{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:33:24Z","timestamp":1761896004245},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2014,12,23]],"date-time":"2014-12-23T00:00:00Z","timestamp":1419292800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2015,6]]},"DOI":"10.1007\/s10620-014-3490-y","type":"journal-article","created":{"date-parts":[[2014,12,22]],"date-time":"2014-12-22T08:36:28Z","timestamp":1419237388000},"page":"1589-1594","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Low Yield and Utilization of Confirmatory Testing in a Cohort of Patients with Liver Disease Assessed for Alpha-1 Antitrypsin Deficiency"],"prefix":"10.1007","volume":"60","author":[{"given":"Elliot B.","family":"Tapper","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vilas R.","family":"Patwardhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Curry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,12,23]]},"reference":[{"key":"3490_CR1","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1111\/j.1572-0241.2003.07486.x","volume":"98","author":"JM Clark","year":"2003","unstructured":"Clark JM, Brancati FL, Diehl AM. The prevalence and etiology of elevated aminotransferase levels in the United States. Am J Gastroenterol. 2003;98:960\u2013967.","journal-title":"Am J Gastroenterol"},{"key":"3490_CR2","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/BF02595919","volume":"3","author":"MJ Lichtenstein","year":"1988","unstructured":"Lichtenstein MJ, Pincus T. How useful are combinations of blood tests in \u201crheumatic panels\u201d in diagnosis of rheumatic diseases? J Gen Intern Med. 1988;3:435\u2013442.","journal-title":"J Gen Intern Med"},{"key":"3490_CR3","doi-asserted-by":"crossref","first-page":"926.e1","DOI":"10.1016\/j.amjmed.2013.01.039","volume":"126","author":"EB Tapper","year":"2013","unstructured":"Tapper EB, Rahni DO, Arnaout R, Lai M. The overuse of serum ceruloplasmin measurement. Am J Med. 2013;126:926.e1\u2013928.e5.","journal-title":"Am J Med"},{"key":"3490_CR4","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0002-9343(83)90615-0","volume":"74","author":"DW Cox","year":"1983","unstructured":"Cox DW, Smyth S. Risk of liver disease in adults with al-anti- trypsin deficiency. Am J Med. 1983;74:221\u2013227.","journal-title":"Am J Med"},{"key":"3490_CR5","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/j.0954-6820.1978.tb08452.x","volume":"204","author":"C Larsson","year":"1978","unstructured":"Larsson C. Natural history and life expectancy in severe alpha 1-antitrypsin deficiency, PiZ. Acta Med Scand. 1978;204:345\u2013351.","journal-title":"Acta Med Scand"},{"key":"3490_CR6","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1056\/NEJM197606102942404","volume":"294","author":"T Sveger","year":"1976","unstructured":"Sveger T. Liver disease in alpha 1-antitrypsin deficiency detected by screening of 200,000 infants. N Engl J Med. 1976;294:1316\u20131321.","journal-title":"N Engl J Med"},{"key":"3490_CR7","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1373\/clinchem.2006.072991","volume":"52","author":"MR Snyder","year":"2006","unstructured":"Snyder MR, Katzmann JA, Butz ML, et al. Diagnosis of A-1-antitrypsin deficiency: an algorithm of quantification, genotyping, and phenotyping. Clin Chem. 2006;52:2236\u20132242.","journal-title":"Clin Chem"},{"key":"3490_CR8","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1111\/j.1572-0241.2008.01955.x","volume":"103","author":"KD Fairbanks","year":"2008","unstructured":"Fairbanks KD, Tavill AS. Liver disease in alpha 1-antitrypsin deficiency: a review. Am J Gastroenterol. 2008;103:2136\u20132141.","journal-title":"Am J Gastroenterol"},{"key":"3490_CR9","doi-asserted-by":"crossref","first-page":"2749","DOI":"10.1056\/NEJMcp0900449","volume":"360","author":"EK Silverman","year":"2009","unstructured":"Silverman EK, Sandhaus RA. Alpha 1-antitrypsin deficiency. N Engl J Med. 2009;360:2749\u20132757.","journal-title":"N Engl J Med"},{"key":"3490_CR10","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/s11894-006-0059-8","volume":"8","author":"JH Teckman","year":"2006","unstructured":"Teckman JH, Lindblad D. Alpha-1-antitrypsin deficiency: diagnosis, pathophysiology, and management. Curr Gastroenterol Rep. 2006;8:14\u201320.","journal-title":"Curr Gastroenterol Rep"},{"key":"3490_CR11","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1056\/NEJM200004273421707","volume":"342","author":"DS Pratt","year":"2000","unstructured":"Pratt DS, Kaplan MM. Evaluation of abnormal liver-enzyme results in asymptomatic patients. N Engl J Med. 2000;342:1266\u20131271.","journal-title":"N Engl J Med"},{"key":"3490_CR12","doi-asserted-by":"crossref","unstructured":"Stoller JK, Snider GL, Brantly ML, et al. American Thoracic Society\/European Respiratory Society statement: standards for the diagnosis and management of individuals with alpha-1 antitrypsin deficiency. Am J Respir Crit Care Med. 2003;168:818\u2013900.","DOI":"10.1164\/rccm.168.7.818"},{"key":"3490_CR13","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.cgh.2011.12.028","volume":"10","author":"DR Nelson","year":"2012","unstructured":"Nelson DR, Teckman J, Di Bisceglie AM, Brenner DA. Diagnosis and management of patients with \u03b11-antitrypsin (A1AT) deficiency. Clin Gastroenterol Hepatol. 2012;10:575\u2013580.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"3490_CR14","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1378\/chest.07-1001","volume":"133","author":"DK Hogarth","year":"2008","unstructured":"Hogarth DK, Rachelefsky G. Screening and familial testing of patients for alpha 1-antitrypsin deficiency. Chest. 2008;133:981\u2013988.","journal-title":"Chest"},{"key":"3490_CR15","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1016\/j.cgh.2012.07.007","volume":"10","author":"VC Clark","year":"2012","unstructured":"Clark VC, Dhanasekaran R, Brantly M, Rouhani F, Schreck P, Nelson DR. Liver test results do not identify liver disease in adults with \u03b1(1)-antitrypsin deficiency. Clin Gastroenterol Hepatol. 2012;10:1278\u20131283.","journal-title":"Clin Gastroenterol Hepatol"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-014-3490-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10620-014-3490-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-014-3490-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T19:44:22Z","timestamp":1559245462000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10620-014-3490-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,23]]},"references-count":15,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["3490"],"URL":"https:\/\/doi.org\/10.1007\/s10620-014-3490-y","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,23]]}}}