{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T09:14:55Z","timestamp":1771924495130,"version":"3.50.1"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2010,10,9]],"date-time":"2010-10-09T00:00:00Z","timestamp":1286582400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2011,5]]},"DOI":"10.1007\/s10620-010-1431-y","type":"journal-article","created":{"date-parts":[[2010,10,13]],"date-time":"2010-10-13T17:57:01Z","timestamp":1286992621000},"page":"1299-1308","source":"Crossref","is-referenced-by-count":10,"title":["Establishment of a Reflux Esophago-Laryngitis Model in Rats"],"prefix":"10.1007","volume":"56","author":[{"given":"Daisuke","family":"Asaoka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihito","family":"Nagahara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masako","family":"Oguro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Mori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kosaburo","family":"Nakae","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Izumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taro","family":"Osada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariko","family":"Hojo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michiro","family":"Otaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumio","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,10,9]]},"reference":[{"key":"1431_CR1","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1053\/S1542-3565(03)00177-0","volume":"1","author":"MF Vaezi","year":"2003","unstructured":"Vaezi MF, Hicks DM, Abelson TI, Richter JE. Laryngeal signs and symptoms and gastroesophageal reflux disease (GERD): a critical assessment of cause and effect association. Clin Gastroenterol Hepatol. 2003;1:333\u2013344.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"1431_CR2","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1001\/jama.294.12.1534","volume":"294","author":"CN Ford","year":"2005","unstructured":"Ford CN. Evaluation and management of laryngopharyngeal reflux. JAMA. 2005;294:1534\u20131540.","journal-title":"JAMA"},{"key":"1431_CR3","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s00535-007-2033-0","volume":"42","author":"S Watanabe","year":"2007","unstructured":"Watanabe S, Hojo M, Nagahara A. Metabolic syndrome and gastrointestinal diseases. J Gastroenterol. 2007;42:267\u2013274.","journal-title":"J Gastroenterol"},{"key":"1431_CR4","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1111\/j.1572-0241.2006.00630.x","volume":"101","author":"N Vakil","year":"2006","unstructured":"Vakil N, van Zanten SV, Kahrilas P, Dent J, Jones R, Global Consensus Group. The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus. Am J Gastroenterol. 2006;101:1900\u20131920.","journal-title":"Am J Gastroenterol"},{"key":"1431_CR5","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1097\/01.MLG.0000163746.81766.45","volume":"115","author":"W Park","year":"2005","unstructured":"Park W, Hicks DM, Khandwala F, et\u00a0al. Laryngopharyngeal reflux: prospective cohort study evaluating optimal dose of proton-pump inhibitor therapy and pretherapy predictors of response. Laryngoscope. 2005;115:1230\u20131238.","journal-title":"Laryngoscope"},{"key":"1431_CR6","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/S0892-1997(88)80060-2","volume":"2","author":"JA Koufman","year":"1988","unstructured":"Koufman JA, Weiner GJ, Wallace CW, Castell DO. Reflux laryngitis and its sequela. J Voice. 1988;2:78\u201379.","journal-title":"J Voice"},{"key":"1431_CR7","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1097\/00005537-200404000-00014","volume":"114","author":"RL Carrau","year":"2004","unstructured":"Carrau RL, Khidr A, Crawley JA, Hillson EM, Davis JK, Pashos CL. The impact of laryngopharyngeal reflux on patient-reported quality of life. Laryngoscope. 2004;114:670\u2013674.","journal-title":"Laryngoscope"},{"key":"1431_CR8","first-page":"1503","volume":"84","author":"GJ Wiener","year":"1989","unstructured":"Wiener GJ, Koufman JA, Wu WC, Cooper JB, Richter JE, Castell DO. Chronic hoarseness secondary to gastroesophageal reflux disease: documentation with 24-h ambulatory pH monitoring. Am J Gastroenterol. 1989;84:1503\u20131508.","journal-title":"Am J Gastroenterol"},{"key":"1431_CR9","first-page":"1","volume":"84","author":"WK Deschner","year":"1989","unstructured":"Deschner WK, Benjamin SB. Extraesophageal manifestations of gastroesophageal reflux disease. Am J Gastroenterol. 1989;84:1\u20135.","journal-title":"Am J Gastroenterol"},{"key":"1431_CR10","doi-asserted-by":"crossref","first-page":"3480","DOI":"10.3748\/wjg.15.3480","volume":"15","author":"D Asaoka","year":"2009","unstructured":"Asaoka D, Nagahara A, Oguro M, et\u00a0al. Characteristic pathological findings and effects of ecabet sodium in rat reflux esophagitis. World J Gastroenterol. 2009;15:3480\u20133485.","journal-title":"World J Gastroenterol"},{"key":"1431_CR11","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1097\/00005537-200108000-00001","volume":"111","author":"PC Belafsky","year":"2001","unstructured":"Belafsky PC, Postma GN, Koufman JA. The validity and reliability of the reflux finding score (RFS). Laryngoscope. 2001;111:1313\u20131317.","journal-title":"Laryngoscope"},{"issue":"suppl 3A","key":"1431_CR12","doi-asserted-by":"crossref","first-page":"105S","DOI":"10.1016\/S0002-9343(03)00206-7","volume":"115","author":"N Maronian","year":"2003","unstructured":"Maronian N, Haggitt R, Oelschlager BK, et\u00a0al. Histologic features of reflux-attributed laryngeal lesions. Am J Med. 2003;115(suppl 3A):105S\u2013108S.","journal-title":"Am J Med"},{"key":"1431_CR13","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1002\/ppul.20715","volume":"42","author":"G Nino","year":"2007","unstructured":"Nino G, Savchenko O, Vastola P, et\u00a0al. Lipid laden macrophage indices and reflux finding score in canine gastroesophageal reflux model. Pediatr Pulmonol. 2007;42:1181\u20131186.","journal-title":"Pediatr Pulmonol"},{"key":"1431_CR14","first-page":"1","volume":"18","author":"R Shimazu","year":"2008","unstructured":"Shimazu R, Kusano K, Kuratomi Y, Inokuchi A. Histological changes of the pharynx and larynx in rats with chronic acid reflux esophagitis. Acta Otolaryngol. 2008;18:1\u20137.","journal-title":"Acta Otolaryngol"},{"key":"1431_CR15","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1080\/003655299750025020","volume":"34","author":"N Omura","year":"1999","unstructured":"Omura N, Kashiwagi H, Chen G, Suzuki Y, Yano F, Aoki T. Establishment of surgically induced chronic acid reflux esophagitis in rats. Scand J Gastroenterol. 1999;34:948\u2013953.","journal-title":"Scand J Gastroenterol"},{"key":"1431_CR16","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1007\/s00535-005-1628-6","volume":"40","author":"D Asaoka","year":"2005","unstructured":"Asaoka D, Miwa H, Hirai S, et\u00a0al. Altered localization and expression of tight-junction proteins in a rat model with chronic acid reflux esophagitis. J Gastroenterol. 2005;40:781\u2013790.","journal-title":"J Gastroenterol"},{"key":"1431_CR17","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.lfs.2009.01.016","volume":"84","author":"Y Izumi","year":"2009","unstructured":"Izumi Y, Otaka M, Takahashi T, et\u00a0al. Specific induction of a 72-kDa heat shock protein protects esophageal mucosa from reflux esophagitis. Life Sci. 2009;84:517\u2013522.","journal-title":"Life Sci"},{"key":"1431_CR18","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1159\/000075698","volume":"68","author":"M Hamaguchi","year":"2003","unstructured":"Hamaguchi M, Fujiwara Y, Takashima T, et\u00a0al. Increased expression of cytokines and adhesion molecules in rat chronic esophagitis. Digestion. 2003;68:189\u2013197. Epub 2003 Dec 19.","journal-title":"Digestion"},{"key":"1431_CR19","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1136\/gut.39.6.787","volume":"39","author":"Y Yasunaga","year":"1996","unstructured":"Yasunaga Y, Shinomura Y, Kanayama S, et\u00a0al. Increased production of interleukin 1 beta and hepatocyte growth factor may contribute to foveolar hyperplasia in enlarged fold gastritis. Gut. 1996;39:787\u2013794.","journal-title":"Gut"},{"issue":"4 Pt 2 suppl 53","key":"1431_CR20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/lary.1991.101.s53.1","volume":"101","author":"JA Koufman","year":"1991","unstructured":"Koufman JA. The otolaryngologic manifestations of gastroesophageal reflux disease (GERD): a clinical investigation of 225 patients using ambulatory 24-h pH monitoring and an experimental investigation of the role of acid and pepsin in the development of laryngeal injury. Laryngoscope. 1991;101(4 Pt 2 suppl 53):1\u201378.","journal-title":"Laryngoscope"},{"key":"1431_CR21","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/0016-5085(91)90196-R","volume":"100","author":"P Jacob","year":"1991","unstructured":"Jacob P, Kahrilas PJ, Herzon G. Proximal esophageal pH-metry in patients with \u2018reflux laryngitis\u2019. Gastroenterology. 1991;100:305\u2013310.","journal-title":"Gastroenterology"},{"key":"1431_CR22","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1288\/00005537-198811000-00009","volume":"98","author":"PH Ward","year":"1988","unstructured":"Ward PH, Hanson DG. Reflux as an etiological factor of carcinoma of the laryngopharynx. Laryngoscope. 1988;98:1195\u20131199.","journal-title":"Laryngoscope"},{"key":"1431_CR23","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1023\/A:1018862814873","volume":"43","author":"MJ Corso","year":"1998","unstructured":"Corso MJ, Pursnani KG, Mohiuddin MA, et\u00a0al. Globus sensation is associated with hypertensive upper esophageal sphincter but not with gastroesophageal reflux. Dig Dis Sci. 1998;43:1513\u20131517.","journal-title":"Dig Dis Sci"},{"key":"1431_CR24","doi-asserted-by":"crossref","first-page":"G262","DOI":"10.1152\/ajpgi.2000.279.2.G262","volume":"279","author":"S Torrico","year":"2000","unstructured":"Torrico S, Kern M, Aslam M, et\u00a0al. Upper esophageal sphincter function during gastroesophageal reflux events revisited. Am J Physiol Gastrointest Liver Physiol. 2000;279:G262\u2013G267.","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"1431_CR25","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1177\/000348940511401204","volume":"114","author":"GA Gill","year":"2005","unstructured":"Gill GA, Johnston N, Buda A, et\u00a0al. Laryngeal epithelial defenses against laryngopharyngeal reflux: investigations of E-cadherin, carbonic anhydrase isoenzyme III, and pepsin. Ann Otol Rhinol Laryngol. 2005;114:913\u2013921.","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"1431_CR26","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1177\/000348940311200601","volume":"112","author":"N Johnston","year":"2003","unstructured":"Johnston N, Bulmer D, Gill GA, et\u00a0al. Cell biology of laryngeal epithelial defenses in health and disease: further studies. Ann Otol Rhinol Laryngol. 2003;112:481\u2013491.","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"1431_CR27","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1177\/000348940111001203","volume":"110","author":"SE Axford","year":"2001","unstructured":"Axford SE, Sharp N, Ross PE, et\u00a0al. Cell biology of laryngeal epithelial defenses in health and disease: preliminary studies. Ann Otol Rhinol Laryngol. 2001;110:1099\u20131108.","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"1431_CR28","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1111\/j.1572-0241.2004.30349.x","volume":"99","author":"O Kawamura","year":"2004","unstructured":"Kawamura O, Aslam M, Rittmann T, Hofmann C, Shaker R. Physical and pH properties of gastroesophagopharyngeal refluxate: a 24-h simultaneous ambulatory impedance and pH monitoring study. Am J Gastroenterol. 2004;99:1000\u20131010.","journal-title":"Am J Gastroenterol"},{"key":"1431_CR29","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.anl.2005.03.002","volume":"32","author":"R Tokashiki","year":"2005","unstructured":"Tokashiki R, Nakamura K, Watanabe Y, Yamaguchi H, Suzuki M. The relationship between esophagoscopic findings and total acid reflux time below pH 4 and pH 5 in the upper esophagus in patients with laryngopharyngeal reflux disease (LPRD). Auris Nasus Larynx. 2005;32:265\u2013268.","journal-title":"Auris Nasus Larynx"},{"key":"1431_CR30","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1016\/0016-5085(95)90646-0","volume":"109","author":"R Shaker","year":"1995","unstructured":"Shaker R, Milbrath M, Ren J, et\u00a0al. Esophagopharyngeal distribution of refluxed gastric acid in patients with reflux laryngitis. Gastroenterology. 1995;109:1575\u20131582.","journal-title":"Gastroenterology"},{"key":"1431_CR31","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1177\/000348940611500108","volume":"115","author":"N Johnston","year":"2006","unstructured":"Johnston N, Dettmar PW, Lively MO, et\u00a0al. Effect of pepsin on laryngeal stress protein (Sep70, Sep53, and Hsp70) response: role in laryngopharyngeal reflux disease. Ann Otol Rhinol Laryngol. 2006;115:47\u201358.","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"1431_CR32","first-page":"127","volume":"27","author":"JP Ludemann","year":"1998","unstructured":"Ludemann JP, Manoukian J, Shaw K, Bernard C, Davis M, al-Jubab A. Effects of simulated gastroesophageal reflux on the untraumatized rabbit larynx. J Otolaryngol. 1998;27:127\u2013131.","journal-title":"J Otolaryngol"},{"key":"1431_CR33","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1007\/s00405-007-0295-z","volume":"264","author":"A Franchi","year":"2007","unstructured":"Franchi A, Brogelli B, Massi D, Santucci M, De Campora E, Gallo O. Dilation of intercellular spaces is associated with laryngo-pharyngeal reflux: an ultrastructural morphometric analysis of laryngeal epithelium. Eur Arch Otorhinolaryngol. 2007;264:907\u2013911.","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"1431_CR34","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1053\/j.gastro.2009.07.055","volume":"137","author":"RF Souza","year":"2009","unstructured":"Souza RF, Huo X, Mittal V, et\u00a0al. Gastroesophageal reflux might cause esophagitis through a cytokine-mediated mechanism rather than caustic acid injury. Gastroenterology. 2009;137:1776\u20131784.","journal-title":"Gastroenterology"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-010-1431-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10620-010-1431-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-010-1431-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,31]],"date-time":"2024-03-31T10:25:59Z","timestamp":1711880759000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10620-010-1431-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10,9]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,5]]}},"alternative-id":["1431"],"URL":"https:\/\/doi.org\/10.1007\/s10620-010-1431-y","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,10,9]]}}}