorphism in the development of human papilloma virus-associated cancer. Nature. 1998;393:229\u2013234. doi: 10.1038\/30400 .","journal-title":"Nature"},{"key":"688_CR12","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1054\/bjoc.2001.2085","volume":"85","author":"S Andersson","year":"2001","unstructured":"Andersson S, Rylander E, Strand A, Sallstrom J, Wilander E. The significance of p53 codon 72 polymorphism for the development of cervical adenocarcinomas. Br J Cancer. 2001;85:1153\u20131156. doi: 10.1054\/bjoc.2001.2085 .","journal-title":"Br J Cancer"},{"key":"688_CR13","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/25034","volume":"396","author":"A Helland","year":"1998","unstructured":"Helland A, Langerod A, Johnsen H, Olsen AO, Skovlund E, Borresen-Dale AL. p53 polymorphism and risk of cervical cancer. Nature. 1998;396:530\u2013531. doi: 10.1038\/25034 .","journal-title":"Nature"},{"key":"688_CR14","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/25037","volume":"396","author":"AM Josefsson","year":"1998","unstructured":"Josefsson AM, Magnusson PK, Ylitalo N, et al. p53 polymorphism and risk of cervical cancer. Nature. 1998;396:531. doi: 10.1038\/25037 .","journal-title":"Nature"},{"key":"688_CR15","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/25040","volume":"396","author":"A Hildesheim","year":"1998","unstructured":"Hildesheim A, Schiffman M, Brinton LA, et al. p53 polymorphism and risk of cervical cancer. Nature. 1998;396:531\u2013532. doi: 10.1038\/25040 .","journal-title":"Nature"},{"key":"688_CR16","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1093\/jnci\/91.6.557","volume":"91","author":"Y Sonoda","year":"1999","unstructured":"Sonoda Y, Saigo PE, Boyd J. p53 and genetic susceptibility to cervical cancer. J Natl Cancer Inst. 1999;91:557. doi: 10.1093\/jnci\/91.6.557 .","journal-title":"J Natl Cancer Inst"},{"key":"688_CR17","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/apm.1965.64.1.31","volume":"64","author":"P Lauren","year":"1965","unstructured":"Lauren P. The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. An attempt at a histo-clinical classification. Acta Pathol Microbiol Scand. 1965;64:31\u201349.","journal-title":"Acta Pathol Microbiol Scand"},{"key":"688_CR18","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1002\/ijc.10466","volume":"100","author":"CA Gonzalez","year":"2002","unstructured":"Gonzalez CA, Sala N, Capella G. Genetic susceptibility and gastric cancer risk. Int J Cancer. 2002;100:249\u2013260. doi: 10.1002\/ijc.10466 .","journal-title":"Int J Cancer"},{"key":"688_CR19","first-page":"6735","volume":"52","author":"P Correa","year":"1992","unstructured":"Correa P. Human gastric carcinogenesis: a multistep and multifactorial process. Cancer Res. 1992;52:6735\u20136740.","journal-title":"Cancer Res"},{"key":"688_CR20","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1080\/00365520410009456","volume":"40","author":"GI Perez-Perez","year":"2005","unstructured":"Perez-Perez GI, Bosques-Padilla FJ, Crosatti ML, Tijerina-Menchaca R, Garza-Gonzalez E. Role of p53 codon 72 polymorphism in the risk of development of distal gastric cancer. Scand J Gastroenterol. 2005;40:56\u201360. doi: 10.1080\/00365520410009456 .","journal-title":"Scand J Gastroenterol"},{"key":"688_CR21","first-page":"1115","volume":"11","author":"H Shen","year":"2004","unstructured":"Shen H, Solari A, Wang X, et al. p53 codon 72 polymorphism and risk of gastric cancer in a Chinese population. Oncol Rep. 2004;11:1115\u20131120.","journal-title":"Oncol Rep"},{"key":"688_CR22","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1023\/B:DDAS.0000017447.02220.f5","volume":"49","author":"ZW Zhang","year":"2004","unstructured":"Zhang ZW, Newcomb P, Hollowood A, et al. A comparison study of gastric cancer risk in patients with duodenal and gastric ulcer: roles of gastric mucosal histology and p53 codon 72 polymorphism. Dig Dis Sci. 2004;49:254\u2013259. doi: 10.1023\/B:DDAS.0000017447.02220.f5 .","journal-title":"Dig Dis Sci"},{"key":"688_CR23","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1093\/carcin\/bgh229","volume":"25","author":"YG Xi","year":"2004","unstructured":"Xi YG, Ding KY, Su XL, et al. p53 polymorphism and p21WAF1\/CIP1 haplotype in the intestinal gastric cancer and the precancerous lesions. Carcinogenesis. 2004;25:2201\u20132206. doi: 10.1093\/carcin\/bgh229 .","journal-title":"Carcinogenesis"},{"key":"688_CR24","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.canlet.2005.07.004","volume":"238","author":"J Sul","year":"2006","unstructured":"Sul J, Yu GP, Lu QY, et al. p53 codon 72 polymorphisms: a case-control study of gastric cancer and potential interactions. Cancer Lett. 2006;238:210\u2013223. doi: 10.1016\/j.canlet.2005.07.004 .","journal-title":"Cancer Lett"},{"key":"688_CR25","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/ijc.10483","volume":"100","author":"T Hiyama","year":"2002","unstructured":"Hiyama T, Tanaka S, Kitadai Y, et al. p53 codon 72 polymorphism in gastric cancer susceptibility in patients with Helicobacter pylori-associated chronic gastritis. Int J Cancer. 2002;100:304\u2013308. doi: 10.1002\/ijc.10483 .","journal-title":"Int J Cancer"},{"key":"688_CR26","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1136\/gut.31.2.134","volume":"31","author":"SJ Hessey","year":"1990","unstructured":"Hessey SJ, Spencer J, Wyatt JI, et al. Bacterial adhesion and disease activity in Helicobacter associated chronic gastritis. Gut. 1990;31:134\u2013138. doi: 10.1136\/gut.31.2.134 .","journal-title":"Gut"},{"key":"688_CR27","first-page":"85","volume":"41","author":"TL Cover","year":"1996","unstructured":"Cover TL, Blaser MJ. Helicobacter pylori infection, a paradigm for chronic mucosal inflammation: pathogenesis and implications for eradication and prevention. Adv Intern Med. 1996;41:85\u2013117.","journal-title":"Adv Intern Med"},{"key":"688_CR28","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1128\/CMR.10.4.720","volume":"10","author":"BE Dunn","year":"1997","unstructured":"Dunn BE, Cohen H, Blaser MJ. Helicobacter pylori. Clin Microbiol Rev. 1997;10:720\u2013741.","journal-title":"Clin Microbiol Rev"},{"key":"688_CR29","first-page":"191","volume":"5","author":"A Labigne","year":"1996","unstructured":"Labigne A, de Reuse H. Determinants of Helicobacter pylori pathogenicity. Infect Agents Dis. 1996;5:191\u2013202.","journal-title":"Infect Agents Dis"},{"issue":"6","key":"688_CR30","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1016\/S0016-5085(97)80006-6","volume":"113","author":"HL Mobley","year":"1997","unstructured":"Mobley HL. Helicobacter pylori factors associated with disease development. Gastroenterology. 1997;113(6):S21\u2013S28.","journal-title":"Gastroenterology"},{"issue":"2 pt 2 Suppl","key":"688_CR31","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/S0016-5085(89)80057-5","volume":"96","author":"DY Graham","year":"1989","unstructured":"Graham DY. Campylobacter pylori and peptic ulcer disease. Gastroenterology. 1989;96(2 pt 2 Suppl):615\u2013625.","journal-title":"Gastroenterology"},{"key":"688_CR32","first-page":"461","volume":"7","author":"A Lee","year":"1995","unstructured":"Lee A, Dixon MF, Danon SJ, et al. Local acid production and Helicobacter pylori: a unifying hypothesis of gastroduodenal disease. Eur J Gastroenterol Hepatol. 1995;7:461\u2013465.","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"688_CR33","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/S0889-8553(05)70138-2","volume":"29","author":"KE McColl","year":"2000","unstructured":"McColl KE, el-Omar E, Gillen D. Helicobacter pylori gastritis and gastric physiology. Gastroenterol Clin North Am. 2000;29:687\u2013703. doi: 10.1016\/S0889-8553(05)70138-2 .","journal-title":"Gastroenterol Clin North Am"},{"key":"688_CR34","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1056\/NEJM199607253350404","volume":"335","author":"LE Hansson","year":"1996","unstructured":"Hansson LE, Nyren O, Hsing AW, et al. The risk of stomach cancer in patients with gastric or duodenal ulcer disease. N Engl J Med. 1996;335:242\u2013249. doi: 10.1056\/NEJM199607253350404 .","journal-title":"N Engl J Med"},{"key":"688_CR35","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/nm1566","volume":"13","author":"Y Mastumoto","year":"2007","unstructured":"Mastumoto Y, Marusawa H, Kinoshita K, et al. Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium. Nat Med. 2007;13:470\u2013476. doi: 10.1038\/nm1566 .","journal-title":"Nat Med"},{"key":"688_CR36","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1002\/1097-0142(19950901)76:5<720::AID-CNCR2820760503>3.0.CO;2-E","volume":"76","author":"HE Gabbert","year":"1995","unstructured":"Gabbert HE, Muller W, Schneiders A, Meier S, Hommel G. The relationship of p53 expression to the prognosis of 418 patients with gastric carcinoma. Cancer. 1995;76:720\u2013726. doi:10.1002\/1097-0142(19950901)76:5<720::AID-CNCR2820760503>3.0.CO;2-E.","journal-title":"Cancer"},{"key":"688_CR37","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1136\/gut.35.12.1697","volume":"35","author":"MJ Brito","year":"1994","unstructured":"Brito MJ, Williams GT, Thompson H, Filippe MI. Expression of p53 in early (T1) gastric carcinoma and precancerous adjacent mucosa. Gut. 1994;35:1697\u20131700. doi: 10.1136\/gut.35.12.1697 .","journal-title":"Gut"},{"key":"688_CR38","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1111\/j.1572-0241.2002.06032.x","volume":"97","author":"M Skacel","year":"2002","unstructured":"Skacel M, Petras RE, Rybicki LA, et al. p53 expression in low grade dysplasia in Barrett\u2019s esophagus: correlation with interobserver agreement and disease progression. Am J Gastroenterol. 2002;97:2508\u20132513. doi: 10.1111\/j.1572-0241.2002.06032.x .","journal-title":"Am J Gastroenterol"},{"key":"688_CR39","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1023\/A:1018828207371","volume":"42","author":"M Younes","year":"1997","unstructured":"Younes M, Erton A, Lechago LV, Somoano JR, Lechago J. p53 protein accumulation is a specific marker of malignant potential in Barrett\u2019s metaplasia. Dig Dis Sci. 1997;42:697\u2013701. doi: 10.1023\/A:1018828207371 .","journal-title":"Dig Dis Sci"},{"key":"688_CR40","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1111\/j.1572-0241.2001.03851.x","volume":"96","author":"AP Weston","year":"2001","unstructured":"Weston AP, Banerjee SK, Sharma P, Tran TM, Richards R, Cherian R. p53 protein overexpression in low grade dysplasia (LGD) in Barrett\u2019s esophagus: immunohistological marker predictive of progression. Am J Gastroenterol. 2001;96:1355\u20131362. doi: 10.1111\/j.1572-0241.2001.03851.x .","journal-title":"Am J Gastroenterol"},{"key":"688_CR41","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/path.1711650111","volume":"165","author":"RJ Loffeld","year":"1991","unstructured":"Loffeld RJ, Stobberingh E, Flendrig JA, Arends JW. Helicobacter pylori in gastric biopsy specimens. Comparison of culture, modified Giemsa stain, and immunohistochemistry. A retrospective study. J Pathol. 1991;165:69\u201373. doi: 10.1002\/path.1711650111 .","journal-title":"J Pathol"},{"key":"688_CR42","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1097\/00000478-199610000-00001","volume":"20","author":"MF Dixon","year":"1996","unstructured":"Dixon MF, Genta RM, Yardley JH, Correa P. The participants on the International workshop on the Histopathology of Gastritis, Houston 1994. Classification and grading of gastritis: the Updated Sydney System. Am J Surg Pathol. 1996;20:1161\u20131181. doi: 10.1097\/00000478-199610000-00001 .","journal-title":"Am J Surg Pathol"},{"key":"688_CR43","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1080\/01971529808005485","volume":"19","author":"SY Kim","year":"1998","unstructured":"Kim SY, Ahn JS, Ha YJ, et al. Serodiagnosis of Helicobacter pylori infection in Korean patients using enzyme-linked immunosorbent assay. J Immunoassay. 1998;19:251\u2013270. doi: 10.1080\/01971529808005485 .","journal-title":"J Immunoassay"},{"key":"688_CR44","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1128\/MCB.19.2.1092","volume":"19","author":"M Thomas","year":"1999","unstructured":"Thomas M, Kalita A, Labrecque S, Pim D, Banks L, Matlashewski G. Two polymorphic variants of wild-type p53 differ biochemically and biologically. Mol Cell Biol. 1999;19:1092\u20131100.","journal-title":"Mol Cell Biol"},{"key":"688_CR45","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1002\/ijc.22833","volume":"121","author":"Y Zhou","year":"2007","unstructured":"Zhou Y, Li Z, Zhuang W, et al. P53 codon 72 polymorphism and gastric cancer: a meta-analysis of the literature. Int J Cancer. 2007;121:1481\u20131486. doi: 10.1002\/ijc.22833 .","journal-title":"Int J Cancer"},{"key":"688_CR46","first-page":"292","volume":"50","author":"JM Kim","year":"2007","unstructured":"Kim JM, Lee OY, Lee CG, et al. p53 codon 72 and 16-bp duplication polymorphisms of gastric cancer in Koreans. Korean J Gastroenterol. 2007;50:292\u2013298.","journal-title":"Korean J Gastroenterol"},{"key":"688_CR47","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1126\/science.2144057","volume":"249","author":"SJ Baker","year":"1990","unstructured":"Baker SJ, Markowitz S, Fearon ER. Suppression of human colorectal cell growth by wild-type p53. Science. 1990;249:912\u2013915. doi: 10.1126\/science.2144057 .","journal-title":"Science"},{"key":"688_CR48","first-page":"571","volume":"1","author":"PW Hinds","year":"1990","unstructured":"Hinds PW, Finlay CA, Quartin RS, et al. Mutant p53 DNA clones from human colon carcinomas cooperate with ras in transforming primary rat cells: a comparison of the \u2018hot\u2019 spot mutant phenotypes. Cell Growth Differ. 1990;1:571\u2013580.","journal-title":"Cell Growth Differ"},{"key":"688_CR49","doi-asserted-by":"crossref","first-page":"7491","DOI":"10.1073\/pnas.89.16.7491","volume":"89","author":"SJ Kuerbitz","year":"1992","unstructured":"Kuerbitz SJ, Plunkett BS, Walsh WV, Kastan MB. Wild-type p53 is a cell cycle check point determinant following irradiation. Proc Natl Acad Sci USA. 1992;89:7491\u20137495. doi: 10.1073\/pnas.89.16.7491 .","journal-title":"Proc Natl Acad Sci USA"},{"key":"688_CR50","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/0092-8674(92)90243-6","volume":"70","author":"LR Livingstone","year":"1992","unstructured":"Livingstone LR, White A, Sprouse J, Livanos E, Jacks T, Tlsty TD. Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53. Cell. 1992;70:923\u2013935. doi: 10.1016\/0092-8674(92)90243-6 .","journal-title":"Cell"},{"key":"688_CR51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/ijc.2910500604","volume":"50","author":"H Martin","year":"1992","unstructured":"Martin H, Filipe MI, Morris R, Lane DP, Silvestre F. p53 expression and prognosis in gastric carcinoma. Int J Cancer. 1992;50:1\u20134. doi: 10.1002\/ijc.2910500604 .","journal-title":"Int J Cancer"},{"key":"688_CR52","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/path.1711700310","volume":"170","author":"BV Joypaul","year":"1993","unstructured":"Joypaul BV, Newman EL, Hopwood D, et al. Expression of p53 protein in normal, dysplastic and malignant gastric mucosa: an immunohistochemical study. J Pathol. 1993;170:279\u2013283.","journal-title":"J Pathol"},{"key":"688_CR53","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.canlet.2004.01.020","volume":"210","author":"F Segal","year":"2004","unstructured":"Segal F, Kaspary AP, Prolla JC, Leistner S. p53 protein overexpression and p53 mutation analysis in patients with intestinal metaplasia of the cardia and Barrett\u2019s esophagus. Cancer Lett. 2004;210:213\u2013218. doi: 10.1016\/j.canlet.2004.01.020 .","journal-title":"Cancer Lett"},{"key":"688_CR54","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/0016-5085(94)90580-0","volume":"107","author":"R Hamelin","year":"1994","unstructured":"Hamelin R, Flejou JF, Muzeau F, et al. Tp53 gene mutations and P53 protein immunoreactivity in malignant and premalignant Barretts-esophagus. Gastroenterology. 1994;107:1012\u20131018.","journal-title":"Gastroenterology"},{"key":"688_CR55","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1002\/(SICI)1097-0142(19970201)79:3<425::AID-CNCR1>3.0.CO;2-H","volume":"79","author":"G Coggi","year":"1997","unstructured":"Coggi G, Bosari S, Roncalli M, et al. p53 protein accumulation and p53 gene mutation in esophageal carcinoma\u2014a molecular and immunochemical study with clinicopathologic correlations. Cancer. 1997;79:425\u2013432. doi:10.1002\/(SICI)1097-0142(19970201)79:3<425::AID-CNCR1>3.0.CO;2-H.","journal-title":"Cancer"},{"key":"688_CR56","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/modpathol.3880324","volume":"14","author":"YS Bian","year":"2001","unstructured":"Bian YS, Osterheld MC, Bosman FT, Benhattar J, Fontolliet C. p53 gene mutation and protein accumulation during neoplastic progression in Barrett\u2019s esophagus. Mod Pathol. 2001;14:397\u2013403. doi: 10.1038\/modpathol.3880324 .","journal-title":"Mod Pathol"},{"key":"688_CR57","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1002\/ijc.2910560406","volume":"56","author":"JH Moore","year":"1994","unstructured":"Moore JH, Lesser EJ, Erdody DH, Matale RB, Orringer MB, Beer DG. Intestinal differentiation and p53 gene alterations in Barrett's-esophagus and esophageal adenocarcinoma. Int J Cancer. 1994;56:487\u2013493. doi: 10.1002\/ijc.2910560406 .","journal-title":"Int J Cancer"},{"key":"688_CR58","doi-asserted-by":"crossref","unstructured":"Munro AJ, Lain S, Lane DP. P53 abnormalities and outcomes in colorectal cancer: a systemic review. Br J Cancer. 2005;92:434\u2013444.","DOI":"10.1038\/sj.bjc.6602358"},{"key":"688_CR59","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/j.dnarep.2004.03.027","volume":"3","author":"DW Meek","year":"2004","unstructured":"Meek DW. The p53 response to DNA damage. DNA Repair (Amst). 2004;3:1049\u20131056. doi: 10.1016\/j.dnarep2004.03.027 .","journal-title":"DNA Repair (Amst)"},{"key":"688_CR60","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1136\/gut.2005.083295","volume":"55","author":"L Murray","year":"2006","unstructured":"Murray L, Sedo A, Scott M, et al. TP53 and progression from Barrett\u2019s metaplasia to oesophageal adenocarcinoma in a UK population cohort. Gut. 2006;55:1390\u20131397. doi: 10.1136\/gut.2005.083295 .","journal-title":"Gut"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-008-0688-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10620-008-0688-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-008-0688-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T15:42:46Z","timestamp":1559230966000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10620-008-0688-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1,29]]},"references-count":60,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,1]]}},"alternative-id":["688"],"URL":"https:\/\/doi.org\/10.1007\/s10620-008-0688-x","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,1,29]]}}}