{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T19:49:33Z","timestamp":1760298573218},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2012,8,3]],"date-time":"2012-08-03T00:00:00Z","timestamp":1343952000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1007\/s10620-012-2326-x","type":"journal-article","created":{"date-parts":[[2012,8,2]],"date-time":"2012-08-02T05:50:41Z","timestamp":1343886641000},"page":"216-221","source":"Crossref","is-referenced-by-count":7,"title":["Increased Fracture Risk Assessed by Fracture Risk Assessment Tool in Greek Patients with Crohn\u2019s Disease"],"prefix":"10.1007","volume":"58","author":[{"given":"Sotirios","family":"Terzoudis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christos","family":"Zavos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Damilakis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Neratzoulakis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daphne Anna","family":"Dimitriadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Roussomoustakaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elias A.","family":"Kouroumalis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioannis E.","family":"Koutroubakis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,8,3]]},"reference":[{"key":"2326_CR1","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.cgh.2005.10.014","volume":"4","author":"CN Bernstein","year":"2006","unstructured":"Bernstein CN. Osteoporosis in patients with inflammatory bowel disease. Clin Gastroenterol Hepatol.. 2006;4:152\u2013156.","journal-title":"Clin Gastroenterol Hepatol."},{"key":"2326_CR2","doi-asserted-by":"crossref","first-page":"795","DOI":"10.7326\/0003-4819-133-10-200011210-00012","volume":"133","author":"CN Bernstein","year":"2000","unstructured":"Bernstein CN, Blanchard JF, Leslie W, Wajda A, Yu BN. The incidence of fracture among patients with inflammatory bowel disease. A population-based cohort study. Ann Intern Med. 2000;133:795\u2013799.","journal-title":"Ann Intern Med"},{"key":"2326_CR3","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1053\/gast.2002.34779","volume":"123","author":"EV Loftus Jr","year":"2002","unstructured":"Loftus EV Jr, Crowson CS, Sandborn WJ, Tremaine WJ, O\u2019Fallon WM, Melton LJ 3rd. Long-term fracture risk in patients with Crohn\u2019s disease: a population-based study in Olmsted County, Minnesota. Gastroenterology. 2002;123:468\u2013475.","journal-title":"Gastroenterology"},{"key":"2326_CR4","doi-asserted-by":"crossref","first-page":"G191","DOI":"10.1152\/ajpgi.00496.2010","volume":"300","author":"FK Ghishan","year":"2011","unstructured":"Ghishan FK, Kiela PR. Advances in the understanding of mineral and bone metabolism in inflammatory bowel diseases. Am J Physiol Gastrointest Liver Physiol. 2011;300:G191\u2013G201.","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"2326_CR5","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1136\/gut.2006.117382","volume":"57","author":"H Tilg","year":"2008","unstructured":"Tilg H, Moschen AR, Kaser A, Pines A, Dotan I. Gut, inflammation and osteoporosis: basic and clinical concepts. Gut. 2008;57:684\u2013694.","journal-title":"Gut"},{"key":"2326_CR6","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1111\/j.1572-0241.1998.468_q.x","volume":"93","author":"RD Pollak","year":"1998","unstructured":"Pollak RD, Karmeli F, Eliakim R, Ackerman Z, Tabb K, Rachmilewitz D. Femoral neck osteopenia in patients with inflammatory bowel disease. Am J Gastroenterol. 1998;93:1483\u20131490.","journal-title":"Am J Gastroenterol"},{"key":"2326_CR7","unstructured":"Lewis NR, Scott BB, Guidelines for osteoporosis in inflammatory disease and coeliac disease. Available at: http:\/\/www.bsg.org.uk\/images\/stories\/clinical\/ost_coe_ibd.pdf ; 2007."},{"key":"2326_CR8","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1053\/gast.2003.50107","volume":"124","author":"American Gastroenterological Association Medical Position Statement","year":"2003","unstructured":"American Gastroenterological Association Medical Position Statement. Guidelines on osteoporosis in gastrointestinal diseases. Gastroenterology. 2003;124:791\u2013794.","journal-title":"Gastroenterology"},{"key":"2326_CR9","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1503\/cmaj.070234","volume":"177","author":"A Cranney","year":"2007","unstructured":"Cranney A, Jamal SA, Tsang JF, Josse RG, Leslie WD. Low bone mineral density and fracture burden in postmenopausal women. CMAJ. 2007;177:575\u2013580.","journal-title":"CMAJ"},{"key":"2326_CR10","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1001\/archinte.164.10.1108","volume":"164","author":"ES Siris","year":"2004","unstructured":"Siris ES, Chen YT, Abbott TA, et al. Bone mineral density thresholds for pharmacological intervention to prevent fractures. Arch Intern Med. 2004;164:1108\u20131112.","journal-title":"Arch Intern Med"},{"key":"2326_CR11","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1016\/S0140-6736(02)08761-5","volume":"359","author":"JA Kanis","year":"2002","unstructured":"Kanis JA. Diagnosis of osteoporosis and assessment of fracture risk. Lancet. 2002;359:1929\u20131936.","journal-title":"Lancet"},{"key":"2326_CR12","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1046\/j.1365-2036.2002.01317.x","volume":"16","author":"RW Stockbrugger","year":"2002","unstructured":"Stockbrugger RW, Schoon EJ, Bollani S, et al. Discordance between the degree of osteopenia and the prevalence of spontaneous vertebral fractures in Crohn\u2019s disease. Aliment Pharmacol Ther. 2002;16:1519\u20131527.","journal-title":"Aliment Pharmacol Ther"},{"key":"2326_CR13","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1053\/j.gastro.2003.09.027","volume":"125","author":"TP Staa van","year":"2003","unstructured":"van Staa TP, Cooper C, Brusse LS, Leufkens H, Javaid MK, Arden NK. Inflammatory bowel disease and the risk of fracture. Gastroenterology. 2003;125:1591\u20131597.","journal-title":"Gastroenterology"},{"key":"2326_CR14","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1136\/gut.2003.026799","volume":"53","author":"T Card","year":"2004","unstructured":"Card T, West J, Hubbard R, Logan RF. Hip fractures in patients with inflammatory bowel disease and their relationship to corticosteroid use: a population based cohort study. Gut. 2004;53:251\u2013255.","journal-title":"Gut"},{"key":"2326_CR15","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1097\/00054725-200608000-00016","volume":"12","author":"GR Lichtenstein","year":"2006","unstructured":"Lichtenstein GR, Sands BE, Pazianas M. Prevention and treatment of osteoporosis in inflammatory bowel disease. Inflamm Bowel Dis. 2006;12:797\u2013813.","journal-title":"Inflamm Bowel Dis"},{"key":"2326_CR16","unstructured":"WHO. Fracture risk assessment tool. Available at: http:\/\/www.shef.ac.uk\/FRAX ."},{"key":"2326_CR17","unstructured":"NOGG recommendations. Pocket guide for healthcare professionals. Available at: http:\/\/www.shef.ac.uk\/NOGG\/downloads.html ."},{"key":"2326_CR18","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/nrrheum.2009.139","volume":"5","author":"JA Kanis","year":"2009","unstructured":"Kanis JA, McCloskey EV, Johansson H, Oden A. Approaches to the targeting of treatment for osteoporosis. Nat Rev Rheumatol. 2009;5:425\u2013431.","journal-title":"Nat Rev Rheumatol"},{"key":"2326_CR19","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1007\/s00198-008-0712-1","volume":"19","author":"JA Kanis","year":"2008","unstructured":"Kanis JA, McCloskey EV, Johansson H, Strom O, Borgstrom F, Oden A. Case finding for the management of osteoporosis with FRAX\u2013assessment and intervention thresholds for the UK. Osteoporos Int. 2008;19:1395\u20131408.","journal-title":"Osteoporos Int"},{"key":"2326_CR20","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1136\/gut.2005.082909","volume":"55","author":"J Satsangi","year":"2006","unstructured":"Satsangi J, Silverberg MS, Vermeire S, Colombel JF. The Montreal classification of inflammatory bowel disease: controversies, consensus, and implications. Gut. 2006;55:749\u2013753.","journal-title":"Gut"},{"key":"2326_CR21","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S0016-5085(76)80163-1","volume":"70","author":"WR Best","year":"1976","unstructured":"Best WR, Becktel JM, Singleton JW, Kern F Jr. Development of a Crohn\u2019s disease activity index. National Cooperative Crohn\u2019s Disease Study. Gastroenterology. 1976;70:439\u2013444.","journal-title":"Gastroenterology"},{"key":"2326_CR22","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1136\/gut.43.1.29","volume":"43","author":"RS Walmsley","year":"1998","unstructured":"Walmsley RS, Ayres RC, Pounder RE, Allan RN. A simple clinical colitis activity index. Gut. 1998;43:29\u201332.","journal-title":"Gut"},{"key":"2326_CR23","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1111\/j.1365-2036.2010.04554.x","volume":"33","author":"JR Goodhand","year":"2011","unstructured":"Goodhand JR, Kamperidis N, Nguyen H, Wahed M, Rampton DS. Application of the WHO fracture risk assessment tool (FRAX) to predict need for DEXA scanning and treatment in patients with inflammatory bowel disease at risk of osteoporosis. Aliment Pharmacol Ther. 2011;33:551\u2013558.","journal-title":"Aliment Pharmacol Ther"},{"key":"2326_CR24","first-page":"41","volume":"24","author":"IE Koutroubakis","year":"2011","unstructured":"Koutroubakis IE, Zavos C, Damilakis J, et al. Low bone mineral density in Greek patients with inflammatory bowel disease: prevalence and risk factors. Ann Gastroenterol. 2011;24:41\u201346.","journal-title":"Ann Gastroenterol"},{"key":"2326_CR25","doi-asserted-by":"crossref","first-page":"e60","DOI":"10.1097\/MCG.0b013e3181f42543","volume":"45","author":"IE Koutroubakis","year":"2011","unstructured":"Koutroubakis IE, Zavos C, Damilakis J, et al. Role of ghrelin and insulin-like growth factor binding protein-3 in the development of osteoporosis in inflammatory bowel disease. J Clin Gastroenterol. 2011;45:e60\u2013e65.","journal-title":"J Clin Gastroenterol"},{"key":"2326_CR26","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1136\/gut.46.2.176","volume":"46","author":"P Vestergaard","year":"2000","unstructured":"Vestergaard P, Krogh K, Rejnmark L, Laurberg S, Mosekilde L. Fracture risk is increased in Crohn\u2019s disease, but not in ulcerative colitis. Gut. 2000;46:176\u2013181.","journal-title":"Gut"},{"key":"2326_CR27","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1136\/gut.40.3.313","volume":"40","author":"J Jahnsen","year":"1997","unstructured":"Jahnsen J, Falch JA, Aadland E, Mowinckel P. Bone mineral density is reduced in patients with Crohn\u2019s disease but not in patients with ulcerative colitis: a population based study. Gut. 1997;40:313\u2013319.","journal-title":"Gut"},{"key":"2326_CR28","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1097\/00005176-199703000-00011","volume":"24","author":"JS Hyams","year":"1997","unstructured":"Hyams JS, Wyzga N, Kreutzer DL, Justinich CJ, Gronowicz GA. Alterations in bone metabolism in children with inflammatory bowel disease: an in vitro study. J Pediatr Gastroenterol Nutr. 1997;24:289\u2013295.","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"2326_CR29","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1097\/MEG.0b013e3282f8888b","volume":"20","author":"AC Heijckmann","year":"2008","unstructured":"Heijckmann AC, Huijberts MS, Schoon EJ, et al. High prevalence of morphometric vertebral deformities in patients with inflammatory bowel disease. Eur J Gastroenterol Hepatol. 2008;20:740\u2013747.","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"2326_CR30","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.cgh.2007.02.024","volume":"5","author":"JS Siffledeen","year":"2007","unstructured":"Siffledeen JS, Siminoski K, Jen H, Fedorak RN. Vertebral fractures and role of low bone mineral density in Crohn\u2019s disease. Clin Gastroenterol Hepatol. 2007;5:721\u2013728.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2326_CR31","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1359\/jbmr.090511","volume":"24","author":"MG Donaldson","year":"2009","unstructured":"Donaldson MG, Palermo L, Schousboe JT, Ensrud KE, Hochberg MC, Cummings SR. FRAX and risk of vertebral fractures: the fracture intervention trial. J Bone Miner Res. 2009;24:1793\u20131799.","journal-title":"J Bone Miner Res"},{"key":"2326_CR32","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1007\/s00198-011-1713-z","volume":"22","author":"JA Kanis","year":"2011","unstructured":"Kanis JA, Hans D, Cooper C, et al. Interpretation and use of FRAX in clinical practice. Osteoporos Int. 2011;22:2395\u20132411.","journal-title":"Osteoporos Int"},{"key":"2326_CR33","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1007\/s00198-010-1502-0","volume":"22","author":"E Czerwinski","year":"2011","unstructured":"Czerwinski E, Kanis JA, Osieleniec J, et al. Evaluation of FRAX to characterise fracture risk in Poland. Osteoporos Int. 2011;22:2507\u20132512.","journal-title":"Osteoporos Int"},{"key":"2326_CR34","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.3899\/jrheum.091368","volume":"37","author":"CK Cheng","year":"2010","unstructured":"Cheng CK, McDonald-Blumer H, Boire G, et al. Care gap in patients with early inflammatory arthritis with a high fracture risk identifies using FRAX. J Rheumatol. 2010;37:2221\u20132225.","journal-title":"J Rheumatol"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-012-2326-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10620-012-2326-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-012-2326-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T12:04:11Z","timestamp":1562069051000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10620-012-2326-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,3]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["2326"],"URL":"https:\/\/doi.org\/10.1007\/s10620-012-2326-x","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,3]]}}}