{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T16:49:16Z","timestamp":1788194956492,"version":"build-2803163510"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2013,12,27]],"date-time":"2013-12-27T00:00:00Z","timestamp":1388102400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.1007\/s10620-013-2943-z","type":"journal-article","created":{"date-parts":[[2013,12,26]],"date-time":"2013-12-26T06:44:32Z","timestamp":1388040272000},"page":"724-736","source":"Crossref","is-referenced-by-count":24,"title":["Characterization of the Syndrome of Acute Liver Failure Caused by Metastases from Breast Carcinoma"],"prefix":"10.1007","volume":"59","author":[{"given":"Estela","family":"Mogrovejo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Palaniappan","family":"Manickam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitual","family":"Amin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell S.","family":"Cappell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,12,27]]},"reference":[{"key":"2943_CR1","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1111\/j.1572-0241.2002.05559.x","volume":"97","author":"K Agrawal","year":"2002","unstructured":"Agrawal K, Jones DE, Burt AD, et al. Metastatic breast carcinoma presenting as acute liver failure and portal hypertension. Am J Gastroenterol. 2002;97:750\u2013751.","journal-title":"Am J Gastroenterol"},{"key":"2943_CR2","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.5858\/2004-128-1418-RODIHM","volume":"128","author":"KH Allison","year":"2004","unstructured":"Allison KH, Fligner CL, Parks WT. Radiographically occult, diffuse intrasinusoidal hepatic metastases from primary breast carcinomas: a clinicopathologic study of 3 autopsy cases. Arch Pathol Lab Med. 2004;128:1418\u20131423.","journal-title":"Arch Pathol Lab Med"},{"key":"2943_CR3","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1078\/0344-0338-00057","volume":"197","author":"LR B\u00e9gin","year":"2001","unstructured":"B\u00e9gin LR, Boucher D, Lamoureux E. Diffuse hepatic intravascular carcinomatous embolization resulting in fatal liver failure: a clinicopathologic study of 4 cases. Pathol Res Pract. 2001;197:433\u2013440.","journal-title":"Pathol Res Pract"},{"issue":"12","key":"2943_CR4","first-page":"836","volume":"144","author":"E Bilavsky","year":"2005","unstructured":"Bilavsky E, Yarden-Bilavsky H, Stein GY, Fradin Z, Zeidmian A. Acute hepatic failure as a presenting sign of breast carcinoma (article in Hebrew). Harefuah. 2005;144:836-838, 911.","journal-title":"Harefuah"},{"key":"2943_CR5","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1002\/1097-0142(197502)35:2<445::AID-CNCR2820350222>3.0.CO;2-G","volume":"35","author":"ER Borja","year":"1975","unstructured":"Borja ER, Hori JM, Pugh RP. Metastatic carcinomatosis of the liver mimicking cirrhosis: case report and review of the literature. Cancer. 1975;35:445\u2013449.","journal-title":"Cancer"},{"key":"2943_CR6","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1136\/jcp.28.6.457","volume":"28","author":"RA Burnett","year":"1975","unstructured":"Burnett RA. Cor pulmonale due to tumour embolism derived from intrasinusoidal metastatic liver carcinoma. J Clin Pathol. 1975;28:457\u2013464.","journal-title":"J Clin Pathol"},{"key":"2943_CR7","first-page":"183","volume":"14","author":"S Romana Di","year":"1993","unstructured":"Di Romana S, Hamels J, Brohee D, Vanhaeverbeek M. Fulminant hepatic failure of neoplastic origin (article in French). Rev Med Brux. 1993;14:183\u2013186.","journal-title":"Rev Med Brux"},{"key":"2943_CR8","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1001\/jama.1961.03040090017003","volume":"4","author":"JR Durham","year":"1961","unstructured":"Durham JR, Ashley PF, Dorencamp D. Cor pulmonale due to tumor emboli: review of literature and report of a case. JAMA. 1961;4:757\u2013760.","journal-title":"JAMA"},{"key":"2943_CR9","first-page":"62","volume":"7","author":"R Goswami","year":"2011","unstructured":"Goswami R, Babich M, Farah KF. Occult breast malignancy masquerading as acute hepatic failure. Gastroenterol Hepatol (NY). 2011;7:62\u201365.","journal-title":"Gastroenterol Hepatol (NY)"},{"key":"2943_CR10","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.3892\/ol.2013.1165","volume":"5","author":"S Hanamornroongruang","year":"2013","unstructured":"Hanamornroongruang S, Sangchay N. Acute liver failure associated with diffuse liver infiltration by metastatic breast carcinoma: a case report. Oncol Lett. 2013;5:1250\u20131252.","journal-title":"Oncol Lett"},{"key":"2943_CR11","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/BF00781680","volume":"410","author":"K Honma","year":"1987","unstructured":"Honma K. Hepar lobatum carcinomatosum due to metastatic breast carcinoma. Virchows Arch A Pathol Anat Histopathol. 1987;410:465\u2013469.","journal-title":"Virchows Arch A Pathol Anat Histopathol"},{"key":"2943_CR12","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1080\/00365520310005370","volume":"38","author":"A Lowenthal","year":"2003","unstructured":"Lowenthal A, Tur-Kaspa R, Brower RG, Almog Y. Acute liver failure complicating ductal breast carcinoma: two cases and literature review. Scand J Gastroenterol. 2003;38:1095\u20131096.","journal-title":"Scand J Gastroenterol"},{"key":"2943_CR13","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1177\/030089160008600512","volume":"86","author":"O Martelli","year":"2000","unstructured":"Martelli O, Coppola L, De Quato AL, et al. Fulminant hepatic failure caused by diffuse intrasinusoidal metastatic liver disease: a case report. Tumori. 2000;86:424\u2013427.","journal-title":"Tumori"},{"key":"2943_CR14","first-page":"56","volume":"65","author":"T Micolonghi","year":"1958","unstructured":"Micolonghi T, Pineda E, Stanley MM. Metastatic carcinomatous cirrhosis of the liver: report of a case in which death followed hemorrhage from esophageal varices and hepatic coma. AMA Arch Pathol. 1958;65:56\u201362.","journal-title":"AMA Arch Pathol"},{"key":"2943_CR15","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.5858\/2001-125-1084-MCCAHH","volume":"125","author":"ML Mitchell","year":"2001","unstructured":"Mitchell ML, Filippone MD, Wozniak TF. Metastatic carcinomatous cirrhosis and hepatic hemosiderosis in a patient heterozygous for the H63D genotype. Arch Pathol Lab Med. 2001;125:1084\u20131087.","journal-title":"Arch Pathol Lab Med"},{"key":"2943_CR16","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.1742-1241.1984.tb07307.x","volume":"38","author":"WL Morrison","year":"1984","unstructured":"Morrison WL, Pennington CR. Liver metastases from an occult breast carcinoma presenting as acute fulminant hepatic failure. Br J Clin Pract. 1984;38:273\u2013274.","journal-title":"Br J Clin Pract"},{"key":"2943_CR17","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1097\/00004836-199008000-00018","volume":"12","author":"MF Myszor","year":"1990","unstructured":"Myszor MF, Record CO. Primary and secondary malignant disease of the liver and fulminant hepatic failure. J Clin Gastroenterol. 1990;12:441\u2013446.","journal-title":"J Clin Gastroenterol"},{"key":"2943_CR18","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1148\/radiol.2211001754","volume":"221","author":"AB Nascimento","year":"2001","unstructured":"Nascimento AB, Mitchell DG, Rubin R, Weaver E. Diffuse desmoplastic breast carcinoma metastases to the liver simulating cirrhosis at MR imaging: report of two cases. Radiology. 2001;221:117\u2013121.","journal-title":"Radiology"},{"key":"2943_CR19","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1177\/030089169808400523","volume":"84","author":"Y Nieto","year":"1998","unstructured":"Nieto Y, Alonso JL, Ayala F, et al. End-stage acute hepatic failure as clinical presentation of liver metastases from breast c\u00e1ncer (article in Italian). Tumori. 1998;84:616\u2013617.","journal-title":"Tumori"},{"key":"2943_CR20","first-page":"135","volume":"3","author":"O Nouel","year":"1979","unstructured":"Nouel O, Bernuau J, Lebrec D, et al. [Severe hepatic failure and portal hypertension due to metastatic carcinoma of the liver (article in French)]. Gastroenterol Clin Biol. 1979;3:135\u2013137.","journal-title":"Gastroenterol Clin Biol"},{"key":"2943_CR21","first-page":"295","volume":"28","author":"PP Razenberg","year":"1985","unstructured":"Razenberg PP, Taal BG, Albus-Lutter CE. Hepatic failure due to liver metastases in breast cancer. Neth J Med. 1985;28:295\u2013298.","journal-title":"Neth J Med"},{"key":"2943_CR22","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1007\/s10620-006-9332-9","volume":"52","author":"DA Sass","year":"2007","unstructured":"Sass DA, Clark K, Grzybicki D, Rabinovitz M, Shaw-Stiffel TA. Diffuse desmoplastic metastatic breast cancer simulating cirrosis with severe portal hypertension: a case of \u201cpseudocirrhosis\u201d. Dig Dis Sci. 2007;52:749\u2013752.","journal-title":"Dig Dis Sci"},{"key":"2943_CR23","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1097\/00007611-198401000-00024","volume":"77","author":"R Schneider","year":"1984","unstructured":"Schneider R, Cohen A. Fulminant hepatic failure complicating metastatic breast carcinoma. South Med J. 1984;77:84\u201386.","journal-title":"South Med J"},{"key":"2943_CR24","doi-asserted-by":"crossref","first-page":"104","DOI":"10.7326\/0003-4819-54-1-104","volume":"54","author":"JC Smith","year":"1961","unstructured":"Smith JC. Diffuse intrasinusoidal metastatic cancer of the liver. Ann Intern Med. 1961;54:104\u2013113.","journal-title":"Ann Intern Med"},{"key":"2943_CR25","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1155\/1989\/595098","volume":"3","author":"MS Trimble","year":"1989","unstructured":"Trimble MS, Ghent CN, Grant DR, McLean CA. Metastatic breast cancer presenting as fulminant hepatic failure: a case report and literature review. Can J Gastroenterol. 1989;3:149\u2013152.","journal-title":"Can J Gastroenterol"},{"key":"2943_CR26","first-page":"65","volume":"7","author":"HE Nazario","year":"2011","unstructured":"Nazario HE, Lepe R, Trotter JF. Metastatic breast cancer presenting as acute liver failure. Gastroenterol Hepatol (NY). 2011;7:65\u201366.","journal-title":"Gastroenterol Hepatol (NY)"},{"key":"2943_CR27","first-page":"163","volume":"59","author":"M Alcalde","year":"1996","unstructured":"Alcalde M, Garcia-Diaz M, Pecellin J, et al. Acute liver failure due to diffuse intrasinusoidal metastases of urothelial carcinoma. Acta Gastroenterol Belg. 1996;59:163\u2013165.","journal-title":"Acta Gastroenterol Belg"},{"key":"2943_CR28","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1177\/030089160609200417","volume":"92","author":"A Alexopoulou","year":"2006","unstructured":"Alexopoulou A, Koskinas J, Deutsch M, et al. Acute liver failure as the initial manifestation of hepatic infiltration by a solid tumor: report of 5 cases and review of the literature. Tumori. 2006;92:354\u2013357.","journal-title":"Tumori"},{"key":"2943_CR29","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/1097-0142(19900101)65:1<169::AID-CNCR2820650132>3.0.CO;2-9","volume":"65","author":"M Sawabe","year":"1990","unstructured":"Sawabe M, Kato Y, Ohashi I, Kitagawa T. Diffuse intrasinusoidal metastasis of gastric carcinoma to the liver leading to fulminant hepatic failure: a case report. Cancer. 1990;65:169\u2013173.","journal-title":"Cancer"},{"key":"2943_CR30","first-page":"370","volume":"67","author":"AM Stein","year":"1977","unstructured":"Stein AM, Fawaz K, Tabrizi A, et al. Multifocal malignant hemangioendothelioma presenting as acute hepatitis. A clinicopathologic study. Am J Gastroenterol. 1977;67:370\u2013374.","journal-title":"Am J Gastroenterol"},{"key":"2943_CR31","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1097\/00042737-200110000-00019","volume":"13","author":"GA Morali","year":"2001","unstructured":"Morali GA, Rozenmann E, Ashkenazi J, et al. Acute liver failure as the sole manifestation of relapsing non-Hodgkin\u2019s lymphoma. Eur J Gastroenterol Hepatol. 2001;13:1241\u20131243.","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"2943_CR32","doi-asserted-by":"crossref","unstructured":"Montero JL, Muntan\u00e9 J, de las Heras S, et al. Acute liver failure caused by diffuse hepatic melanoma infiltration. J Hepatol. 2002;37:540\u2013541.","DOI":"10.1016\/S0168-8278(02)00219-2"},{"key":"2943_CR33","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1111\/j.1572-0241.1999.00811.x","volume":"94","author":"HS Te","year":"1999","unstructured":"Te HS, Schiano TD, Kahaleh M, et al. Fulminant hepatic failure secondary to malignant melanoma: case report and review of the literature. Am J Gastroenterol. 1999;94:262\u2013266.","journal-title":"Am J Gastroenterol"},{"key":"2943_CR34","first-page":"376","volume":"80","author":"M Wang","year":"1985","unstructured":"Wang M, McGrew W, Wofford B, et al. Merkel cell tumor with liver metastases: presentation as fulminant hepatic failure. Am J Gastroenterol. 1985;80:376\u2013380.","journal-title":"Am J Gastroenterol"},{"key":"2943_CR35","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/j.1600-0676.1996.tb00744.x","volume":"16","author":"YT Hwang","year":"1996","unstructured":"Hwang YT, Chen PJ, Kao JH, et al. Rapid hepatic failure associated with a contracted liver mimicking cirrhosis in a case of nasopharyngeal carcinoma with liver metastasis. Liver. 1996;16:283\u2013287.","journal-title":"Liver"},{"key":"2943_CR36","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1097\/SMJ.0b013e31817c74c3","volume":"101","author":"FA Shakir","year":"2008","unstructured":"Shakir FA, Madhoun M, Whorton J, Harty R. Metastatic prostatic carcinoma presenting as fulminant hepatic failure. South Med J. 2008;101:1049\u20131050.","journal-title":"South Med J"},{"key":"2943_CR37","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1097\/00042737-200311000-00014","volume":"15","author":"E Athanasakis","year":"2003","unstructured":"Athanasakis E, Mouloudi E, Prinianakis G, et al. Metastatic liver disease and fulminant hepatic failure: presentation of a case and review of the literature. Eur J Gastroenterol Hepatol. 2003;15:1235\u20131240.","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"2943_CR38","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1097\/01.mcg.0000155123.97418.06","volume":"39","author":"P Rajvanshi","year":"2005","unstructured":"Rajvanshi P, Kowdley KV, Hirota WK, et al. Fulminant hepatic failure secondary to neoplastic infiltration of the liver. J Clin Gastroenterol. 2005;39:339\u2013343.","journal-title":"J Clin Gastroenterol"},{"key":"2943_CR39","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/ncpgasthep1154","volume":"5","author":"J Gilbert","year":"2008","unstructured":"Gilbert J, Rutledge H, Koch A. Diffuse malignant infiltration of the liver manifesting as a case of acute liver failure. Nat Clin Pract Gastroenterol Hepatol. 2008;5:405\u2013408.","journal-title":"Nat Clin Pract Gastroenterol Hepatol"},{"key":"2943_CR40","volume-title":"Statistical methods for rates and proportions","author":"JL Fleiss","year":"1981","unstructured":"Fleiss JL. Statistical methods for rates and proportions. 2nd ed. New York: Wiley; 1981.","edition":"2"},{"key":"2943_CR41","unstructured":"Lakhani SR, Ellis IO, Schnitt SJ, et al. WHO Classification of Tumours, Volume 4 (Breast), 4th edition. IARC, WHO Press, Lyon, France; 2012 (ISBN-13:\u00a09789283224334)."},{"key":"2943_CR42","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1002\/hep.22177","volume":"47","author":"WM Lee","year":"2008","unstructured":"Lee WM, Squires RH Jr, Nyberg SL, et al. Acute liver failure: summary of a workshop. Hepatology. 2008;47:1401\u20131415.","journal-title":"Hepatology"},{"key":"2943_CR43","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1097\/00004836-200109000-00005","volume":"33","author":"RQ Gill","year":"2001","unstructured":"Gill RQ, Sterling RK. Acute liver failure. J Clin Gastroenterol. 2001;33:191\u2013198.","journal-title":"J Clin Gastroenterol"},{"key":"2943_CR44","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1111\/j.1572-0241.2003.07536.x","volume":"98","author":"CJ Lettieri","year":"2003","unstructured":"Lettieri CJ, Berg BW. Clinical features of non-Hodgkins lymphoma presenting with acute liver failure: a report of five cases and review of published experience. Am J Gastroenterol. 2003;98:1641\u20131646.","journal-title":"Am J Gastroenterol"},{"key":"2943_CR45","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1136\/gut.42.4.576","volume":"42","author":"D Rowbotham","year":"1998","unstructured":"Rowbotham D, Wendon J, Williams R. Acute liver failure secondary to hepatic infiltration: a single centre experience of 18 cases. Gut. 1998;42:576\u2013580.","journal-title":"Gut"},{"key":"2943_CR46","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.cld.2012.03.001","volume":"16","author":"A Bonder","year":"2012","unstructured":"Bonder A, Afdhal N. Evaluation of liver lesions. Clin Liver Dis. 2012;16:271\u2013283.","journal-title":"Clin Liver Dis"},{"key":"2943_CR47","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/S1470-2045(09)70029-4","volume":"10","author":"JR Diamond","year":"2009","unstructured":"Diamond JR, Finlayson CA, Borges VF. Hepatic complications of breast cancer. Lancet Oncol. 2009;10:615\u2013621.","journal-title":"Lancet Oncol"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-013-2943-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10620-013-2943-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-013-2943-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T09:09:47Z","timestamp":1746090587000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10620-013-2943-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,27]]},"references-count":47,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["2943"],"URL":"https:\/\/doi.org\/10.1007\/s10620-013-2943-z","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,27]]}}}