{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T15:02:50Z","timestamp":1776870170358,"version":"3.51.2"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2013,7]]},"DOI":"10.1007\/s10620-013-2571-7","type":"journal-article","created":{"date-parts":[[2013,1,31]],"date-time":"2013-01-31T10:48:26Z","timestamp":1359629306000},"page":"2019-2027","source":"Crossref","is-referenced-by-count":11,"title":["Backwash Ileitis and the Risk of Colon Neoplasia in Ulcerative Colitis Patients Undergoing Restorative Proctocolectomy"],"prefix":"10.1007","volume":"58","author":[{"given":"Udayakumar","family":"Navaneethan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramprasad","family":"Jegadeesan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norma G.","family":"Gutierrez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Preethi G. K.","family":"Venkatesh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea V.","family":"Arrossi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana E.","family":"Bennett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tarun","family":"Rai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feza H.","family":"Remzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravi P.","family":"Kiran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,2,1]]},"reference":[{"key":"2571_CR1","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1056\/NEJM194901272400401","volume":"240","author":"FJ McCready","year":"1949","unstructured":"McCready FJ, Bargen A, Dockerty MB, Waugh JM. Involvement of the ileum m chronic ulcerative colitis. N Engl J Med. 1949;240:119\u2013127.","journal-title":"N Engl J Med"},{"key":"2571_CR2","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1093\/ajcp\/40.6.610","volume":"40","author":"SL Saltzstein","year":"1963","unstructured":"Saltzstein SL, Rosenberg BF. Ulcerative colitis of the ileum, and regional enteritis of the colon: a comparative histopathologic study. Am J Clin Pathol. 1963;40:610\u2013623.","journal-title":"Am J Clin Pathol"},{"key":"2571_CR3","volume-title":"Inflammatory bowel disease","author":"RH Riddell","year":"1995","unstructured":"Riddell RH. Pathology of idiopathic inflammatory bowel disease. In: Kirsner JB, Shorter RG, eds. Inflammatory bowel disease. 4th ed. Baltimore, MD: Williams & Wilkins; 1995.","edition":"4"},{"key":"2571_CR4","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1053\/gast.2001.22434","volume":"120","author":"U Heuschen","year":"2001","unstructured":"Heuschen U, Hinz U, Allemeyer E, et al. Backwash ileitis is strongly associated with colorectal carcinoma in ulcerative colitis. Gastroenterology. 2001;120:841\u2013847.","journal-title":"Gastroenterology"},{"key":"2571_CR5","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/BF02556916","volume":"30","author":"S Gustavsson","year":"1987","unstructured":"Gustavsson S, Weiland LH, Kelly KA. Relationship of backwash ileitis or ileal pouchitis after ileal pouch-anal anastomosis. Dis Colon Rectum. 1987;30:25\u201328.","journal-title":"Dis Colon Rectum"},{"key":"2571_CR6","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1056\/NEJM199011013231802","volume":"323","author":"A Ekbom","year":"1990","unstructured":"Ekbom A, Helmick C, Zack M, et al. Ulcerative colitis and colorectal cancer: a population-based study. N Engl J Med. 1990;323:1228\u20131233.","journal-title":"N Engl J Med"},{"key":"2571_CR7","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1053\/j.gastro.2007.08.001","volume":"133","author":"RB Gupta","year":"2007","unstructured":"Gupta RB, Harpaz N, Itzkowitz S, et al. Histologic inflammation is a risk factor for progression to colorectal neoplasia in ulcerative colitis: a cohort study. Gastroenterology. 2007;133:1099\u20131105.","journal-title":"Gastroenterology"},{"key":"2571_CR8","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1002\/ibd.21219","volume":"16","author":"U Navaneethan","year":"2010","unstructured":"Navaneethan U, Shen B. Hepatopancreatobiliary manifestations and complications associated with inflammatory bowel disease. Inflamm Bowel Dis. 2010;16:1598\u20131619.","journal-title":"Inflamm Bowel Dis"},{"key":"2571_CR9","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1136\/gut.2004.046615","volume":"54","author":"EV Loftus","year":"2005","unstructured":"Loftus EV, Harewood GC, Loftus CG, et al. PSC-IBD: a unique form of inflammatory bowel disease associated with primary sclerosing cholangitis. Gut. 2005;54:91\u201396.","journal-title":"Gut"},{"key":"2571_CR10","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1111\/j.1572-0241.1999.01156.x","volume":"94","author":"K Shetty","year":"1999","unstructured":"Shetty K, Rybicki L, Brzezinski A, et al. The risk for cancer or dysplasia in ulcerative colitis patients with primary sclerosing cholangitis. Am J Gastroenterol. 1999;94:1643\u20131649.","journal-title":"Am J Gastroenterol"},{"key":"2571_CR11","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.jhep.2008.08.013","volume":"50","author":"MMH Claessen","year":"2008","unstructured":"Claessen MMH, Vleggaar FP, Tytgat KMAJ, et al. High lifetime risk of cancer in primary sclerosing cholangitis. J Hepatol. 2008;50:158\u2013164.","journal-title":"J Hepatol"},{"key":"2571_CR12","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1097\/01.pas.0000176435.19197.88","volume":"29","author":"H Haskell","year":"2005","unstructured":"Haskell H, Andrews CW Jr, Reddy SI, et al. Pathologic features and clinical significance of \u201cbackwash\u201d ileitis in ulcerative colitis. Am J Surg Pathol. 2005;29:1472\u20131481.","journal-title":"Am J Surg Pathol"},{"key":"2571_CR13","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.cgh.2011.07.018","volume":"9","author":"AV Arrossi","year":"2011","unstructured":"Arrossi AV, Kariv Y, Bronner MP, et al. Backwash ileitis does not affect pouch outcome in patients with ulcerative colitis with restorative proctocolectomy. Clin Gastroenterol Hepatol. 2011;9:981\u2013988.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2571_CR14","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1056\/NEJM198712243172603","volume":"317","author":"KW Schroeder","year":"1987","unstructured":"Schroeder KW, Tremaine WJ, Ilstrup DM. Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. N Engl J Med. 1987;317:1625\u20131629.","journal-title":"N Engl J Med"},{"key":"2571_CR15","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/S0046-8177(83)80175-0","volume":"14","author":"RH Riddell","year":"1983","unstructured":"Riddell RH, Goldman H, Ransohoff DF, et al. Dysplasia in inflammatory bowel disease: standardized classification with provisional clinical applications. Hum Pathol. 1983;14:931\u2013968.","journal-title":"Hum Pathol"},{"key":"2571_CR16","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1097\/PAS.0b013e318196d018","volume":"33","author":"M Joo","year":"2009","unstructured":"Joo M, Abreu-e-Lima P, Farraye F, et al. Pathologic features of ulcerative colitis in patients with primary sclerosing cholangitis: a case-control study. Am J Surg Pathol. 2009;33:854\u2013862.","journal-title":"Am J Surg Pathol"},{"key":"2571_CR17","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1136\/gut.2003.038505","volume":"53","author":"MD Rutter","year":"2004","unstructured":"Rutter MD, Saunders BP, Wilkinson KH, et al. Cancer surveillance in longstanding ulcerative colitis: endoscopic appearances help predict cancer risk. Gut. 2004;53:1813\u20131816.","journal-title":"Gut"},{"key":"2571_CR18","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/0959-8049(95)00216-6","volume":"31","author":"FM Nagengast","year":"1995","unstructured":"Nagengast FM, Grubben MJ, van Munster IP. Role of bile acids in colorectal carcinogenesis. Eur J Cancer. 1995;31:1067\u20131070.","journal-title":"Eur J Cancer"},{"key":"2571_CR19","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1053\/j.gastro.2003.11.010","volume":"126","author":"M Rutter","year":"2004","unstructured":"Rutter M, Saunders B, Wilkinson K, et al. Severity of inflammation is a risk factor for colorectal neoplasia in ulcerative colitis. Gastroenterology. 2004;126:451\u2013459.","journal-title":"Gastroenterology"},{"key":"2571_CR20","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/S1471-4914(01)02194-3","volume":"8","author":"JM Rhodes","year":"2002","unstructured":"Rhodes JM, Campbell BJ. Inflammation and colorectal cancer: IBD-associated and sporadic cancer compared. Trends Mol Med. 2002;8:10\u201316.","journal-title":"Trends Mol Med"},{"key":"2571_CR21","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/0092-8674(95)90127-2","volume":"83","author":"M Tsujii","year":"1995","unstructured":"Tsujii M, DuBois RN. Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2. Cell. 1995;83:493\u2013501.","journal-title":"Cell"},{"key":"2571_CR22","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1111\/j.1572-0241.2005.41442.x","volume":"100","author":"FS Velayos","year":"2005","unstructured":"Velayos FS, Terdiman JP, Walsh JM. Effect of 5-aminosalicylate use on colorectal cancer and dysplasia risk: a systematic review and metaanalysis of observational studies. Am J Gastroenterol. 2005;100:1345\u20131353.","journal-title":"Am J Gastroenterol"},{"key":"2571_CR23","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/ajg.2011.50","volume":"106","author":"CN Bernstein","year":"2011","unstructured":"Bernstein CN, Nugent Z, Blanchard JF. 5-aminosalicylate is not chemoprophylactic for colorectal cancer in IBD: a population based study. Am J Gastroenterol. 2011;106:731\u2013736.","journal-title":"Am J Gastroenterol"},{"key":"2571_CR24","doi-asserted-by":"crossref","unstructured":"Nguyen GC, Gulamhusein A, Bernstein CN. 5-Aminosalicylic acid is not protective against colorectal cancer in inflammatory bowel disease: a meta-analysis of non-referral populations. Am J Gastroenterol. 2012;107:1298-304. doi: 10.1038\/ajg.2012.198 .","DOI":"10.1038\/ajg.2012.198"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-013-2571-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10620-013-2571-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-013-2571-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T19:45:10Z","timestamp":1559245510000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10620-013-2571-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2,1]]},"references-count":24,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["2571"],"URL":"https:\/\/doi.org\/10.1007\/s10620-013-2571-7","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,1]]}}}