{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:04:23Z","timestamp":1790773463057,"version":"4.1.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2010,3,21]],"date-time":"2010-03-21T00:00:00Z","timestamp":1269129600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1007\/s10620-010-1178-5","type":"journal-article","created":{"date-parts":[[2010,3,20]],"date-time":"2010-03-20T10:30:41Z","timestamp":1269081041000},"page":"3488-3494","source":"Crossref","is-referenced-by-count":39,"title":["The Association of Inflammatory Bowel Disease and Mediterranean Fever Gene (MEFV) Mutations in Turkish Children"],"prefix":"10.1007","volume":"55","author":[{"given":"Nuray","family":"Uslu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aysel","family":"Y\u00fcce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00fclya","family":"Demir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inci N.","family":"Saltik-Temizel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuf","family":"Usta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Engin","family":"Yilmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nesrin","family":"Be\u015fba\u015f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Figen","family":"G\u00fcrakan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasan","family":"\u00d6zen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seza","family":"\u00d6zen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,3,21]]},"reference":[{"key":"1178_CR1","doi-asserted-by":"crossref","first-page":"413","DOI":"10.3748\/wjg.14.413","volume":"14","author":"M Dubinsky","year":"2008","unstructured":"Dubinsky M. Special issues in pediatric inflammatory bowel disease. World J Gastroenterol. 2008;14:413\u2013420.","journal-title":"World J Gastroenterol"},{"key":"1178_CR2","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/35079107","volume":"411","author":"JP Hugot","year":"2001","unstructured":"Hugot JP, Chamaillard M, Zouali H, et al. Association of NOD-2 leucine rich repeat variants with susceptibility to Crohn\u2019s disease. Nature. 2001;411:599\u2013603.","journal-title":"Nature"},{"key":"1178_CR3","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/35079114","volume":"411","author":"Y Ogura","year":"2001","unstructured":"Ogura Y, Bonen DK, Inohara N, et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn\u2019s disease. Nature. 2001;411:603\u2013606.","journal-title":"Nature"},{"key":"1178_CR4","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1038\/ng.175","volume":"40","author":"JC Barrett","year":"2008","unstructured":"Barrett JC, Hansoul S, Nicolae D, et al. Genome-wide association defines more than thirty distinct susceptibility loci for Crohn\u2019s disease. Nat Genet. 2008;40:955\u2013962.","journal-title":"Nat Genet"},{"key":"1178_CR5","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1002\/art.1780401023","volume":"40","author":"A Livneh","year":"1997","unstructured":"Livneh A, Langevitz P, Zemer D, et al. Criteria for the diagnosis of familial Mediterranean fever. Arthritis Rheum. 1997;40:1879\u20131885.","journal-title":"Arthritis Rheum"},{"key":"1178_CR6","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s00431-003-1223-x","volume":"162","author":"S Ozen","year":"2003","unstructured":"Ozen S. Familial Mediterranean fever: revisiting an ancient disease. Eur J Pediatr. 2003;162:449\u2013454.","journal-title":"Eur J Pediatr"},{"key":"1178_CR7","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1136\/ard.2008.092031","volume":"68","author":"S Ozen","year":"2009","unstructured":"Ozen S, Aktay N, Lainka E, Duzova A, Bakkaloglu A, Kallinich T. Disease severity in children and adolescents with familial Mediterranean fever: a comparative study to explore environmental effects on a monogenic disease. Ann Rheum Dis. 2009;68:246\u2013248.","journal-title":"Ann Rheum Dis"},{"key":"1178_CR8","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1136\/ard.2006.052688","volume":"65","author":"S Ozen","year":"2006","unstructured":"Ozen S, Hoffman HM, Frenkerl J, Kastner D. Familial Mediterranean fever (FMF) and beyond: a new horizon. Fourth international congress on the systemic autoinflammatory disease held in Bethesda, USA, 6\u201310 November 2005. Ann Rheum Dis. 2006;65:961\u2013964.","journal-title":"Ann Rheum Dis"},{"key":"1178_CR9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/01.md.0000152370.84628.0c","volume":"84","author":"Turkish FMF study group","year":"2005","unstructured":"Turkish FMF study group. Familial Mediterranean fever (FMF) disease in Turkey. Medicine. 2005;84:1\u201311.","journal-title":"Medicine"},{"key":"1178_CR10","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/sj.ejhg.5200674","volume":"9","author":"E Yilmaz","year":"2001","unstructured":"Yilmaz E, Ozen S, Balci B, et al. Mutation frequency of familial Mediterranean fever and evidence for a high carrier rate in the Turkish population. Eur J Hum Genet. 2001;9:553\u2013555.","journal-title":"Eur J Hum Genet"},{"key":"1178_CR11","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1093\/rheumatology\/ken409","volume":"48","author":"NA Ayaz","year":"2009","unstructured":"Ayaz NA, Ozen S, Bilginer Y, et al. MEFV mutations in systemic onset juvenile idiopathic arthritis. Rheumatology. 2009;48:23\u201325.","journal-title":"Rheumatology"},{"key":"1178_CR12","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/S0140-6736(99)02134-0","volume":"355","author":"D Cattan","year":"2000","unstructured":"Cattan D, Notarnicola C, Molinari N, Touitou I. Inflammatory bowel disease in non-Ashkenazi Jews with familial Mediterranean fever. Lancet. 2000;355:378\u2013379.","journal-title":"Lancet"},{"key":"1178_CR13","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1111\/j.1572-0241.2005.40810.x","volume":"100","author":"HH Fidder","year":"2005","unstructured":"Fidder HH, Chowers Y, Ackerman Z, et al. The familial Mediterranean fever (MEFV) gene as a modifier of Crohn\u2019s disease. Am J Gatroenterol. 2005;100:338\u2013343.","journal-title":"Am J Gatroenterol"},{"key":"1178_CR14","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1097\/00005792-200211000-00001","volume":"81","author":"HH Fidder","year":"2002","unstructured":"Fidder HH, Chowers Y, Lidar M, Sternberg M, Langevitz P, Livneh A. Crohn's disease in patients with familial Mediterranean fever. Medicine. 2002;81:411\u2013416.","journal-title":"Medicine"},{"key":"1178_CR15","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1007\/s10620-006-3192-1","volume":"51","author":"S Giaglis","year":"2006","unstructured":"Giaglis S, Mimidis K, Papadopoulos V, et al. Increased frequency of mutations in the gene responsible for familial Mediterranean fever (MEFV) in a cohort of patients with ulcerative colitis: evidence for a potential disease-modifying effect? Dig Dis Sci. 2006;51:687\u2013692.","journal-title":"Dig Dis Sci"},{"key":"1178_CR16","first-page":"2014","volume":"30","author":"S Ozen","year":"2003","unstructured":"Ozen S, Bakkaloglu A, Yilmaz E, et al. Mutations in the gene for familial Mediterranean fever: do they predispose to inflammation? J Rheum. 2003;30:2014\u20132018.","journal-title":"J Rheum"},{"key":"1178_CR17","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s00431-007-0508-x","volume":"167","author":"S Sari","year":"2006","unstructured":"Sari S, Egritas O, Dalgic B. The familial Mediterranean fever (MEFV) gene may be a modifier factor of inflammatory bowel disease in infancy. Eur J Pediatr. 2006;167:391\u2013393.","journal-title":"Eur J Pediatr"},{"key":"1178_CR18","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1089\/gtmb.2008.0094","volume":"13","author":"E Yurtcu","year":"2009","unstructured":"Yurtcu E, Gokcan H, Yilmaz U, Sahin FI. Detection of MEFV gene mutations in patients with inflammatory bowel disease. Genet Test Mol Biomarkers. 2009;13:87\u201390.","journal-title":"Genet Test Mol Biomarkers"},{"key":"1178_CR19","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1136\/ard.60.2.146","volume":"60","author":"E Ben-Chetrit","year":"2001","unstructured":"Ben-Chetrit E, Backenroth R. Amyloidosis induced, end stage renal disease in patients with familial Mediterranean fever is highly associated with point mutations in the MEFV gene. Ann Rheum Dis. 2001;60:146\u2013149.","journal-title":"Ann Rheum Dis"},{"key":"1178_CR20","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/ng0997-25","volume":"17","author":"FMF The French","year":"1997","unstructured":"The French FMF. Consortium: a candidate gene for familial Mediterranean fever. Nat Genet. 1997;17:25\u201331.","journal-title":"Nat Genet"},{"key":"1178_CR21","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/S0092-8674(00)80539-5","volume":"90","author":"The International FMF Consortium","year":"1997","unstructured":"The International FMF Consortium. Ancient missense mutations in a new member of RoRet gene family are likely to cause familial Mediterranean fever. Cell. 1997;90:797\u2013807.","journal-title":"Cell"},{"key":"1178_CR22","doi-asserted-by":"crossref","first-page":"9982","DOI":"10.1073\/pnas.0602081103","volume":"103","author":"JJ Chae","year":"2006","unstructured":"Chae JJ, Wood G, Masters SL, et al. The B30.2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-1 modulate IL-1 beta production. Proc Natl Acad Sci USA. 2006;103:9982\u20139987.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1178_CR23","first-page":"120","volume":"24","author":"M Kalyoncu","year":"2006","unstructured":"Kalyoncu M, Acar BC, Cakar N, et al. Are carriers for MEFV mutations \u201chealthy\u201d? Clin Exp Rheumatol. 2006;24:120\u2013122.","journal-title":"Clin Exp Rheumatol"},{"key":"1178_CR24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/01.MPG.0000163736.30261.82","volume":"41","author":"IBD Working Group of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition","year":"2005","unstructured":"IBD Working Group of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition. Inflammatory bowel disease in children and adolescents: recommendations for diagnosis\u2014the Porto criteria. J Pediatr Gastroenterol Nutr. 2005;41:1\u20137.","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"1178_CR25","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1097\/MPG.0b013e31805563f3","volume":"44","author":"A Bousvaros","year":"2007","unstructured":"North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition: Colitis Foundation of America, Bousvaros A, Antonioli DA, Colletti RB, et al. Differentiating ulcerative colitis from Crohn\u2019s disease in children and young adults: report of a working group of the North American society for pediatric gastroenterology, hepatology and the Crohn\u2019s and colitis foundation of America. J Pediatr Gastroenterol Nutr. 2007;44:653\u2013674.","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"1178_CR26","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1097\/00005176-199105000-00005","volume":"12","author":"JS Hyams","year":"1991","unstructured":"Hyams JS, Ferry GD, Mandel FS, et al. Development and validation of a pediatric Crohn\u2019s disease activity index. J Pediatr Gastroenterol Nutr. 1991;12:439\u2013447.","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"1178_CR27","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1053\/j.gastro.2007.05.029","volume":"133","author":"D Turner","year":"2007","unstructured":"Turner D, Otley AR, Mack D, et al. Development, validation, and evaluation of a pediatric ulcerative colitis activity index: a prospective multicenter study. Gastroenterology. 2007;133:423\u2013432.","journal-title":"Gastroenterology"},{"key":"1178_CR28","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.jpeds.2007.04.062","volume":"151","author":"F Yalcinkaya","year":"2007","unstructured":"Yalcinkaya F, Ozcakar ZB, Kasapcopur O, et al. Prevalence of MEFV gene mutations in childhood polyarteris nodosa. J Pediatr. 2007;151:675\u2013678.","journal-title":"J Pediatr"},{"key":"1178_CR29","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/ncprheum0681","volume":"4","author":"LD Church","year":"2008","unstructured":"Church LD, Cook GP, McDermott MF. Primer: inflammasomes and interleukin 1beta in inflammatory disorders. Nat Clin Pract Rheumatol. 2008;4:34\u201342.","journal-title":"Nat Clin Pract Rheumatol"},{"key":"1178_CR30","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1067\/S0022-3476(03)00502-X","volume":"143","author":"R Gershoni Baruch","year":"2003","unstructured":"Gershoni Baruch R, Broza Y, Brik R. Prevalence and significance of mutations in the familial Mediterranean fever gene in Henoch-Sch\u00f6nlein purpura. J Pediatr. 2003;143:658\u2013661.","journal-title":"J Pediatr"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-010-1178-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10620-010-1178-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-010-1178-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T15:42:56Z","timestamp":1559230976000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10620-010-1178-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3,21]]},"references-count":30,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["1178"],"URL":"https:\/\/doi.org\/10.1007\/s10620-010-1178-5","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,3,21]]}}}