{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T10:41:41Z","timestamp":1772793701863,"version":"3.50.1"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2013,6,14]],"date-time":"2013-06-14T00:00:00Z","timestamp":1371168000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2013,10]]},"DOI":"10.1007\/s10620-013-2734-6","type":"journal-article","created":{"date-parts":[[2013,6,13]],"date-time":"2013-06-13T06:44:44Z","timestamp":1371105884000},"page":"3037-3043","source":"Crossref","is-referenced-by-count":15,"title":["Clinicopathological Significance of Serum Fractalkine in Primary Biliary Cirrhosis"],"prefix":"10.1007","volume":"58","author":[{"given":"Kenichi","family":"Harada","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Kakuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minoru","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Shimoda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuni","family":"Nakanuma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,6,14]]},"reference":[{"key":"2734_CR1","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1111\/j.1582-4934.2009.00787.x","volume":"13","author":"K Bourd-Boittin","year":"2009","unstructured":"Bourd-Boittin K, Basset L, Bonnier D, L\u2019Helgoualc\u2019h A, Samson M, Theret N. CX3CL1\/fractalkine shedding by human hepatic stellate cells: contribution to chronic inflammation in the liver. J Cell Mol Med. 2009;13:1526\u20131535.","journal-title":"J Cell Mol Med"},{"key":"2734_CR2","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1124\/mi.10.5.3","volume":"10","author":"BA Jones","year":"2010","unstructured":"Jones BA, Beamer M, Ahmed S. Fractalkine\/CX3CL1: a potential new target for inflammatory diseases. Mol Interv. 2010;10:263\u2013270.","journal-title":"Mol Interv"},{"key":"2734_CR3","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1111\/j.1749-6632.2009.04738.x","volume":"1173","author":"M Nishimura","year":"2009","unstructured":"Nishimura M, Kuboi Y, Muramoto K, Kawano T, Imai T. Chemokines as novel therapeutic targets for inflammatory bowel disease. Ann N Y Acad Sci. 2009;1173:350\u2013356.","journal-title":"Ann N Y Acad Sci"},{"key":"2734_CR4","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1016\/0016-5085(79)90396-2","volume":"76","author":"Y Nakanuma","year":"1979","unstructured":"Nakanuma Y, Ohta G. Histometric and serial section observations of the intrahepatic bile ducts in primary biliary cirrhosis. Gastroenterology. 1979;76:1326\u20131332.","journal-title":"Gastroenterology"},{"key":"2734_CR5","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1053\/j.gastro.2006.05.056","volume":"131","author":"S Shimoda","year":"2006","unstructured":"Shimoda S, Ishikawa F, Kamihira T, et al. Autoreactive T-cell responses in primary biliary cirrhosis are proinflammatory whereas those of controls are regulatory. Gastroenterology. 2006;131:606\u2013618.","journal-title":"Gastroenterology"},{"key":"2734_CR6","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jaut.2008.05.003","volume":"31","author":"S Shimoda","year":"2008","unstructured":"Shimoda S, Miyakawa H, Nakamura M, et al. CD4 T-cell autoreactivity to the mitochondrial autoantigen PDC-E2 in AMA-negative primary biliary cirrhosis. J Autoimmun. 2008;31:110\u2013115.","journal-title":"J Autoimmun"},{"key":"2734_CR7","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1084\/jem.181.5.1835","volume":"181","author":"S Shimoda","year":"1995","unstructured":"Shimoda S, Nakamura M, Ishibashi H, Hayashida K, Niho Y. HLA DRB4 0101-restricted immunodominant T cell autoepitope of pyruvate dehydrogenase complex in primary biliary cirrhosis: evidence of molecular mimicry in human autoimmune diseases. J Exp Med. 1995;181:1835\u20131845.","journal-title":"J Exp Med"},{"key":"2734_CR8","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1016\/S0016-5085(03)00387-1","volume":"124","author":"S Shimoda","year":"2003","unstructured":"Shimoda S, Nakamura M, Ishibashi H, et al. Molecular mimicry of mitochondrial and nuclear autoantigens in primary biliary cirrhosis. Gastroenterology. 2003;124:1915\u20131925.","journal-title":"Gastroenterology"},{"key":"2734_CR9","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1002\/hep.20582","volume":"41","author":"K Isse","year":"2005","unstructured":"Isse K, Harada K, Zen Y, et al. Fractalkine and CX3CR1 are involved in the recruitment of intraepithelial lymphocytes of intrahepatic bile ducts. Hepatology. 2005;41:506\u2013516.","journal-title":"Hepatology"},{"key":"2734_CR10","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1002\/hep.24194","volume":"53","author":"S Shimoda","year":"2011","unstructured":"Shimoda S, Harada K, Niiro H, et al. Interaction between Toll-like receptors and natural killer cells in the destruction of bile ducts in primary biliary cirrhosis. Hepatology. 2011;53:1270\u20131281.","journal-title":"Hepatology"},{"key":"2734_CR11","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1097\/01.LAB.0000097190.56734.FE","volume":"83","author":"K Harada","year":"2003","unstructured":"Harada K, Ohira S, Isse K, et al. Lipopolysaccharide activates nuclear factor-kappaB through toll-like receptors and related molecules in cultured biliary epithelial cells. Lab Invest. 2003;83:1657\u20131667.","journal-title":"Lab Invest"},{"key":"2734_CR12","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/j.1440-1827.2009.02500.x","volume":"60","author":"Y Nakanuma","year":"2010","unstructured":"Nakanuma Y, Zen Y, Harada K, et al. Application of a new histological staging and grading system for primary biliary cirrhosis to liver biopsy specimens: Interobserver agreement. Pathol Int. 2010;60:167\u2013174.","journal-title":"Pathol Int"},{"key":"2734_CR13","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1136\/gut.2003.036558","volume":"54","author":"EI Rigopoulou","year":"2005","unstructured":"Rigopoulou EI, Davies ET, Pares A, et al. Prevalence and clinical significance of isotype specific antinuclear antibodies in primary biliary cirrhosis. Gut. 2005;54:528\u2013532.","journal-title":"Gut"},{"key":"2734_CR14","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1055\/s-2005-916321","volume":"25","author":"P Invernizzi","year":"2005","unstructured":"Invernizzi P, Selmi C, Ranftler C, Podda M, Wesierska-Gadek J. Antinuclear antibodies in primary biliary cirrhosis. Semin Liver Dis. 2005;25:298\u2013310.","journal-title":"Semin Liver Dis"},{"key":"2734_CR15","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1002\/hep.21472","volume":"45","author":"M Nakamura","year":"2007","unstructured":"Nakamura M, Kondo H, Mori T, et al. Anti-gp210 and anti-centromere antibodies are different risk factors for the progression of primary biliary cirrhosis. Hepatology. 2007;45:118\u2013127.","journal-title":"Hepatology"},{"key":"2734_CR16","doi-asserted-by":"crossref","first-page":"S412","DOI":"10.1111\/j.1872-034X.2007.00244.x","volume":"37","author":"M Nakamura","year":"2007","unstructured":"Nakamura M, Komori A, Ito M, et al. Predictive role of anti-gp210 and anticentromere antibodies in long-term outcome of primary biliary cirrhosis. Hepatol Res. 2007;37:S412\u2013S419.","journal-title":"Hepatol Res"},{"key":"2734_CR17","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.jhep.2004.11.016","volume":"42","author":"M Nakamura","year":"2005","unstructured":"Nakamura M, Shimizu-Yoshida Y, Takii Y, et al. Antibody titer to gp210-C terminal peptide as a clinical parameter for monitoring primary biliary cirrhosis. J Hepatol. 2005;42:386\u2013392.","journal-title":"J Hepatol"},{"key":"2734_CR18","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/j.1440-1746.1998.01553.x","volume":"13","author":"S Itoh","year":"1998","unstructured":"Itoh S, Ichida T, Yoshida T, et al. Autoantibodies against a 210\u00a0kDa glycoprotein of the nuclear pore complex as a prognostic marker in patients with primary biliary cirrhosis. J Gastroenterol Hepatol. 1998;13:257\u2013265.","journal-title":"J Gastroenterol Hepatol"},{"key":"2734_CR19","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1046\/j.1440-1746.2001.02376.x","volume":"16","author":"D Kumar","year":"2001","unstructured":"Kumar D, Tandon RK. Use of ursodeoxycholic acid in liver diseases. J Gastroenterol Hepatol. 2001;16:3\u201314.","journal-title":"J Gastroenterol Hepatol"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-013-2734-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10620-013-2734-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-013-2734-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,15]],"date-time":"2019-07-15T08:34:44Z","timestamp":1563179684000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10620-013-2734-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,14]]},"references-count":19,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["2734"],"URL":"https:\/\/doi.org\/10.1007\/s10620-013-2734-6","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,14]]}}}