{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T03:44:21Z","timestamp":1789703061666,"version":"4.0.1"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2016,2,26]],"date-time":"2016-02-26T00:00:00Z","timestamp":1456444800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1007\/s10620-016-4080-y","type":"journal-article","created":{"date-parts":[[2016,2,26]],"date-time":"2016-02-26T07:23:35Z","timestamp":1456471415000},"page":"2118-2126","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Increased Hepatic Arterial Blood Flow Measured by Hepatic Perfusion Index in Hepatosplenic Schistosomiasis: New Concepts for an Old Disease"],"prefix":"10.1007","volume":"61","author":[{"given":"Bernardo Times","family":"de Carvalho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana L\u00facia","family":"Coutinho Domingues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edmundo Pessoa","family":"de Almeida Lopes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone Cristina Soares","family":"Brand\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,2,26]]},"reference":[{"key":"4080_CR1","unstructured":"Pereira GJM, Torres MEG. Epidemiologia. In: Malta J, ed. Esquistossomose Mans\u00f4nica. Primeira. Recife: Editora Universit\u00e1ria da UFPE; 1994:47\u201348."},{"key":"4080_CR2","first-page":"67","volume":"3","author":"WHO","year":"2013","unstructured":"WHO. Sustaining the drive to overcome the global impact of neglected tropical diseases. Second WHO Rep Neglected Trop Dis. 2013;3:67\u201371.","journal-title":"Second WHO Rep Neglected Trop Dis"},{"key":"4080_CR3","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/S0140-6736(06)69440-3","volume":"368","author":"B Gryseels","year":"2006","unstructured":"Gryseels B, Polman K, Clerinx J, Kestens L. Human schistosomiasis. Lancet. 2006;368:1106\u20131118.","journal-title":"Lancet"},{"key":"4080_CR4","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1056\/NEJMra012396","volume":"346","author":"AG Ross","year":"2002","unstructured":"Ross AG, Bartley PB, Sleigh AC, et al. Schistosomiasis. N Engl J Med. 2002;346:1212\u20131220.","journal-title":"N Engl J Med"},{"key":"4080_CR5","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1590\/S0074-02762004000900009","volume":"99","author":"ZA Andrade","year":"2004","unstructured":"Andrade ZA. Schistosomal hepatopathy. Mem Inst Oswaldo Cruz. 2004;99:51\u201357.","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"4080_CR6","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1111\/j.1365-3024.2009.01157.x","volume":"31","author":"ZA Andrade","year":"2009","unstructured":"Andrade ZA. Schistosomiasis and liver fibrosis. Parasite Immunol. 2009;31:656\u2013663.","journal-title":"Parasite Immunol"},{"key":"4080_CR7","first-page":"997","volume":"132","author":"M Hidayat","year":"1971","unstructured":"Hidayat M, Wahid H. A study of the vascular changes in bilharzic hepatic fibrosis and their significance. Surg Gynecol Obstet. 1971;132:997\u20131004.","journal-title":"Surg Gynecol Obstet"},{"key":"4080_CR8","first-page":"284","volume":"6","author":"A Magalh\u00e3es-Filho","year":"1960","unstructured":"Magalh\u00e3es-Filho A, Menezes H, de Coelho R. B. Patog\u00eanese da fibrose hep\u00e1tica na esquistossomose mansoni (Estudo das altera\u00e7\u00f5es vasculares portais mediante modelo pl\u00e1stico). Rev Assoc Med Bras. 1960;6:284\u2013294.","journal-title":"Rev Assoc Med Bras"},{"key":"4080_CR9","first-page":"121","volume":"35","author":"S Mies","year":"1980","unstructured":"Mies S, Larsson E, Mori T, Williams GM. Sistema porta e as art\u00e9rias hepatica, espl\u00eanica e mesent\u00e9rica superior na esquistossomose hepatoespl\u00eanica. Estudo angiogr\u00e1fico. Rev do Hosp das Cl\u00ednicas Fac Med S\u00e3o Paulo. 1980;35:121\u2013131.","journal-title":"Rev do Hosp das Cl\u00ednicas Fac Med S\u00e3o Paulo"},{"key":"4080_CR10","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1016\/S0002-9270(99)00142-2","volume":"94","author":"R Cleva","year":"1999","unstructured":"Cleva R, Pugliese V, Zilberstein B, Saad WA, Pinotti W, Laudanna AA. Systemic hemodynamic changes in mansonic schistosomiasis with portal hypertension treated by azygoportal disconnection and splenectomy. Am J Gastroenterol. 1999;94:1632\u20131637.","journal-title":"Am J Gastroenterol"},{"key":"4080_CR11","doi-asserted-by":"crossref","first-page":"5471","DOI":"10.3748\/wjg.v13.i41.5471","volume":"13","author":"R Cleva","year":"2007","unstructured":"Cleva R, Herman P, D\u2019albuquerque LA, Pugliese V, Santarem OL, Saad WA. Pre- and postoperative systemic hemodynamic evaluation in patients subjected to esophagogastric devascularization plus splenectomy and distal splenorenal shunt: a comparative study in schistosomal portal hypertension. World J Gastroenterol. 2007;13:5471\u20135475.","journal-title":"World J Gastroenterol"},{"key":"4080_CR12","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1046\/j.1365-2168.1998.00975.x","volume":"85","author":"HW Warren","year":"1998","unstructured":"Warren HW, Gallagher H, Hemingway DM, et al. Prospective assessment of the hepatic perfusion index in patients with colorectal cancer. Br J Surg. 1998;85:1708\u20131712.","journal-title":"Br J Surg"},{"key":"4080_CR13","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1097\/00003072-199907000-00007","volume":"24","author":"P Koranda","year":"1999","unstructured":"Koranda P, Myslivecek M, Erban J, Seidlov\u00e1 V, Hus\u00e1k V. Hepatic perfusion changes in patients with cirrhosis indices of hepatic arterial blood flow. Clin Nucl Med. 1999;24:507\u2013510.","journal-title":"Clin Nucl Med"},{"key":"4080_CR14","first-page":"239","volume":"33","author":"MK O\u2019Connor","year":"1992","unstructured":"O\u2019Connor MK, Krom RF, Carton EG, et al. Ratio of hepatic arterial-to-portal venous blood flow-validation of radionuclide techniques in an animal model. J Nucl Med. 1992;33:239\u2013245.","journal-title":"J Nucl Med"},{"key":"4080_CR15","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1148\/radiol.2343031362","volume":"234","author":"PV Pandharipande","year":"2005","unstructured":"Pandharipande PV, Krinsky GA, Rusinek H, Lee VS. Perfusion imaging of the liver: current challenges and future goals. Radiology. 2005;234:661\u2013673.","journal-title":"Radiology"},{"key":"4080_CR16","doi-asserted-by":"crossref","first-page":"3841","DOI":"10.3748\/wjg.14.3841","volume":"14","author":"M Dragoteanu","year":"2008","unstructured":"Dragoteanu M, Balea IA, Dina LA, et al. Staging of portal hypertension and portosystemic shunts using dynamic nuclear medicine investigations. World J Gastroenterol. 2008;14:3841\u20133848.","journal-title":"World J Gastroenterol"},{"key":"4080_CR17","first-page":"125","volume":"5","author":"MA Razzak","year":"1964","unstructured":"Razzak MA. The use of radioactive isotopes to study the hemodynamic pattern, function and morphology of the liver in hepato-splenic bilharziasis (schistosomiasis). J Nucl Med. 1964;5:125\u2013133.","journal-title":"J Nucl Med"},{"key":"4080_CR18","first-page":"909","volume":"7","author":"AG Mustafa","year":"1966","unstructured":"Mustafa AG, Razzak MA, Mahfouz M, Guirgis B. Radioisotope photoscanning of the liver in bilharzial hepatic fibrosis. J Nucl Med. 1966;7:909\u2013916.","journal-title":"J Nucl Med"},{"key":"4080_CR19","first-page":"655","volume":"12","author":"M Iio","year":"1971","unstructured":"Iio M, Iuchi M, Kitani K, Yamada H, Ishiwa M. Scintigraphic evaluation of the liver with schistosomiasis japonica. J Nucl Med. 1971;12:655\u2013659.","journal-title":"J Nucl Med"},{"key":"4080_CR20","doi-asserted-by":"crossref","first-page":"86","DOI":"10.4269\/ajtmh.1988.38.86","volume":"38","author":"M Homeida","year":"1988","unstructured":"Homeida M, Abdel-Gradir AF, Cheever AW, et al. Diagnosis of pathologically confirmed Symmers\u2019 periportal fibrosis by ultrasonography: a prospective blinded study. Am J Trop Med Hyg. 1988;38:86\u201391.","journal-title":"Am J Trop Med Hyg"},{"key":"4080_CR21","doi-asserted-by":"crossref","first-page":"72","DOI":"10.4269\/ajtmh.1989.40.72","volume":"40","author":"MF Abdel-Wahab","year":"1989","unstructured":"Abdel-Wahab MF, Esmat G, Milad M, Abdel-Razek S, Strickland GT. Characteristic sonographic pattern of schistosomal hepatic fibrosis. Am J Trop Med Hyg. 1989;40:72\u201376.","journal-title":"Am J Trop Med Hyg"},{"key":"4080_CR22","unstructured":"Richter J, Hatz C, Campagne G, Bergquist NR, Jenkins JM, eds. Ultrasound in Schistosomiasis: A Practical Guide to Standardized Use of Ultrasonography for the Assessment of Schistosomiasis-related Morbidity. Geneva: World Health Organization, TDR\/STR\/SCH\/00.1; 2000."},{"key":"4080_CR23","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1590\/S0074-02762001000900023","volume":"96","author":"J Richter","year":"2001","unstructured":"Richter J, Coutinho Domingues AL, Barata CH, Prata AR, Lambertucci JR. Report of the second satellite symposium on ultrasound in schistosomiasis. Mem Inst Oswaldo Cruz. 2001;96:151\u2013156.","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"4080_CR24","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0016-5085(56)80066-8","volume":"30","author":"E Palmer","year":"1956","unstructured":"Palmer E, Brick I. Correlation between the severity of esophageal varices in cirrhosis and their propensity toward hemorrhage. Gastroenterology. 1956;30:85\u201390.","journal-title":"Gastroenterology"},{"key":"4080_CR25","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/bjc.1983.111","volume":"47","author":"SH Leveson","year":"1983","unstructured":"Leveson SH, Wiggins PA, Nasiru TA, Giles GR, Robinson PJ, Parkin A. Improving the detection of hepatic metastases by the use of dynamic flow scintigraphy. Br J Cancer. 1983;47:719\u2013721.","journal-title":"Br J Cancer"},{"key":"4080_CR26","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1002\/hep.1840130329","volume":"13","author":"S Sarin","year":"1991","unstructured":"Sarin S, Mosca P, Sabba C, Groszmann R. Hyperdynamic circulation in a chronic murine schistosomiasis model of portal hypertension. Hepatology. 1991;13:581\u2013584.","journal-title":"Hepatology"},{"key":"4080_CR27","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/j.1600-0676.1996.tb00751.x","volume":"16","author":"C Deni\u00e9","year":"1996","unstructured":"Deni\u00e9 C, Vachiery F, Elman A, et al. Systemic and splanchnic hemodynamic changes in patients with hepatic schistosomiasis. Liver. 1996;16:309\u2013312.","journal-title":"Liver"},{"key":"4080_CR28","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1590\/S0100-39842010000200004","volume":"43","author":"LM Azeredo","year":"2010","unstructured":"Azeredo LM, Queiroz LCD, Marinho CC, et al. Sonographic and hemodynamic findings of schistosomiasis mansoni: Doppler sonography assessment in endemic areas. Radiol Bras. 2010;43:69\u201376.","journal-title":"Radiol Bras"},{"key":"4080_CR29","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1590\/S0004-28032008000100003","volume":"45","author":"SMB Arruda De","year":"2008","unstructured":"De Arruda SMB, Barreto VST, Do Amaral FJ. Duplex sonography study in schistosomiasis portal hypertension: characterization of patients with and without a history of variceal bleeding. Arq Gastroenterol. 2008;45:11\u201316.","journal-title":"Arq Gastroenterol"},{"key":"4080_CR30","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1053\/jhep.2003.50065","volume":"37","author":"A Zipprich","year":"2003","unstructured":"Zipprich A, Steudel N, Behrmann C, et al. Functional significance of hepatic arterial flow reserve in patients with cirrhosis. Hepatology. 2003;37:385\u2013392.","journal-title":"Hepatology"},{"key":"4080_CR31","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/S0016-5085(99)70074-0","volume":"116","author":"G Kleber","year":"1999","unstructured":"Kleber G, Steudel N, Behrmann C, et al. Hepatic arterial flow volume and reserve in patients with cirrhosis: use of intra-arterial Doppler and adenosine infusion. Gastroenterology. 1999;116:906\u2013914.","journal-title":"Gastroenterology"},{"key":"4080_CR32","doi-asserted-by":"crossref","first-page":"G549","DOI":"10.1152\/ajpgi.1985.249.5.G549","volume":"249","author":"WW Lautt","year":"1985","unstructured":"Lautt WW. Mechanism and role of intrinsic regulation of hepatic arterial blood flow: hepatic arterial buffer response. Am J Physiol Gastrointest Liver Physiol. 1985;249:G549\u2013G556.","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"4080_CR33","doi-asserted-by":"crossref","unstructured":"Lautt WW. Hepatic circulation physiology and pathophysiology. In: Lautt WW, ed. Colloquium Series on Integrated Systems Physiology: From Molecule to Function. San Rafael: Morgan & Claypool Life Sciences; 2009.","DOI":"10.4199\/C00004ED1V01Y200910ISP001"},{"key":"4080_CR34","doi-asserted-by":"crossref","first-page":"G1534","DOI":"10.1152\/ajpgi.00503.2006","volume":"292","author":"O Kollmar","year":"2007","unstructured":"Kollmar O, Corsten M, Scheuer C, Vollmar B, Schilling MK, Menger MD. Portal branch ligation induces a hepatic arterial buffer response, microvascular remodeling, normoxygenation, and cell proliferation in portal blood-deprived liver tissue. Am J Physiol Gastrointest Liver Physiol. 2007;292:G1534\u2013G1542.","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"4080_CR35","doi-asserted-by":"crossref","first-page":"e0121229","DOI":"10.1371\/journal.pone.0121229","volume":"10","author":"M Moeller","year":"2015","unstructured":"Moeller M, Thonig A, Pohl S, Ripoll C, Zipprich A. Hepatic arterial vasodilation is independent of portal hypertension in early stages of cirrhosis. PLoS One. 2015;10:e0121229.","journal-title":"PLoS One"},{"key":"4080_CR36","first-page":"H836","volume":"252","author":"WR Ezzat","year":"1987","unstructured":"Ezzat WR, Lautt WW. Hepatic arterial pressure-flow autoregulation is adenosine mediated. Am J Physiol. 1987;252:H836\u2013H845.","journal-title":"Am J Physiol"},{"key":"4080_CR37","first-page":"549","volume":"249","author":"WW Lautt","year":"1985","unstructured":"Lautt WW. Mechanism and role of intrinsic regulation of hepatic arterial blood flow: hepatic arterial buffer response. Am J Physiol. 1985;249:549\u2013556.","journal-title":"Am J Physiol"},{"key":"4080_CR38","first-page":"H559","volume":"239","author":"WW Lautt","year":"1980","unstructured":"Lautt WW. Control of hepatic arterial blood flow: independence from liver metabolic activity. Am J Physiol. 1980;239:H559\u2013H564.","journal-title":"Am J Physiol"},{"key":"4080_CR39","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1152\/physrev.00027.2008","volume":"89","author":"B Vollmar","year":"2009","unstructured":"Vollmar B, Menger MD. The hepatic microcirculation: mechanistic contributions and therapeutic targets in liver injury and repair. Physiol Rev. 2009;89:1269\u20131339.","journal-title":"Physiol Rev"},{"key":"4080_CR40","doi-asserted-by":"crossref","first-page":"6046","DOI":"10.3748\/wjg.v16.i48.6046","volume":"28","author":"C Eipel","year":"2010","unstructured":"Eipel C, Abshagen K, Vollmar B. Regulation of hepatic blood flow: the hepatic arterial buffer response revisited. World J Gastroenterol. 2010;28:6046\u20136057.","journal-title":"World J Gastroenterol"},{"key":"4080_CR41","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/S1665-2681(19)32186-6","volume":"1","author":"E Strauss","year":"2002","unstructured":"Strauss E. Hepatosplenic schistosomiasis: a model for the study of portal hypertension. Ann Hepatol. 2002;1:6\u201311.","journal-title":"Ann Hepatol"},{"key":"4080_CR42","first-page":"545","volume":"51","author":"KS Warren","year":"1975","unstructured":"Warren KS. Hepatosplenic schistosomiasis mansoni: an immunologic disease. Bull N Y Acad Med. 1975;51:545\u2013550.","journal-title":"Bull N Y Acad Med"},{"key":"4080_CR43","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1590\/S0074-02761992000800028","volume":"87","author":"LC Silva Da","year":"1992","unstructured":"Da Silva LC. Portal hypertension in schistosomiasis: pathophysiology and treatment. Mem Inst Oswaldo Cruz. 1992;87:183\u2013186.","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"4080_CR44","first-page":"435","volume":"13","author":"PAR Jorge","year":"1967","unstructured":"Jorge PAR, dos Carvalhal SS. Sobre a rede vascular intra-hep\u00e1tica na esquistossomose mansonica, forma de Symmers: Estudo com modelos pl\u00e1sticos. Rev Assoc Med Bras. 1967;13:435\u2013441.","journal-title":"Rev Assoc Med Bras"},{"key":"4080_CR45","first-page":"177","volume":"28","author":"A Widman","year":"1973","unstructured":"Widman A, Speranzini MB, de Lima JT, Wierman P, de Oliveira MR, Raia A. Arterial and operative portography in patients with portal hypertension caused by hepato-splenic schistosomiasis and those with spleno-renal anastomosis (comparative study). Rev do Hosp das Cl\u00ednicas Fac Med S\u00e3o Paulo. 1973;28:177\u2013187.","journal-title":"Rev do Hosp das Cl\u00ednicas Fac Med S\u00e3o Paulo"},{"key":"4080_CR46","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/S0016-5085(77)80315-6","volume":"72","author":"C Alves","year":"1977","unstructured":"Alves C, Alves A, Abreu W, Andrade ZA. Hepatic artery hypertrophy and sinusoidal hypertension in advanced schistosomiasis. Gastroenterology. 1977;72:126\u2013128.","journal-title":"Gastroenterology"},{"key":"4080_CR47","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1023\/A:1018803911915","volume":"42","author":"S Mies","year":"1997","unstructured":"Mies S, Braghirolli-Neto O, Beer A, et al. Systemic and hepatic hemodynamics in hepatosplenic manson\u2019s schistosomiasis with and without propranolol. Dig Dis Sci. 1997;42:751\u2013761.","journal-title":"Dig Dis Sci"},{"key":"4080_CR48","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1590\/S0074-02762005000200012","volume":"100","author":"AP Baptista","year":"2005","unstructured":"Baptista AP, Andrade ZA. Angiogenesis and schistosomal granuloma formation. Mem Inst Oswaldo Cruz. 2005;100:183\u2013185.","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"4080_CR49","first-page":"113","volume":"8","author":"CM Lacerda","year":"1993","unstructured":"Lacerda CM, Ramos H, Raia S, Kelner S. Fisiopatologia da hipertens\u00e3o portal esquistossom\u00f3tica e efeitos da esplenectomia com ligadura de varizes de es\u00f4fago. Acta Cir Bras. 1993;8:113\u2013117.","journal-title":"Acta Cir Bras"},{"key":"4080_CR50","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1590\/S0102-67202013000400010","volume":"26","author":"FM Pereira","year":"2013","unstructured":"Pereira FM, Evangelista-Neto J, Brito N, Amaral F, da Fonseca-Neto OC, Lacerda CM. Angiografic and pressoric changes determined by splenectomy with left gastric vein ligature in mansoni schistosomiasis. Arq Bras Cir Dig. 2013;26:302\u2013308.","journal-title":"Arq Bras Cir Dig"},{"key":"4080_CR51","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/0002-9343(68)90055-7","volume":"44","author":"A Coutinho","year":"1968","unstructured":"Coutinho A. Hemodynamic studies of portal hypertension in schistosomiasis. Am J Med. 1968;44:547\u2013555.","journal-title":"Am J Med"},{"key":"4080_CR52","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1002\/hep.1840110117","volume":"11","author":"J Morgan","year":"1990","unstructured":"Morgan J, Groszmann R, Rojkind M, Enriquez R. Hemodynamic mechanism of emerging portal hypertension caused by schistosomiasis in the hamster. Hepatology. 1990;11:98\u2013104.","journal-title":"Hepatology"},{"key":"4080_CR53","first-page":"259","volume":"42","author":"ZA Andrade","year":"2013","unstructured":"Andrade ZA. A double and paradoxical role for angiogenesis. Rev Patol Trop. 2013;42:259\u2013264.","journal-title":"Rev Patol Trop"},{"key":"4080_CR54","first-page":"G1000","volume":"277","author":"B Rocheleau","year":"1999","unstructured":"Rocheleau B, Ethier C, Houle R, Huet PM, Bilodeau M. Hepatic artery buffer response following left portal vein ligation: its role in liver tissue homeostasis. Am J Physiol. 1999;277:G1000\u2013G1007.","journal-title":"Am J Physiol"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-016-4080-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10620-016-4080-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-016-4080-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T03:35:07Z","timestamp":1600227307000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10620-016-4080-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,26]]},"references-count":54,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["4080"],"URL":"https:\/\/doi.org\/10.1007\/s10620-016-4080-y","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,26]]}}}