{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T00:37:27Z","timestamp":1778891847832,"version":"3.51.4"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2010,2,3]],"date-time":"2010-02-03T00:00:00Z","timestamp":1265155200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2010,11]]},"DOI":"10.1007\/s10620-010-1127-3","type":"journal-article","created":{"date-parts":[[2010,2,2]],"date-time":"2010-02-02T21:35:48Z","timestamp":1265146548000},"page":"3138-3146","source":"Crossref","is-referenced-by-count":23,"title":["Human Macrophage Metalloelastase Correlates with Angiogenesis and Prognosis of Gastric Carcinoma"],"prefix":"10.1007","volume":"55","author":[{"given":"Peng","family":"Cheng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fo Hu","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li Min","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Dai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen Yan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li Ming","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bi Jun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ci","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu Jie","family":"Bao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan Jie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,2,3]]},"reference":[{"key":"1127_CR1","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1007\/s10555-007-9089-4","volume":"26","author":"MD Martin","year":"2007","unstructured":"Martin MD, Matrisian LM. The other side of MMPs: protective roles in tumor progression. Cancer Metastasis Rev. 2007;26:717\u2013724.","journal-title":"Cancer Metastasis Rev"},{"key":"1127_CR2","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1387\/ijdb.041811af","volume":"48","author":"AR Folgueras","year":"2004","unstructured":"Folgueras AR, Pend\u00e1s AM, S\u00e1nchez LM, L\u00f3pez-Ot\u00edn C. Matrix metalloproteinases in cancer: from new functions to improved inhibition strategies. Int J Dev Biol. 2004;48:411\u2013424.","journal-title":"Int J Dev Biol"},{"key":"1127_CR3","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/jcp.21208","volume":"213","author":"MP Vincenti","year":"2007","unstructured":"Vincenti MP, Brinckerhoff CE. Signal transduction and cell-type specific regulation of matrix metalloproteinase gene expression: can MMPs be good for you? J Cell Physiol. 2007;213:355\u2013364.","journal-title":"J Cell Physiol"},{"key":"1127_CR4","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1002\/hep.510280413","volume":"28","author":"MJ Rivas","year":"1998","unstructured":"Rivas MJ, Arii S, Furutani M, et al. Expression of human macrophage metalloelastase gene in hepatocellular carcinoma: correlation with angiostatin generation and its clinical significance. Hepatology. 1998;28:986\u2013993.","journal-title":"Hepatology"},{"key":"1127_CR5","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1097\/00000658-200001000-00010","volume":"231","author":"MJ Gorrin-Rivas","year":"2000","unstructured":"Gorrin-Rivas MJ, Arii S, Mori A, et al. Implications of human macrophage metalloelastase and vascular endothelial growth factor gene expression in angiogenesis of hepatocellular carcinoma. Ann Surg. 2000;231:67\u201373.","journal-title":"Ann Surg"},{"key":"1127_CR6","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1002\/1097-0142(20010401)91:7<1277::AID-CNCR1129>3.0.CO;2-H","volume":"91","author":"W Yang","year":"2001","unstructured":"Yang W, Arii S, Gorrin-Rivas MJ, Mori A, Onodera H, Imamura M. Human macrophage metalloelastase gene expression in colorectal carcinoma and its clinicopathologic significance. Cancer. 2001;91:1277\u20131283.","journal-title":"Cancer"},{"key":"1127_CR7","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1023\/A:1025867130437","volume":"23","author":"S Zucker","year":"2004","unstructured":"Zucker S, Vacirca J. Role of matrix metalloproteinases (MMPs) in colorectal cancer. Cancer Metastasis Rev. 2004;23:101\u2013117.","journal-title":"Cancer Metastasis Rev"},{"key":"1127_CR8","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1097\/00000658-200204000-00010","volume":"235","author":"P Balaz","year":"2002","unstructured":"Balaz P, Friess H, Kondo Y, Zhu Z, Zimmermann A, B\u00fcchler MW. Human macrophage metalloelastase worsens the prognosis of pancreatic cancer. Ann Surg. 2002;235:519\u2013527.","journal-title":"Ann Surg"},{"key":"1127_CR9","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1159\/000066231","volume":"63","author":"Y Ding","year":"2002","unstructured":"Ding Y, Shimada Y, Gorrin-Rivas MJ, et al. Clinicopathological significance of human macrophage metalloelastase expression in esophageal squamous cell carcinoma. Oncology. 2002;63:378\u2013384.","journal-title":"Oncology"},{"key":"1127_CR10","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.prp.2007.03.008","volume":"203","author":"X Yang","year":"2007","unstructured":"Yang X, Dong Y, Zhao J, et al. Increased expression of human macrophage metalloelastase (MMP-12) is associated with the invasion of endometrial adenocarcinoma. Pathol Res Pract. 2007;203:499\u2013505.","journal-title":"Pathol Res Pract"},{"key":"1127_CR11","first-page":"361","volume":"26","author":"H Zhang","year":"2007","unstructured":"Zhang H, Li Y, Xu G. Human macrophage metalloelastase expression in gastric cancer and its relationship with gastric cancer prognosis. J Exp Clin Cancer Res. 2007;26:361\u2013366.","journal-title":"J Exp Clin Cancer Res"},{"key":"1127_CR12","doi-asserted-by":"crossref","first-page":"3820","DOI":"10.2174\/138161208786898680","volume":"14","author":"Y Fujita","year":"2008","unstructured":"Fujita Y, Abe R, Shimizu H. Clinical approaches toward tumor angiogenesis: past, present and future. Curr Pharm Des. 2008;14:3820\u20133834.","journal-title":"Curr Pharm Des"},{"key":"1127_CR13","doi-asserted-by":"crossref","first-page":"23824","DOI":"10.1016\/S0021-9258(20)80459-1","volume":"268","author":"SD Shapiro","year":"1993","unstructured":"Shapiro SD, Kobayashi DK, Ley TJ. Cloning and characterization of a unique elastolytic metalloproteinase produced by human alveolar macrophages. J Biol Chem. 1993;268:23824\u201323829.","journal-title":"J Biol Chem"},{"key":"1127_CR14","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1136\/gut.48.4.496","volume":"48","author":"MT Salmela","year":"2001","unstructured":"Salmela MT, Pender SL, Reunala T, MacDonald T, Saarialho-Kere U. Parallel expression of macrophage metalloelastase(MMP-12) in duodenal and skin lesions of patients with dermatitis herpetiformis. Gut. 2001;48:496\u2013502.","journal-title":"Gut"},{"key":"1127_CR15","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1172\/JCI2182","volume":"102","author":"JA Curci","year":"1998","unstructured":"Curci JA, Liao SX, Huffman MD, et al. Expression and localization of macrophage elastase (matrix metalloproteinase-12) in abdominal aortic aneurysms. J Clin Invest. 1998;102:1900\u20131910.","journal-title":"J Clin Invest"},{"key":"1127_CR16","doi-asserted-by":"crossref","first-page":"2617","DOI":"10.1245\/s10434-009-0555-9","volume":"16","author":"YJ Zhang","year":"2009","unstructured":"Zhang YJ, Dai Q, Sun DF, et al. mTOR signaling pathway is a target for the treatment of colorectal cancer. Ann Surg Oncol. 2009;16:2617\u20132628.","journal-title":"Ann Surg Oncol"},{"key":"1127_CR17","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1054\/bjoc.2001.1929","volume":"85","author":"MT Salmela","year":"2001","unstructured":"Salmela MT, Karjalainen-Lindsberg ML, Puolakkainen P, et al. Upregulation and differential expression of matrilysin (MMP-7) andmetalloelastase (MMP-12) and their inhibitors TIMP-1 and TIMP-3 in Barrett\u2019s oesophageal adenocarcinoma. Br J Cancer. 2001;85:383\u2013392.","journal-title":"Br J Cancer"},{"key":"1127_CR18","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1080\/07357900801944872","volume":"26","author":"YJ Zhang","year":"2008","unstructured":"Zhang YJ, Dai Q, Wu SM, et al. Susceptibility for NSAIDs-induced apoptosis correlates to p53 gene status in gastric cancer cells. Cancer Invest. 2008;26:868\u2013877.","journal-title":"Cancer Invest"},{"key":"1127_CR19","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.ceb.2009.06.006","volume":"21","author":"CJ Morrison","year":"2009","unstructured":"Morrison CJ, Butler GS, Rodr\u00edguez D, Overall CM. Matrix metalloproteinase proteomics: substrates, targets, and therapy. Curr Opin Cell Biol. 2009;21:645\u2013653.","journal-title":"Curr Opin Cell Biol"},{"key":"1127_CR20","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.2174\/092986708784567680","volume":"15","author":"G Tu","year":"2008","unstructured":"Tu G, Xu W, Huang H, Li S. Progress in the development of matrix metalloproteinase inhibitors. Curr Med Chem. 2008;15:1388\u20131395.","journal-title":"Curr Med Chem"},{"key":"1127_CR21","doi-asserted-by":"crossref","first-page":"8781","DOI":"10.1016\/j.bmc.2008.08.058","volume":"16","author":"D Georgiadis","year":"2008","unstructured":"Georgiadis D, Yiotakis A. Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge. Bioorg Med Chem. 2008;16:8781\u20138794.","journal-title":"Bioorg Med Chem"},{"key":"1127_CR22","first-page":"9","volume":"238","author":"RT Poon","year":"2003","unstructured":"Poon RT, Fan ST, Wong J. Clinical significance of angiogenesis in gastrointestinal cancers: a target for novel prognostic and therapeutic approaches. Ann Surg. 2003;238:9\u201328.","journal-title":"Ann Surg"},{"key":"1127_CR23","doi-asserted-by":"crossref","first-page":"97","DOI":"10.2147\/vhrm.2006.2.2.97","volume":"2","author":"RW Pang","year":"2006","unstructured":"Pang RW, Poon RT. Clinical implications of angiogenesis in cancers. Vasc Health Risk Manag. 2006;2:97\u2013108.","journal-title":"Vasc Health Risk Manag"},{"key":"1127_CR24","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/nrclinonc.2009.110","volume":"6","author":"A Grothey","year":"2009","unstructured":"Grothey A, Galanis E. Targeting angiogenesis: progress with anti-VEGF treatment with large molecules. Nat Rev Clin Oncol. 2009;6:507\u2013518.","journal-title":"Nat Rev Clin Oncol"},{"key":"1127_CR25","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1517\/14712590802666397","volume":"9","author":"QS Chu","year":"2009","unstructured":"Chu QS. Aflibercept (AVE0005): an alternative strategy for inhibiting tumour angiogenesis by vascular endothelial growth factors. Expert Opin Biol Ther. 2009;9:263\u2013271.","journal-title":"Expert Opin Biol Ther"},{"key":"1127_CR26","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/nrc745","volume":"2","author":"M Egeblad","year":"2002","unstructured":"Egeblad M, Werb Z. New functions for the matrix metalloproteinases in cancer progression. Nat Rev Cancer. 2002;2:161\u2013174.","journal-title":"Nat Rev Cancer"},{"key":"1127_CR27","first-page":"1647","volume":"6","author":"MJ Gorrin-Rivas","year":"2000","unstructured":"Gorrin-Rivas MJ, Arii S, Furutani M, et al. Mouse macrophage metalloelastase gene transfer into a murine melanoma suppresses primary tumor growth by halting angiogenesis. Clin Cancer Res. 2000;6:1647\u20131654.","journal-title":"Clin Cancer Res"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-010-1127-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10620-010-1127-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-010-1127-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T12:36:25Z","timestamp":1634819785000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10620-010-1127-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2,3]]},"references-count":27,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2010,11]]}},"alternative-id":["1127"],"URL":"https:\/\/doi.org\/10.1007\/s10620-010-1127-3","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,2,3]]}}}