{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T07:28:00Z","timestamp":1791012480034,"version":"4.1.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2012,1,20]],"date-time":"2012-01-20T00:00:00Z","timestamp":1327017600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2012,5]]},"DOI":"10.1007\/s10620-012-2033-7","type":"journal-article","created":{"date-parts":[[2012,1,19]],"date-time":"2012-01-19T10:57:08Z","timestamp":1326970628000},"page":"1321-1329","source":"Crossref","is-referenced-by-count":165,"title":["The Prevalence of Overgrowth by Aerobic Bacteria in the Small Intestine by Small Bowel Culture: Relationship with Irritable Bowel Syndrome"],"prefix":"10.1007","volume":"57","author":[{"given":"Emmannouil","family":"Pyleris","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelos J.","family":"Giamarellos-Bourboulis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Tzivras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vassilios","family":"Koussoulas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charalambos","family":"Barbatzas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Pimentel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,1,20]]},"reference":[{"key":"2033_CR1","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1097\/MEG.0b013e328312eb97","volume":"21","author":"P Katsinelos","year":"2009","unstructured":"Katsinelos P, Lazaraki G, Kountouras J, et al. Prevalence, bowel habit subtypes and medical care-seeking behavior of patients with irritable bowel syndrome in Northern Greece. Eur J Gastroenterol Hepatol. 2009;21:183\u2013189.","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"2033_CR2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000081988","volume":"51","author":"E Husebye","year":"2005","unstructured":"Husebye E. The pathogenesis of gastrointestinal bacterial overgrowth. Chemotherapy. 2005;51:1\u201322.","journal-title":"Chemotherapy"},{"key":"2033_CR3","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1097\/01.mog.0000245544.80160.46","volume":"22","author":"SM Riordan","year":"2006","unstructured":"Riordan SM, Kim R. Bacterial overgrowth as a cause of irritable bowel syndrome. Curr Opin Gastroenterol. 2006;22:669\u2013673.","journal-title":"Curr Opin Gastroenterol"},{"key":"2033_CR4","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1111\/j.1365-2036.2005.02690.x","volume":"22","author":"A Lupascu","year":"2005","unstructured":"Lupascu A, Gabrielli M, Lauritano EC, et al. Hydrogen glucose breath test to detect small intestinal bacterial overgrowth: a prevalence case-control study in irritable bowel syndrome. Aliment Pharmacol Ther. 2005;22:1157\u20131160.","journal-title":"Aliment Pharmacol Ther"},{"key":"2033_CR5","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1111\/j.1365-2036.2005.02493.x","volume":"2","author":"G Nucera","year":"2005","unstructured":"Nucera G, Gabrielli M, Lupascu A, et al. Abnormal breath tests to lactose, fructose and sorbitol in irritable bowel syndrome may be explained by small intestinal bacterial overgrowth. Aliment Pharmacol Ther. 2005;2:1391\u20131395.","journal-title":"Aliment Pharmacol Ther"},{"key":"2033_CR6","first-page":"2241","volume":"55","author":"ED Shah","year":"2010","unstructured":"Shah ED, Basseri RJ, Chong K, Pimentel M. Abnormal breath testing in IBS: a meta-analysis. Dig Dis Sci. 2010;55:2241\u20132249.","journal-title":"Dig Dis Sci"},{"key":"2033_CR7","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1136\/gut.2009.205476","volume":"60","author":"D Yu","year":"2011","unstructured":"Yu D, Cheeseman F, Vanner S. Combined oro-caecal scintigraphy and lactulose hydrogen breath testing demonstrate that breath testing detects oro-caecal transit, not small intestinal bacterial overgrowth in patients with IBS. Gut. 2011;60:334\u2013340.","journal-title":"Gut"},{"key":"2033_CR8","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1186\/1471-2458-8-403","volume":"8","author":"L Welin","year":"2009","unstructured":"Welin L, Adlerberth A, Caidahl K, et al. Prevalence of cardiovascular risk factors and the metabolic syndrome in middle-age women and women in Gothenburg, Sweden. BMC Public Health. 2009;8:403.","journal-title":"BMC Public Health"},{"key":"2033_CR9","first-page":"1143","volume":"45","author":"WG Thompson","year":"1999","unstructured":"Thompson WG, Longstreth GF, Drossman DA, Heaton KW, Irvine EJ, M\u00fcller-Lissner SA. Functional bowel disorders and functional abdominal pain. Gut. 1999;45:1143\u20131147.","journal-title":"Gut"},{"key":"2033_CR10","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1053\/gast.2002.33741","volume":"122","author":"KW Olden","year":"2002","unstructured":"Olden KW. Diagnosis of irritable bowel syndrome. Gastroenterology. 2002;122:1701\u20131714.","journal-title":"Gastroenterology"},{"key":"2033_CR11","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s11894-006-0051-3","volume":"8","author":"HR Lee","year":"2006","unstructured":"Lee HR, Pimentel M. Bacteria and irritable bowel syndrome: the evidence for small intestinal bacterial overgrowth. Curr Gastroenterol Rep. 2006;8:305\u2013311.","journal-title":"Curr Gastroenterol Rep"},{"key":"2033_CR12","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1111\/j.1365-2036.2007.03259.x","volume":"25","author":"E Scarpellini","year":"2007","unstructured":"Scarpellini E, Gabrielli M, Lauritano CE, et al. High dosage rifaximin for treatment of small intestinal bacterial overgrowth. Aliment Pharmacol Ther. 2007;25:781\u2013786.","journal-title":"Aliment Pharmacol Ther"},{"key":"2033_CR13","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.3748\/wjg.15.2628","volume":"15","author":"S Peralta","year":"2009","unstructured":"Peralta S, Cottone C, Doveri T, Almasio PL, Craxi A. Small intestine bacterial overgrowth and irritable bowel syndrome-related symptoms: experience with rifaximin. World J Gastroenterol. 2009;15:2628\u20132631.","journal-title":"World J Gastroenterol"},{"key":"2033_CR14","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/j.1365-2036.2005.02516.x","volume":"22","author":"EC Lauritano","year":"2005","unstructured":"Lauritano EC, Gabrielli M, Lupascu A, et al. Rifaximin dose-finding study for the treatment of small intestinal bacterial overgrowth. Aliment Pharmacol Ther. 2005;22:31\u201335.","journal-title":"Aliment Pharmacol Ther"},{"key":"2033_CR15","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1111\/j.1572-0241.2006.00458.x","volume":"101","author":"AI Sharara","year":"2006","unstructured":"Sharara AI, Aoun E, Abdul-Baki H, Mounzer R, Sidani S, Elhajj I. A randomized double-blind placebo-controlled trial of rifaximin in patients with abdominal bloating and flatulence. Am J Gastroenterol. 2006;101:326\u2013333.","journal-title":"Am J Gastroenterol"},{"key":"2033_CR16","doi-asserted-by":"crossref","first-page":"557","DOI":"10.7326\/0003-4819-145-8-200610170-00004","volume":"145","author":"M Pimentel","year":"2006","unstructured":"Pimentel M, Park S, Mirocha J, Kane SV, Kong Y. The effect of a non-absorbed antibiotic (rifaximin) on the symptoms of the irritable bowel syndrome. Ann Intern Med. 2006;145:557\u2013563.","journal-title":"Ann Intern Med"},{"key":"2033_CR17","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1056\/NEJMoa1004409","volume":"364","author":"M Pimentel","year":"2011","unstructured":"Pimentel M, Lembo A, Chey WD, et al. Rifaximin therapy for patients with irritable bowel syndrome without constipation. N Engl J Med. 2011;364:22\u201332.","journal-title":"N Engl J Med"},{"key":"2033_CR18","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.cgh.2009.07.020","volume":"8","author":"AC Ford","year":"2010","unstructured":"Ford AC, Marwaha A, Lim A, Moayyedi P. Systematic review and meta-analysis of the prevalence of irritable bowel syndrome in individuals with dyspepsia. Clin Gastroenterol Hepatol. 2010;8:401\u2013409.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2033_CR19","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1471-230X-10-23","volume":"10","author":"SC Reddymasu","year":"2011","unstructured":"Reddymasu SC, Sostarich S, McCallum RW. Small intestinal bacterial overgrowth in irritable bowel syndrome: are there any predictors? BMC Gastroenterol. 2011;10:23.","journal-title":"BMC Gastroenterol"},{"key":"2033_CR20","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1440-1746.2011.06654.x","volume":"26","author":"S Sachdeva","year":"2011","unstructured":"Sachdeva S, Rawat AK, Reddy RS, Puri AS. Small intestinal bacterial overgrowth (SIBO) in irritable bowel syndrome: frequency and predictors. J Gastroenterol Hepatol. 2011;26:135\u2013138.","journal-title":"J Gastroenterol Hepatol"},{"key":"2033_CR21","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1097\/MCG.0b013e3181ef3476","volume":"44","author":"D Yamini","year":"2010","unstructured":"Yamini D, Pimentel M. Irritable bowel syndrome and small intestinal bacterial overgrowth. J Clin Gastroenterol. 2010;44:672\u2013675.","journal-title":"J Clin Gastroenterol"},{"key":"2033_CR22","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1136\/gut.2006.108712","volume":"56","author":"I Posserud","year":"2007","unstructured":"Posserud I, Stotzer PO, Bj\u00f6rnsson ES, Abrahamsson H, Simr\u00e9n M. Small intestinal bacterial overgrowth in patients with irritable bowel syndrome. Gut. 2007;56:802\u2013808.","journal-title":"Gut"},{"key":"2033_CR23","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1046\/j.1440-1746.2003.03006.x","volume":"18","author":"UC Ghoshal","year":"2003","unstructured":"Ghoshal UC, Ghoshal U, Ayyagari A, et al. Tropical sprue is associated with contamination of small bowel with aerobic bacteria and reversible prolongation of orocecal transit time. J Gastroenterol Hepatol. 2003;18:540\u2013547.","journal-title":"J Gastroenterol Hepatol"},{"key":"2033_CR24","doi-asserted-by":"crossref","first-page":"2972","DOI":"10.1111\/j.1572-0241.2008.01992.x","volume":"103","author":"BMR Spiegel","year":"2008","unstructured":"Spiegel BMR, Chey WD, Chang L. Bacterial overgrowth and irritable bowel syndrome: unifying hypothesis or a spurious consequence of proton pump inhibitors? Am J Gastroenterol. 2008;103:2972\u20132976.","journal-title":"Am J Gastroenterol"},{"key":"2033_CR25","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1443-9573.2007.00277.x","volume":"8","author":"EMM Quigley","year":"2007","unstructured":"Quigley EMM. Bacterial flora in irritable bowel syndrome: role in pathophysiology, implications for management. J Dig Dis. 2007;8:2\u20137.","journal-title":"J Dig Dis"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-012-2033-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10620-012-2033-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-012-2033-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T19:44:57Z","timestamp":1559245497000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10620-012-2033-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1,20]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["2033"],"URL":"https:\/\/doi.org\/10.1007\/s10620-012-2033-7","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1,20]]}}}