{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T17:18:16Z","timestamp":1779297496144,"version":"3.51.4"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1007\/s10620-016-4261-8","type":"journal-article","created":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T09:43:18Z","timestamp":1470044598000},"page":"3335-3345","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Diabetes Is Associated with Clinical Decompensation Events in Patients with Cirrhosis"],"prefix":"10.1007","volume":"61","author":[{"given":"Tsai-Ling","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin","family":"Trogdon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morris","family":"Weinberger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce","family":"Fried","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"IV","given":"A. Sidney","family":"Barritt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,8,1]]},"reference":[{"key":"4261_CR1","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1186\/s12916-014-0145-y","volume":"12","author":"AA Mokdad","year":"2014","unstructured":"Mokdad AA, Lopez AD, Shahraz S, et al. Liver cirrhosis mortality in 187 countries between 1980 and 2010: a systematic analysis. BMC Med. 2014;12:145.","journal-title":"BMC Med"},{"key":"4261_CR2","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1001\/jama.2013.13805","volume":"310","author":"CJL Murray","year":"2013","unstructured":"Murray CJL. The State of US Health, 1990\u20132010. JAMA. 2013;310:591\u2013606.","journal-title":"JAMA"},{"key":"4261_CR3","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1097\/MCG.0000000000000208","volume":"49","author":"S Scaglione","year":"2015","unstructured":"Scaglione S, Kliethermes S, Cao G, et al. The epidemiology of cirrhosis in the United States: a population-based study. J Clin Gastroenterol. 2015;49:690\u2013696.","journal-title":"J Clin Gastroenterol"},{"key":"4261_CR4","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1053\/j.gastro.2009.09.067","volume":"138","author":"GL Davis","year":"2010","unstructured":"Davis GL, Alter MJ, El-Serag H, Poynard T, Jennings LW. Aging of hepatitis C virus (HCV)-infected persons in the United States: a multiple cohort model of HCV prevalence and disease progression. Gastroenterology. 2010;138:513\u2013521.","journal-title":"Gastroenterology"},{"key":"4261_CR5","first-page":"661","volume":"7","author":"GW Neff","year":"2011","unstructured":"Neff GW, Duncan CW, Schiff ER. The current economic burden of cirrhosis. Gastroenterol Hepatol (NY). 2011;7:661\u2013671.","journal-title":"Gastroenterol Hepatol (NY)"},{"key":"4261_CR6","first-page":"1","volume":"61","author":"BD Smith","year":"2012","unstructured":"Smith BD, Morgan RL, Beckett GA, et al. Recommendations for the identification of chronic hepatitis C virus infection among persons born during 1945\u20131965. MMWR Recomm Rep. 2012;61:1\u201332.","journal-title":"MMWR Recomm Rep"},{"key":"4261_CR7","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.1002\/hep.22246","volume":"47","author":"M Charlton","year":"2008","unstructured":"Charlton M. Cirrhosis and liver failure in nonalcoholic fatty liver disease: molehill or mountain? Hepatology. 2008;47:1431\u20131433.","journal-title":"Hepatology"},{"key":"4261_CR8","first-page":"455","volume":"51","author":"JM Petit","year":"2014","unstructured":"Petit JM, Hamza S, Rollot F, et al. Impact of liver disease severity and etiology on the occurrence of diabetes mellitus in patients with liver cirrhosis. Acta Diabetol. 2014;51:455\u2013460.","journal-title":"Acta Diabetol"},{"key":"4261_CR9","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/S0168-8278(00)80065-3","volume":"32","author":"NN Zein","year":"2000","unstructured":"Zein NN, Abdulkarim AS, Wiesner RH, Egan KS, Persing DH. Prevalence of diabetes mellitus in patients with end-stage liver cirrhosis due to hepatitis C, alcohol, or cholestatic disease. J Hepatol. 2000;32:209\u2013217.","journal-title":"J Hepatol"},{"key":"4261_CR10","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1046\/j.1440-1746.2002.02755.x","volume":"17","author":"A Holstein","year":"2002","unstructured":"Holstein A, Hinze S, Thie\u00dfen E, Plaschke A, Egberts E-H. Clinical implications of hepatogenous diabetes in liver cirrhosis. J Gastroenterol Hepatol. 2002;17:677\u2013681.","journal-title":"J Gastroenterol Hepatol"},{"key":"4261_CR11","first-page":"119","volume":"20","author":"G Bianchi","year":"1994","unstructured":"Bianchi G, Wchesini G, Zoli M, Bugianesi E, Fabbri A, Pisi E. Prognostic significance of diabetes in patients with cirrhosis. Hepatology. 1994;20:119\u2013125.","journal-title":"Hepatology"},{"key":"4261_CR12","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1042\/CS20120596","volume":"125","author":"N Wlazlo","year":"2013","unstructured":"Wlazlo N, van Greevenbroek MM, Curvers J, et al. Diabetes mellitus at the time of diagnosis of cirrhosis is associated with higher incidence of spontaneous bacterial peritonitis, but not with increased mortality. Clin Sci (Lond). 2013;125:341\u2013348.","journal-title":"Clin Sci (Lond)"},{"key":"4261_CR13","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1111\/1753-0407.12067","volume":"5","author":"Z Butt","year":"2013","unstructured":"Butt Z, Jadoon NA, Salaria ON, et al. Diabetes mellitus and decompensated cirrhosis: risk of hepatic encephalopathy in different age groups. J Diabetes. 2013;5:449\u2013455.","journal-title":"J Diabetes"},{"key":"4261_CR14","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1016\/j.kjms.2014.06.002","volume":"30","author":"C-H Yang","year":"2014","unstructured":"Yang C-H, Chiu Y-C, Chen C-H, et al. Diabetes mellitus is associated with gastroesophageal variceal bleeding in cirrhotic patients. Kaohsiung J Med Sci. 2014;30:515\u2013520.","journal-title":"Kaohsiung J Med Sci"},{"key":"4261_CR15","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1136\/gut.2004.052167","volume":"54","author":"JA Davila","year":"2005","unstructured":"Davila JA, Morgan RO, Shaib Y, McGlynn KA, El-Serag HB. Diabetes increases the risk of hepatocellular carcinoma in the United States: a population based case control study. Gut. 2005;54:533\u2013539.","journal-title":"Gut"},{"key":"4261_CR16","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1053\/j.gastro.2003.10.065","volume":"126","author":"HB El-serag","year":"2004","unstructured":"El-serag HB, Tran T, Everhart JE. Diabetes increases the risk of chronic liver disease and hepatocellular carcinoma. Gastroenterology. 2004;126:460\u2013468.","journal-title":"Gastroenterology"},{"key":"4261_CR17","doi-asserted-by":"publisher","first-page":"1822","DOI":"10.1053\/gast.2002.33650","volume":"122","author":"HB El-Serag","year":"2002","unstructured":"El-Serag HB, Everhart JE. Diabetes increases the risk of acute hepatic failure. Gastroenterology. 2002;122:1822\u20131828.","journal-title":"Gastroenterology"},{"key":"4261_CR18","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1002\/hep.27228","volume":"60","author":"L Elkrief","year":"2014","unstructured":"Elkrief L, Chouinard P, Bendersky N, et al. Diabetes mellitus is an independent prognostic factor for major liver-related outcomes in patients with cirrhosis and chronic hepatitis C. Hepatology. 2014;60:823\u2013831.","journal-title":"Hepatology"},{"key":"4261_CR19","unstructured":"CDC. Long-term Trends in Diabetes. CDC's Division of Diabetes Translation; 2014:1\u20136."},{"key":"4261_CR20","first-page":"1","volume":"63","author":"CDC","year":"2012","unstructured":"CDC. Deaths: final data for 2012. Natl Vital Stat Rep. 2012;63:1\u201385.","journal-title":"Natl Vital Stat Rep"},{"key":"4261_CR21","first-page":"1","volume-title":"Health Research Data for the Real World: The MarketScan \u00ae Databases","author":"LG Hansen","year":"2013","unstructured":"Hansen LG, Chang S. Health Research Data for the Real World: The MarketScan\n                           \u00ae \n                           Databases; 2013:1\u201348."},{"key":"4261_CR22","doi-asserted-by":"publisher","first-page":"e2","DOI":"10.1053\/j.gastro.2015.01.032","volume":"148","author":"ML Schmidt","year":"2015","unstructured":"Schmidt ML, Barritt AS, Orman ES, Hayashi PH. Decreasing mortality among patients hospitalized with cirrhosis in the United States from 2002 through 2010. Gastroenterology. 2015;148:e2.","journal-title":"Gastroenterology"},{"key":"4261_CR23","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1111\/j.1365-2036.2007.03572.x","volume":"27","author":"JR Kramer","year":"2008","unstructured":"Kramer JR, Davila JA, Miller ED, Richardson P, Giordano TP, El-Serag HB. The validity of viral hepatitis and chronic liver disease diagnoses in Veterans Affairs Administrative Databases. Aliment Pharmacol Ther. 2008;27:274\u2013282.","journal-title":"Aliment Pharmacol Ther"},{"key":"4261_CR24","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1002\/pds.2148","volume":"20","author":"VLR Iii","year":"2011","unstructured":"Iii VLR, Lim JK, Goetz MB, et al. Validity of diagnostic codes and liver-related laboratory abnormalities to identify hepatic decompensation events in the Veterans Aging Cohort Study. Pharmacoepidemiol Drug Saf. 2011;20:689\u2013699.","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"4261_CR25","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1016\/j.cgh.2013.08.025","volume":"12","author":"ES Orman","year":"2014","unstructured":"Orman ES, Hayashi PH, Bataller R, Barritt AS. Paracentesis is associated with reduced mortality in patients hospitalized with cirrhosis and ascites. Clin Gastroenterol Hepatol. 2014;12:e1.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"4261_CR26","doi-asserted-by":"publisher","first-page":"S35","DOI":"10.1053\/j.gastro.2004.09.014","volume":"127","author":"G Fattovich","year":"2004","unstructured":"Fattovich G, Stroffolini T, Zagni I, Donato F. Hepatocellular carcinoma in cirrhosis: incidence and risk factors. Gastroenterology. 2004;127:S35\u2013S50.","journal-title":"Gastroenterology"},{"key":"4261_CR27","doi-asserted-by":"publisher","first-page":"5442","DOI":"10.3748\/wjg.v20.i18.5442","volume":"20","author":"S Nusrat","year":"2014","unstructured":"Nusrat S, Khan MS, Fazili J, Madhoun MF. Cirrhosis and its complications: evidence based treatment. World J Gastroenterol. 2014;20:5442\u20135460.","journal-title":"World J Gastroenterol"},{"key":"4261_CR28","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1007\/s00134-005-2842-7","volume":"31","author":"D Cheyron du","year":"2005","unstructured":"du Cheyron D, Bouchet B, Parienti J-J, Ramakers M, Charbonneau P. The attributable mortality of acute renal failure in critically ill patients with liver cirrhosis. Intensive Care Med. 2005;31:1693\u20131699.","journal-title":"Intensive Care Med"},{"key":"4261_CR29","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1053\/jhep.2003.50084","volume":"37","author":"R Moreau","year":"2003","unstructured":"Moreau R, Lebrec D. Acute renal failure in patients with cirrhosis: perspectives in the age of MELD. Hepatology. 2003;37:233\u2013243.","journal-title":"Hepatology"},{"key":"4261_CR30","first-page":"1","volume-title":"Quality Rating System\u2014Measure Technical Specifications","author":"CMS","year":"2014","unstructured":"CMS. Quality Rating System\u2014Measure Technical Specifications; 2014:1\u2013175."},{"key":"4261_CR31","doi-asserted-by":"publisher","first-page":"2665","DOI":"10.2337\/dc12-0788","volume":"35","author":"S Suissa","year":"2012","unstructured":"Suissa S, Azoulay L. Metformin and the risk of cancer: time-related biases in observational studies. Diabetes Care. 2012;35:2665\u20132673.","journal-title":"Diabetes Care"},{"key":"4261_CR32","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1001\/archinte.167.9.921","volume":"167","author":"MA Bethel","year":"2007","unstructured":"Bethel MA, Sloan FA, Belsky D, Feinglos MN. Longitudinal incidence and prevalence of adverse outcomes of diabetes mellitus in elderly patients. Arch Intern Med. 2007;167:921\u2013927.","journal-title":"Arch Intern Med"},{"key":"4261_CR33","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1097\/MLR.0b013e31825f64d0","volume":"50","author":"MTA Sharabiani","year":"2012","unstructured":"Sharabiani MTA, Aylin P, Bottle A. Systematic review of comorbidity indices for administrative data. Med Care. 2012;50:1109\u20131118.","journal-title":"Med Care"},{"key":"4261_CR34","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1097\/01.mlr.0000118861.56848.ee","volume":"42","author":"DA Southern","year":"2004","unstructured":"Southern DA, Quan H, Ghali WA. Comparison of the Elixhauser and Charlson\/Deyo methods of comorbidity measurement in administrative data. Med Care. 2004;42:355\u2013360.","journal-title":"Med Care"},{"key":"4261_CR35","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1007\/s10620-010-1507-8","volume":"56","author":"BK Abu Dayyeh","year":"2011","unstructured":"Abu Dayyeh BK, Yang M, Dienstag JL, Chung RT. The effects of angiotensin blocking agents on the progression of liver fibrosis in the HALT-C trial cohort. Dig Dis Sci. 2011;56:564\u2013568.","journal-title":"Dig Dis Sci"},{"key":"4261_CR36","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.jhep.2010.03.013","volume":"53","author":"P Tandon","year":"2010","unstructured":"Tandon P, Abraldes JG, Berzigotti A, Garcia-Pagan JC, Bosch J. Renin-angiotensin-aldosterone inhibitors in the reduction of portal pressure: a systematic review and meta-analysis. J Hepatol. 2010;53:273\u2013282.","journal-title":"J Hepatol"},{"key":"4261_CR37","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1016\/j.jacc.2012.05.019","volume":"60","author":"K-L Wang","year":"2012","unstructured":"Wang K-L, Liu C-J, Chao T-F, et al. Statins, risk of diabetes, and implications on outcomes in the general population. J Am Coll Cardiol. 2012;60:1231\u20131238.","journal-title":"J Am Coll Cardiol"},{"key":"4261_CR38","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1038\/ajg.2010.475","volume":"106","author":"H-F Chiu","year":"2011","unstructured":"Chiu H-F, Ho S-C, Chen C-C, Yang C-Y. Statin use and the risk of liver cancer: a population-based case\u2013control study. Am J Gastroenterol. 2011;106:894\u2013898.","journal-title":"Am J Gastroenterol"},{"key":"4261_CR39","doi-asserted-by":"publisher","first-page":"1958","DOI":"10.1007\/s10620-014-3179-2","volume":"59","author":"S Kumar","year":"2014","unstructured":"Kumar S, Grace ND, Qamar AA. Statin use in patients with cirrhosis: a retrospective cohort study. Dig Dis Sci. 2014;59:1958\u20131965.","journal-title":"Dig Dis Sci"},{"key":"4261_CR40","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/j.jacc.2008.10.008","volume":"53","author":"JS Skyler","year":"2009","unstructured":"Skyler JS, Bergenstal R, Bonow RO, et al. Intensive Glycemic Control and the Prevention of Cardiovascular Events: implications of the ACCORD, ADVANCE, and VA Diabetes Trials. A position statement of the American Diabetes Association and a Scientific Statement of the American College of Cardiology. J Am Coll Cardiol. 2009;53:298\u2013304.","journal-title":"J Am Coll Cardiol"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-016-4261-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10620-016-4261-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-016-4261-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,17]],"date-time":"2020-02-17T19:36:19Z","timestamp":1581968179000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10620-016-4261-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,1]]},"references-count":40,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["4261"],"URL":"https:\/\/doi.org\/10.1007\/s10620-016-4261-8","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,1]]},"assertion":[{"value":"30 December 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 July 2016","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 August 2016","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}