{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T05:38:28Z","timestamp":1789623508816,"version":"build-2803163510"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2014,12,10]],"date-time":"2014-12-10T00:00:00Z","timestamp":1418169600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1007\/s10620-014-3474-y","type":"journal-article","created":{"date-parts":[[2014,12,9]],"date-time":"2014-12-09T06:39:00Z","timestamp":1418107140000},"page":"1284-1289","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Histone Deacetylase Regulates Trypsin Activation, Inflammation, and Tissue Damage in Acute Pancreatitis in Mice"],"prefix":"10.1007","volume":"60","author":[{"given":"Hannes","family":"Hartman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Wetterholm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Thorlacius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Regn\u00e9r","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,12,10]]},"reference":[{"key":"3474_CR1","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1159\/000161011","volume":"8","author":"S Regner","year":"2008","unstructured":"Regner S, Manjer J, Appelros S, Hjalmarsson C, Sadic J, Borgstrom A. Protease activation, pancreatic leakage, and inflammation in acute pancreatitis: differences between mild and severe cases and changes over the first three days. Pancreatology. 2008;8:600\u2013607.","journal-title":"Pancreatology"},{"key":"3474_CR2","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1111\/j.1476-5381.2011.01225.x","volume":"163","author":"D Awla","year":"2011","unstructured":"Awla D, Abdulla A, Zhang S, et al. Lymphocyte function antigen-1 regulates neutrophil recruitment and tissue damage in acute pancreatitis. Br J Pharmacol. 2011;163:413\u2013423.","journal-title":"Br J Pharmacol"},{"key":"3474_CR3","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1002\/bjs.7775","volume":"99","author":"H Hartman","year":"2012","unstructured":"Hartman H, Abdulla A, Awla D, et al. P-selectin mediates neutrophil rolling and recruitment in acute pancreatitis. Br J Surg. 2012;99:246\u2013255.","journal-title":"Br J Surg"},{"key":"3474_CR4","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1097\/01.LAB.0000063928.91314.9F","volume":"83","author":"CM Pastor","year":"2003","unstructured":"Pastor CM, Rubbia-Brandt L, Hadengue A, Jordan M, Morel P, Frossard JL. Role of macrophage inflammatory peptide-2 in cerulein-induced acute pancreatitis and pancreatitis-associated lung injury. Lab Invest. 2003;83:471\u2013478.","journal-title":"Lab Invest"},{"key":"3474_CR5","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1056\/NEJM199802123380706","volume":"338","author":"AD Luster","year":"1998","unstructured":"Luster AD. Chemokines\u2013chemotactic cytokines that mediate inflammation. N Engl J Med. 1998;338:436\u2013445.","journal-title":"N Engl J Med"},{"key":"3474_CR6","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1136\/gut.2007.124115","volume":"57","author":"Z Rakonczay Jr","year":"2008","unstructured":"Rakonczay Z Jr, Hegyi P, Takacs T, McCarroll J, Saluja AK. The role of NF-kappaB activation in the pathogenesis of acute pancreatitis. Gut. 2008;57:259\u2013267.","journal-title":"Gut"},{"key":"3474_CR7","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1053\/gast.2002.35951","volume":"123","author":"RT Ethridge","year":"2002","unstructured":"Ethridge RT, Chung DH, Slogoff M, et al. Cyclooxygenase-2 gene disruption attenuates the severity of acute pancreatitis and pancreatitis-associated lung injury. Gastroenterology. 2002;123:1311\u20131322.","journal-title":"Gastroenterology"},{"key":"3474_CR8","first-page":"G1259","volume":"288","author":"M Bhatia","year":"2005","unstructured":"Bhatia M, Ramnath RD, Chevali L, Guglielmotti A. Treatment with bindarit, a blocker of MCP-1 synthesis, protects mice against acute pancreatitis. Am J Physiol. 2005;288:G1259\u2013G1265.","journal-title":"Am J Physiol"},{"key":"3474_CR9","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1023\/A:1018886120711","volume":"42","author":"JG Norman","year":"1997","unstructured":"Norman JG, Fink GW, Denham W, et al. Tissue-specific cytokine production during experimental acute pancreatitis. A probable mechanism for distant organ dysfunction. Dig Dis Sci. 1997;42:1783\u20131788.","journal-title":"Dig Dis Sci"},{"key":"3474_CR10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-1119(99)00405-9","volume":"240","author":"VA Spencer","year":"1999","unstructured":"Spencer VA, Davie JR. Role of covalent modifications of histones in regulating gene expression. Gene. 1999;240:1\u201312.","journal-title":"Gene"},{"key":"3474_CR11","doi-asserted-by":"crossref","first-page":"28171","DOI":"10.1074\/jbc.272.45.28171","volume":"272","author":"C Wu","year":"1997","unstructured":"Wu C. Chromatin remodeling and the control of gene expression. J Biol Chem. 1997;272:28171\u201328174.","journal-title":"J Biol Chem"},{"key":"3474_CR12","doi-asserted-by":"crossref","first-page":"5459","DOI":"10.1200\/JCO.2009.22.1291","volume":"27","author":"AA Lane","year":"2009","unstructured":"Lane AA, Chabner BA. Histone deacetylase inhibitors in cancer therapy. J Clin Oncol. 2009;27:5459\u20135468.","journal-title":"J Clin Oncol"},{"key":"3474_CR13","first-page":"F133","volume":"298","author":"T Marumo","year":"2010","unstructured":"Marumo T, Hishikawa K, Yoshikawa M, Hirahashi J, Kawachi S, Fujita T. Histone deacetylase modulates the proinflammatory and -fibrotic changes in tubulointerstitial injury. Am J Physiol. 2010;298:F133\u2013F141.","journal-title":"Am J Physiol"},{"key":"3474_CR14","doi-asserted-by":"crossref","first-page":"3175","DOI":"10.1523\/JNEUROSCI.20-09-03175.2000","volume":"20","author":"M Endres","year":"2000","unstructured":"Endres M, Meisel A, Biniszkiewicz D, et al. DNA methyltransferase contributes to delayed ischemic brain injury. J Neurosci. 2000;20:3175\u20133181.","journal-title":"J Neurosci"},{"key":"3474_CR15","doi-asserted-by":"crossref","first-page":"e65474","DOI":"10.1371\/journal.pone.0065474","volume":"8","author":"TC Zhao","year":"2013","unstructured":"Zhao TC, Du J, Zhuang S, Liu P, Zhang LX. HDAC inhibition elicits myocardial protective effect through modulation of MKK3\/Akt-1. PLoS ONE. 2013;8:e65474.","journal-title":"PLoS ONE"},{"key":"3474_CR16","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1007\/s00268-010-0493-5","volume":"34","author":"L Zhang","year":"2010","unstructured":"Zhang L, Jin S, Wang C, Jiang R, Wan J. Histone deacetylase inhibitors attenuate acute lung injury during cecal ligation and puncture-induced polymicrobial sepsis. World J Surg. 2010;34:1676\u20131683.","journal-title":"World J Surg"},{"key":"3474_CR17","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1136\/gut.2007.124230","volume":"56","author":"JM Laukkarinen","year":"2007","unstructured":"Laukkarinen JM, Van Acker GJ, Weiss ER, Steer ML, Perides G. A mouse model of acute biliary pancreatitis induced by retrograde pancreatic duct infusion of Na-taurocholate. Gut. 2007;56:1590\u20131598.","journal-title":"Gut"},{"key":"3474_CR18","doi-asserted-by":"crossref","first-page":"619","DOI":"10.2144\/000112776","volume":"44","author":"HD VanGuilder","year":"2008","unstructured":"VanGuilder HD, Vrana KE, Freeman WM. Twenty-five years of quantitative PCR for gene expression analysis. Biotechniques. 2008;44:619\u2013626.","journal-title":"Biotechniques"},{"key":"3474_CR19","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/0003-2697(83)90019-2","volume":"132","author":"K Suzuki","year":"1983","unstructured":"Suzuki K, Ota H, Sasagawa S, Sakatani T, Fujikura T. Assay method for myeloperoxidase in human polymorphonuclear leukocytes. Anal Biochem. 1983;132:345\u2013352.","journal-title":"Anal Biochem"},{"key":"3474_CR20","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1097\/00000658-199201000-00007","volume":"215","author":"J Schmidt","year":"1992","unstructured":"Schmidt J, Rattner DW, Lewandrowski K, et al. A better model of acute pancreatitis for evaluating therapy. Ann Surg. 1992;215:44\u201356.","journal-title":"Ann Surg"},{"key":"3474_CR21","first-page":"G835","volume":"276","author":"AK Saluja","year":"1999","unstructured":"Saluja AK, Bhagat L, Lee HS, Bhatia M, Frossard JL, Steer ML. Secretagogue-induced digestive enzyme activation and cell injury in rat pancreatic acini. Am J Physiol. 1999;276:G835\u2013G842.","journal-title":"Am J Physiol"},{"key":"3474_CR22","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1432-1033.1988.tb13849.x","volume":"172","author":"S Kawabata","year":"1988","unstructured":"Kawabata S, Miura T, Morita T, et al. Highly sensitive peptide-4-methylcoumaryl-7-amide substrates for blood-clotting proteases and trypsin. Eur J Biochem. 1988;172:17\u201325.","journal-title":"Eur J Biochem"},{"key":"3474_CR23","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1002\/j.1460-2075.1990.tb08268.x","volume":"9","author":"A Rubartelli","year":"1990","unstructured":"Rubartelli A, Cozzolino F, Talio M, Sitia R. A novel secretory pathway for interleukin-1 beta, a protein lacking a signal sequence. EMBO J. 1990;9:1503\u20131510.","journal-title":"EMBO J"},{"key":"3474_CR24","first-page":"G71","volume":"274","author":"K Mithofer","year":"1998","unstructured":"Mithofer K, Fernandez-del Castillo C, Rattner D, Warshaw AL. Subcellular kinetics of early trypsinogen activation in acute rodent pancreatitis. Am J Physiol. 1998;274:G71\u2013G79.","journal-title":"Am J Physiol"},{"key":"3474_CR25","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1189\/jlb.0411195","volume":"90","author":"A Abdulla","year":"2011","unstructured":"Abdulla A, Awla D, Thorlacius H, Regner S. Role of neutrophils in the activation of trypsinogen in severe acute pancreatitis. J Leukoc Biol. 2011;90:975\u2013982.","journal-title":"J Leukoc Biol"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-014-3474-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10620-014-3474-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-014-3474-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,18]],"date-time":"2019-08-18T04:23:11Z","timestamp":1566102191000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10620-014-3474-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,10]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["3474"],"URL":"https:\/\/doi.org\/10.1007\/s10620-014-3474-y","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,10]]}}}