{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T05:39:25Z","timestamp":1770701965640,"version":"3.49.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2016,3,12]],"date-time":"2016-03-12T00:00:00Z","timestamp":1457740800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1007\/s10620-016-4102-9","type":"journal-article","created":{"date-parts":[[2016,3,11]],"date-time":"2016-03-11T23:25:32Z","timestamp":1457738732000},"page":"1950-1960","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["WAVE3 Induces EMT and Promotes Migration and Invasion in Intrahepatic Cholangiocarcinoma"],"prefix":"10.1007","volume":"61","author":[{"given":"Zebin","family":"Zhu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyu","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaming","family":"Lai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijian","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anxun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaoxu","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,3,12]]},"reference":[{"key":"4102_CR1","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.1016\/S0140-6736(13)61903-0","volume":"383","author":"N Razumilava","year":"2014","unstructured":"Razumilava N, Gores GJ. Cholangiocarcinoma. Lancet. 2014;383:2168\u20132179.","journal-title":"Lancet"},{"key":"4102_CR2","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1097\/SLA.0b013e318176c4d3","volume":"248","author":"I Endo","year":"2008","unstructured":"Endo I, Gonen M, Yopp AC, et al. Intrahepatic cholangiocarcinoma: rising frequency, improved survival, and determinants of outcome after resection. Ann Surg. 2008;248:84\u201396.","journal-title":"Ann Surg"},{"key":"4102_CR3","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1007\/s11605-011-1813-2","volume":"16","author":"T Hirashita","year":"2012","unstructured":"Hirashita T, Iwashita Y, Ohta M, et al. Expression of matrix metalloproteinase-7 is an unfavorable prognostic factor in intrahepatic cholangiocarcinoma. J Gastrointest Surg. 2012;16:842\u2013848.","journal-title":"J Gastrointest Surg"},{"key":"4102_CR4","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1007\/s10620-012-2524-6","volume":"58","author":"YB Ding","year":"2013","unstructured":"Ding YB, Deng B, Huang YS, et al. A high level of integrin \u03b16 expression in human intrahepatic cholangiocarcinoma cells is associated with a migratory and invasive phenotype. Dig Dis Sci. 2013;58:1627\u20131635.","journal-title":"Dig Dis Sci"},{"key":"4102_CR5","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/s13046-014-0103-8","volume":"33","author":"S Zhao","year":"2014","unstructured":"Zhao S, Wang J, Qin C. Blockade of CXCL12\/CXCR4 signaling inhibits intrahepatic cholangiocarcinoma progression and metastasis via inactivation of canonical Wnt pathway. J Exp Clin Cancer Res. 2014;33:103.","journal-title":"J Exp Clin Cancer Res"},{"key":"4102_CR6","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1002\/hep.24466","volume":"54","author":"L Fabris","year":"2011","unstructured":"Fabris L, Cadamuro M, Moserle L, et al. Nuclear expression of S100A4 calcium-binding protein increases cholangiocarcinoma invasiveness and metastasization. Hepatology. 2011;54:890\u2013899.","journal-title":"Hepatology"},{"key":"4102_CR7","doi-asserted-by":"crossref","first-page":"18905","DOI":"10.18632\/oncotarget.4305","volume":"6","author":"J Wang","year":"2015","unstructured":"Wang J, Zhang K, Wang J, et al. Underexpression of LKB1 tumor suppressor is associated with enhanced Wnt signaling and malignant characteristics of human intrahepatic cholangiocarcinoma. Oncotarget. 2015;6:18905\u201318920.","journal-title":"Oncotarget"},{"key":"4102_CR8","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.18632\/oncotarget.1706","volume":"5","author":"MH Chen","year":"2014","unstructured":"Chen MH, Chiang KC, Cheng CT, et al. Antitumor activity of the combination of an HSP90 inhibitor and a PI3K\/mTOR dual inhibitor against cholangiocarcinoma. Oncotarget. 2014;5:2372\u20132389.","journal-title":"Oncotarget"},{"key":"4102_CR9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj20040176","volume":"380","author":"TH Millard","year":"2004","unstructured":"Millard TH, Sharp SJ, Machesky LM. Signalling to actin assembly via the WASP (Wiskott\u2013Aldrich syndrome protein)-family proteins and the Arp2\/3 complex. Biochem J. 2004;380:1\u201317.","journal-title":"Biochem J"},{"key":"4102_CR10","doi-asserted-by":"crossref","first-page":"3739","DOI":"10.1073\/pnas.96.7.3739","volume":"96","author":"LM Machesky","year":"1999","unstructured":"Machesky LM, Mullins RD, Higgs HN, et al. Scar, a WASp-related protein, activates nucleation of actin filaments by the Arp2\/3 complex. Proc Natl Acad Sci USA. 1999;96:3739\u20133744.","journal-title":"Proc Natl Acad Sci USA"},{"key":"4102_CR11","doi-asserted-by":"crossref","first-page":"6181","DOI":"10.1073\/pnas.95.11.6181","volume":"95","author":"RD Mullins","year":"1998","unstructured":"Mullins RD, Heuser JA, Pollard TD. The interaction of Arp2\/3 complex with actin: nucleation, high affinity pointed end capping, and formation of branching networks of filaments. Proc Natl Acad Sci USA. 1998;95:6181\u20136186.","journal-title":"Proc Natl Acad Sci USA"},{"key":"4102_CR12","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.2353\/ajpath.2007.060975","volume":"170","author":"K Sossey-Alaoui","year":"2007","unstructured":"Sossey-Alaoui K, Safina A, Li X, et al. Down-regulation of WAVE3, a metastasis promoter gene, inhibits invasion and metastasis of breast cancer cells. Am J Pathol. 2007;170:2112\u20132121.","journal-title":"Am J Pathol"},{"key":"4102_CR13","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.urolonc.2008.12.022","volume":"28","author":"HS Fernando","year":"2010","unstructured":"Fernando HS, Sanders AJ, Kynaston HG, Jiang WG. WAVE3 is associated with invasiveness in prostate cancer cells. Urol Oncol. 2010;28:320\u2013327.","journal-title":"Urol Oncol"},{"key":"4102_CR14","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.biopha.2014.11.001","volume":"69","author":"Y Ji","year":"2015","unstructured":"Ji Y, Li B, Zhu Z, et al. Overexpression of WAVE3 promotes tumor invasiveness and confers an unfavorable prognosis in human hepatocellular carcinoma. Biomed Pharmacother. 2015;69:409\u2013415.","journal-title":"Biomed Pharmacother"},{"key":"4102_CR15","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/cgt.2014.52","volume":"21","author":"Z Yue","year":"2014","unstructured":"Yue Z, Feng W, Xiangke L, Liuxing W, Qingxia F, Jianbo G. WAVE3 promotes epithelial-mesenchymal transition of gastric cancer through upregulation of snail. Cancer Gene Ther. 2014;21:499\u2013506.","journal-title":"Cancer Gene Ther"},{"key":"4102_CR16","doi-asserted-by":"crossref","first-page":"3285","DOI":"10.1016\/j.bbagen.2014.08.005","volume":"1840","author":"B Chang","year":"2014","unstructured":"Chang B, Li S, He Q, et al. Deregulation of Bmi-1 is associated with enhanced migration, invasion and poor prognosis in salivary adenoid cystic carcinoma. Biochim Biophys Acta. 2014;1840:3285\u20133291.","journal-title":"Biochim Biophys Acta"},{"key":"4102_CR17","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/j.gastro.2003.07.013","volume":"125","author":"T Kamihira","year":"2003","unstructured":"Kamihira T, Shimoda S, Harada K, et al. Distinct costimulation dependent and independent autoreactive T-cell clones in primary biliary cirrhosis. Gastroenterology. 2003;125:1379\u20131387.","journal-title":"Gastroenterology"},{"key":"4102_CR18","doi-asserted-by":"crossref","first-page":"3998","DOI":"10.1002\/cncr.29619","volume":"121","author":"G Spolverato","year":"2015","unstructured":"Spolverato G, Vitale A, Cucchetti A, et al. Can hepatic resection provide a long-term cure for patients with intrahepatic cholangiocarcinoma? Cancer. 2015;121:3998\u20134006.","journal-title":"Cancer"},{"key":"4102_CR19","first-page":"287","volume":"24","author":"K Sossey-Alaoui","year":"2013","unstructured":"Sossey-Alaoui K. Surfing the big WAVE: insights into the role of WAVE3 as a driving force in cancer progression and metastasis. Semin Cell Dev Biol. 2013;24:287\u2013297.","journal-title":"Semin Cell Dev Biol"},{"key":"4102_CR20","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1093\/carcin\/bgt167","volume":"34","author":"Y Teng","year":"2013","unstructured":"Teng Y, Ghoshal P, Ngoka L, Mei Y, Cowell JK. Critical role of the WASF3 gene in JAK2\/STAT3 regulation of cancer cell motility. Carcinogenesis. 2013;34:1994\u20131999.","journal-title":"Carcinogenesis"},{"key":"4102_CR21","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.yexcr.2005.04.011","volume":"308","author":"K Sossey-Alaoui","year":"2005","unstructured":"Sossey-Alaoui K, Ranalli TA, Li X, Bakin AV, Cowell JK. WAVE3 promotes cell motility and invasion through the regulation of MMP-1, MMP-3, and MMP-9 expression. Exp Cell Res. 2005;308:135\u2013145.","journal-title":"Exp Cell Res"},{"key":"4102_CR22","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/onc.2012.565","volume":"33","author":"Y Teng","year":"2014","unstructured":"Teng Y, Mei Y, Hawthorn L, Cowell JK. WASF3 regulates miR-200 inactivation by ZEB1 through suppression of KISS1 leading to increased invasiveness in breast cancer cells. Oncogene. 2014;33:203\u2013211.","journal-title":"Oncogene"},{"key":"4102_CR23","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1007\/s00432-012-1274-3","volume":"138","author":"Y Zhang","year":"2012","unstructured":"Zhang Y, Guan XY, Dong B, et al. Expression of MMP-9 and WAVE3 in colorectal cancer and its relationship to clinicopathological features. J Cancer Res Clin Oncol. 2012;138:2035\u20132044.","journal-title":"J Cancer Res Clin Oncol"},{"key":"4102_CR24","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.3892\/ol.2014.2276","volume":"8","author":"J Wu","year":"2014","unstructured":"Wu J, Wang G, Chen X, Xue Z. Expression of WASF3 in patients with non-small cell lung cancer: correlation with clinicopathological features and prognosis. Oncol Lett. 2014;8:1169\u20131174.","journal-title":"Oncol Lett"},{"key":"4102_CR25","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1038\/sj.bjc.6605850","volume":"103","author":"Y Teng","year":"2010","unstructured":"Teng Y, Ren MQ, Cheney R, Sharma S, Cowell JK. Inactivation of the WASF3 gene in prostate cancer cells leads to suppression of tumorigenicity and metastases. Br J Cancer. 2010;103:1066\u20131075.","journal-title":"Br J Cancer"},{"key":"4102_CR26","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s10549-013-2753-1","volume":"142","author":"MA Taylor","year":"2013","unstructured":"Taylor MA, Davuluri G, Parvani JG, et al. Upregulated WAVE3 expression is essential for TGF-beta-mediated EMT and metastasis of triple-negative breast cancer cells. Breast Cancer Res Treat. 2013;142:341\u2013353.","journal-title":"Breast Cancer Res Treat"},{"key":"4102_CR27","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1016\/j.febslet.2012.02.037","volume":"586","author":"CH Heldin","year":"2012","unstructured":"Heldin CH, Vanlandewijck M, Moustakas A. Regulation of EMT by TGF\u03b2 in cancer. FEBS Lett. 2012;586:1959\u20131970.","journal-title":"FEBS Lett"},{"key":"4102_CR28","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/nrc822","volume":"2","author":"JP Thiery","year":"2002","unstructured":"Thiery JP. Epithelial\u2013mesenchymal transitions in tumour progression. Nat Rev Cancer. 2002;2:442\u2013454.","journal-title":"Nat Rev Cancer"},{"key":"4102_CR29","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1002\/hep.28149","volume":"62","author":"LX Yang","year":"2015","unstructured":"Yang LX, Gao Q, Shi JY, et al. Mitogen-activated protein kinase kinase kinase 4 deficiency in intrahepatic cholangiocarcinoma leads to invasive growth and epithelial-mesenchymal transition. Hepatology. 2015;62:1804\u20131816.","journal-title":"Hepatology"},{"key":"4102_CR30","doi-asserted-by":"crossref","first-page":"e96860","DOI":"10.1371\/journal.pone.0096860","volume":"9","author":"XY Huang","year":"2014","unstructured":"Huang XY, Zhang C, Cai JB, et al. Comprehensive multiple molecular profile of epithelial mesenchymal transition in intrahepatic cholangiocarcinoma patients. PLoS ONE. 2014;9:e96860.","journal-title":"PLoS ONE"},{"key":"4102_CR31","doi-asserted-by":"crossref","first-page":"255","DOI":"10.2147\/OTT.S36213","volume":"5","author":"X Yao","year":"2012","unstructured":"Yao X, Wang X, Wang Z, et al. Clinicopathological and prognostic significance of epithelial mesenchymal transition-related protein expression in intrahepatic cholangiocarcinoma. Onco Targets Ther. 2012;5:255\u2013261.","journal-title":"Onco Targets Ther"},{"key":"4102_CR32","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1111\/j.1349-7006.2010.01654.x","volume":"101","author":"S Kurisu","year":"2010","unstructured":"Kurisu S, Takenawa T. WASP and WAVE family proteins: friends or foes in cancer invasion? Cancer Sci. 2010;101:2093\u20132104.","journal-title":"Cancer Sci"},{"key":"4102_CR33","doi-asserted-by":"crossref","first-page":"5820","DOI":"10.1158\/0008-5472.CAN-08-2819","volume":"69","author":"T Arumugam","year":"2009","unstructured":"Arumugam T, Ramachandran V, Fournier KF, et al. Epithelial to mesenchymal transition contributes to drug resistance in pancreatic cancer. Cancer Res. 2009;69:5820\u20135828.","journal-title":"Cancer Res"},{"key":"4102_CR34","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1136\/jclinpath-2013-201806","volume":"67","author":"MJ Gu","year":"2014","unstructured":"Gu MJ, Choi JH. Epithelial-mesenchymal transition phenotypes are associated with patient survival in intrahepatic cholangiocarcinoma. J Clin Pathol. 2014;67:229\u2013234.","journal-title":"J Clin Pathol"},{"key":"4102_CR35","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1136\/jclinpath-2013-201806","volume":"67","author":"Y Teng","year":"2014","unstructured":"Teng Y, Xie X, Walker S, White DT, Mumm JS, Cowell JK. Evaluating human cancer cell metastasis in zebrafish. J Clin Pathol. 2014;67:229\u2013234.","journal-title":"J Clin Pathol"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-016-4102-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10620-016-4102-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-016-4102-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T09:36:50Z","timestamp":1567676210000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10620-016-4102-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,12]]},"references-count":35,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["4102"],"URL":"https:\/\/doi.org\/10.1007\/s10620-016-4102-9","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,12]]}}}