{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:33:03Z","timestamp":1792513983616,"version":"4.5.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2013,8,4]],"date-time":"2013-08-04T00:00:00Z","timestamp":1375574400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2013,11]]},"DOI":"10.1007\/s10620-013-2802-y","type":"journal-article","created":{"date-parts":[[2013,8,3]],"date-time":"2013-08-03T06:50:15Z","timestamp":1375512615000},"page":"3335-3341","source":"Crossref","is-referenced-by-count":36,"title":["Hepatogenous Diabetes in Cirrhosis Is Related to Portal Pressure and Variceal Hemorrhage"],"prefix":"10.1007","volume":"58","author":[{"given":"Hyo Keun","family":"Jeon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moon Young","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soon Koo","family":"Baik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong Jun","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoon","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So Yeon","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo Ra","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Heon","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki Won","family":"Jo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Yong","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Min","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Woo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Soo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Ok","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Ju","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Hwan","family":"Cha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Joon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki Tae","family":"Suk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gab Jin","family":"Cheon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Don","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae Hee","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Joon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,8,4]]},"reference":[{"key":"2802_CR1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0168-8227(90)90093-9","volume":"8","author":"C Del Vecchio Blanco","year":"1990","unstructured":"Del Vecchio Blanco C, Gentile S, Marmo R, Carbone L, Coltorti M. Alterations of glucose metabolism in chronic liver disease. Diabetes Res Clin Pract. 1990;8:29\u201336.","journal-title":"Diabetes Res Clin Pract"},{"key":"2802_CR2","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1111\/j.1600-0676.1988.tb01016.x","volume":"8","author":"G Buzzelli","year":"1988","unstructured":"Buzzelli G, Chiarantini E, Cotrozzi G, et al. Estimate of prevalence of glucose intolerance in chronic liver disease. Degree of agreement among some diagnostic criteria. Liver. 1988;8:354\u2013359.","journal-title":"Liver"},{"key":"2802_CR3","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/S0140-6736(67)90334-0","volume":"2","author":"C Megyesi","year":"1967","unstructured":"Megyesi C, Samols E, Marks V. Glucose tolerance and diabetes in chronic liver disease. Lancet. 1967;2:1051\u20131056.","journal-title":"Lancet"},{"key":"2802_CR4","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1046\/j.1440-1746.2002.02755.x","volume":"17","author":"A Holstein","year":"2002","unstructured":"Holstein A, Hinze S, Thiessen E, Plaschke A, Egberts EH. Clinical implications of hepatogenous diabetes in liver cirrhosis. J Gastroenterol Hepatol. 2002;17:677\u2013681.","journal-title":"J Gastroenterol Hepatol"},{"key":"2802_CR5","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/j.1572-0241.2005.00307.x","volume":"101","author":"T Nishida","year":"2006","unstructured":"Nishida T, Tsuji S, Tsujii M, et al. Oral glucose tolerance test predicts prognosis of patients with liver cirrhosis. Am J Gastroenterol. 2006;101:70\u201375.","journal-title":"Am J Gastroenterol"},{"key":"2802_CR6","first-page":"119","volume":"20","author":"G Bianchi","year":"1994","unstructured":"Bianchi G, Marchesini G, Zoli M, et al. Prognostic significance of diabetes in patients with cirrhosis. Hepatology. 1994;20:119\u2013125.","journal-title":"Hepatology"},{"key":"2802_CR7","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/j.1365-2036.2005.02590.x","volume":"22","author":"M Trombetta","year":"2005","unstructured":"Trombetta M, Spiazzi G, Zoppini G, Muggeo M. Review article: type 2 diabetes and chronic liver disease in the Verona diabetes study. Aliment Pharmacol Ther. 2005;22:24\u201327.","journal-title":"Aliment Pharmacol Ther"},{"key":"2802_CR8","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1002\/hep.21907","volume":"46","author":"G Garcia-Tsao","year":"2007","unstructured":"Garcia-Tsao G, Sanyal AJ, Grace ND, Carey W. Prevention and management of gastroesophageal varices and variceal hemorrhage in cirrhosis. Hepatology. 2007;46:922\u2013938.","journal-title":"Hepatology"},{"key":"2802_CR9","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1002\/hep.20062","volume":"39","author":"RJ Groszmann","year":"2004","unstructured":"Groszmann RJ, Wongcharatrawee S. The hepatic venous pressure gradient: anything worth doing should be done right. Hepatology. 2004;39:280\u2013282.","journal-title":"Hepatology"},{"key":"2802_CR10","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0889-8553(21)00177-1","volume":"21","author":"D Lebrec","year":"1992","unstructured":"Lebrec D. Methods to evaluate portal hypertension. Gastroenterol Clin N Am. 1992;21:41\u201359.","journal-title":"Gastroenterol Clin N Am"},{"key":"2802_CR11","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1097\/MEG.0b013e32832a21c1","volume":"21","author":"MY Kim","year":"2009","unstructured":"Kim MY, Baik SK, Yea CJ, et al. Hepatic venous pressure gradient can predict the development of hepatocellular carcinoma and hyponatremia in decompensated alcoholic cirrhosis. Eur J Gastroenterol Hepatol. 2009;21:1241\u20131246.","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"2802_CR12","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s11892-003-0018-9","volume":"3","author":"MA Vincent","year":"2003","unstructured":"Vincent MA, Montagnani M, Quon MJ. Molecular and physiologic actions of insulin related to production of nitric oxide in vascular endothelium. Curr Diab Rep. 2003;3:279\u2013288.","journal-title":"Curr Diab Rep"},{"key":"2802_CR13","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.jhep.2007.02.006","volume":"46","author":"Y Iwakiri","year":"2007","unstructured":"Iwakiri Y, Groszmann RJ. Vascular endothelial dysfunction in cirrhosis. J Hepatol. 2007;46:927\u2013934.","journal-title":"J Hepatol"},{"key":"2802_CR14","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1002\/hep.510290632","volume":"29","author":"G Svegliati-Baroni","year":"1999","unstructured":"Svegliati-Baroni G, Ridolfi F, Di Sario A, et al. Insulin and insulin-like growth factor-1 stimulate proliferation and type I collagen accumulation by human hepatic stellate cells: differential effects on signal transduction pathways. Hepatology. 1999;29:1743\u20131751.","journal-title":"Hepatology"},{"key":"2802_CR15","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1053\/jhep.2001.28055","volume":"34","author":"V Paradis","year":"2001","unstructured":"Paradis V, Perlemuter G, Bonvoust F, et al. High glucose and hyperinsulinemia stimulate connective tissue growth factor expression: a potential mechanism involved in progression to fibrosis in nonalcoholic steatohepatitis. Hepatology. 2001;34:738\u2013744.","journal-title":"Hepatology"},{"key":"2802_CR16","doi-asserted-by":"crossref","unstructured":"Rockey DC. Hepatic fibrosis, stellate cells, and portal hypertension. Clin Liver Dis. 2006;10:459\u2013479, vii\u2013viii.","DOI":"10.1016\/j.cld.2006.08.017"},{"key":"2802_CR17","first-page":"1","volume":"18","author":"KT Suk","year":"2012","unstructured":"Suk KT, Baik SK, Yoon JH, et al. Revision and update on clinical practice guideline for liver cirrhosis. Clin Mol Hepatol. 2012;18:1\u201321.","journal-title":"Clin Mol Hepatol"},{"key":"2802_CR18","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/ncpendmet0190","volume":"2","author":"M Roden","year":"2006","unstructured":"Roden M. Mechanisms of disease: hepatic steatosis in type 2 diabetes\u2014pathogenesis and clinical relevance. Nat Clin Pract Endocrinol Metab. 2006;2:335\u2013348.","journal-title":"Nat Clin Pract Endocrinol Metab"},{"key":"2802_CR19","doi-asserted-by":"crossref","first-page":"347","DOI":"10.3350\/kjhep.2010.16.4.347","volume":"16","author":"MY Kim","year":"2010","unstructured":"Kim MY, Baik SK, Lee SS. Hemodynamic alterations in cirrhosis and portal hypertension. Korean J Hepatol. 2010;16:347\u2013352.","journal-title":"Korean J Hepatol"},{"key":"2802_CR20","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/0016-5085(81)90144-X","volume":"80","author":"DY Graham","year":"1981","unstructured":"Graham DY, Smith JL. The course of patients after variceal hemorrhage. Gastroenterology. 1981;80:800\u2013809.","journal-title":"Gastroenterology"},{"key":"2802_CR21","doi-asserted-by":"crossref","first-page":"S85","DOI":"10.1016\/j.jhep.2004.12.006","volume":"42","author":"G Garcia-Tsao","year":"2005","unstructured":"Garcia-Tsao G. Bacterial infections in cirrhosis: treatment and prophylaxis. J Hepatol. 2005;42:S85\u2013S92.","journal-title":"J Hepatol"},{"key":"2802_CR22","first-page":"193","volume":"81","author":"BJ Pardy","year":"1977","unstructured":"Pardy BJ, Spencer RC, Dudley HA. Hepatic reticuloendothelial protection against bacteremia in experimental hemorrhagic shock. Surgery. 1977;81:193\u2013197.","journal-title":"Surgery"},{"key":"2802_CR23","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1002\/hep.1840080334","volume":"8","author":"D Pugliese","year":"1988","unstructured":"Pugliese D, Lee SS, Koshy A, et al. Systemic and splanchnic hemodynamic effects of intravenous hypertonic glucose in patients with cirrhosis. Hepatology. 1988;8:643\u2013646.","journal-title":"Hepatology"},{"key":"2802_CR24","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1080\/003655201750074654","volume":"36","author":"R Moreau","year":"2001","unstructured":"Moreau R, Chagneau C, Heller J, et al. Hemodynamic, metabolic and hormonal responses to oral glibenclamide in patients with cirrhosis receiving glucose. Scand J Gastroenterol. 2001;36:303\u2013308.","journal-title":"Scand J Gastroenterol"},{"key":"2802_CR25","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1016\/0016-5085(93)90651-R","volume":"104","author":"WT Sorell","year":"1993","unstructured":"Sorell WT, Quigley EM, Jin G, Johnson TJ, Rikkers LF. Bacterial translocation in the portal-hypertensive rat: studies in basal conditions and on exposure to hemorrhagic shock. Gastroenterology. 1993;104:1722\u20131726.","journal-title":"Gastroenterology"},{"key":"2802_CR26","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/BF00400692","volume":"36","author":"YT Kruszynska","year":"1993","unstructured":"Kruszynska YT, Harry DS, Bergman RN, McIntyre N. Insulin sensitivity, insulin secretion and glucose effectiveness in diabetic and non-diabetic cirrhotic patients. Diabetologia. 1993;36:121\u2013128.","journal-title":"Diabetologia"},{"key":"2802_CR27","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1172\/JCI111873","volume":"75","author":"P Cavallo-Perin","year":"1985","unstructured":"Cavallo-Perin P, Cassader M, Bozzo C, et al. Mechanism of insulin resistance in human liver cirrhosis. Evidence of a combined receptor and postreceptor defect. J Clin Invest. 1985;75:1659\u20131665.","journal-title":"J Clin Invest"},{"key":"2802_CR28","unstructured":"Petrides AS. Hepatogenic diabetes: pathophysiology, therapeutic options and prognosis. Zeitschrift fur Gastroenterologie. 1999;15\u201321."},{"key":"2802_CR29","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1016\/0016-5085(92)90329-W","volume":"102","author":"MJ Muller","year":"1992","unstructured":"Muller MJ, Willmann O, Rieger A, et al. Mechanism of insulin resistance associated with liver cirrhosis. Gastroenterology. 1992;102:2033\u20132041.","journal-title":"Gastroenterology"},{"key":"2802_CR30","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/hep.22655","volume":"49","author":"C Camma","year":"2009","unstructured":"Camma C, Petta S, Di Marco V, et al. Insulin resistance is a risk factor for esophageal varices in hepatitis C virus cirrhosis. Hepatology. 2009;49:195\u2013203.","journal-title":"Hepatology"},{"key":"2802_CR31","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1046\/j.1463-1326.2001.00103.x","volume":"3","author":"S Gentile","year":"2001","unstructured":"Gentile S, Turco S, Guarino G, et al. Effect of treatment with acarbose and insulin in patients with non-insulin-dependent diabetes mellitus associated with non-alcoholic liver cirrhosis. Diabetes Obes Metab. 2001;3:33\u201340.","journal-title":"Diabetes Obes Metab"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-013-2802-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10620-013-2802-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-013-2802-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T22:06:47Z","timestamp":1646258807000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10620-013-2802-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,4]]},"references-count":31,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["2802"],"URL":"https:\/\/doi.org\/10.1007\/s10620-013-2802-y","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,4]]}}}