{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T01:56:03Z","timestamp":1773885363312,"version":"3.50.1"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2009,12,9]],"date-time":"2009-12-09T00:00:00Z","timestamp":1260316800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2010,9]]},"DOI":"10.1007\/s10620-009-1064-1","type":"journal-article","created":{"date-parts":[[2009,12,8]],"date-time":"2009-12-08T20:56:03Z","timestamp":1260305763000},"page":"2520-2528","source":"Crossref","is-referenced-by-count":18,"title":["The Redox State of the Glutathione\/Glutathione Disulfide Couple Mediates Intracellular Arginase Activation in HCT-116 Colon Cancer Cells"],"prefix":"10.1007","volume":"55","author":[{"given":"Efemwonkiekie W.","family":"Iyamu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2009,12,9]]},"reference":[{"key":"1064_CR1","first-page":"57","volume-title":"Cellular and Molecular Biology of Nitric Oxide","author":"SM Morris Jr","year":"1999","unstructured":"Morris SM Jr. Arginine synthesis, metabolism, and transport: regulators of nitric oxide synthesis. In: Laskin JD, Laskin DL, eds. Cellular and Molecular Biology of Nitric Oxide. New York, NY: Dekker; 1999:57\u201385."},{"key":"1064_CR2","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1152\/ajpregu.2000.279.2.R554","volume":"279","author":"G Wu","year":"2000","unstructured":"Wu G, Flynn NE, Knabe DA, Jaeger LA. A cortisol surge mediates the enhanced polyamine synthesis in porcine enterocytes during weaning. Am J Physiol Regul Integr Comp Physiol. 2000;279:554\u2013559.","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"1064_CR3","first-page":"342","volume":"274","author":"CI Chang","year":"1998","unstructured":"Chang CI, Liao JC, Kuo L. Arginase modulates nitric oxide production in activated macrophages. Am J Physiol. 1998;274:342\u2013348.","journal-title":"Am J Physiol"},{"key":"1064_CR4","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1152\/ajpregu.2000.279.6.R2237","volume":"279","author":"D Kepka-Lenhart","year":"2000","unstructured":"Kepka-Lenhart D, Mistry SK, Wu G, Morris SM Jr. Arginase I: a limiting factor for nitric oxide and polyamine synthesis by activated macrophages? Am J Physiol Regul Integr Comp Physiol. 2000;279:2237\u20132242.","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"1064_CR5","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1096\/fj.01-0260com","volume":"15","author":"C Zhang","year":"2001","unstructured":"Zhang C, Hein TW, Wang W, Chang CI, Kuo L. Constitutive expression of arginase in microvascular endothelial cells counteracts nitric oxide-mediated vasodilatory function. FASEB J. 2001;15:1264\u20131266.","journal-title":"FASEB J"},{"key":"1064_CR6","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1093\/jnci\/89.8.533","volume":"89","author":"M Auvinen","year":"1997","unstructured":"Auvinen M. Cell transformation, invasion, and angiogenesis: a regulatory role for ornithine decarboxylase and polyamines? J Natl Cancer Inst. 1997;89:533\u2013537.","journal-title":"J Natl Cancer Inst"},{"key":"1064_CR7","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1038\/nrc1454","volume":"4","author":"EW Gerner","year":"2004","unstructured":"Gerner EW, Meyskens FL Jr. Polyamines and cancer: old molecules, new understanding. Nat Rev Cancer. 2004;4:781\u2013792.","journal-title":"Nat Rev Cancer"},{"key":"1064_CR8","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1152\/ajpgi.00499.2006","volume":"292","author":"S Horowitz","year":"2007","unstructured":"Horowitz S, Binion DG, Nelson VM, et al. Increased arginase activity and Endothelial dysfunction in human inflammatory bowel disease. Am J Physiol Gastrointest Liver Physiol. 2007;292:1323\u20131336.","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"1064_CR9","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1002\/mc.20246","volume":"45","author":"HF Yerushalmi","year":"2006","unstructured":"Yerushalmi HF, Besselsen DG, Ignatenko NA, et al. Role of polyamines in arginine-dependent colon carcinogenesis in Apc(Min) (\/+) mice. Mol Carcinog. 2006;45:764\u2013773.","journal-title":"Mol Carcinog"},{"key":"1064_CR10","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0009-8981(00)00432-0","volume":"305","author":"Z Perembska","year":"2001","unstructured":"Perembska Z, Zabek J, Grabo\u0144 W, Rahden-Strar\u014fn I, Barao\u0144czyk-Kuzma A. Increase arginase in colon cancer. Clin Chim Acta. 2001;305:157\u2013165.","journal-title":"Clin Chim Acta"},{"key":"1064_CR11","first-page":"241","volume":"473","author":"J J\u00e4nne","year":"1978","unstructured":"J\u00e4nne J, P\u00f6s\u00f6 H, Raina A. Polyamines in rapid growth and cancer. Biochim Biophys Acta. 1978;473:241\u2013293.","journal-title":"Biochim Biophys Acta"},{"key":"1064_CR12","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/0076-6879(90)86143-J","volume":"186","author":"RE Pacifi","year":"1990","unstructured":"Pacifi RE, Davies KJA. Protein degradation as an index of oxidative stress. Methods Enzymol. 1990;186:485\u2013502.","journal-title":"Methods Enzymol"},{"key":"1064_CR13","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0076-6879(95)58057-3","volume":"258","author":"ER Stadtman","year":"1995","unstructured":"Stadtman ER. Role of oxidized amino acids in protein breakdown and stability. Methods Enzymol. 1995;258:379\u2013393.","journal-title":"Methods Enzymol"},{"key":"1064_CR14","doi-asserted-by":"crossref","first-page":"9943","DOI":"10.1073\/pnas.87.24.9943","volume":"87","author":"FJT Staal","year":"1990","unstructured":"Staal FJT, Roederer M, Herzenberg LA, Herzenberg LA. Intracellular thiols regulate activation of nuclear factor kappa B and transcription of human immunodeficiency virus. Proc Natl Acad Sci USA. 1990;87:9943\u20139947.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1064_CR15","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1002\/j.1460-2075.1991.tb07761.x","volume":"10","author":"R Schreck","year":"1991","unstructured":"Schreck R, Rieber P, Baeuerle PA. Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1. EMBO J. 1991;10:2247\u20132258.","journal-title":"EMBO J"},{"key":"1064_CR16","doi-asserted-by":"crossref","first-page":"4328","DOI":"10.1073\/pnas.88.10.4328","volume":"88","author":"MB Toledano","year":"1991","unstructured":"Toledano MB, Leonard WJ. Modulation of transcription factor NF-kappa B binding activity by oxidation-reduction in\u00a0vitro. Proc Natl Acad Sci USA. 1991;88:4328\u20134332.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1064_CR17","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1126\/science.2118682","volume":"249","author":"C Abate","year":"1990","unstructured":"Abate C, Patel L, Rausche FJ III, Curran T. Redox regulation of fos and jun DNA-binding activity in\u00a0vitro. Science. 1990;249:1157\u20131161.","journal-title":"Science"},{"key":"1064_CR18","first-page":"69","volume":"63","author":"HF Gilbert","year":"1990","unstructured":"Gilbert HF. Molecular and cellular aspects of thiol-disulfide exchange. Adv Enzymol Relat Areas Mol Biol. 1990;63:69\u2013172.","journal-title":"Adv Enzymol Relat Areas Mol Biol"},{"key":"1064_CR19","volume-title":"Oxidation-Reduction Potentials of Organic Systems","author":"WM Clark","year":"1960","unstructured":"Clark WM. Oxidation-Reduction Potentials of Organic Systems. Baltimore, MD: Williams & Wilkins; 1960."},{"key":"1064_CR20","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.bbrc.2008.08.102","volume":"376","author":"EW Iyamu","year":"2008","unstructured":"Iyamu EW, Perdew H, Woods GM. Cysteine-iron promotes arginase activity by driving the Fenton reaction. Biochem Biophy Res Commun. 2008;376:116\u2013120.","journal-title":"Biochem Biophy Res Commun"},{"key":"1064_CR21","doi-asserted-by":"crossref","first-page":"2532","DOI":"10.1073\/pnas.78.4.2532","volume":"78","author":"CA Rouzer","year":"1981","unstructured":"Rouzer CA, Scott WA, Griffith OW, Hamill AL, Cohn ZA. Depletion of glutathione selectively inhibits synthesis of leukotriene C by macrophages. Proc Natl Acad Sci USA. 1981;78:2532\u20132536.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1064_CR22","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0021-9258(18)44814-4","volume":"199","author":"FP Chinard","year":"1952","unstructured":"Chinard FP. Photometric estimation of proline and ornithine. J Biol Chem. 1952;199:91\u201395.","journal-title":"J Biol Chem"},{"key":"1064_CR23","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.ab.2008.08.016","volume":"383","author":"EW Iyamu","year":"2008","unstructured":"Iyamu EW, Asakura T, Woods GM. A colorimetric microplate assay method for high throughput analysis of arginase activity in\u00a0vitro. Anal Biochem. 2008;383:332\u2013334.","journal-title":"Anal Biochem"},{"key":"1064_CR24","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0003-2697(80)90139-6","volume":"106","author":"OW Griffith","year":"1980","unstructured":"Griffith OW. Determination of glutathione and glutathione disulfide using glutathione reductase and vinylpyridine. Anal Biochem. 1980;106:207\u2013212.","journal-title":"Anal Biochem"},{"key":"1064_CR25","doi-asserted-by":"crossref","first-page":"14497","DOI":"10.1074\/jbc.272.23.14497","volume":"272","author":"Y Akamatsu","year":"1997","unstructured":"Akamatsu Y, Ohno T, Hirota K, Kagoshima H, Yodoi J, Shigesada K. Redox regulation of the DNA binding activity in transcription factor PEBP2. The roles of two conserved cysteine residues. J Biol Chem. 1997;272:14497\u201314500.","journal-title":"J Biol Chem"},{"key":"1064_CR26","doi-asserted-by":"crossref","first-page":"17395","DOI":"10.1074\/jbc.272.28.17395","volume":"272","author":"CN Shrimpton","year":"1997","unstructured":"Shrimpton CN, Glucksman MJ, Lew RA, et al. Thiolactivation of endopeptidase EC 3.4.24.15. J Biol Chem. 1997;272:17395\u201317399.","journal-title":"J Biol Chem"},{"key":"1064_CR27","doi-asserted-by":"crossref","first-page":"4805","DOI":"10.1074\/jbc.271.9.4805","volume":"271","author":"H Liu","year":"1996","unstructured":"Liu H, Lightfoot R, Stevens JL. Activation of heat shock factor by alkylating agents is triggered by glutathione depletion and oxidation of protein thiols. J Biol Chem. 1996;271:4805\u20134812.","journal-title":"J Biol Chem"},{"key":"1064_CR28","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1161\/01.ATV.0000233334.24805.62","volume":"26","author":"N Thengchaisri","year":"2006","unstructured":"Thengchaisri N, Hein TW, Wang W, et al. Upregulation of arginase by H2O2 impairs endothelium-dependent nitric oxide-mediated dilation of coronary arterioles. Arterioscler Thromb Vasc Biol. 2006;26:2035\u20132042.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"1064_CR29","doi-asserted-by":"crossref","first-page":"270","DOI":"10.4049\/jimmunol.170.1.270","volume":"170","author":"V Bronte","year":"2003","unstructured":"Bronte V, Serafini P, De Santo C, et al. IL-4-induced arginase 1 suppresses alloreactive T cells in tumor bearing mice. J Immunol. 2003;170:270\u2013278.","journal-title":"J Immunol"},{"key":"1064_CR30","doi-asserted-by":"crossref","first-page":"28316","DOI":"10.1074\/jbc.M003080200","volume":"275","author":"F Rodrigues-Lima","year":"2000","unstructured":"Rodrigues-Lima F, Fensome AC, Josephs M, Evans J, Veldan RJ, Katan M. Structural requirements for catalysis and membrane targeting of mammalian enzymes with neutral sphingomyelinase and lysophospholipid phospholipase C activities. Analysis by chemical modification and site-directed mutagenesis. J Biol Chem. 2000;275:28316\u201328325.","journal-title":"J Biol Chem"},{"key":"1064_CR31","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1096\/fasebj.12.7.561","volume":"12","author":"M Obin","year":"1998","unstructured":"Obin M, Shang F, Gong X, Handelman G, Blumberg J, Taylor A. Redox regulation of ubiquitin-conjugating enzymes: mechanistic insights using the thiol-specific oxidant diamide. FASEB J. 1998;12:561\u2013569.","journal-title":"FASEB J"},{"key":"1064_CR32","first-page":"90","volume-title":"Free Radicals in Biology and Medicine","author":"B Halliwell","year":"1989","unstructured":"Halliwell B, Gutteridge JMC. Free Radicals in Biology and Medicine. 2nd ed. Clarendon: Oxford; 1989:90.","edition":"2"},{"key":"1064_CR33","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1126\/science.6836290","volume":"220","author":"A Meister","year":"1983","unstructured":"Meister A. Selective modification of glutathione metabolism. Science. 1983;220:472\u2013477.","journal-title":"Science"},{"key":"1064_CR34","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0076-6879(95)51106-7","volume":"251","author":"A Meister","year":"1995","unstructured":"Meister A. Glutathione metabolism. Methods Enzymol. 1995;251:3\u20137.","journal-title":"Methods Enzymol"},{"key":"1064_CR35","first-page":"69","volume":"63","author":"HF Gilbert","year":"1990","unstructured":"Gilbert HF. Molecular and cellular aspects of thiol-disulfide exchange. Adv Enzymol. 1990;63:69\u201385.","journal-title":"Adv Enzymol"},{"key":"1064_CR36","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1089\/152308603770380025","volume":"5","author":"PV Usatyuk","year":"2003","unstructured":"Usatyuk PV, Vepa S, Watkins T, He D, Parinandi NL, Natarajan V. Redox regulation of reactive oxygen species-induced p38 MAP kinase activation and barrier dysfunction in lung microvascular endothelial cells. Antioxid Redox Signal. 2003;5:23\u201330.","journal-title":"Antioxid Redox Signal"},{"key":"1064_CR37","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.bbrc.2006.05.122","volume":"346","author":"HS Park","year":"2006","unstructured":"Park HS, Huh SH, Kim MS, et al. Neuronal nitric oxide synthase (nNOS) modulates the JNK1 activity through redox mechanism: a cGMP independent pathway. Biochem Biophys Res Commun. 2006;346:408\u2013414.","journal-title":"Biochem Biophys Res Commun"},{"key":"1064_CR38","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.bbrc.2006.06.067","volume":"348","author":"CW Kho","year":"2006","unstructured":"Kho CW, Lee PY, Bae KH, et al. Glutathione peroxidase 3 of Saccharomyces cerevisiae regulates the activity of methionine sulfoxide reductase in a redox state-dependent way. Biochem Biophys Res Commun. 2006;348:25\u201335.","journal-title":"Biochem Biophys Res Commun"},{"key":"1064_CR39","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1006\/abbi.1993.1325","volume":"304","author":"XS Wan","year":"1993","unstructured":"Wan XS, St Clair DK. Thiol-modulating agents increase manganese superoxide dismutase activity in human lung fibroblasts. Arch Biochem Biophys. 1993;304:89\u201393.","journal-title":"Arch Biochem Biophys"},{"key":"1064_CR40","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1089\/ars.1999.1.2-193","volume":"1","author":"NL Parinandi","year":"1999","unstructured":"Parinandi NL, Scribner WM, Vepa S, Shi S, Natarajan V. Phospholipase D activation in endothelial cells is redox sensitive. Antioxid Redox Signal. 1999;1:193\u2013210.","journal-title":"Antioxid Redox Signal"},{"key":"1064_CR41","doi-asserted-by":"crossref","first-page":"14242","DOI":"10.1074\/jbc.M010575200","volume":"276","author":"LT Lavulo","year":"2001","unstructured":"Lavulo LT, Sossong TM Jr, Brigham-Burke MR, et al. Subunit-subunit interactions in trimeric arginase. Generation of active monomers by mutation of a single amino acid. J Biol Chem. 2001;276:14242\u201314248.","journal-title":"J Biol Chem"},{"key":"1064_CR42","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1038\/383554a0","volume":"383","author":"ZF Kanyo","year":"1996","unstructured":"Kanyo ZF, Scolnick LR, Ash DE, Christianson DW. Structure of a unique binuclear manganese cluster in arginase. Nature. 1996;383:554\u2013557.","journal-title":"Nature"},{"key":"1064_CR43","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1039\/B406180B","volume":"2","author":"C Jacob","year":"2004","unstructured":"Jacob C, Holme AL, Fry FH. The sulfinic switch in proteins. Org Biomol Chem. 2004;2:1953\u20131956.","journal-title":"Org Biomol Chem"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-009-1064-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10620-009-1064-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-009-1064-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,15]],"date-time":"2021-10-15T18:44:18Z","timestamp":1634323458000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10620-009-1064-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12,9]]},"references-count":43,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2010,9]]}},"alternative-id":["1064"],"URL":"https:\/\/doi.org\/10.1007\/s10620-009-1064-1","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,12,9]]}}}