{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T06:44:11Z","timestamp":1791096251247,"version":"4.1.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2013,11,2]],"date-time":"2013-11-02T00:00:00Z","timestamp":1383350400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2014,2]]},"DOI":"10.1007\/s10620-013-2920-6","type":"journal-article","created":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T08:06:20Z","timestamp":1383293180000},"page":"358-364","source":"Crossref","is-referenced-by-count":71,"title":["Chemokine\u2013Chemokine Receptor CCL2\u2013CCR2 and CX3CL1\u2013CX3CR1 Axis May Play a Role in the Aggravated Inflammation in Primary Biliary Cirrhosis"],"prefix":"10.1007","volume":"59","author":[{"given":"Motoko","family":"Sasaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masami","family":"Miyakoshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasunori","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuni","family":"Nakanuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,11,2]]},"reference":[{"key":"2920_CR1","doi-asserted-by":"crossref","first-page":"3525","DOI":"10.4049\/jimmunol.138.10.3525","volume":"138","author":"ME Gershwin","year":"1987","unstructured":"Gershwin ME, Mackay IR, Sturgess A, Coppel RL. Identification and specificity of a cDNA encoding the 70 kd mitochondrial antigen recognized in primary biliary cirrhosis. J Immunol. 1987;138:3525\u20133531.","journal-title":"J Immunol"},{"key":"2920_CR2","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1056\/NEJM199611213352107","volume":"335","author":"M Kaplan","year":"1996","unstructured":"Kaplan M. Primary biliary cirrhosis. New Engl J Med. 1996;335:1570\u20131580.","journal-title":"New Engl J Med"},{"key":"2920_CR3","first-page":"435","volume-title":"Pathology of the Liver","author":"B Portmann","year":"2001","unstructured":"Portmann B, Nakanuma Y. Diseases of the bile ducts. In: Ishak K, Scheuer P, Anthony P, MacSween R, Burt A, BC P, eds. Pathology of the Liver. London: Churchill Livingstone; 2001:435\u2013506."},{"key":"2920_CR4","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1016\/0016-5085(79)90396-2","volume":"76","author":"Y Nakanuma","year":"1979","unstructured":"Nakanuma Y, Ohta G. Histometric and serial section observations of the intrahepatic bile ducts in primary biliary cirrhosis. Gastroenterology. 1979;76:1326\u20131332.","journal-title":"Gastroenterology"},{"key":"2920_CR5","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1002\/hep.22348","volume":"48","author":"M Sasaki","year":"2008","unstructured":"Sasaki M, Ikeda H, Yamaguchi J, Nakada S, Nakanuma Y. Telomere shortening in the damaged small bile ducts in primary biliary cirrhosis reflects ongoing cellular senescence. Hepatology. 2008;48:186\u2013195.","journal-title":"Hepatology"},{"key":"2920_CR6","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1002\/path.1729","volume":"205","author":"M Sasaki","year":"2005","unstructured":"Sasaki M, Ikeda H, Haga H, Manabe T, Nakanuma Y. Frequent cellular senescence in small bile ducts in primary biliary cirrhosis: a possible role in bile duct loss. J Pathol. 2005;205:451\u2013459.","journal-title":"J Pathol"},{"key":"2920_CR7","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jaut.2008.03.005","volume":"31","author":"M Sasaki","year":"2008","unstructured":"Sasaki M, Ikeda H, Nakanuma Y. Activation of ATM signaling pathway is involved in oxidative stress-induced expression of mito-inhibitory p21(WAF1\/Cip1) in chronic non-suppurative destructive cholangitis in primary biliary cirrhosis: an immunohistochemical study. J Autoimmun. 2008;31:73\u201378.","journal-title":"J Autoimmun"},{"key":"2920_CR8","doi-asserted-by":"crossref","first-page":"831","DOI":"10.2353\/ajpath.2006.051237","volume":"169","author":"M Sasaki","year":"2006","unstructured":"Sasaki M, Ikeda H, Sato Y, Nakanuma Y. Decreased expression of Bmi1 is closely associated with cellular senescence in small bile ducts in primary biliary cirrhosis. Am J Pathol. 2006;169:831\u2013845.","journal-title":"Am J Pathol"},{"key":"2920_CR9","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/S0002-9440(10)64089-8","volume":"158","author":"JG Lunz 3rd","year":"2001","unstructured":"Lunz JG 3rd, Contrucci S, Ruppert K, et al. Replicative senescence of biliary epithelial cells precedes bile duct loss in chronic liver allograft rejection: increased expression of p21(WAF1\/Cip1) as a disease marker and the influence of immunosuppressive drugs. Am J Pathol. 2001;158:1379\u20131390.","journal-title":"Am J Pathol"},{"key":"2920_CR10","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.cell.2008.06.049","volume":"134","author":"V Krizhanovsky","year":"2008","unstructured":"Krizhanovsky V, Yon M, Dickins RA, et al. Senescence of activated stellate cells limits liver fibrosis. Cell. 2008;134:657\u2013667.","journal-title":"Cell"},{"key":"2920_CR11","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1002\/hep.21552","volume":"45","author":"RR Plentz","year":"2007","unstructured":"Plentz RR, Park YN, Lechel A, et al. Telomere shortening and inactivation of cell cycle checkpoints characterize human hepatocarcinogenesis. Hepatology. 2007;45:968\u2013976.","journal-title":"Hepatology"},{"key":"2920_CR12","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/j.cell.2008.03.038","volume":"133","author":"JC Acosta","year":"2008","unstructured":"Acosta JC, O\u2019Loghlen A, Banito A, et al. Chemokine signaling via the CXCR2 receptor reinforces senescence. Cell. 2008;133:1006\u20131018.","journal-title":"Cell"},{"key":"2920_CR13","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/j.cell.2008.03.039","volume":"133","author":"T Kuilman","year":"2008","unstructured":"Kuilman T, Michaloglou C, Vredeveld LC, et al. Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network. Cell. 2008;133:1019\u20131031.","journal-title":"Cell"},{"key":"2920_CR14","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.cell.2007.12.032","volume":"132","author":"N Wajapeyee","year":"2008","unstructured":"Wajapeyee N, Serra RW, Zhu X, Mahalingam M, Green MR. Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7. Cell. 2008;132:363\u2013374.","journal-title":"Cell"},{"key":"2920_CR15","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/S0960-9822(99)80420-5","volume":"9","author":"DN Shelton","year":"1999","unstructured":"Shelton DN, Chang E, Whittier PS, Choi D, Funk WD. Microarray analysis of replicative senescence. Curr Biol. 1999;9:939\u2013945.","journal-title":"Curr Biol"},{"key":"2920_CR16","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.1371\/journal.pbio.0060301","volume":"6","author":"JP Coppe","year":"2008","unstructured":"Coppe JP, Patil CK, Rodier F, et al. Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol. 2008;6:2853\u20132868.","journal-title":"PLoS Biol"},{"key":"2920_CR17","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.jhep.2010.03.008","volume":"53","author":"M Sasaki","year":"2010","unstructured":"Sasaki M, Miyakoshi M, Sato Y, Nakanuma Y. Modulation of the microenvironment by senescent biliary epithelial cells may be involved in the pathogenesis of primary biliary cirrhosis. J Hepatol. 2010;53:318\u2013325.","journal-title":"J Hepatol"},{"key":"2920_CR18","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1002\/hep.1840100209","volume":"10","author":"Y Nakanuma","year":"1989","unstructured":"Nakanuma Y, Sasaki M. Expression of blood-group-related antigens in the intrahepatic biliary tree and hepatocytes in normal livers and various hepatobiliary diseases. Hepatology. 1989;10:174\u2013178.","journal-title":"Hepatology"},{"key":"2920_CR19","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1055\/s-2008-1040417","volume":"11","author":"J Ludwig","year":"1991","unstructured":"Ludwig J. Small-duct primary sclerosing cholangitis. Semin Liver Dis. 1991;11:11\u201317.","journal-title":"Semin Liver Dis"},{"key":"2920_CR20","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1002\/hep.1840190629","volume":"19","author":"V Desmet","year":"1994","unstructured":"Desmet V, Gerber M, Hoofnagle J, Manns M, Scheuer P. Classification of chronic hepatitis: diagnosis, grading and staging. Hepatology. 1994;19:1513\u20131520.","journal-title":"Hepatology"},{"key":"2920_CR21","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1111\/j.1365-2249.2012.04609.x","volume":"169","author":"D Degre","year":"2012","unstructured":"Degre D, Lemmers A, Gustot T, et al. Hepatic expression of CCL2 in alcoholic liver disease is associated with disease severity and neutrophil infiltrates. Clin Exp Immunol. 2012;169:302\u2013310.","journal-title":"Clin Exp Immunol"},{"key":"2920_CR22","doi-asserted-by":"crossref","first-page":"G1310","DOI":"10.1152\/ajpgi.00365.2011","volume":"302","author":"K Miura","year":"2012","unstructured":"Miura K, Yang L, van Rooijen N, Ohnishi H, Seki E. Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2. Am J Physiol Gastrointest Liver Physiol. 2012;302:G1310\u2013G1321.","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"2920_CR23","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.jhep.2010.04.010","volume":"53","author":"CS Viebahn","year":"2010","unstructured":"Viebahn CS, Benseler V, Holz LE, et al. Invading macrophages play a major role in the liver progenitor cell response to chronic liver injury. J Hepatol. 2010;53:500\u2013507.","journal-title":"J Hepatol"},{"key":"2920_CR24","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1136\/jcp.2011.090175","volume":"64","author":"M Chiba","year":"2011","unstructured":"Chiba M, Sasaki M, Kitamura S, Ikeda H, Sato Y, Nakanuma Y. Participation of bile ductular cells in the pathological progression of non-alcoholic fatty liver disease. J Clin Pathol. 2011;64:564\u2013570.","journal-title":"J Clin Pathol"},{"key":"2920_CR25","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1101\/gad.625811","volume":"25","author":"M Ohanna","year":"2011","unstructured":"Ohanna M, Giuliano S, Bonet C, et al. Senescent cells develop a PARP-1 and nuclear factor-{kappa}B-associated secretome (PNAS). Genes Dev. 2011;25:1245\u20131261.","journal-title":"Genes Dev"},{"key":"2920_CR26","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1002\/hep.23318","volume":"51","author":"S Shimoda","year":"2010","unstructured":"Shimoda S, Harada K, Niiro H, et al. CX3CL1 (fractalkine): a signpost for biliary inflammation in primary biliary cirrhosis. Hepatology. 2010;51:567\u2013575.","journal-title":"Hepatology"},{"key":"2920_CR27","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1002\/hep.20582","volume":"41","author":"K Isse","year":"2005","unstructured":"Isse K, Harada K, Zen Y, et al. Fractalkine and CX3CR1 are involved in the recruitment of intraepithelial lymphocytes of intrahepatic bile ducts. Hepatology. 2005;41:506\u2013516.","journal-title":"Hepatology"},{"key":"2920_CR28","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jaut.2011.05.009","volume":"37","author":"W Zhang","year":"2011","unstructured":"Zhang W, Ono Y, Miyamura Y, Bowlus CL, Gershwin ME, Maverakis E. T cell clonal expansions detected in patients with primary biliary cirrhosis express CX3CR1. J Autoimmun. 2011;37:71\u201378.","journal-title":"J Autoimmun"},{"key":"2920_CR29","doi-asserted-by":"crossref","first-page":"533","DOI":"10.4049\/jimmunol.0802189","volume":"183","author":"AF Vos de","year":"2009","unstructured":"de Vos AF, Pater JM, van den Pangaart PS, de Kruif MD, van \u2018t Veer C, van der Poll Y. In vivo lipopolysaccharide exposure of human blood leukocytes induces cross-tolerance to multiple TLR ligands. J Immunol. 2009;183:533\u2013542.","journal-title":"J Immunol"},{"key":"2920_CR30","doi-asserted-by":"crossref","unstructured":"van \u2018t Veer C, van den Pangaart PS, van Zoelen MA et al. Induction of IRAK-M is associated with lipopolysaccharide tolerance in a human endotoxemia model. J Immunol. 2007;179:7110\u20137120.","DOI":"10.4049\/jimmunol.179.10.7110"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-013-2920-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10620-013-2920-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-013-2920-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T22:57:14Z","timestamp":1688597834000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10620-013-2920-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,2]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["2920"],"URL":"https:\/\/doi.org\/10.1007\/s10620-013-2920-6","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,2]]}}}