{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T10:03:59Z","timestamp":1786356239221,"version":"build-2736575974"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2015,6,16]],"date-time":"2015-06-16T00:00:00Z","timestamp":1434412800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.1007\/s10620-015-3745-2","type":"journal-article","created":{"date-parts":[[2015,6,15]],"date-time":"2015-06-15T01:11:08Z","timestamp":1434330668000},"page":"3418-3423","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Platelet Activation Markers Are Associated with Crohn\u2019s Disease Activity in Patients with Low C-Reactive Protein"],"prefix":"10.1007","volume":"60","author":[{"given":"Hiroshi","family":"Takeyama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsunekazu","family":"Mizushima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Iijima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinzaki","family":"Shinichiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamoru","family":"Uemura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junichi","family":"Nishimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taishi","family":"Hata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Takemasa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirofumi","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichiro","family":"Doki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,6,16]]},"reference":[{"key":"3745_CR1","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1111\/j.1365-2036.2011.04827.x","volume":"34","author":"LS Kiss","year":"2011","unstructured":"Kiss LS, Szamosi T, Molnar T, et al. Early clinical remission and normalisation of CRP are the strongest predictors of efficacy, mucosal healing and dose escalation during the first year of adalimumab therapy in Crohn\u2019s disease. Aliment Pharmacol Ther. 2011;34:911\u2013922.","journal-title":"Aliment Pharmacol Ther"},{"key":"3745_CR2","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/0016-5085(79)90384-6","volume":"77","author":"WR Best","year":"1979","unstructured":"Best WR, Becktel JM, Singleton JW. Rederived values of the eight coefficients of the Crohn\u2019s Disease Activity Index (CDAI). Gastroenterology. 1979;77:843\u2013846.","journal-title":"Gastroenterology"},{"key":"3745_CR3","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.cgh.2006.02.003","volume":"4","author":"P Chamouard","year":"2006","unstructured":"Chamouard P, Richert Z, Meyer N, et al. Diagnostic value of C-reactive protein for predicting activity level of Crohn\u2019s disease. Clin Gastroenterol Hepatol. 2006;4:882\u2013887.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"3745_CR4","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1016\/j.cgh.2008.06.010","volume":"6","author":"J Jones","year":"2008","unstructured":"Jones J, Loftus EV Jr, Panaccione R, et al. Relationships between disease activity and serum and fecal biomarkers in patients with Crohn\u2019s disease. Clin Gastroenterol Hepatol. 2008;6:1218\u20131224.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"3745_CR5","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.3748\/wjg.v17.i17.2181","volume":"17","author":"D Diaz-Jimenez","year":"2011","unstructured":"Diaz-Jimenez D, Nunez LE, Beltran CJ, et al. Soluble ST2: a new and promising activity marker in ulcerative colitis. World J Gastroenterol. 2011;17:2181\u20132190.","journal-title":"World J Gastroenterol"},{"key":"3745_CR6","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1007\/BF02850054","volume":"23","author":"L Filik","year":"2006","unstructured":"Filik L, Dagli U, Ulker A. C-reactive protein and monitoring the activity of Crohn\u2019s disease. Adv Ther. 2006;23:655\u2013662.","journal-title":"Adv Ther"},{"key":"3745_CR7","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1097\/MCG.0b013e3182582cdb","volume":"47","author":"N Husain","year":"2013","unstructured":"Husain N, Tokoro K, Popov JM, et al. Neopterin concentration as an index of disease activity in Crohn\u2019s disease and ulcerative colitis. J Clin Gastroenterol. 2013;47:246\u2013251.","journal-title":"J Clin Gastroenterol"},{"key":"3745_CR8","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1007\/s10620-006-9691-2","volume":"52","author":"AD Rodgers","year":"2007","unstructured":"Rodgers AD, Cummins AG. CRP correlates with clinical score in ulcerative colitis but not in Crohn\u2019s disease. Dig Dis Sci. 2007;52:2063\u20132068.","journal-title":"Dig Dis Sci"},{"key":"3745_CR9","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1365-2036.2006.03184.x","volume":"25","author":"D Desai","year":"2007","unstructured":"Desai D, Faubion WA, Sandborn WJ. Review article: biological activity markers in inflammatory bowel disease. Aliment Pharmacol Ther. 2007;25:247\u2013255.","journal-title":"Aliment Pharmacol Ther"},{"key":"3745_CR10","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1002\/ibd.20178","volume":"13","author":"MA Denis","year":"2007","unstructured":"Denis MA, Reenaers C, Fontaine F, et al. Assessment of endoscopic activity index and biological inflammatory markers in clinically active Crohn\u2019s disease with normal C-reactive protein serum level. Inflamm Bowel Dis. 2007;13:1100\u20131105.","journal-title":"Inflamm Bowel Dis"},{"key":"3745_CR11","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1080\/00365520500217118","volume":"41","author":"TH Florin","year":"2006","unstructured":"Florin TH, Paterson EW, Fowler EV, et al. Clinically active Crohn\u2019s disease in the presence of a low C-reactive protein. Scand J Gastroenterol. 2006;41:306\u2013311.","journal-title":"Scand J Gastroenterol"},{"key":"3745_CR12","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S0140-6736(09)61963-2","volume":"375","author":"MJ Grainge","year":"2010","unstructured":"Grainge MJ, West J, Card TR. Venous thromboembolism during active disease and remission in inflammatory bowel disease: a cohort study. Lancet. 2010;375:657\u2013663.","journal-title":"Lancet"},{"key":"3745_CR13","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1136\/gut.2003.025411","volume":"53","author":"W Miehsler","year":"2004","unstructured":"Miehsler W, Reinisch W, Valic E, et al. Is inflammatory bowel disease an independent and disease specific risk factor for thromboembolism? Gut. 2004;53:542\u2013548.","journal-title":"Gut"},{"key":"3745_CR14","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1136\/gut.34.2.247","volume":"34","author":"MJ Webberley","year":"1993","unstructured":"Webberley MJ, Hart MT, Melikian V. Thromboembolism in inflammatory bowel disease: role of platelets. Gut. 1993;34:247\u2013251.","journal-title":"Gut"},{"key":"3745_CR15","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1097\/00042737-200203000-00008","volume":"14","author":"M Hayat","year":"2002","unstructured":"Hayat M, Ariens RA, Moayyedi P, et al. Coagulation factor XIII and markers of thrombin generation and fibrinolysis in patients with inflammatory bowel disease. Eur J Gastroenterol Hepatol. 2002;14:249\u2013256.","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"3745_CR16","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/S1542-3565(05)00154-0","volume":"3","author":"PM Irving","year":"2005","unstructured":"Irving PM, Pasi KJ, Rampton DS. Thrombosis and inflammatory bowel disease. Clin Gastroenterol Hepatol. 2005;3:617\u2013628.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"3745_CR17","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s00384-002-0408-5","volume":"17","author":"M Thornton","year":"2002","unstructured":"Thornton M, Solomon MJ. Crohn\u2019s disease: in defense of a microvascular aetiology. Int J Colorectal Dis. 2002;17:287\u2013297.","journal-title":"Int J Colorectal Dis"},{"key":"3745_CR18","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1002\/ibd.21631","volume":"17","author":"H Bernhard","year":"2011","unstructured":"Bernhard H, Deutschmann A, Leschnik B, et al. Thrombin generation in pediatric patients with Crohn\u2019s disease. Inflamm Bowel Dis. 2011;17:2333\u20132339.","journal-title":"Inflamm Bowel Dis"},{"key":"3745_CR19","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1111\/j.1572-0241.2004.04129.x","volume":"99","author":"S Danese","year":"2004","unstructured":"Danese S, de la Motte C, Fiocchi C. Platelets in inflammatory bowel disease: clinical, pathogenic, and therapeutic implications. Am J Gastroenterol. 2004;99:938\u2013945.","journal-title":"Am J Gastroenterol"},{"key":"3745_CR20","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1136\/gut.36.1.5","volume":"36","author":"CE Collins","year":"1995","unstructured":"Collins CE, Rampton DS. Platelet dysfunction: a new dimension in inflammatory bowel disease. Gut. 1995;36:5\u20138.","journal-title":"Gut"},{"key":"3745_CR21","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1046\/j.1365-2362.2000.00616.x","volume":"30","author":"AA Vrij","year":"2000","unstructured":"Vrij AA, Rijken J, Van Wersch JW, et al. Platelet factor 4 and beta-thromboglobulin in inflammatory bowel disease and giant cell arteritis. Eur J Clin Invest. 2000;30:188\u2013194.","journal-title":"Eur J Clin Invest"},{"key":"3745_CR22","first-page":"1","volume":"16","author":"A Kasperska-Zajac","year":"2006","unstructured":"Kasperska-Zajac A, Rogala B. Platelet function in anaphylaxis. J Investig Allergol Clin Immunol. 2006;16:1\u20134.","journal-title":"J Investig Allergol Clin Immunol"},{"key":"3745_CR23","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s10753-007-9033-3","volume":"30","author":"A Kasperska-Zajac","year":"2007","unstructured":"Kasperska-Zajac A, Rogala B. Platelet activation during allergic inflammation. Inflammation. 2007;30:161\u2013166.","journal-title":"Inflammation"},{"key":"3745_CR24","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1136\/gut.28.3.336","volume":"28","author":"M Simi","year":"1987","unstructured":"Simi M, Leardi S, Tebano MT, et al. Raised plasma concentrations of platelet factor 4 (PF4) in Crohn\u2019s disease. Gut. 1987;28:336\u2013338.","journal-title":"Gut"},{"key":"3745_CR25","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.cgh.2013.02.030","volume":"11","author":"L Rosenberg","year":"2013","unstructured":"Rosenberg L, Nanda KS, Zenlea T, et al. Histologic markers of inflammation in patients with ulcerative colitis in clinical remission. Clin Gastroenterol Hepatol. 2013;11:991\u2013996.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"3745_CR26","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1053\/gast.2002.31072","volume":"122","author":"WJ Sandborn","year":"2002","unstructured":"Sandborn WJ, Feagan BG, Hanauer SB, et al. A review of activity indices and efficacy endpoints for clinical trials of medical therapy in adults with Crohn\u2019s disease. Gastroenterology. 2002;122:512\u2013530.","journal-title":"Gastroenterology"},{"key":"3745_CR27","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1080\/713773647","volume":"10","author":"AR Gear","year":"2003","unstructured":"Gear AR, Camerini D. Platelet chemokines and chemokine receptors: linking hemostasis, inflammation, and host defense. Microcirculation. 2003;10:335\u2013350.","journal-title":"Microcirculation"}],"updated-by":[{"DOI":"10.1007\/s10620-015-3829-z","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2015,8,12]],"date-time":"2015-08-12T00:00:00Z","timestamp":1439337600000}}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-015-3745-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10620-015-3745-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-015-3745-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,26]],"date-time":"2019-08-26T19:32:33Z","timestamp":1566847953000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10620-015-3745-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,16]]},"references-count":27,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["3745"],"URL":"https:\/\/doi.org\/10.1007\/s10620-015-3745-2","relation":{"correction":[{"id-type":"doi","id":"10.1007\/s10620-015-3829-z","asserted-by":"object"}]},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,16]]}}}