{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T08:16:07Z","timestamp":1788336967371,"version":"build-2803163510"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2016,6,4]],"date-time":"2016-06-04T00:00:00Z","timestamp":1464998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1007\/s10620-016-4213-3","type":"journal-article","created":{"date-parts":[[2016,6,4]],"date-time":"2016-06-04T11:22:41Z","timestamp":1465039361000},"page":"2710-2720","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":83,"title":["Natural History of Patients Presenting with Autoimmune Hepatitis and Coincident Nonalcoholic Fatty Liver Disease"],"prefix":"10.1007","volume":"61","author":[{"given":"Javier","family":"De Luca-Johnson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirk J.","family":"Wangensteen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Hanson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Krawitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Wilcox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,6,4]]},"reference":[{"key":"4213_CR1","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/nyas.12016","volume":"1281","author":"HC Masuoka","year":"2013","unstructured":"Masuoka HC, Chalasani N. Nonalcoholic fatty liver disease: an emerging threat to obese and diabetic individuals. Ann NY Acad Sci. 2013;1281:106\u2013122.","journal-title":"Ann NY Acad Sci"},{"key":"4213_CR2","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1111\/j.1365-2036.2011.04724.x","volume":"34","author":"G Vernon","year":"2011","unstructured":"Vernon G, Baranova A, Younossi ZM. Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults. Aliment Pharmacol Ther. 2011;34:274\u2013285.","journal-title":"Aliment Pharmacol Ther"},{"key":"4213_CR3","first-page":"9050","volume":"20","author":"G Bedogni","year":"2014","unstructured":"Bedogni G, Nobili V, Tribelli C. Epidemiology of fatty liver: an update. World J Gastroenterol. 2014;20:9050\u20139054.","journal-title":"World J Gastroenterol"},{"key":"4213_CR4","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1053\/j.gastro.2010.09.038","volume":"140","author":"CD Williams","year":"2011","unstructured":"Williams CD, Stengel J, Asike MI, et al. Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: a prospective study. Gastroenterology. 2011;140:124\u2013131.","journal-title":"Gastroenterology"},{"key":"4213_CR5","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1097\/01.MP.0000042420.21088.C7","volume":"16","author":"EM Brunt","year":"2003","unstructured":"Brunt EM, Ramrakhiani S, Cordes BG, et al. Concurrence of histologic features of steatohepatitis with other forms of chronic liver disease. Mod Pathol. 2003;16:49\u201356.","journal-title":"Mod Pathol"},{"key":"4213_CR6","doi-asserted-by":"crossref","first-page":"469","DOI":"10.5009\/gnl.2013.7.4.469","volume":"7","author":"H Yoon","year":"2013","unstructured":"Yoon H, Lee JG, Yoo JH, et al. Effects of metabolic syndrome on fibrosis in chronic viral hepatitis. Gut Liver. 2013;7:469\u2013474.","journal-title":"Gut Liver"},{"key":"4213_CR7","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1111\/j.1572-0241.2003.07640.x","volume":"98","author":"AJ Sanyal","year":"2003","unstructured":"Sanyal AJ, Contos MJ, Sterling RK, et al. Nonalcoholic fatty liver disease in patients with hepatitis C is associated with features of the metabolic syndrome. Am J Gastroenterol. 2003;98:2064\u20132071.","journal-title":"Am J Gastroenterol"},{"key":"4213_CR8","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1002\/hep.21711","volume":"46","author":"P Bedossa","year":"2007","unstructured":"Bedossa P, Moucari R, Chelbi E, et al. Evidence for a role of nonalcoholic steatohepatitis in hepatitis C: a prospective study. Hepatology. 2007;46:380\u2013387.","journal-title":"Hepatology"},{"key":"4213_CR9","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1023\/B:DDAS.0000004522.36120.08","volume":"48","author":"P Loria","year":"2003","unstructured":"Loria P, Lonardo A, Leonardi F, et al. Non-organ specific autoantibodies in nonalcoholic fatty liver disease: prevalence and correlates. Dig Dis Sci. 2003;48:2173\u20132181.","journal-title":"Dig Dis Sci"},{"key":"4213_CR10","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1097\/01.mcg.0000139072.38580.a0","volume":"38","author":"S Cotler","year":"2004","unstructured":"Cotler S, Kanji K, Keshavarzian A, Jensen DM, Jakate S. Prevalence and significance of autoantibodies in patients with non-alcoholic steatohepatitis. J Clin Gastroenterol. 2004;38:801\u2013804.","journal-title":"J Clin Gastroenterol"},{"key":"4213_CR11","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1159\/000332152","volume":"5","author":"S Fukuda","year":"2011","unstructured":"Fukuda S, Komori A, Itoh M, et al. Histological remission during corticosteroid therapy of overlapping nonalcoholic steatohepatitis and autoimmune hepatitis: case report and literature review. Case Rep Gastroenterol. 2011;5:553\u2013557.","journal-title":"Case Rep Gastroenterol"},{"key":"4213_CR12","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1111\/j.1572-0241.2004.30444.x","volume":"99","author":"LA Adams","year":"2004","unstructured":"Adams LA, Lindor KD, Angulo P. The prevalence of autoantibodies and autoimmune hepatitis in patients with nonalcoholic fatty liver disease. Am J Gastroenterol. 2004;99:1316\u20131320.","journal-title":"Am J Gastroenterol"},{"key":"4213_CR13","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1007\/s00535-005-1711-z","volume":"40","author":"S Yatsuji","year":"2005","unstructured":"Yatsuji S, Hashimoto E, Kaneda H, Taniai M, Tokushige K, Shiratori K. Diagnosing autoimmune hepatitis in nonalcoholic fatty liver disease: is the International Autoimmune Hepatitis Group scoring system useful? J Gastroenterol. 2005;40:1130\u20131138.","journal-title":"J Gastroenterol"},{"key":"4213_CR14","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1111\/j.1872-034X.2007.00150.x","volume":"37","author":"H Niwa","year":"2007","unstructured":"Niwa H, Sasaki M, Haratake J, et al. Clinicopathological significance of antinuclear antibodies in non-alcoholic steatohepatitis. Hepatol Res. 2007;37:923\u2013931.","journal-title":"Hepatol Res"},{"key":"4213_CR15","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s12072-011-9277-8","volume":"6","author":"R Vuppalanchi","year":"2012","unstructured":"Vuppalanchi R, Gould RJ, Wilson LA, et al. Clinical significance of serum autoantibodies in patients with NAFLD: results from the nonalcoholic steatohepatitis clinical research network. Hepatol Int. 2012;6:379\u2013385.","journal-title":"Hepatol Int"},{"key":"4213_CR16","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/hep.22322","volume":"48","author":"EM Hennes","year":"2008","unstructured":"Hennes EM, Zeniya M, Czaja AJ, et al. Simplified criteria for the diagnosis of autoimmune hepatitis. Hepatology. 2008;48:169\u2013176.","journal-title":"Hepatology"},{"key":"4213_CR17","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1097\/00000478-199512000-00007","volume":"19","author":"KP Batts","year":"1995","unstructured":"Batts KP, Ludwig J. Chronic hepatitis. An update on terminology and reporting. Am J Surg Pathol. 1995;19:1409\u20131417.","journal-title":"Am J Surg Pathol"},{"key":"4213_CR18","volume-title":"Autoimmune Liver Diseases","author":"KP Batts","year":"1998","unstructured":"Batts KP, Ludwig J. Histopathology of autoimmune hepatitis, primary biliary cirrhosis and primary sclerosing cholangitis. In: Krawitt EL, Wiesner RH, Nishioka M, eds. Autoimmune Liver Diseases. 2nd ed. Amsterdam: Elsevier; 1998.","edition":"2"},{"key":"4213_CR19","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1111\/j.1572-0241.1999.01377.x","volume":"94","author":"EM Brunt","year":"1999","unstructured":"Brunt EM, Janney CG, Di Bisceglie AM, Neuschwander-Tetri BA, Bacon BR. Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions. Am J Gastroenterol. 1999;94:2467\u20132474.","journal-title":"Am J Gastroenterol"},{"key":"4213_CR20","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/nrgastro.2010.21","volume":"7","author":"EM Brunt","year":"2010","unstructured":"Brunt EM. Pathology of nonalcoholic fatty liver disease. Nat Rev Gastroenterol Hepatol. 2010;7:195\u2013203.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"4213_CR21","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.jhep.2012.02.023","volume":"57","author":"SE Keating","year":"2012","unstructured":"Keating SE, Hackett DA, George J, Johnson NA. Exercise and non-alcoholic fatty liver disease: a systematic review and meta-analysis. J Hepatol. 2012;57:157\u2013166.","journal-title":"J Hepatol"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-016-4213-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10620-016-4213-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-016-4213-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,24]],"date-time":"2017-06-24T11:44:36Z","timestamp":1498304676000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10620-016-4213-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,4]]},"references-count":21,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["4213"],"URL":"https:\/\/doi.org\/10.1007\/s10620-016-4213-3","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,4]]}}}