{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T20:12:33Z","timestamp":1776456753914,"version":"3.51.2"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2016,2,10]],"date-time":"2016-02-10T00:00:00Z","timestamp":1455062400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1007\/s10620-015-4023-z","type":"journal-article","created":{"date-parts":[[2016,2,10]],"date-time":"2016-02-10T07:14:26Z","timestamp":1455088466000},"page":"1501-1511","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Involvement of Transient Receptor Potential Vanilloid Receptor 1, (TRPV1)-Expressing Vagal Nerve in the Inhibitory Effect of Gastric Acidification on Exogenous Motilin-Induced Gastric Phase III Contractions in Suncus murinus"],"prefix":"10.1007","volume":"61","author":[{"given":"Makoto","family":"Yoshimura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Mikami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kayuri","family":"Kuroda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maki","family":"Nishida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuma","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anupom","family":"Mondal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kouhei","family":"Koyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takamichi","family":"Jogahara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ichiro","family":"Sakata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takafumi","family":"Sakai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,2,10]]},"reference":[{"key":"4023_CR1","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1152\/ajplegacy.1969.217.6.1757","volume":"217","author":"JH Szurszewski","year":"1969","unstructured":"Szurszewski JH. A migrating electric complex of canine small intestine. Am J Physiol. 1969;217:1757\u20131763.","journal-title":"Am J Physiol"},{"key":"4023_CR2","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/BF01489315","volume":"24","author":"G Vantrappen","year":"1979","unstructured":"Vantrappen G, Janssens J, Peeters TL, Bloom SR, Christofides ND, Hellemans J. Motilin and the interdigestive migrating motor complex in man. Dig Dis Sci. 1979;24:497\u2013500.","journal-title":"Dig Dis Sci"},{"key":"4023_CR3","first-page":"93","volume":"39","author":"Z Itoh","year":"1976","unstructured":"Itoh Z, Honda R, Hiwatashi K, et al. Motilin-induced mechanical activity in the canine alimentary tract. Scand J Gastroenterol Suppl. 1976;39:93\u2013110.","journal-title":"Scand J Gastroenterol Suppl"},{"key":"4023_CR4","first-page":"714","volume":"56","author":"R Tomita","year":"2009","unstructured":"Tomita R. Relationship between interdigestive migrating motor complex and gut hormones in human. Hepatogastroenterology. 2009;56:714\u2013717.","journal-title":"Hepatogastroenterology"},{"key":"4023_CR5","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/0167-0115(83)90265-3","volume":"6","author":"J Janssens","year":"1983","unstructured":"Janssens J, Vantrappen G, Peeters TL. The activity front of the migrating motor complex of the human stomach but not of the small intestine is motilin-dependent. Regul Pept. 1983;6:363\u2013369.","journal-title":"Regul Pept"},{"key":"4023_CR6","first-page":"G547","volume":"245","author":"KY Lee","year":"1983","unstructured":"Lee KY, Chang TM, Chey WY. Effect of rabbit antimotilin serum on myoelectric activity and plasma motilin concentration in fasting dog. Am J Physiol. 1983;245:G547\u2013G553.","journal-title":"Am J Physiol"},{"key":"4023_CR7","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.ejphar.2009.04.059","volume":"615","author":"K Ozaki","year":"2009","unstructured":"Ozaki K, Onoma M, Muramatsu H, et al. An orally active motilin receptor antagonist, MA-2029, inhibits motilin-induced gastrointestinal motility, increase in fundic tone, and diarrhea in conscious dogs without affecting gastric emptying. Eur J Pharmacol. 2009;615:185\u2013192.","journal-title":"Eur J Pharmacol"},{"key":"4023_CR8","doi-asserted-by":"crossref","first-page":"4437","DOI":"10.1210\/en.2015-1561","volume":"156","author":"K Kuroda","year":"2015","unstructured":"Kuroda K, Hequing H, Mondal A, et al. Ghrelin is an essential factor for motilin-induced gastric contraction in Suncus murinus. Endocrinology. 2015;156:4437\u20134447.","journal-title":"Endocrinology"},{"key":"4023_CR9","first-page":"G1209","volume":"275","author":"M Verkijk","year":"1998","unstructured":"Verkijk M, Gielkens HA, Lamers CB, Masclee AA. Effect of gastrin on antroduodenal motility: role of intraluminal acidity. Am J Physiol. 1998;275:G1209\u2013G1216.","journal-title":"Am J Physiol"},{"key":"4023_CR10","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1159\/000199768","volume":"41","author":"M Bortolotti","year":"1988","unstructured":"Bortolotti M, Barbara L. Interdigestive gastroduodenal motor activity in subjects with increased gastric acid secretion. Digestion. 1988;41:156\u2013160.","journal-title":"Digestion"},{"key":"4023_CR11","doi-asserted-by":"crossref","first-page":"943","DOI":"10.3109\/00365529309098289","volume":"28","author":"J Dalenback","year":"1993","unstructured":"Dalenback J, Mellander A, Olbe L, Sjovall H. Motility-related cyclic fluctuations of interdigestive gastric acid and bicarbonate secretion in man. A source of substantial variability in gastric secretion studies. Scand J Gastroenterol. 1993;28:943\u2013948.","journal-title":"Scand J Gastroenterol"},{"key":"4023_CR12","first-page":"G113","volume":"270","author":"J Dalenback","year":"1996","unstructured":"Dalenback J, Fandriks L, Olbe L, Sjovall H. Mechanisms behind changes in gastric acid and bicarbonate outputs during the human interdigestive motility cycle. Am J Physiol. 1996;270:G113\u2013G122.","journal-title":"Am J Physiol"},{"key":"4023_CR13","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1046\/j.1365-2036.1998.00267.x","volume":"12","author":"HA Gielkens","year":"1998","unstructured":"Gielkens HA, Nieuwenhuizen A, Biemond I, Lamers CB, Masclee AA. Interdigestive antroduodenal motility and gastric acid secretion. Aliment Pharmacol Ther. 1998;12:27\u201333.","journal-title":"Aliment Pharmacol Ther"},{"key":"4023_CR14","first-page":"17","volume":"84","author":"M Bortolotti","year":"1989","unstructured":"Bortolotti M. Interdigestive gastroduodenal motility in duodenal ulcer: role of gastric acid hypersecretion. Am J Gastroenterol. 1989;84:17\u201321.","journal-title":"Am J Gastroenterol"},{"key":"4023_CR15","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1007\/BF01295907","volume":"38","author":"M Kusano","year":"1993","unstructured":"Kusano M, Sekiguchi T, Nishioka T, et al. Gastric acid inhibits antral phase III activity in duodenal ulcer patients. Dig Dis Sci. 1993;38:824\u2013831.","journal-title":"Dig Dis Sci"},{"key":"4023_CR16","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1159\/000199897","volume":"44","author":"M Bortolotti","year":"1989","unstructured":"Bortolotti M, Pinotti R, Sarti P, Barbara L. Interdigestive gastroduodenal motility in patients with active and inactive duodenal ulcer disease. Digestion. 1989;44:95\u2013100.","journal-title":"Digestion"},{"key":"4023_CR17","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1016\/0016-5085(94)90407-3","volume":"106","author":"O Yamamoto","year":"1994","unstructured":"Yamamoto O, Matsunaga Y, Haga N, Mizumoto A, Itoh Z. Inhibition of phase III activity by acidifying stomach in vagally denervated and innervated dogs with gastric pouches. Gastroenterology. 1994;106:1533\u20131541.","journal-title":"Gastroenterology"},{"key":"4023_CR18","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1016\/S0022-3565(25)24033-2","volume":"271","author":"O Yamamoto","year":"1994","unstructured":"Yamamoto O, Matsunaga Y, Shiba Y, Haga N, Sano I, Itoh Z. Inhibition of motilin-induced phase III contractions by pentagastrin in Heidenhain pouch dogs. J Pharmacol Exp Ther. 1994;271:1471\u20131476.","journal-title":"J Pharmacol Exp Ther"},{"key":"4023_CR19","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0167-0115(94)90022-1","volume":"52","author":"Y Matsunaga","year":"1994","unstructured":"Matsunaga Y, Yamamoto O, Ueki S, et al. Inhibition of phase III activity by acid in canine stomach. Regul Pept. 1994;52:61\u201372.","journal-title":"Regul Pept"},{"key":"4023_CR20","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1111\/j.1365-2982.2006.00797.x","volume":"18","author":"JJ Haans","year":"2006","unstructured":"Haans JJ, Masclee AA. Intragastric acidification inhibits motilin-induced phase III activity in humans. Neurogastroenterol Motil. 2006;18:637\u2013646.","journal-title":"Neurogastroenterol Motil"},{"key":"4023_CR21","first-page":"G129","volume":"267","author":"O Yamamoto","year":"1994","unstructured":"Yamamoto O, Matsunaga Y, Haga N, Itoh Z. Vagovagal inhibition of motilin-induced phase III contractions by antral acidification in dog stomach. Am J Physiol. 1994;267:G129\u2013G134.","journal-title":"Am J Physiol"},{"key":"4023_CR22","doi-asserted-by":"crossref","first-page":"e64777","DOI":"10.1371\/journal.pone.0064777","volume":"8","author":"Y Miyano","year":"2013","unstructured":"Miyano Y, Sakata I, Kuroda K, et al. The role of the vagus nerve in the migrating motor complex and ghrelin- and motilin-induced gastric contraction in suncus. PLoS ONE. 2013;8:e64777.","journal-title":"PLoS ONE"},{"key":"4023_CR23","first-page":"145","volume":"67","author":"HT Debas","year":"1994","unstructured":"Debas HT, Carvajal SH. Vagal regulation of acid secretion and gastrin release. Yale J Biol Med. 1994;67:145\u2013151.","journal-title":"Yale J Biol Med"},{"key":"4023_CR24","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1006\/bbrc.2000.3568","volume":"276","author":"Y Masuda","year":"2000","unstructured":"Masuda Y, Tanaka T, Inomata N, et al. Ghrelin stimulates gastric acid secretion and motility in rats. Biochem Biophys Res Commun. 2000;276:905\u2013908.","journal-title":"Biochem Biophys Res Commun"},{"key":"4023_CR25","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0016-5085(19)32581-8","volume":"69","author":"F Marik","year":"1975","unstructured":"Marik F, Code CF. Control of the interdigestive myoelectric activity in dogs by the vagus nerves and pentagastrin. Gastroenterology. 1975;69:387\u2013395.","journal-title":"Gastroenterology"},{"key":"4023_CR26","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.peptides.2008.10.006","volume":"30","author":"C Tsutsui","year":"2009","unstructured":"Tsutsui C, Kajihara K, Yanaka T, et al. House musk shrew (Suncus murinus, order: Insectivora) as a new model animal for motilin study. Peptides. 2009;30:318\u2013329.","journal-title":"Peptides"},{"key":"4023_CR27","doi-asserted-by":"crossref","first-page":"R1106","DOI":"10.1152\/ajpregu.00278.2010","volume":"299","author":"S Sakahara","year":"2010","unstructured":"Sakahara S, Xie Z, Koike K, et al. Physiological characteristics of gastric contractions and circadian gastric motility in the free-moving conscious house musk shrew (Suncus murinus). Am J Physiol Regul Integr Comp Physiol. 2010;299:R1106\u2013R1113.","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"4023_CR28","doi-asserted-by":"crossref","first-page":"e0131554","DOI":"10.1371\/journal.pone.0131554","volume":"10","author":"C Goswami","year":"2015","unstructured":"Goswami C, Shimada Y, Yoshimura M, et al. Motilin stimulates gastric acid secretion in coordination with ghrelin in Suncus murinus. PLoS ONE. 2015;10:e0131554.","journal-title":"PLoS ONE"},{"key":"4023_CR29","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1677\/JME-09-0095","volume":"44","author":"J He","year":"2010","unstructured":"He J, Irwin DM, Chen R, Zhang YP. Stepwise loss of motilin and its specific receptor genes in rodents. J Mol Endocrinol. 2010;44:37\u201344.","journal-title":"J Mol Endocrinol"},{"key":"4023_CR30","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.peptides.2012.04.019","volume":"36","author":"A Suzuki","year":"2012","unstructured":"Suzuki A, Ishida Y, Aizawa S, et al. Molecular identification of GHS-R and GPR38 in Suncus murinus. Peptides. 2012;36:29\u201338.","journal-title":"Peptides"},{"key":"4023_CR31","first-page":"G800","volume":"267","author":"SA Chung","year":"1994","unstructured":"Chung SA, Rotstein O, Greenberg GR, Diamant NE. Mechanisms coordinating gastric and small intestinal MMC: role of extrinsic innervation rather than motilin. Am J Physiol. 1994;267:G800\u2013G809.","journal-title":"Am J Physiol"},{"key":"4023_CR32","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/0016-5085(83)90151-8","volume":"84","author":"S Sarna","year":"1983","unstructured":"Sarna S, Condon RE, Cowles V. Enteric mechanisms of initiation of migrating myoelectric complexes in dogs. Gastroenterology. 1983;84:814\u2013822.","journal-title":"Gastroenterology"},{"key":"4023_CR33","doi-asserted-by":"crossref","first-page":"e60365","DOI":"10.1371\/journal.pone.0060365","volume":"8","author":"A Mondal","year":"2013","unstructured":"Mondal A, Aizawa S, Sakata I, Goswami C, Oda S, Sakai T. Mechanism of ghrelin-induced gastric contractions in Suncus murinus (house musk shrew): involvement of intrinsic primary afferent neurons. PLoS ONE. 2013;8:e60365.","journal-title":"PLoS ONE"},{"key":"4023_CR34","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1111\/j.1365-2982.2011.01801.x","volume":"23","author":"A Mondal","year":"2011","unstructured":"Mondal A, Kawamoto Y, Yanaka T, et al. Myenteric neural network activated by motilin in the stomach of Suncus murinus (house musk shrew). Neurogastroenterol Motil. 2011;23:1123\u20131131.","journal-title":"Neurogastroenterol Motil"},{"key":"4023_CR35","doi-asserted-by":"crossref","first-page":"G1207","DOI":"10.1152\/ajpgi.00379.2011","volume":"302","author":"A Mondal","year":"2012","unstructured":"Mondal A, Xie Z, Miyano Y, et al. Coordination of motilin and ghrelin regulates the migrating motor complex of gastrointestinal motility in Suncus murinus. Am J Physiol Gastrointest Liver Physiol. 2012;302:G1207\u2013G1215.","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"4023_CR36","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1210\/endo-114-3-743","volume":"114","author":"LR Johnson","year":"1984","unstructured":"Johnson LR. Effects of somatostatin and acid on inhibition of gastrin release in newborn rats. Endocrinology. 1984;114:743\u2013746.","journal-title":"Endocrinology"},{"key":"4023_CR37","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1210\/endo-99-6-1653","volume":"99","author":"R Guillemin","year":"1976","unstructured":"Guillemin R. Somatostatin inhibits the release of acetylcholine induced electrically in the myenteric plexus. Endocrinology. 1976;99:1653\u20131654.","journal-title":"Endocrinology"},{"key":"4023_CR38","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1007\/BF01079786","volume":"23","author":"HS Ormsbee 3rd","year":"1978","unstructured":"Ormsbee HS 3rd, Koehler SL Jr, Telford GL. Somatostatin inhibits motilin-induced interdigestive contractile activity in the dog. Am J Dig Dis. 1978;23:781\u2013788.","journal-title":"Am J Dig Dis"},{"key":"4023_CR39","first-page":"G501","volume":"250","author":"KE Hall","year":"1986","unstructured":"Hall KE, el-Sharkawy TY, Diamant NE. Vagal control of canine postprandial upper gastrointestinal motility. Am J Physiol. 1986;250:G501\u2013G510.","journal-title":"Am J Physiol"},{"key":"4023_CR40","doi-asserted-by":"crossref","first-page":"G487","DOI":"10.1152\/ajpgi.00195.2004","volume":"288","author":"T Ueno","year":"2005","unstructured":"Ueno T, Uemura K, Harris MB, Pappas TN, Takahashi T. Role of vagus nerve in postprandial antropyloric coordination in conscious dogs. Am J Physiol Gastrointest Liver Physiol. 2005;288:G487\u2013G495.","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"4023_CR41","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1016\/j.neuroscience.2006.12.025","volume":"145","author":"P Holzer","year":"2007","unstructured":"Holzer P, Wultsch T, Edelsbrunner M, et al. Increase in gastric acid-induced afferent input to the brainstem in mice with gastritis. Neuroscience. 2007;145:1108\u20131119.","journal-title":"Neuroscience"},{"key":"4023_CR42","doi-asserted-by":"crossref","first-page":"G403","DOI":"10.1152\/ajpgi.00308.2003","volume":"286","author":"M Danzer","year":"2004","unstructured":"Danzer M, Jocic M, Samberger C, et al. Stomach-brain communication by vagal afferents in response to luminal acid backdiffusion, gastrin, and gastric acid secretion. Am J Physiol Gastrointest Liver Physiol. 2004;286:G403\u2013G411.","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"4023_CR43","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1046\/j.1365-2982.2003.00382.x","volume":"15","author":"P Holzer","year":"2003","unstructured":"Holzer P, Painsipp E, Jocic M, Heinemann A. Acid challenge delays gastric pressure adaptation, blocks gastric emptying and stimulates gastric fluid secretion in the rat. Neurogastroenterol Motil. 2003;15:45\u201355.","journal-title":"Neurogastroenterol Motil"},{"key":"4023_CR44","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/1471-2202-6-60","volume":"6","author":"P Holzer","year":"2005","unstructured":"Holzer P, Painsipp E, Schuligoi R. Differential effects of intragastric acid and capsaicin on gastric emptying and afferent input to the rat spinal cord and brainstem. BMC Neurosci. 2005;6:60.","journal-title":"BMC Neurosci."},{"key":"4023_CR45","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1146\/annurev.physiol.68.040504.094635","volume":"68","author":"RA Travagli","year":"2006","unstructured":"Travagli RA, Hermann GE, Browning KN, Rogers RC. Brainstem circuits regulating gastric function. Annu Rev Physiol. 2006;68:279\u2013305.","journal-title":"Annu Rev Physiol"},{"key":"4023_CR46","doi-asserted-by":"crossref","first-page":"G357","DOI":"10.1152\/ajpgi.00478.2002","volume":"284","author":"HY Chang","year":"2003","unstructured":"Chang HY, Mashimo H, Goyal RK. Musings on the wanderer: What\u2019s new in our understanding of vago-vagal reflex? IV. Current concepts of vagal efferent projections to the gut. Am J Physiol Gastrointest Liver Physiol. 2003;284:G357\u2013G366.","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"4023_CR47","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0304-3940(01)02021-3","volume":"309","author":"Y Nozawa","year":"2001","unstructured":"Nozawa Y, Nishihara K, Yamamoto A, Nakano M, Ajioka H, Matsuura N. Distribution and characterization of vanilloid receptors in the rat stomach. Neurosci Lett. 2001;309:33\u201336.","journal-title":"Neurosci Lett"},{"key":"4023_CR48","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s00441-002-0682-0","volume":"311","author":"LM Patterson","year":"2003","unstructured":"Patterson LM, Zheng H, Ward SM, Berthoud HR. Vanilloid receptor (VR1) expression in vagal afferent neurons innervating the gastrointestinal tract. Cell Tissue Res. 2003;311:277\u2013287.","journal-title":"Cell Tissue Res"},{"key":"4023_CR49","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1111\/j.1460-9568.2004.03290.x","volume":"19","author":"R Schicho","year":"2004","unstructured":"Schicho R, Florian W, Liebmann I, Holzer P, Lippe IT. Increased expression of TRPV1 receptor in dorsal root ganglia by acid insult of the rat gastric mucosa. Eur J Neurosci. 2004;19:1811\u20131818.","journal-title":"Eur J Neurosci"},{"key":"4023_CR50","first-page":"433","volume":"15","author":"R Rahmati","year":"2012","unstructured":"Rahmati R. The transient receptor potential vanilloid receptor 1, TRPV1 (VR1) inhibits peristalsis in the mouse jejunum. Arch Iran Med. 2012;15:433\u2013438.","journal-title":"Arch Iran Med"},{"key":"4023_CR51","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/0016-5085(95)90376-3","volume":"109","author":"FD Manela","year":"1995","unstructured":"Manela FD, Ren J, Gao J, McGuigan JE, Harty RF. Calcitonin gene-related peptide modulates acid-mediated regulation of somatostatin and gastrin release from rat antrum. Gastroenterology. 1995;109:701\u2013706.","journal-title":"Gastroenterology"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-015-4023-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10620-015-4023-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-015-4023-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T10:26:58Z","timestamp":1748773618000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10620-015-4023-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,10]]},"references-count":51,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["4023"],"URL":"https:\/\/doi.org\/10.1007\/s10620-015-4023-z","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,10]]}}}