{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T23:16:21Z","timestamp":1768000581665,"version":"3.49.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2015,7,3]],"date-time":"2015-07-03T00:00:00Z","timestamp":1435881600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB TRR 57 P18"],"award-info":[{"award-number":["SFB TRR 57 P18"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"H. J. & W. Hector Foundation","award":["M60.2"],"award-info":[{"award-number":["M60.2"]}]},{"DOI":"10.13039\/501100001825","name":"Styrelsen for Forskning og Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001825","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001732","name":"Danish National Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001732","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.1007\/s10620-015-3783-9","type":"journal-article","created":{"date-parts":[[2015,7,2]],"date-time":"2015-07-02T07:10:37Z","timestamp":1435821037000},"page":"3456-3464","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Circulating Elastin Fragments Are Not Affected by Hepatic, Renal and Hemodynamic Changes, But Reflect Survival in Cirrhosis with TIPS"],"prefix":"10.1007","volume":"60","author":[{"given":"M. J.","family":"Nielsen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Lehmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. J.","family":"Leeming","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Schierwagen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Klein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Jansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. P.","family":"Strassburg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Bendtsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"M\u00f8ller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Sauerbruch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. A.","family":"Karsdal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Krag","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Trebicka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,7,3]]},"reference":[{"key":"3783_CR1","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0168-8278(00)80422-5","volume":"32","author":"J Bosch","year":"2000","unstructured":"Bosch J. Complications of cirrhosis. I. Portal hypertension. J Hepatol. 2000;32:141\u2013156.","journal-title":"J Hepatol"},{"key":"3783_CR2","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1002\/hep.23383","volume":"51","author":"TD Boyer","year":"2010","unstructured":"Boyer TD, Haskal ZJ, American Association for the Study of Liver Diseases. The role of transjugular intrahepatic portosystemic shunt (TIPS) in the management of portal hypertension: update 2009. Hepatology. 2010;51:306.","journal-title":"Hepatology"},{"key":"3783_CR3","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1053\/j.gastro.2007.06.020","volume":"133","author":"F Salerno","year":"2007","unstructured":"Salerno F, Camma C, Enea M, Rossle M, Wong F. Transjugular intrahepatic portosystemic shunt for refractory ascites: a meta-analysis of individual patient data. Gastroenterology. 2007;133:825\u2013834.","journal-title":"Gastroenterology"},{"key":"3783_CR4","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.1056\/NEJMoa0910102","volume":"362","author":"JC Garcia-Pagan","year":"2010","unstructured":"Garcia-Pagan JC, Caca K, Bureau C, et al. Early use of TIPS in patients with cirrhosis and variceal bleeding. N Engl J Med. 2010;362:2370\u20132379.","journal-title":"N Engl J Med"},{"key":"3783_CR5","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1097\/MEG.0b013e32834a75dc","volume":"23","author":"J Trebicka","year":"2011","unstructured":"Trebicka J, Krag A, Gansweid S, et al. Endotoxin and tumor necrosis factor-receptor levels in portal and hepatic vein of patients with alcoholic liver cirrhosis receiving elective transjugular intrahepatic portosystemic shunt. Eur J Gastroenterol Hepatol. 2011;23:1218\u20131225.","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"3783_CR6","doi-asserted-by":"crossref","first-page":"e83341","DOI":"10.1371\/journal.pone.0083341","volume":"8","author":"J Trebicka","year":"2013","unstructured":"Trebicka J, Krag A, Gansweid S, et al. Soluble TNF-alpha-receptors I are prognostic markers in TIPS-treated patients with cirrhosis and portal hypertension. PLoS One. 2013;8:e83341.","journal-title":"PLoS One"},{"key":"3783_CR7","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.jhep.2014.09.032","volume":"62","author":"Marie-Luise Berres","year":"2015","unstructured":"Berres Marie-Luise, Asmacher Sonja, Lehmann Jennifer, et al. CXCL9 is a prognostic marker in patients with liver cirrhosis receiving transjugular intrahepatic portosystemic shunt. J Hepatol. 2015;62:332\u2013339.","journal-title":"J Hepatol"},{"key":"3783_CR8","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1053\/j.gastro.2008.03.003","volume":"134","author":"SL Friedman","year":"2008","unstructured":"Friedman SL. Mechanisms of hepatic fibrogenesis. Gastroenterology. 2008;134:1655\u20131669.","journal-title":"Gastroenterology"},{"key":"3783_CR9","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1172\/JCI24282","volume":"115","author":"R Bataller","year":"2005","unstructured":"Bataller R, Brenner DA. Liver fibrosis. J Clin Investig. 2005;115:209\u2013218.","journal-title":"J Clin Investig"},{"key":"3783_CR10","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1172\/JCI30542","volume":"117","author":"JP Iredale","year":"2007","unstructured":"Iredale JP. Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ. J Clin Investig. 2007;117:539\u2013548.","journal-title":"J Clin Investig"},{"key":"3783_CR11","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1089\/adt.2012.474","volume":"11","author":"MA Karsdal","year":"2013","unstructured":"Karsdal MA, Nielsen MJ, Sand JM, et al. Extracellular matrix remodeling: the common denominator in connective tissue diseases. Possibilities for evaluation and current understanding of the matrix as more than a passive architecture, but a key player in tissue failure. Assay Drug Dev Technol. 2013;11:70\u201392.","journal-title":"Assay Drug Dev Technol"},{"key":"3783_CR12","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1111\/j.1872-034X.2011.00946.x","volume":"42","author":"DJ Leeming","year":"2012","unstructured":"Leeming DJ, Nielsen MJ, Dai Y, et al. Enzyme-linked immunosorbent serum assay specific for the 7S domain of Collagen Type IV (P4NP 7S): a marker related to the extracellular matrix remodeling during liver fibrogenesis. Hepatol Res. 2012;42:482\u2013493.","journal-title":"Hepatol Res"},{"key":"3783_CR13","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1111\/apt.12484","volume":"38","author":"DJ Leeming","year":"2013","unstructured":"Leeming DJ, Karsdal MA, Byrjalsen I, et al. Novel serological neo-epitope markers of extracellular matrix proteins for the detection of portal hypertension. Aliment Pharmacol Ther. 2013;38:1086\u20131096.","journal-title":"Aliment Pharmacol Ther"},{"key":"3783_CR14","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1755-1536-4-22","volume":"4","author":"SS Veidal","year":"2011","unstructured":"Veidal SS, Karsdal MA, Nawrocki A, et al. Assessment of proteolytic degradation of the basement membrane: a fragment of type IV collagen as a biochemical marker for liver fibrosis. Fibrogenesis Tissue Repair. 2011;4:22.","journal-title":"Fibrogenesis Tissue Repair"},{"key":"3783_CR15","doi-asserted-by":"crossref","first-page":"e108544","DOI":"10.1371\/journal.pone.0108544","volume":"9","author":"C Jansen","year":"2014","unstructured":"Jansen C, Leeming DJ, Mandorfer M, et al. PRO-C3-levels in patients with HIV\/HCV-Co-infection reflect fibrosis stage and degree of portal hypertension. PLoS One. 2014;9:e108544.","journal-title":"PLoS One"},{"key":"3783_CR16","doi-asserted-by":"crossref","first-page":"195","DOI":"10.3389\/fphys.2013.00195","volume":"4","author":"R Schierwagen","year":"2013","unstructured":"Schierwagen R, Leeming DJ, Klein S, et al. Serum markers of the extracellular matrix remodeling reflect antifibrotic therapy in bile-duct ligated rats. Front Physiol. 2013;4:195.","journal-title":"Front Physiol"},{"key":"3783_CR17","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1097\/QAD.0000000000000388","volume":"28","author":"DJ Leeming","year":"2014","unstructured":"Leeming DJ, Anadol E, Schierwagen R, et al. Combined antiretroviral therapy attenuates hepatic extracellular matrix remodeling in HIV patients assessed by novel protein fingerprint markers. Aids. 2014;28:2081\u20132090.","journal-title":"Aids"},{"key":"3783_CR18","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1136\/gut.2007.144584","volume":"57","author":"M Hennenberg","year":"2008","unstructured":"Hennenberg M, Trebicka J, Sauerbruch T, Heller J. Mechanisms of extrahepatic vasodilation in portal hypertension. Gut. 2008;57:1300\u20131314.","journal-title":"Gut"},{"key":"3783_CR19","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1016\/j.jhep.2014.05.047","volume":"61","author":"Y Iwakiri","year":"2014","unstructured":"Iwakiri Y, Shah V, Rockey DC. Vascular pathobiology in chronic liver disease and cirrhosis\u2014current status and future directions. J Hepatol. 2014;61:912\u2013924.","journal-title":"J Hepatol"},{"key":"3783_CR20","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1002\/hep.25567","volume":"55","author":"A Pellicoro","year":"2012","unstructured":"Pellicoro A, Aucott RL, Ramachandran P, et al. Elastin accumulation is regulated at the level of degradation by macrophage metalloelastase (MMP-12) during experimental liver fibrosis. Hepatology. 2012;55:1965\u20131975.","journal-title":"Hepatology"},{"key":"3783_CR21","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1002\/hep.26326","volume":"58","author":"J Ehling","year":"2013","unstructured":"Ehling J, Bartneck M, Fech V, et al. Elastin-based molecular MRI of liver fibrosis. Hepatology. 2013;58:1517\u20131518.","journal-title":"Hepatology"},{"key":"3783_CR22","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1080\/003655202320378284","volume":"37","author":"KA Brensing","year":"2002","unstructured":"Brensing KA, Horsch M, Textor J, et al. Hemodynamic effects of propranolol and nitrates in cirrhotics with transjugular intrahepatic portosystemic stent-shunt. Scand J Gastroenterol. 2002;37:1070\u20131076.","journal-title":"Scand J Gastroenterol"},{"key":"3783_CR23","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1136\/gut.47.2.288","volume":"47","author":"KA Brensing","year":"2000","unstructured":"Brensing KA, Textor J, Perz J, et al. Long term outcome after transjugular intrahepatic portosystemic stent-shunt in non-transplant cirrhotics with hepatorenal syndrome: a phase II study. Gut. 2000;47:288\u2013295.","journal-title":"Gut"},{"key":"3783_CR24","doi-asserted-by":"crossref","first-page":"e103779","DOI":"10.1371\/journal.pone.0103779","volume":"9","author":"C Jansen","year":"2014","unstructured":"Jansen C, Eischeid H, Goertzen J, et al. The role of miRNA-34a as a prognostic biomarker for cirrhotic patients with portal hypertension receiving TIPS. PLoS One. 2014;9:e103779.","journal-title":"PLoS One"},{"key":"3783_CR25","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1471-2466-12-34","volume":"12","author":"H Skjot-Arkil","year":"2012","unstructured":"Skjot-Arkil H, Clausen RE, Nguyen QH, et al. Measurement of MMP-9 and -12 degraded elastin (ELM) provides unique information on lung tissue degradation. BMC Pulm Med. 2012;12:34.","journal-title":"BMC Pulm Med"},{"key":"3783_CR26","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1053\/gast.2002.33367","volume":"122","author":"MJ Arthur","year":"2002","unstructured":"Arthur MJ. Reversibility of liver fibrosis and cirrhosis following treatment for hepatitis C. Gastroenterology. 2002;122:1525\u20131528.","journal-title":"Gastroenterology"},{"key":"3783_CR27","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1053\/ejvs.2001.1404","volume":"22","author":"E Petersen","year":"2001","unstructured":"Petersen E, Gineitis A, Wagberg F, Angquist KA. Serum levels of elastin-derived peptides in patients with ruptured and asymptomatic abdominal aortic aneurysms. Eur J Vasc Endovasc Surg. 2001;22:48\u201352.","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"3783_CR28","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1053\/j.gastro.2006.09.013","volume":"131","author":"G D\u2019Amico","year":"2006","unstructured":"D\u2019Amico G, Garcia-Pagan JC, Luca A, Bosch J. Hepatic vein pressure gradient reduction and prevention of variceal bleeding in cirrhosis: a systematic review. Gastroenterology. 2006;131:1611\u20131624.","journal-title":"Gastroenterology"},{"key":"3783_CR29","doi-asserted-by":"crossref","unstructured":"Moreau R, Jalan R, Gines P, Pavesi M, Angeli P, Cordoba J, et al. Acute-on-chronic liver failure is a distinct syndrome that develops in patients with acute decompensation of cirrhosis. Gastroenterology 2013;144:1426\u20131437, 37.e1-9.","DOI":"10.1053\/j.gastro.2013.02.042"},{"key":"3783_CR30","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1002\/hep.24805","volume":"55","author":"S Sethasine","year":"2012","unstructured":"Sethasine S, Jain D, Groszmann RJ, Garcia-Tsao G. Quantitative histological-hemodynamic correlations in cirrhosis. Hepatology. 2012;55:1146\u20131153.","journal-title":"Hepatology"},{"key":"3783_CR31","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1053\/he.2000.5852","volume":"31","author":"M Malinchoc","year":"2000","unstructured":"Malinchoc M, Kamath PS, Gordon FD, Peine CJ, Rank J, Ter Borg PC. A model to predict poor survival in patients undergoing transjugular intrahepatic portosystemic shunts. Hepatology. 2000;31:864\u2013871.","journal-title":"Hepatology"},{"key":"3783_CR32","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1056\/NEJMoa0801209","volume":"359","author":"WR Kim","year":"2008","unstructured":"Kim WR, Biggins SW, Kremers WK, et al. Hyponatremia and mortality among patients on the liver-transplant waiting list. N Engl J Med. 2008;359:1018\u20131026.","journal-title":"N Engl J Med"},{"key":"3783_CR33","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1136\/gut.2006.102764","volume":"56","author":"MC Londono","year":"2007","unstructured":"Londono MC, Cardenas A, Guevara M, et al. MELD score and serum sodium in the prediction of survival of patients with cirrhosis awaiting liver transplantation. Gut. 2007;56:1283\u20131290.","journal-title":"Gut"},{"key":"3783_CR34","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1053\/j.gastro.2006.02.017","volume":"130","author":"MC Londono","year":"2006","unstructured":"Londono MC, Guevara M, Rimola A, et al. Hyponatremia impairs early posttransplantation outcome in patients with cirrhosis undergoing liver transplantation. Gastroenterology. 2006;130:1135\u20131143.","journal-title":"Gastroenterology"},{"key":"3783_CR35","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.jhep.2012.03.018","volume":"57","author":"T Serste","year":"2012","unstructured":"Serste T, Gustot T, Rautou PE, et al. Severe hyponatremia is a better predictor of mortality than MELDNa in patients with cirrhosis and refractory ascites. J Hepatol. 2012;57:274\u2013280.","journal-title":"J Hepatol"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-015-3783-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10620-015-3783-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-015-3783-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T18:49:59Z","timestamp":1566931799000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10620-015-3783-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,3]]},"references-count":35,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["3783"],"URL":"https:\/\/doi.org\/10.1007\/s10620-015-3783-9","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,3]]}}}