{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T17:27:51Z","timestamp":1780766871065,"version":"3.54.1"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2010,11,3]],"date-time":"2010-11-03T00:00:00Z","timestamp":1288742400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2011,2]]},"DOI":"10.1007\/s10620-010-1444-6","type":"journal-article","created":{"date-parts":[[2010,11,2]],"date-time":"2010-11-02T17:01:38Z","timestamp":1288717298000},"page":"578-585","source":"Crossref","is-referenced-by-count":62,"title":["Development of Hepatocellular Carcinoma in Autoimmune Hepatitis Patients: A Case Series"],"prefix":"10.1007","volume":"56","author":[{"given":"Robert J.","family":"Wong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Gish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd","family":"Frederick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Bzowej","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Frenette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,11,3]]},"reference":[{"key":"1444_CR1","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1002\/hep.20933","volume":"42","author":"J Bruix","year":"2005","unstructured":"Bruix J, Sherman M. Management of hepatocellular carcinoma. Hepatology. 2005;42:1208\u20131236.","journal-title":"Hepatology"},{"key":"1444_CR2","first-page":"iii1","volume":"53(Suppl. III)","author":"SG Ryder","year":"2003","unstructured":"Ryder SG. Guidelines for the diagnosis and treatment of hepatocellular carcinoma (HCC) in adults. Gut. 2003;53(Suppl. III):iii1\u2013iii8.","journal-title":"Gut"},{"key":"1444_CR3","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1002\/hep.1840080635","volume":"8","author":"KK Wang","year":"1988","unstructured":"Wang KK, Czaja AJ. Hepatocellular carcinoma in corticosteroid treated severe autoimmune chronic active hepatitis. Hepatology. 1988;8:1679\u20131683.","journal-title":"Hepatology"},{"key":"1444_CR4","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1023\/A:1005638500236","volume":"45","author":"SZ Park","year":"2000","unstructured":"Park SZ, Nagorney DM, Czaja AJ. Hepatocellular carcinoma in autoimmune hepatitis. Dig Dis Sci. 2000;45:1944\u20131948.","journal-title":"Dig Dis Sci"},{"key":"1444_CR5","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1097\/00004836-200006000-00020","volume":"30","author":"JT Hardee","year":"2000","unstructured":"Hardee JT, Breth GF, El-Serag HB. Hepatocellular carcinoma associated with autoimmune hepatitis. J Clin Gastroenterol. 2000;30:445\u2013446.","journal-title":"J Clin Gastroenterol"},{"key":"1444_CR6","doi-asserted-by":"crossref","first-page":"578","DOI":"10.3748\/wjg.15.578","volume":"15","author":"A Teufel","year":"2009","unstructured":"Teufel A, Weinmann A, Centner C, et al. Hepatocellular carcinoma in patients with autoimmune hepatitis. World J Gastroenterol. 2009;15:578\u2013582.","journal-title":"World J Gastroenterol"},{"key":"1444_CR7","doi-asserted-by":"crossref","first-page":"231","DOI":"10.3748\/wjg.15.231","volume":"15","author":"T Watanabe","year":"2009","unstructured":"Watanabe T, Soga K, Hirono H, et al. Features of hepatocellular carcinoma in cases with autoimmune hepatitis and primary biliary cirrhosis. World J Gastroenterol. 2009;15:231\u2013239.","journal-title":"World J Gastroenterol"},{"key":"1444_CR8","first-page":"718","volume":"22","author":"SD Ryder","year":"1995","unstructured":"Ryder SD, Koskonas J, Rizzi PM. Hepatocellular carcinoma complicating autoimmune hepatitis: role of hepatitis C virus. Hepatology. 1995;22:718\u2013722.","journal-title":"Hepatology"},{"key":"1444_CR9","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s005350300034","volume":"38","author":"K Hori","year":"2003","unstructured":"Hori K, Fukada Y, Tomita T. Hepatocellular carcinoma complicating autoimmune hepatitis without either hepatitis C viral infection or corticosteroid therapy. J Gastroenterol. 2003;38:197\u2013199.","journal-title":"J Gastroenterol"},{"key":"1444_CR10","doi-asserted-by":"crossref","first-page":"949","DOI":"10.2169\/internalmedicine.44.949","volume":"44","author":"Y Miyake","year":"2005","unstructured":"Miyake Y, Sakaguchi K, Tanaka H. Development of hepatocellular carcinoma in a woman with HBV and HCV-negative autoimmune hepatitis with unsatisfactory response to corticosteroid. Intern Med. 2005;44:949\u2013953.","journal-title":"Intern Med"},{"key":"1444_CR11","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1111\/j.1572-0241.2008.01922.x","volume":"103","author":"AJ Montano-Loza","year":"2008","unstructured":"Montano-Loza AJ, Carpenter HA, Czaja AJ. Predictive factors of hepatocellular carcinoma in type 1 autoimmune hepatitis. Am J Gastroenterol. 2008;103:1944\u20131951.","journal-title":"Am J Gastroenterol"},{"key":"1444_CR12","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1002\/hep.22432","volume":"48","author":"AD Yeoman","year":"2008","unstructured":"Yeoman AD, Al-Chalabi T, Karani JB, et al. Evaluation of risk factors in the development of hepatocellular carcinoma in autoimmune hepatitis: implications of follow-up and screening. Hepatology. 2008;48:863\u2013870.","journal-title":"Hepatology"},{"key":"1444_CR13","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1002\/hep.23584","volume":"51","author":"MP Manns","year":"2010","unstructured":"Manns MP, Czaja AJ, Gorham JD, et al. Diagnosis and management of autoimmune hepatitis. Hepatology. 2010;51:2193\u20132223.","journal-title":"Hepatology"},{"key":"1444_CR14","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1111\/j.1572-0241.2001.03707.x","volume":"96","author":"AJ Czaja","year":"2001","unstructured":"Czaja AJ. Understanding the pathogenesis of autoimmune hepatitis. Am J Gastroenterol. 2001;96:1224\u20131231.","journal-title":"Am J Gastroenterol"},{"key":"1444_CR15","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.1002\/(SICI)1097-0142(19990515)85:10<2132::AID-CNCR6>3.0.CO;2-H","volume":"85","author":"M Chiaramonte","year":"1999","unstructured":"Chiaramonte M, Stroffolini T, Vian A, et al. Rate of incidence of hepatocellular carcinoma in patients with compensated viral cirrhosis. Cancer. 1999;85:2132\u20132137.","journal-title":"Cancer"},{"key":"1444_CR16","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1001\/jama.295.1.65","volume":"295","author":"CJ Chen","year":"2006","unstructured":"Chen CJ, Yang HI, Su J, et al. Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level. JAMA. 2006;295:65\u201373.","journal-title":"JAMA"},{"key":"1444_CR17","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1002\/hep.510260508","volume":"26","author":"D Jones","year":"1997","unstructured":"Jones D, Metcalf J, Collier J, Bassendine MF, James OF. Hepatocellular carcinoma in primary biliary cirrhosis and its impact on outcomes. Hepatology. 1997;26:1138\u20131142.","journal-title":"Hepatology"},{"key":"1444_CR18","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1053\/j.gastro.2007.04.061","volume":"132","author":"HB El-Serag","year":"2007","unstructured":"El-Serag HB, Rudolph KL. Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology. 2007;132:2557\u20132576.","journal-title":"Gastroenterology"},{"key":"1444_CR19","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.jhep.2007.08.013","volume":"48","author":"T Al-Chalabi","year":"2008","unstructured":"Al-Chalabi T, Underhill JA, Portmann BC, McFarlane IG, Heneghan MA. Impact of gender on the long term outcome and survival of patients with autoimmune hepatitis. J Hepatol. 2008;48:140\u2013147.","journal-title":"J Hepatol"},{"key":"1444_CR20","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/S0168-8278(99)80297-9","volume":"31","author":"F Alvarez","year":"1999","unstructured":"Alvarez F, Berg PA, Bianchi FB, et al. International Autoimmune Hepatitis Group Report: review of criteria for diagnosis of autoimmune hepatitis. J Hepatol. 1999;31:929\u2013938.","journal-title":"J Hepatol"},{"key":"1444_CR21","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/hep.22906","volume":"50","author":"KD Lindor","year":"2009","unstructured":"Lindor KD, Gershwin ME, Poupon R, Kaplan M, Bergasa NV, Heathcote EJ. Primary biliary cirrhosis. Hepatology. 2009;50:291\u2013308.","journal-title":"Hepatology"},{"key":"1444_CR22","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/jso.1101","volume":"77","author":"ID Fleming","year":"2001","unstructured":"Fleming ID. AJCC\/TNM cancer staging, present and future. J Surg Oncol. 2001;77:233\u2013236.","journal-title":"J Surg Oncol"},{"key":"1444_CR23","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1055\/s-2007-1007122","volume":"19","author":"JM Llovet","year":"1999","unstructured":"Llovet JM, Bru C, Bruix J. Prognosis of hepatocellular carcinoma: the BCLC staging classification. Semin Liver Dis. 1999;19:329\u2013338.","journal-title":"Semin Liver Dis"},{"key":"1444_CR24","volume-title":"Cancer Epidemiology: Principles and Methods","author":"IS Silva","year":"1999","unstructured":"Silva IS. Cancer Epidemiology: Principles and Methods. Geneva, Switzerland: World Health Organization; 1999."},{"key":"1444_CR25","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/S0140-6736(81)90585-7","volume":"2","author":"RP Beasley","year":"1981","unstructured":"Beasley RP, Hwang LY, Lin CC, Chien CS. Hepatocellular carcinoma and hepatitis B virus. A prospective study of 22,707 men in Taiwan. Lancet. 1981;2:1129\u20131133.","journal-title":"Lancet"},{"issue":"Suppl","key":"1444_CR26","first-page":"21S","volume":"2","author":"RP Beasley","year":"1982","unstructured":"Beasley RP. Hepatitis B virus as the etiologic agent in hepatocellular carcinoma. Hepatology. 1982;2(Suppl):21S\u201326S.","journal-title":"Hepatology"},{"key":"1444_CR27","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1053\/gast.1997.v112.pm9024300","volume":"112","author":"G Fattovich","year":"1997","unstructured":"Fattovich G, Giustina G, Degos F, et al. Morbidity and mortality in compensated cirrhosis type C: a retrospective follow-up study of 384 patients. Gastroenterology. 1997;112:463\u2013472.","journal-title":"Gastroenterology"},{"key":"1444_CR28","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1002\/hep.510280632","volume":"28","author":"C Niederau","year":"1998","unstructured":"Niederau C, Lange S, Heintges T, et al. Prognosis of chronic hepatitis C: results of a large, prospective cohort study. Hepatology. 1998;28:1687\u20131695.","journal-title":"Hepatology"},{"key":"1444_CR29","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1136\/gut.47.1.131","volume":"47","author":"F Degos","year":"2000","unstructured":"Degos F, Christidis C, Ganne-Carrie N, et al. Hepatitis C virus related cirrhosis: time to occurrence of hepatocellular carcinoma and death. Gut. 2000;47:131\u2013136.","journal-title":"Gut"},{"key":"1444_CR30","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1053\/j.gastro.2003.09.035","volume":"125","author":"M Elmberg","year":"2003","unstructured":"Elmberg M, Hultcrantz R, Ekbom A, et al. Cancer risk in patients with hereditary hemochromatosis and in their first-degree relatives. Gastroenterology. 2003;125:1733\u20131741.","journal-title":"Gastroenterology"},{"key":"1444_CR31","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/ijc.2910600204","volume":"60","author":"AW Hsing","year":"1995","unstructured":"Hsing AW, McLaughlin JK, Olsen JH, Mellemkjar L, Wacholder S, Fraumeni JF Jr. Cancer risk following primary hemochromatosis: a population-based cohort study in Denmark. Int J Cancer. 1995;60:160\u2013162.","journal-title":"Int J Cancer"},{"key":"1444_CR32","first-page":"1160","volume":"96","author":"L Caballeria","year":"2001","unstructured":"Caballeria L, Pares A, Castells A, Gines A, Bru C, Rodes J. Hepatocellular carcinoma in primary biliary cirrhosis: similar incidence to that in hepatitis C virus-related cirrhosis. Am J Gastroenterol. 2001;96:1160\u20131163.","journal-title":"Am J Gastroenterol"},{"key":"1444_CR33","unstructured":"CDC. Hepatocellular carcinoma\u2014United States, 2001\u20132006. MMWR. 2010;59(No. 17)."}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-010-1444-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10620-010-1444-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-010-1444-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T15:43:02Z","timestamp":1559230982000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10620-010-1444-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11,3]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,2]]}},"alternative-id":["1444"],"URL":"https:\/\/doi.org\/10.1007\/s10620-010-1444-6","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,11,3]]}}}