{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T10:49:36Z","timestamp":1789382976635,"version":"build-2803163510"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2014,10,4]],"date-time":"2014-10-04T00:00:00Z","timestamp":1412380800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1007\/s10620-014-3373-2","type":"journal-article","created":{"date-parts":[[2014,10,3]],"date-time":"2014-10-03T06:48:27Z","timestamp":1412318907000},"page":"492-501","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["The Risk of Colorectal Cancer in Patients with Ulcerative Colitis"],"prefix":"10.1007","volume":"60","author":[{"given":"Tobias M.","family":"Nowacki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Br\u00fcckner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Eveslage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phil","family":"Tepasse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friederike","family":"Pott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils H.","family":"Thoennissen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Hengst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Ross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik","family":"Bettenworth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,10,4]]},"reference":[{"key":"3373_CR1","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.cell.2010.01.025","volume":"140","author":"SI Grivennikov","year":"2010","unstructured":"Grivennikov SI, Greten FR, Karin M. Immunity, inflammation, and cancer. Cell. 2010;140:883\u2013899.","journal-title":"Cell"},{"key":"3373_CR2","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1056\/NEJM199011013231802","volume":"323","author":"A Ekbom","year":"1990","unstructured":"Ekbom A, Helmick C, Zack M, Adami HO. Ulcerative colitis and colorectal cancer. A population-based study. N Engl J Med. 1990;323:1228\u20131233.","journal-title":"N Engl J Med"},{"key":"3373_CR3","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/0140-6736(90)91889-I","volume":"336","author":"A Ekbom","year":"1990","unstructured":"Ekbom A, Helmick C, Zack M, Adami HO. Increased risk of large-bowel cancer in Crohn\u2019s disease with colonic involvement. Lancet. 1990;336:357\u2013359.","journal-title":"Lancet"},{"key":"3373_CR4","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1136\/gut.35.7.950","volume":"35","author":"PM Choi","year":"1994","unstructured":"Choi PM, Zelig MP. Similarity of colorectal cancer in Crohn\u2019s disease and ulcerative colitis: implications for carcinogenesis and prevention. Gut. 1994;35:950\u2013954.","journal-title":"Gut"},{"key":"3373_CR5","doi-asserted-by":"crossref","first-page":"373","DOI":"10.7326\/0003-4819-113-5-373","volume":"113","author":"DM Eddy","year":"1990","unstructured":"Eddy DM. Screening for colorectal cancer. Ann Intern Med. 1990;113:373\u2013384.","journal-title":"Ann Intern Med"},{"key":"3373_CR6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1365-2036.18.s2.2.x","volume":"18","author":"P Munkholm","year":"2003","unstructured":"Munkholm P. Review article: the incidence and prevalence of colorectal cancer in inflammatory bowel disease. Alim Pharmacol Ther. 2003;18:1\u20135.","journal-title":"Alim Pharmacol Ther"},{"key":"3373_CR7","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1002\/ibd.20886","volume":"15","author":"MM Claessen","year":"2009","unstructured":"Claessen MM, Lutgens MW, van Buuren HR, et al. More right-sided IBD-associated colorectal cancer in patients with primary sclerosing cholangitis. Inflamm Bowel Dis. 2009;15:1331\u20131336.","journal-title":"Inflamm Bowel Dis"},{"key":"3373_CR8","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1136\/gut.48.4.526","volume":"48","author":"JA Eaden","year":"2001","unstructured":"Eaden JA, Abrams KR, Mayberry JF. The risk of colorectal cancer in ulcerative colitis: a meta-analysis. Gut. 2001;48:526\u2013535.","journal-title":"Gut"},{"key":"3373_CR9","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1053\/j.gastro.2003.11.010","volume":"126","author":"M Rutter","year":"2004","unstructured":"Rutter M, Saunders B, Wilkinson K, et al. Severity of inflammation is a risk factor for colorectal neoplasia in ulcerative colitis. Gastroenterology. 2004;126:451\u2013459.","journal-title":"Gastroenterology"},{"key":"3373_CR10","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1067\/mge.2002.125367","volume":"56","author":"RM Soetikno","year":"2002","unstructured":"Soetikno RM, Lin OS, Heidenreich PA, Young HS, Blackstone MO. Increased risk of colorectal neoplasia in patients with primary sclerosing cholangitis and ulcerative colitis: a meta-analysis. Gastrointest Endosc. 2002;56:48\u201354.","journal-title":"Gastrointest Endosc"},{"key":"3373_CR11","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1053\/gast.2001.24052","volume":"120","author":"J Askling","year":"2001","unstructured":"Askling J, Dickman PW, Karlen P, et al. Family history as a risk factor for colorectal cancer in inflammatory bowel disease. Gastroenterology. 2001;120:1356\u20131362.","journal-title":"Gastroenterology"},{"key":"3373_CR12","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1056\/NEJM197107012850103","volume":"285","author":"GJ Devroede","year":"1971","unstructured":"Devroede GJ, Taylor WF, Sauer WG, Jackman RJ, Stickler GB. Cancer risk and life expectancy of children with ulcerative colitis. N Engl J Med. 1971;285:17\u201321.","journal-title":"N Engl J Med"},{"key":"3373_CR13","doi-asserted-by":"crossref","unstructured":"Jess T, Simonsen J, Jorgensen KT, Pedersen BV, Nielsen NM, Frisch M. Decreasing risk of colorectal cancer in patients with inflammatory bowel disease over 30\u00a0years Gastroenterology. 2012;143:375\u2013381 e371; quiz e313-374.","DOI":"10.1053\/j.gastro.2012.04.016"},{"key":"3373_CR14","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1016\/S1542-3565(04)00543-9","volume":"2","author":"KV Winther","year":"2004","unstructured":"Winther KV, Jess T, Langholz E, Munkholm P, Binder V. Long-term risk of cancer in ulcerative colitis: a population-based cohort study from Copenhagen County. Clin Gastroenterol Hepatol. 2004;2:1088\u20131095.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"3373_CR15","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.cgh.2012.01.010","volume":"10","author":"T Jess","year":"2012","unstructured":"Jess T, Rungoe C, Peyrin-Biroulet L. Risk of colorectal cancer in patients with ulcerative colitis: a meta-analysis of population-based cohort studies. Clin Gastroenterol Hepatol. 2012;10:639\u2013645.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"3373_CR16","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/0016-5085(93)90715-O","volume":"105","author":"PM Choi","year":"1993","unstructured":"Choi PM, Nugent FW, Schoetz DJ Jr, Silverman ML, Haggitt RC. Colonoscopic surveillance reduces mortality from colorectal cancer in ulcerative colitis. Gastroenterology. 1993;105:418\u2013424.","journal-title":"Gastroenterology"},{"key":"3373_CR17","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.1365-2036.2007.03487.x","volume":"26","author":"FP Vleggaar","year":"2007","unstructured":"Vleggaar FP, Lutgens MW, Claessen MM. Review article: The relevance of surveillance endoscopy in long-lasting inflammatory bowel disease. Alim Pharmacol Ther. 2007;26:47\u201352.","journal-title":"Alim Pharmacol Ther"},{"key":"3373_CR18","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1053\/j.gastro.2009.12.037","volume":"138","author":"FA Farraye","year":"2010","unstructured":"Farraye FA, Odze RD, Eaden J, et al. AGA medical position statement on the diagnosis and management of colorectal neoplasia in inflammatory bowel disease. Gastroenterology. 2010;138:738\u2013745.","journal-title":"Gastroenterology"},{"key":"3373_CR19","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1111\/j.1572-0241.2006.01000.x","volume":"102","author":"T Jess","year":"2007","unstructured":"Jess T, Gamborg M, Munkholm P, Sorensen TI. Overall and cause-specific mortality in ulcerative colitis: meta-analysis of population-based inception cohort studies. Am J Gastroenterol. 2007;102:609\u2013617.","journal-title":"Am J Gastroenterol"},{"key":"3373_CR20","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1136\/gut.2007.143453","volume":"57","author":"MW Lutgens","year":"2008","unstructured":"Lutgens MW, Vleggaar FP, Schipper ME, et al. High frequency of early colorectal cancer in inflammatory bowel disease. Gut. 2008;57:1246\u20131251.","journal-title":"Gut"},{"key":"3373_CR21","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1111\/j.1365-2036.2011.04711.x","volume":"34","author":"A Vienne","year":"2011","unstructured":"Vienne A, Simon T, Cosnes J, et al. Low prevalence of colonoscopic surveillance of inflammatory bowel disease patients with longstanding extensive colitis: a clinical practice survey nested in the CESAME cohort. Alim Pharmacol Ther. 2011;34:188\u2013195.","journal-title":"Alim Pharmacol Ther"},{"key":"3373_CR22","doi-asserted-by":"crossref","unstructured":"Subramaniam K, Richardson A, Dodd J, Platten J, Shadbolt B, Pavli P. Early predictors of colectomy and long-term maintenance of remission in ulcerative colitis patients treated using anti-TNF therapy Intern Med J 2014.","DOI":"10.1111\/imj.12397"},{"key":"3373_CR23","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1136\/gut.2005.082909","volume":"55","author":"J Satsangi","year":"2006","unstructured":"Satsangi J, Silverberg MS, Vermeire S, Colombel JF, Satsangi J. The Montreal classification of inflammatory bowel disease: controversies, consensus, and implications. Gut. 2006;55:749\u2013753.","journal-title":"Gut"},{"key":"3373_CR24","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1056\/NEJM198712243172603","volume":"317","author":"KW Schroeder","year":"1987","unstructured":"Schroeder KW, Tremaine WJ, Ilstrup DM. Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. N Engl J Med. 1987;317:1625\u20131629.","journal-title":"N Engl J Med"},{"key":"3373_CR25","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/S0046-8177(83)80175-0","volume":"14","author":"RH Riddell","year":"1983","unstructured":"Riddell RH, Goldman H, Ransohoff DF, et al. Dysplasia in inflammatory bowel disease: standardized classification with provisional clinical applications. Hum Pathol. 1983;14:931\u2013968.","journal-title":"Hum Pathol"},{"key":"3373_CR26","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1111\/j.1572-0241.2005.41442.x","volume":"100","author":"FS Velayos","year":"2005","unstructured":"Velayos FS, Terdiman JP, Walsh JM. Effect of 5-aminosalicylate use on colorectal cancer and dysplasia risk: a systematic review and metaanalysis of observational studies. Am J Gastroenterol. 2005;100:1345\u20131353.","journal-title":"Am J Gastroenterol"},{"key":"3373_CR27","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1097\/MIB.0b013e31828029c0","volume":"19","author":"MW Lutgens","year":"2013","unstructured":"Lutgens MW, van Oijen MG, van der Heijden GJ, Vleggaar FP, Siersema PD, Oldenburg B. Declining risk of colorectal cancer in inflammatory bowel disease: an updated meta-analysis of population-based cohort studies. Inflamm Bowel Dis. 2013;19:789\u2013799.","journal-title":"Inflamm Bowel Dis"},{"key":"3373_CR28","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1097\/DCR.0000000000000003","volume":"57","author":"SE Moore","year":"2014","unstructured":"Moore SE, McGrail KM, Peterson S, et al. Infliximab in ulcerative colitis: the impact of preoperative treatment on rates of colectomy and prescribing practices in the province of British Columbia, Canada. Dis Colon Rectum. 2014;57:83\u201390.","journal-title":"Dis Colon Rectum"},{"key":"3373_CR29","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1053\/j.gastro.2005.12.035","volume":"130","author":"MD Rutter","year":"2006","unstructured":"Rutter MD, Saunders BP, Wilkinson KH, et al. Thirty-year analysis of a colonoscopic surveillance program for neoplasia in ulcerative colitis. Gastroenterology. 2006;130:1030\u20131038.","journal-title":"Gastroenterology"},{"key":"3373_CR30","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1111\/j.1572-0241.1998.00592.x","volume":"93","author":"ML Cravo","year":"1998","unstructured":"Cravo ML, Albuquerque CM, Salazar de Sousa L, et al. Microsatellite instability in non-neoplastic mucosa of patients with ulcerative colitis: effect of folate supplementation. Am J Gastroenterol. 1998;93:2060\u20132064.","journal-title":"Am J Gastroenterol"},{"key":"3373_CR31","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/nature06005","volume":"448","author":"RJ Xavier","year":"2007","unstructured":"Xavier RJ, Podolsky DK. Unravelling the pathogenesis of inflammatory bowel disease. Nature. 2007;448:427\u2013434.","journal-title":"Nature"},{"key":"3373_CR32","doi-asserted-by":"crossref","unstructured":"Rubin DT, Huo D, Kinnucan JA et al. Inflammation is an independent risk factor for colonic neoplasia in patients with ulcerative colitis: a case-control study Clin Gastroenterol Hepatol. 2013;11:1601\u20131608 e1601\u20131604.","DOI":"10.1016\/j.cgh.2013.06.023"},{"key":"3373_CR33","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1159\/000320276","volume":"28","author":"M Lukas","year":"2010","unstructured":"Lukas M. Inflammatory bowel disease as a risk factor for colorectal cancer. Dig Dis. 2010;28:619\u2013624.","journal-title":"Dig Dis"},{"key":"3373_CR34","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1111\/j.1572-0241.2007.01070.x","volume":"102","author":"T Jess","year":"2007","unstructured":"Jess T, Loftus EV, Velayos FS Jr, et al. Risk factors for colorectal neoplasia in inflammatory bowel disease: a nested case-control study from Copenhagen county, Denmark and Olmsted county, Minnesota. Am J Gastroenterol. 2007;102:829\u2013836.","journal-title":"Am J Gastroenterol"},{"key":"3373_CR35","doi-asserted-by":"crossref","unstructured":"Ullman T, Croog V, Harpaz N et al. Progression to colorectal neoplasia in ulcerative colitis: effect of mesalamine. Clin Gastroenterol Hepatol. 2008;6:1225\u20131230; quiz 1177.","DOI":"10.1016\/j.cgh.2008.05.020"},{"key":"3373_CR36","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/ajg.2011.50","volume":"106","author":"CN Bernstein","year":"2011","unstructured":"Bernstein CN, Nugent Z, Blanchard JF. 5-Aminosalicylate is not chemoprophylactic for colorectal cancer in IBD: a population based study. Am J Gastroenterol. 2011;106:731\u2013736.","journal-title":"Am J Gastroenterol"},{"key":"3373_CR37","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.2174\/138945011796818270","volume":"12","author":"RA Ali","year":"2011","unstructured":"Ali RA, Egan LJ. How to manage the risk of colorectal cancer in ulcerative colitis. Curr Drug Targets. 2011;12:1424\u20131432.","journal-title":"Curr Drug Targets"},{"key":"3373_CR38","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1159\/000341894","volume":"30","author":"H Herfarth","year":"2012","unstructured":"Herfarth H. The role of chemoprevention of colorectal cancer with 5-aminosalicylates in ulcerative colitis. Dig Dis. 2012;30:55\u201359.","journal-title":"Dig Dis"},{"key":"3373_CR39","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.crohns.2007.12.001","volume":"2","author":"L Biancone","year":"2008","unstructured":"Biancone L, Michetti P, Travis S, et al. European evidence-based Consensus on the management of ulcerative colitis: special situations. J Crohns Colitis. 2008;2:63\u201392.","journal-title":"J Crohns Colitis"},{"key":"3373_CR40","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1055\/s-0031-1281666","volume":"49","author":"A Dignass","year":"2011","unstructured":"Dignass A, Preiss JC, Aust DE, et al. [Updated German guideline on diagnosis and treatment of ulcerative colitis, 2011]. Z Gastroenterol. 2011;49:1276\u20131341.","journal-title":"Z Gastroenterol"},{"key":"3373_CR41","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1055\/s-2004-813510","volume":"42","author":"JC Hoffmann","year":"2004","unstructured":"Hoffmann JC, Zeitz M, Bischoff SC, et al. [Diagnosis and therapy of ulcerative colitis: results of an evidence based consensus conference by the German society of digestive and metabolic diseases and the competence network on inflammatory bowel disease]. Z Gastroenterol. 2004;42:979\u2013983.","journal-title":"Z Gastroenterol"},{"key":"3373_CR42","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1136\/gutjnl-2012-302830","volume":"61","author":"MF Neurath","year":"2012","unstructured":"Neurath MF, Travis SP. Mucosal healing in inflammatory bowel diseases: a systematic review. Gut. 2012;61:1619\u20131635.","journal-title":"Gut"},{"key":"3373_CR43","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1053\/j.gastro.2006.03.028","volume":"130","author":"FS Velayos","year":"2006","unstructured":"Velayos FS, Loftus EV Jr, Jess T, et al. Predictive and protective factors associated with colorectal cancer in ulcerative colitis: a case-control study. Gastroenterology. 2006;130:1941\u20131949.","journal-title":"Gastroenterology"},{"key":"3373_CR44","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1053\/j.gastro.2010.02.007","volume":"138","author":"S Soderlund","year":"2010","unstructured":"Soderlund S, Granath F, Brostrom O, et al. Inflammatory bowel disease confers a lower risk of colorectal cancer to females than to males. Gastroenterology. 2010;138:1697\u20131703.","journal-title":"Gastroenterology"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-014-3373-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10620-014-3373-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-014-3373-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,15]],"date-time":"2019-08-15T20:02:16Z","timestamp":1565899336000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10620-014-3373-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,4]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["3373"],"URL":"https:\/\/doi.org\/10.1007\/s10620-014-3373-2","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,4]]}}}