{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T03:44:13Z","timestamp":1791258253464,"version":"4.1.0"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2014,1,19]],"date-time":"2014-01-19T00:00:00Z","timestamp":1390089600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2014,6]]},"DOI":"10.1007\/s10620-013-3014-1","type":"journal-article","created":{"date-parts":[[2014,1,18]],"date-time":"2014-01-18T06:14:26Z","timestamp":1390025666000},"page":"1142-1151","source":"Crossref","is-referenced-by-count":32,"title":["Anti-inflammatory Effects of Carbon Monoxide-Releasing Molecule on Trinitrobenzene Sulfonic Acid-Induced Colitis in Mice"],"prefix":"10.1007","volume":"59","author":[{"given":"Wataru","family":"Fukuda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohisa","family":"Takagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Katada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsura","family":"Mizushima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Okayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naohisa","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Kamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiko","family":"Uchiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Ishikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Handa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideyuki","family":"Konishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuaki","family":"Yagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Ichikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshikazu","family":"Yoshikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gediminas","family":"Cepinskas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Naito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshito","family":"Itoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,1,19]]},"reference":[{"key":"3014_CR1","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/nature06005","volume":"448","author":"RJ Xavier","year":"2007","unstructured":"Xavier RJ, Podolsky DK. Unravelling the pathogenesis of inflammatory bowel disease. Nature. 2007;448:427\u2013434.","journal-title":"Nature"},{"key":"3014_CR2","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1146\/annurev.pharmtox.37.1.517","volume":"37","author":"MD Maines","year":"1997","unstructured":"Maines MD. The heme oxygenase system: a regulator of second messenger gases. Annu Rev Pharmacol Toxicol. 1997;37:517\u2013554.","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"3014_CR3","first-page":"L688","volume":"276","author":"LE Otterbein","year":"1999","unstructured":"Otterbein LE, Mantell LL, Choi AM. Carbon monoxide provides protection against hyperoxic lung injury. Am J Physiol. 1999;276:L688\u2013L694.","journal-title":"Am J Physiol"},{"key":"3014_CR4","doi-asserted-by":"crossref","first-page":"G236","DOI":"10.1152\/ajpgi.00144.2007","volume":"294","author":"T Kaizu","year":"2008","unstructured":"Kaizu T, Ikeda A, Nakao A, et al. Protection of transplant-induced hepatic ischemia\/reperfusion injury with carbon monoxide via MEK\/ERK1\/2 pathway downregulation. Am J Physiol Gastrointest Liver Physiol. 2008;294:G236\u2013G244.","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"3014_CR5","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1016\/S0002-9440(10)63515-8","volume":"163","author":"A Nakao","year":"2003","unstructured":"Nakao A, Kimizuka K, Stolz DB, et al. Carbon monoxide inhalation protects rat intestinal grafts from ischemia\/reperfusion injury. Am J Pathol. 2003;163:1587\u20131598.","journal-title":"Am J Pathol"},{"key":"3014_CR6","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1097\/01.tp.0000188637.80695.7f","volume":"81","author":"A Nakao","year":"2006","unstructured":"Nakao A, Toyokawa H, Abe M, et al. Heart allograft protection with low-dose carbon monoxide inhalation: effects on inflammatory mediators and alloreactive T-cell responses. Transplantation. 2006;81:220\u2013230.","journal-title":"Transplantation"},{"key":"3014_CR7","doi-asserted-by":"crossref","first-page":"F979","DOI":"10.1152\/ajprenal.00158.2004","volume":"287","author":"JS Neto","year":"2004","unstructured":"Neto JS, Nakao A, Kimizuka K, et al. Protection of transplant-induced renal ischemia-reperfusion injury with carbon monoxide. Am J Physiol Renal Physiol. 2004;287:F979\u2013F989.","journal-title":"Am J Physiol Renal Physiol"},{"key":"3014_CR8","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s10753-009-9106-6","volume":"32","author":"T Takagi","year":"2009","unstructured":"Takagi T, Naito Y, Inoue M, et al. Inhalation of carbon monoxide ameliorates collagen-induced arthritis in mice and regulates the articular expression of IL-1beta and mcp-1. Inflammation. 2009;32:83\u201388.","journal-title":"Inflammation"},{"key":"3014_CR9","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1097\/01.shk.0000239781.71516.61","volume":"27","author":"TY Tsui","year":"2007","unstructured":"Tsui TY, Obed A, Siu YT, et al. Carbon monoxide inhalation rescues mice from fulminant hepatitis through improving hepatic energy metabolism. Shock. 2007;27:165\u2013171.","journal-title":"Shock"},{"key":"3014_CR10","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1084\/jem.20051047","volume":"202","author":"RA Hegazi","year":"2005","unstructured":"Hegazi RA, Rao KN, Mayle A, et al. Carbon monoxide ameliorates chronic murine colitis through a heme oxygenase 1-dependent pathway. J Exp Med. 2005;202:1703\u20131713.","journal-title":"J Exp Med"},{"key":"3014_CR11","doi-asserted-by":"crossref","first-page":"G607","DOI":"10.1152\/ajpgi.00055.2005","volume":"289","author":"BS Zuckerbraun","year":"2005","unstructured":"Zuckerbraun BS, Otterbein LE, Boyle P, et al. Carbon monoxide protects against the development of experimental necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol. 2005;289:G607\u2013G613.","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"3014_CR12","doi-asserted-by":"crossref","first-page":"S229","DOI":"10.1111\/j.1440-1746.2008.05443.x","volume":"23","author":"T Takagi","year":"2008","unstructured":"Takagi T, Naito Y, Mizushima K, et al. Increased intestinal expression of heme oxygenase-1 and its localization in patients with ulcerative colitis. J Gastroenterol Hepatol. 2008;23:S229\u2013S233.","journal-title":"J Gastroenterol Hepatol"},{"key":"3014_CR13","doi-asserted-by":"crossref","first-page":"126","DOI":"10.3164\/jcbn.10-61","volume":"48","author":"Y Naito","year":"2011","unstructured":"Naito Y, Takagi T, Uchiyama K, et al. Heme oxygenase-1: a novel therapeutic target for gastrointestinal diseases. J Clin Biochem Nutr. 2011;48:126\u2013133.","journal-title":"J Clin Biochem Nutr"},{"key":"3014_CR14","doi-asserted-by":"crossref","first-page":"2797","DOI":"10.1007\/s10620-009-1112-x","volume":"55","author":"T Takagi","year":"2010","unstructured":"Takagi T, Naito Y, Mizushima K, et al. Inhalation of carbon monoxide ameliorates TNBS-induced colitis in mice through the inhibition of TNF-\u03b1 expression. Dig Dis Sci. 2010;55:2797\u20132804.","journal-title":"Dig Dis Sci"},{"key":"3014_CR15","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1056\/NEJM198703193161202","volume":"12","author":"EJ Boyko","year":"1987","unstructured":"Boyko EJ, Koepsell TD, Perera DR, et al. Risk of ulcerative colitis among former and current cigarette smokers. N Engl J Med. 1987;12:707\u2013710.","journal-title":"N Engl J Med"},{"key":"3014_CR16","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1056\/NEJM198302033080507","volume":"308","author":"H Jick","year":"1983","unstructured":"Jick H, Walker AM. Cigarette smoking and ulcerative colitis. N Engl J Med. 1983;308:261\u2013263.","journal-title":"N Engl J Med"},{"key":"3014_CR17","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1038\/nrd3228","volume":"9","author":"R Motterlini","year":"2010","unstructured":"Motterlini R, Otterbein LE. The therapeutic potential of carbon monoxide. Nat Rev Drug Discov. 2010;9:728\u2013743.","journal-title":"Nat Rev Drug Discov"},{"key":"3014_CR18","doi-asserted-by":"crossref","first-page":"H1649","DOI":"10.1152\/ajpheart.00971.2003","volume":"286","author":"Y Guo","year":"2004","unstructured":"Guo Y, Stein AB, Wu WJ, et al. Administration of a CO-releasing molecule at the time of reperfusion reduces infarct size in vivo. Am J Physiol Heart Circ Physiol. 2004;286:H1649\u2013H1653.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"3014_CR19","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1136\/gut.2008.155481","volume":"58","author":"O Backer De","year":"2009","unstructured":"De Backer O, Elinck E, Blanckaert B, et al. Water-soluble CO-releasing molecules reduce the development of postoperative ileus via modulation of MAPK\/HO-1 signalling and reduction of oxidative stress. Gut. 2009;58:347\u2013356.","journal-title":"Gut"},{"key":"3014_CR20","doi-asserted-by":"crossref","first-page":"E17","DOI":"10.1161\/hh0202.104530","volume":"90","author":"R Motterlini","year":"2002","unstructured":"Motterlini R, Clark JE, Foresti R, et al. Carbon monoxide-releasing molecules: characterization of biochemical and vascular activities. Circ Res. 2002;90:E17\u2013E24.","journal-title":"Circ Res"},{"key":"3014_CR21","doi-asserted-by":"crossref","first-page":"25350","DOI":"10.1074\/jbc.M503512200","volume":"280","author":"C Taill\u00e9","year":"2005","unstructured":"Taill\u00e9 C, El-Benna J, Lanone S, et al. Mitochondrial respiratory chain and NAD(P)H oxidase are targets for the antiproliferative effect of carbon monoxide in human airway smooth muscle. J Biol Chem. 2005;280:25350\u201325360.","journal-title":"J Biol Chem"},{"key":"3014_CR22","doi-asserted-by":"crossref","first-page":"e2","DOI":"10.1161\/01.RES.0000084381.86567.08","volume":"93","author":"JE Clark","year":"2003","unstructured":"Clark JE, Naughton P, Shurey S, et al. Cardioprotective actions by a water-soluble carbon monoxide-releasing molecule. Circ Res. 2003;93:e2\u2013e8.","journal-title":"Circ Res"},{"key":"3014_CR23","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1016\/j.bbrc.2009.12.035","volume":"391","author":"K Uchiyama","year":"2010","unstructured":"Uchiyama K, Naito Y, Takagi T, et al. Carbon monoxide enhance colonic epithelial restitution via FGF15 derived from colonic myofibroblasts. Biochem Biophys Res Commun. 2010;391:1122\u20131126.","journal-title":"Biochem Biophys Res Commun"},{"key":"3014_CR24","doi-asserted-by":"crossref","first-page":"G184","DOI":"10.1152\/ajpgi.00348.2007","volume":"294","author":"G Cepinskas","year":"2008","unstructured":"Cepinskas G, Katada K, Bihari A, et al. Carbon monoxide liberated from carbon monoxide-releasing molecule CORM-2 attenuates inflammation in the liver of septic mice. Am J Physiol Gastrointest Liver Physiol. 2008;294:G184\u2013G191.","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"3014_CR25","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1007\/s00535-012-0719-4","volume":"48","author":"Y Higashimura","year":"2013","unstructured":"Higashimura Y, Naito Y, Takagi T, et al. Oligosaccharides from agar inhibit murine intestinal inflammation through the induction of heme oxygenase-1 expression. J Gastroenterol. 2013;48:897\u2013909.","journal-title":"J Gastroenterol"},{"key":"3014_CR26","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1097\/MIB.0b013e3182802968","volume":"19","author":"A Harusato","year":"2013","unstructured":"Harusato A, Naito Y, Takagi T, et al. BTB and CNC homolog 1 (Bach1) deficiency ameliorates TNBS colitis in mice: role of M2 macrophages and heme oxygenase-1. Inflamm Bowel Dis. 2013;19:740\u2013753.","journal-title":"Inflamm Bowel Dis"},{"key":"3014_CR27","doi-asserted-by":"crossref","first-page":"H920","DOI":"10.1152\/ajpheart.00305.2009","volume":"297","author":"S Mizuguchi","year":"2009","unstructured":"Mizuguchi S, Stephen J, Bihari R, et al. CORM-3-derived CO modulates polymorphonuclear leukocyte migration across the vascular endothelium by reducing levels of cell surface-bound elastase. Am J Physiol Heart Circ Physiol. 2009;297:H920\u2013H929.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"3014_CR28","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1097\/ALN.0b013e318286d085","volume":"118","author":"A Hervera","year":"2013","unstructured":"Hervera A, Le\u00e1nez S, Motterlini R, et al. Treatment with carbon monoxide-releasing molecules and an HO-1 inducer enhances the effects and expression of \u03bc-opioid receptors during neuropathic pain. Anesthesiology. 2013;118:1180\u20131197.","journal-title":"Anesthesiology"},{"key":"3014_CR29","doi-asserted-by":"crossref","first-page":"e41836","DOI":"10.1371\/journal.pone.0041836","volume":"7","author":"S Lancel","year":"2012","unstructured":"Lancel S, Montaigne D, Marechal X, et al. Carbon monoxide improves cardiac function and mitochondrial population quality in a mouse model of metabolic syndrome. PLoS One. 2012;7:e41836.","journal-title":"PLoS One"},{"key":"3014_CR30","doi-asserted-by":"crossref","first-page":"F789","DOI":"10.1152\/ajprenal.00363.2005","volume":"290","author":"Y Tayem","year":"2006","unstructured":"Tayem Y, Johnson TR, Mann BE, et al. Protection against cisplatin-induced nephrotoxicity by a carbon monoxide-releasing molecule. Am J Physiol Renal Physiol. 2006;290:F789\u2013F794.","journal-title":"Am J Physiol Renal Physiol"},{"key":"3014_CR31","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1136\/gut.45.6.864","volume":"45","author":"DM McCafferty","year":"1999","unstructured":"McCafferty DM, Miampamba M, Sihota E, et al. Role of inducible nitric oxide synthase in trinitrobenzene sulphonic acid induced colitis in mice. Gut. 1999;45:864\u2013873.","journal-title":"Gut"},{"key":"3014_CR32","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.4049\/jimmunol.181.3.2145","volume":"181","author":"N Sugimoto","year":"2008","unstructured":"Sugimoto N, Rui T, Yang M, et al. Points of control exerted along the macrophage-endothelial cell-polymorphonuclear neutrophil axis by PECAM-1 in the innate immune response of acute colonic inflammation. J Immunol. 2008;181:2145\u20132154.","journal-title":"J Immunol"},{"key":"3014_CR33","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.4049\/jimmunol.157.5.2174","volume":"157","author":"CO Elson","year":"1996","unstructured":"Elson CO, Beagley KW, Sharmanov AT, et al. Hapten-induced model of murine inflammatory bowel disease. J Immunol. 1996;157:2174\u20132185.","journal-title":"J Immunol"},{"key":"3014_CR34","first-page":"G567","volume":"251","author":"MB Grisham","year":"1986","unstructured":"Grisham MB, Hernandez LA, Granger DN. Xanthine oxidase and neutrophil infiltration in intestinal ischemia. Am J Physiol. 1986;251:G567\u2013G574.","journal-title":"Am J Physiol"},{"key":"3014_CR35","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1007\/s10620-010-1484-y","volume":"56","author":"T Takagi","year":"2011","unstructured":"Takagi T, Naito Y, Uchiyama K, et al. Carbon monoxide liberated from carbon monoxide-releasing molecule exerts an anti-inflammatory effect on dextran sulfate sodium-induced colitis in mice. Dig Dis Sci. 2011;56:1663\u20131671.","journal-title":"Dig Dis Sci"},{"key":"3014_CR36","doi-asserted-by":"crossref","first-page":"5506","DOI":"10.4049\/jimmunol.1002433","volume":"186","author":"SZ Sheikh","year":"2011","unstructured":"Sheikh SZ, Hegazi RA, Kobayashi T, et al. An anti-inflammatory role for carbon monoxide and heme oxygenase-1 in chronic Th2-mediated murine colitis. J Immunol. 2011;186:5506\u20135513.","journal-title":"J Immunol"},{"key":"3014_CR37","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1111\/apt.12086","volume":"36","author":"PC Lunney","year":"2012","unstructured":"Lunney PC, Leong RW. Review article: ulcerative colitis, smoking and nicotine therapy. Aliment Pharmacol Ther. 2012;36:997\u20131008.","journal-title":"Aliment Pharmacol Ther"},{"key":"3014_CR38","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.2174\/1381612033453785","volume":"9","author":"R Motterilini","year":"2003","unstructured":"Motterilini R, Mann BE, Johnson TR, et al. Bioactivity and pharmacological actions of carbon monoxide-releasing molecules. Curr Pharm Des. 2003;9:2525\u20132539.","journal-title":"Curr Pharm Des"},{"key":"3014_CR39","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1007\/s10753-009-9162-y","volume":"33","author":"K Katada","year":"2010","unstructured":"Katada K, Bihari A, Mizuguchi S, et al. Carbon monoxide liberated from CO-releasing molecule (CORM-2) attenuates ischemia\/reperfusion (I\/R)-induced inflammation in the small intestine. Inflammation. 2010;33:92\u2013100.","journal-title":"Inflammation"},{"key":"3014_CR40","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1124\/jpet.106.104729","volume":"318","author":"MG Bani-Hani","year":"2006","unstructured":"Bani-Hani MG, Greenstein D, Mann BE, et al. Modulation of thrombin-induced neuroinflammation in BV-2 microglia by carbon monoxide-releasing molecule 3. J Pharmacol Exp Ther. 2006;318:1315\u20131322.","journal-title":"J Pharmacol Exp Ther"},{"key":"3014_CR41","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1097\/TP.0b013e318160516a","volume":"27","author":"A Bagul","year":"2008","unstructured":"Bagul A, Hosgood SA, Kaushik M, et al. Carbon monoxide protects against ischemia-reperfusion injury in an experimental model of controlled nonheartbeating donor kidney. Transplantation. 2008;27:576\u2013581.","journal-title":"Transplantation"},{"key":"3014_CR42","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.juro.2012.12.020","volume":"190","author":"A Sener","year":"2013","unstructured":"Sener A, Tran KC, Deng JP, et al. Carbon monoxide releasing molecules inhibit cell death resulting from renal transplantation related stress. J Urol. 2013;190:772\u2013778.","journal-title":"J Urol"},{"key":"3014_CR43","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1007\/s00535-007-2096-y","volume":"42","author":"Y Naito","year":"2007","unstructured":"Naito Y, Takagi T, Yoshikawa T. Molecular fingerprints of neutrophil-dependent oxidative stress in inflammatory bowel disease. J Gastroenterol. 2007;42:787\u2013798.","journal-title":"J Gastroenterol"},{"key":"3014_CR44","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3164\/jcbn.2007003","volume":"41","author":"Y Naito","year":"2007","unstructured":"Naito Y, Takagi T, Yoshikawa T. Neutrophil-dependent oxidative stress in ulcerative colitis. J Clin Biochem Nutr. 2007;41:18\u201326.","journal-title":"J Clin Biochem Nutr"},{"key":"3014_CR45","doi-asserted-by":"crossref","first-page":"70","DOI":"10.2174\/092986712803413935","volume":"19","author":"Y Naito","year":"2012","unstructured":"Naito Y, Uchiyama K, Takagi T, et al. Therapeutic potential of carbon monoxide (CO) for intestinal inflammation. Curr Med Chem. 2012;19:70\u201376.","journal-title":"Curr Med Chem"},{"key":"3014_CR46","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/sj.bjp.0706882","volume":"149","author":"A Freitas","year":"2006","unstructured":"Freitas A, Alves-Filho JC, Secco DD, et al. Heme oxygenase\/carbon monoxide-biliverdin pathway down regulates neutrophil rolling, adhesion and migration in acute inflammation. Br J Pharmacol. 2006;149:345\u2013354.","journal-title":"Br J Pharmacol"},{"key":"3014_CR47","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.freeradbiomed.2011.11.035","volume":"52","author":"C Bergstraesser","year":"2012","unstructured":"Bergstraesser C, Hoeger S, Song H, et al. Inhibition of VCAM-1 expression in endothelial cells by CORM-3: the role of the ubiquitin-proteasome system, p38, and mitochondrial respiration. Free Radic Biol Med. 2012;52:794\u2013802.","journal-title":"Free Radic Biol Med"},{"key":"3014_CR48","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1038\/sj.bjp.0707184","volume":"150","author":"J Meg\u00edas","year":"2007","unstructured":"Meg\u00edas J, Busserolles J, Alcaraz MJ. The carbon monoxide-releasing molecule CORM-2 inhibits the inflammatory response induced by cytokines in Caco-2 cells. Br J Pharmacol. 2007;150:977\u2013986.","journal-title":"Br J Pharmacol"},{"key":"3014_CR49","doi-asserted-by":"crossref","first-page":"3450","DOI":"10.1096\/fj.07-8472com","volume":"21","author":"SS Lee","year":"2007","unstructured":"Lee SS, Gao W, Mazzola S, et al. Heme oxygenase-1, carbon monoxide, and bilirubin induce tolerance in recipients toward islet allografts by modulating T regulatory cells. FASEB J. 2007;21:3450\u20133457.","journal-title":"FASEB J"},{"key":"3014_CR50","doi-asserted-by":"crossref","first-page":"5181","DOI":"10.4049\/jimmunol.174.9.5181","volume":"174","author":"TM Brusko","year":"2005","unstructured":"Brusko TM, Wasserfall CH, Agarwal A, et al. An integral role for heme oxygenase-1 and carbon monoxide in maintain peripheral tolerance by CD4\u00a0+\u00a0CD25\u00a0+\u00a0regulatory T cells. J Immunol. 2005;174:5181\u20135186.","journal-title":"J Immunol"},{"key":"3014_CR51","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1053\/j.gastro.2012.12.025","volume":"144","author":"JC Onyiah","year":"2012","unstructured":"Onyiah JC, Sheikh SZ, Maharshak N, et al. Carbon monoxide and heme oxygenase-1 prevent intestinal inflammation in mice by promoting bacterial clearance. Gastroenterology. 2012;144:789\u2013798.","journal-title":"Gastroenterology"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-013-3014-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10620-013-3014-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-013-3014-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,9]],"date-time":"2023-07-09T22:31:29Z","timestamp":1688941889000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10620-013-3014-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,19]]},"references-count":51,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["3014"],"URL":"https:\/\/doi.org\/10.1007\/s10620-013-3014-1","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,19]]}}}