{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:46:05Z","timestamp":1791276365794,"version":"4.1.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2010,6,19]],"date-time":"2010-06-19T00:00:00Z","timestamp":1276905600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2011,2]]},"DOI":"10.1007\/s10620-010-1296-0","type":"journal-article","created":{"date-parts":[[2010,6,18]],"date-time":"2010-06-18T16:59:03Z","timestamp":1276880343000},"page":"406-416","source":"Crossref","is-referenced-by-count":84,"title":["Loss of Matrix Metalloproteinase-2 Amplifies Murine Toxin-Induced Liver Fibrosis by Upregulating Collagen\u00a0I Expression"],"prefix":"10.1007","volume":"56","author":[{"given":"Brian D.","family":"Radbill","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritu","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Celeste M.","family":"Ramirez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Analisa","family":"DiFeo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Martignetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos E.","family":"Alvarez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott L.","family":"Friedman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goutham","family":"Narla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raluca","family":"Vrabie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Bowles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yedidya","family":"Saiman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meena B.","family":"Bansal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,6,19]]},"reference":[{"key":"1296_CR1","doi-asserted-by":"crossref","first-page":"5872","DOI":"10.1074\/jbc.270.11.5872","volume":"270","author":"RT Aimes","year":"1995","unstructured":"Aimes RT, Quigley JP. Matrix metalloproteinase-2 is an interstitial collagenase. Inhibitor-free enzyme catalyzes the cleavage of collagen fibrils and soluble native type i collagen generating the specific 3\/4- and 1\/4-length fragments. J Biol Chem. 1995;270:5872\u20135876.","journal-title":"J Biol Chem"},{"key":"1296_CR2","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1172\/JCI114270","volume":"84","author":"MJ Arthur","year":"1989","unstructured":"Arthur MJ, Friedman SL, Roll FJ, Bissell DM. Lipocytes from normal rat liver release a neutral metalloproteinase that degrades basement membrane (type iv) collagen. J Clin Invest. 1989;84:1076\u20131085.","journal-title":"J Clin Invest"},{"key":"1296_CR3","doi-asserted-by":"crossref","first-page":"25454","DOI":"10.1016\/S0021-9258(18)47272-9","volume":"269","author":"JM Tournier","year":"1994","unstructured":"Tournier JM, Polette M, Hinnrasky J, Beck J, et\u00a0al. Expression of gelatinase a, a mediator of extracellular matrix remodeling, by tracheal gland serous cells in culture and in\u00a0vivo. J Biol Chem. 1994;269:25454\u201325464.","journal-title":"J Biol Chem"},{"key":"1296_CR4","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1002\/hep.1840210328","volume":"21","author":"T Takahara","year":"1995","unstructured":"Takahara T, Furui K, Funaki J, Nakayama Y, et\u00a0al. Increased expression of matrix metalloproteinase-ii in experimental liver fibrosis in rats. Hepatology. 1995;21:787\u2013795.","journal-title":"Hepatology"},{"key":"1296_CR5","first-page":"528","volume":"144","author":"S Milani","year":"1994","unstructured":"Milani S, Herbst H, Schuppan D, Grappone C, et\u00a0al. Differential expression of matrix-metalloproteinase-1 and -2 genes in normal and fibrotic human liver. Am J Pathol. 1994;144:528\u2013537.","journal-title":"Am J Pathol"},{"key":"1296_CR6","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1055\/s-2001-17552","volume":"21","author":"RC Benyon","year":"2001","unstructured":"Benyon RC, Arthur MJ. Extracellular matrix degradation and the role of hepatic stellate cells. Semin Liver Dis. 2001;21:373\u2013384.","journal-title":"Semin Liver Dis"},{"key":"1296_CR7","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1002\/hep.510300431","volume":"30","author":"RC Benyon","year":"1999","unstructured":"Benyon RC, Hovell CJ, Da Gaca M, Jones EH, et\u00a0al. Progelatinase a is produced and activated by rat hepatic stellate cells and promotes their proliferation. Hepatology. 1999;30:977\u2013986.","journal-title":"Hepatology"},{"key":"1296_CR8","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1053\/j.gastro.2004.03.009","volume":"126","author":"R Issa","year":"2004","unstructured":"Issa R, Zhou X, Constandinou CM, Fallowfield J, et\u00a0al. Spontaneous recovery from micronodular cirrhosis: Evidence for incomplete resolution associated with matrix cross-linking. Gastroenterology. 2004;126:1795\u20131808.","journal-title":"Gastroenterology"},{"key":"1296_CR9","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1172\/JCI1018","volume":"102","author":"JP Iredale","year":"1998","unstructured":"Iredale JP, Benyon RC, Pickering J, McCullen M, et\u00a0al. Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors. J Clin Invest. 1998;102:538\u2013549.","journal-title":"J Clin Invest"},{"key":"1296_CR10","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1053\/jhep.2002.35279","volume":"36","author":"AM Preaux","year":"2002","unstructured":"Preaux AM, D\u2019Ortho MP, Bralet MP, Laperche Y, Mavier P. Apoptosis of human hepatic myofibroblasts promotes activation of matrix metalloproteinase-2. Hepatology. 2002;36:615\u2013622.","journal-title":"Hepatology"},{"key":"1296_CR11","doi-asserted-by":"crossref","first-page":"22389","DOI":"10.1074\/jbc.272.36.22389","volume":"272","author":"T Itoh","year":"1997","unstructured":"Itoh T, Ikeda T, Gomi H, Nakao S, et\u00a0al. Unaltered secretion of beta-amyloid precursor protein in gelatinase a (matrix metalloproteinase 2)-deficient mice. J Biol Chem. 1997;272:22389\u201322392.","journal-title":"J Biol Chem"},{"key":"1296_CR12","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1093\/hmg\/ddm060","volume":"16","author":"RA Mosig","year":"2007","unstructured":"Mosig RA, Dowling O, DiFeo A, Ramirez MC, et\u00a0al. Loss of mmp-2 disrupts skeletal and craniofacial development and results in decreased bone mineralization, joint erosion and defects in osteoblast and osteoclast growth. Hum Mol Genet. 2007;16:1113\u20131123.","journal-title":"Hum Mol Genet"},{"key":"1296_CR13","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1053\/j.gastro.2004.04.062","volume":"127","author":"R Safadi","year":"2004","unstructured":"Safadi R, Ohta M, Alvarez CE, Fiel MI, et\u00a0al. Immune stimulation of hepatic fibrogenesis by cd8 cells and attenuation by transgenic interleukin-10 from hepatocytes. Gastroenterology. 2004;127:870\u2013882.","journal-title":"Gastroenterology"},{"key":"1296_CR14","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/hep.510310123","volume":"31","author":"K Kovalovich","year":"2000","unstructured":"Kovalovich K, DeAngelis RA, Li W, Furth EE, et\u00a0al. Increased toxin-induced liver injury and fibrosis in interleukin-6-deficient mice. Hepatology. 2000;31:149\u2013159.","journal-title":"Hepatology"},{"key":"1296_CR15","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1136\/gut.2004.042127","volume":"54","author":"L Xu","year":"2005","unstructured":"Xu L, Hui AY, Albanis E, Arthur MJ, et\u00a0al. Human hepatic stellate cell lines, LX-1 and LX-2: New tools for analysis of hepatic fibrosis. Gut. 2005;54:142\u2013151.","journal-title":"Gut"},{"key":"1296_CR16","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1002\/hep.22890","volume":"49","author":"F Hong","year":"2009","unstructured":"Hong F, Tuyama A, Lee T, Loke J, et\u00a0al. Hepatic stellate cells express functional CXCR4: Role in stromal cell-derived factor -1\u03b1 -mediated stellate cell activation. Hepatology. 2009;49:2055\u20132067.","journal-title":"Hepatology"},{"key":"1296_CR18","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.jhep.2004.11.043","volume":"42","author":"MB Bansal","year":"2005","unstructured":"Bansal MB, Kovalovich K, Gupta R, Li W, et\u00a0al. Interleukin-6 protects hepatocytes from CCl4-mediated necrosis and apoptosis in mice by reducing MMP-2 expression. J Hepatol. 2005;42:548\u2013556.","journal-title":"J Hepatol"},{"key":"1296_CR19","doi-asserted-by":"crossref","first-page":"2824","DOI":"10.1002\/(SICI)1522-2683(19991001)20:14<2824::AID-ELPS2824>3.0.CO;2-H","volume":"20","author":"J Le","year":"1999","unstructured":"Le J, Dauchot P, Perrot JL, Cambazard F, et\u00a0al. Quantitative zymography of matrix metalloproteinases by measuring hydroxyproline: Application to gelatinases a and b. Electrophoresis. 1999;20:2824\u20132829.","journal-title":"Electrophoresis"},{"key":"1296_CR20","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1038\/nm1101-1202","volume":"7","author":"B Wielockx","year":"2001","unstructured":"Wielockx B, Lannoy K, Shapiro SD, Itoh T, et\u00a0al. Inhibition of matrix metalloproteinases blocks lethal hepatitis and apoptosis induced by tumor necrosis factor and allows safe antitumor therapy. Nat Med. 2001;7:1202\u20131208.","journal-title":"Nat Med"},{"key":"1296_CR21","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1046\/j.1440-1746.1999.01928.x","volume":"14","author":"D Li","year":"1999","unstructured":"Li D, Friedman SL. Liver fibrogenesis and the role of hepatic stellate cells: New insights and prospects for therapy. J Gastroenterol Hepatol. 1999;14:618\u2013633.","journal-title":"J Gastroenterol Hepatol"},{"key":"1296_CR22","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1074\/jbc.275.4.2247","volume":"275","author":"SL Friedman","year":"2000","unstructured":"Friedman SL. Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J Biol Chem. 2000;275:2247\u20132250.","journal-title":"J Biol Chem"},{"key":"1296_CR17","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1056\/NEJM199306243282508","volume":"328","author":"SL Friedman","year":"1993","unstructured":"Friedman SL. Seminars in medicine of the beth Israel hospital, Boston. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies. N Engl J Med. 1993;328:1828\u20131835.","journal-title":"N Engl J Med"},{"key":"1296_CR23","first-page":"293","volume":"29","author":"AM Gressner","year":"1991","unstructured":"Gressner AM. Liver fibrosis: Perspectives in pathobiochemical research and clinical outlook. Eur J Clin Chem Clin Biochem. 1991;29:293\u2013311.","journal-title":"Eur J Clin Chem Clin Biochem"},{"key":"1296_CR24","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1053\/gast.2003.50012","volume":"124","author":"C Yang","year":"2003","unstructured":"Yang C, Zeisberg M, Mosterman B, Sudhakar A, et\u00a0al. Liver fibrosis: Insights into migration of hepatic stellate cells in response to extracellular matrix and growth factors. Gastroenterology. 2003;124:147\u2013159.","journal-title":"Gastroenterology"},{"key":"1296_CR25","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s004180000150","volume":"113","author":"T Knittel","year":"2000","unstructured":"Knittel T, Mehde M, Grundmann A, Saile B, et\u00a0al. Expression of matrix metalloproteinases and their inhibitors during hepatic tissue repair in the rat. Histochem Cell Biol. 2000;113:443\u2013453.","journal-title":"Histochem Cell Biol"},{"key":"1296_CR26","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0168-8278(00)00037-4","volume":"34","author":"R Lichtinghagen","year":"2001","unstructured":"Lichtinghagen R, Michels D, Haberkorn CI, Arndt B, et\u00a0al. Matrix metalloproteinase (mmp)-2, mmp-7, and tissue inhibitor of metalloproteinase-1 are closely related to the fibroproliferative process in the liver during chronic hepatitis c. J Hepatol. 2001;34:239\u2013247.","journal-title":"J Hepatol"},{"key":"1296_CR27","doi-asserted-by":"crossref","unstructured":"Ebrahimkhani MR, Kiani S, Oakley F, Kendall T, et\u00a0al. Naltrexone, an opioid receptor antagonist, attenuates liver fibrosis in bile duct ligated rats. Gut. 2006.","DOI":"10.1136\/gut.2005.076778"},{"key":"1296_CR28","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.jhep.2004.04.010","volume":"41","author":"S Reif","year":"2004","unstructured":"Reif S, Aeed H, Shilo Y, Reich R, et\u00a0al. Treatment of thioacetamide-induced liver cirrhosis by the ras antagonist, farnesylthiosalicylic acid. J Hepatol. 2004;41:235\u2013241.","journal-title":"J Hepatol"},{"key":"1296_CR29","first-page":"1114","volume":"48","author":"HS Lee","year":"2001","unstructured":"Lee HS, Huang GT, Miau LH, Chiou LL, et\u00a0al. Expression of matrix metalloproteinases in spontaneous regression of liver fibrosis. Hepato-Gastroenterology. 2001;48:1114\u20131117.","journal-title":"Hepato-Gastroenterology"},{"key":"1296_CR30","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/370555a0","volume":"370","author":"AJ Gearing","year":"1994","unstructured":"Gearing AJ, Beckett P, Christodoulou M, Churchill M, et\u00a0al. Processing of tumour necrosis factor-alpha precursor by metalloproteinases. Nature. 1994;370:555\u2013557.","journal-title":"Nature"},{"key":"1296_CR31","doi-asserted-by":"crossref","first-page":"7069","DOI":"10.1073\/pnas.93.14.7069","volume":"93","author":"E Levi","year":"1996","unstructured":"Levi E, Fridman R, Miao HQ, Ma YS, et\u00a0al. Matrix metalloproteinase 2 releases active soluble ectodomain of fibroblast growth factor receptor 1. Proc Natl Acad Sci USA. 1996;93:7069\u20137074.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1296_CR32","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1055\/s-2001-17556","volume":"21","author":"D Schuppan","year":"2001","unstructured":"Schuppan D, Ruehl M, Somasundaram R, Hahn EG. Matrix as a modulator of hepatic fibrogenesis. Semin Liver Dis. 2001;21:351\u2013372.","journal-title":"Semin Liver Dis"},{"key":"1296_CR33","doi-asserted-by":"crossref","first-page":"21352","DOI":"10.1074\/jbc.M111663200","volume":"277","author":"SL Dallas","year":"2002","unstructured":"Dallas SL, Rosser JL, Mundy GR, Bonewald LF. Proteolysis of latent transforming growth factor-beta (tgf-beta)-binding protein-1 by osteoclasts. A cellular mechanism for release of tgf-beta from bone matrix. J Biol Chem. 2002;277:21352\u201321360.","journal-title":"J Biol Chem"},{"key":"1296_CR34","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s00395-008-0715-2","volume":"103","author":"S Linthout Van","year":"2008","unstructured":"Van Linthout S, Seeland U, Riad A, Eckhardt O, et\u00a0al. Reduced mmp-2 activity contributes to cardiac fibrosis in experimental diabetic cardiomyopathy. Basic Res Cardiol. 2008;103:319\u2013327.","journal-title":"Basic Res Cardiol"},{"key":"1296_CR35","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/nrc745","volume":"2","author":"M Egeblad","year":"2002","unstructured":"Egeblad M, Werb Z. New functions for the matrix metalloproteinases in cancer progression. Nat Rev Cancer. 2002;2:161\u2013174.","journal-title":"Nat Rev Cancer"},{"key":"1296_CR36","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1161\/01.CIR.0000028818.33488.7B","volume":"106","author":"W Wang","year":"2002","unstructured":"Wang W, Schulze CJ, Suarez-Pinzon WL, Dyck JR, et\u00a0al. Intracellular action of matrix metalloproteinase-2 accounts for acute myocardial ischemia and reperfusion injury. Circulation. 2002;106:1543\u20131549.","journal-title":"Circulation"},{"key":"1296_CR37","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1096\/fj.02-1202fje","volume":"18","author":"JA Kwan","year":"2004","unstructured":"Kwan JA, Schulze CJ, Wang W, Leon H, et\u00a0al. Matrix metalloproteinase-2 (mmp-2) is present in the nucleus of cardiac myocytes and is capable of cleaving poly (adp-ribose) polymerase (parp) in\u00a0vitro. FASEB J. 2004;18:690\u2013692.","journal-title":"FASEB J"},{"key":"1296_CR38","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.yexmp.2005.03.008","volume":"80","author":"C Garciade Leon Mdel","year":"2006","unstructured":"Garciade Leon Mdel C, Montfort I, Tello Montes E, Lopez Vancell R, et\u00a0al. Hepatocyte production of modulators of extracellular liver matrix in normal and cirrhotic rat liver. Exp Mol Pathol. 2006;80:97\u2013108.","journal-title":"Exp Mol Pathol"},{"key":"1296_CR39","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1002\/hep.510260418","volume":"26","author":"AG Upadhya","year":"1997","unstructured":"Upadhya AG, Harvey RP, Howard TK, Lowell JA, et\u00a0al. Evidence of a role for matrix metalloproteinases in cold preservation injury of the liver in humans and in the rat. Hepatology. 1997;26:922\u2013928.","journal-title":"Hepatology"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-010-1296-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10620-010-1296-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-010-1296-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T20:36:26Z","timestamp":1635539786000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10620-010-1296-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6,19]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,2]]}},"alternative-id":["1296"],"URL":"https:\/\/doi.org\/10.1007\/s10620-010-1296-0","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,6,19]]}}}