{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T08:25:00Z","timestamp":1782289500628,"version":"3.54.5"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2017,7,17]],"date-time":"2017-07-17T00:00:00Z","timestamp":1500249600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1007\/s10620-017-4672-1","type":"journal-article","created":{"date-parts":[[2017,7,17]],"date-time":"2017-07-17T04:26:00Z","timestamp":1500265560000},"page":"2433-2439","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Application of the Biopsy-Sparing ESPGHAN Guidelines for Celiac Disease Diagnosis in Adults: A Real-Life Study"],"prefix":"10.1007","volume":"62","author":[{"given":"Konstantinos","family":"Efthymakis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariaelena","family":"Serio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Milano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Laterza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Bonitatibus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Di Nicola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Neri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,7,17]]},"reference":[{"key":"4672_CR1","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1111\/j.1365-2036.2008.03609.x","volume":"27","author":"PG Hill","year":"2008","unstructured":"Hill PG, Holmes GK. Coeliac disease: a biopsy is not always necessary for diagnosis. Aliment Pharmacol Ther. 2008;27:572\u2013577. doi:\n                        10.1111\/j.1365-2036.2008.03609.x\n                        \n                    .","journal-title":"Aliment Pharmacol Ther"},{"key":"4672_CR2","doi-asserted-by":"crossref","first-page":"4775","DOI":"10.3748\/wjg.15.4775","volume":"15","author":"S Vivas","year":"2009","unstructured":"Vivas S, Ruiz de Morales JG, Riestra S, et al. Duodenal biopsy may be avoided when high transglutaminase antibody titers are present. World J Gastroenterol. 2009;15:4775\u20134780.","journal-title":"World J Gastroenterol"},{"key":"4672_CR3","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1097\/MPG.0b013e3181a81384","volume":"50","author":"I Dahlbom","year":"2010","unstructured":"Dahlbom I, Korponay-Szab\u00f3 IR, Kov\u00e1cs JB, Szalai Z, M\u00e4ki M, Hansson T. Prediction of clinical and mucosal severity of coeliac disease and dermatitis herpetiformis by quantification of IgA\/IgG serum antibodies to tissue transglutaminase. J Pediatr Gastroenterol Nutr. 2010;50:140\u2013146. doi:\n                        10.1097\/MPG.0b013e3181a81384\n                        \n                    .","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"4672_CR4","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1097\/MPG.0b013e3181ef8e50","volume":"52","author":"A Mubarak","year":"2011","unstructured":"Mubarak A, Wolters VM, Gerritsen SA, Gmelig-Meyling FH, Ten Kate FJ, Houwen RH. A biopsy is not always necessary to diagnose celiac disease. J Pediatr Gastroenterol Nutr. 2011;52:554\u2013557. doi:\n                        10.1097\/MPG.0b013e3181ef8e50\n                        \n                    .","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"4672_CR5","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1097\/MCG.0b013e31802e70b1","volume":"42","author":"MR Donaldson","year":"2008","unstructured":"Donaldson MR, Book LS, Leiferman KM, Zone JJ, Neuhausen SL. Strongly positive tissue transglutaminase antibodies are associated with Marsh 3 histopathology in adult and pediatric celiac disease. J Clin Gastroenterol. 2008;42:256\u2013260. doi:\n                        10.1097\/MCG.0b013e31802e70b1\n                        \n                    .","journal-title":"J Clin Gastroenterol"},{"key":"4672_CR6","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1097\/MPG.0b013e31821a23d0","volume":"54","author":"S Husby","year":"2012","unstructured":"Husby S, Koletzko S, Korponay-Szab\u00f3 IR, et al. European society for pediatric gastroenterology, hepatology, and nutrition guidelines for the diagnosis of coeliac disease. J Pediatr Gastroenterol Nutr. 2012;54:136\u2013160. doi:\n                        10.1097\/MPG.0b013e31821a23d0\n                        \n                    .","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"4672_CR7","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.dld.2011.10.013","volume":"44","author":"B Zanini","year":"2012","unstructured":"Zanini B, Magni A, Caselani F, et al. High tissue-transglutaminase antibody level predicts small intestinal villous atrophy in adult patients at high risk of celiac disease. Dig Liver Dis. 2012;44:280\u2013285. doi:\n                        10.1016\/j.dld.2011.10.013\n                        \n                    .","journal-title":"Dig Liver Dis"},{"key":"4672_CR8","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1038\/ajg.2015.242","volume":"110","author":"E Sugai","year":"2015","unstructured":"Sugai E, Hwang HJ, V\u00e1zquez H, et al. Should ESPGHAN guidelines for serologic diagnosis of celiac disease be used in adults? A prospective analysis in an adult patient cohort with high pretest probability. Am J Gastroenterol. 2015;110:1504\u20131505.","journal-title":"Am J Gastroenterol"},{"key":"4672_CR9","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1111\/apt.12970","volume":"40","author":"R Tortora","year":"2014","unstructured":"Tortora R, Imperatore N, Capone P, et al. The presence of anti-endomysial antibodies and the level of anti-tissue transglutaminases can be used to diagnose adult coeliac disease without duodenal biopsy. Aliment Pharmacol Ther. 2014;40:1223\u20131229. doi:\n                        10.1111\/apt.12970\n                        \n                    .","journal-title":"Aliment Pharmacol Ther"},{"key":"4672_CR10","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1007\/s00535-016-1188-y","volume":"51","author":"M Tola Di","year":"2016","unstructured":"Di Tola M, Marino M, Goetze S, et al. Identification of a serum transglutaminase threshold value for the noninvasive diagnosis of symptomatic adult celiac disease patients: a retrospective study. J Gastroenterol. 2016;51:1031\u20131039.","journal-title":"J Gastroenterol"},{"key":"4672_CR11","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1097\/MPG.0b013e31826531f6","volume":"55","author":"W Egner","year":"2012","unstructured":"Egner W, Shrimpton A, Sargur R, Patel D, Swallow K. ESPGHAN guidance on coeliac disease 2012: multiples of ULN for decision making do not harmonise assay performance across centres. J Pediatr Gastroenterol Nutr. 2012;55:733\u2013735. doi:\n                        10.1097\/MPG.0b013e31826531f6\n                        \n                    .","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"4672_CR12","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1111\/cei.12249","volume":"176","author":"L Beltran","year":"2014","unstructured":"Beltran L, Koenig M, Egner W, et al. High-titre circulating tissue transglutaminase-2 antibodies predict small bowel villous atrophy, but decision cut-off limits must be locally validated. Clin Exp Immunol. 2014;176:190\u2013198. doi:\n                        10.1111\/cei.12249\n                        \n                    .","journal-title":"Clin Exp Immunol"},{"key":"4672_CR13","doi-asserted-by":"publisher","first-page":"e0146276","DOI":"10.1371\/journal.pone.0146276","volume":"11","author":"V Pascual","year":"2016","unstructured":"Pascual V, Medrano LM, L\u00f3pez-Palacios N, et al. Different gene expression signatures in children and adults with celiac disease. PLoS ONE. 2016;11:e0146276. doi:\n                        10.1371\/journal.pone.0146276\n                        \n                    .","journal-title":"PLoS ONE"},{"key":"4672_CR14","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1097\/MPG.0b013e3182716861","volume":"56","author":"Z Mi\u0161ak","year":"2013","unstructured":"Mi\u0161ak Z, Hojsak I, Jadre\u0161in O, Kekez AJ, Abdovi\u0107 S, Kola\u010dek S. Diagnosis of coeliac disease in children younger than 2 years. J Pediatr Gastroenterol Nutr. 2013;56:201\u2013205. doi:\n                        10.1097\/MPG.0b013e3182716861\n                        \n                    .","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"4672_CR15","doi-asserted-by":"publisher","first-page":"2360","DOI":"10.1111\/j.1572-0241.2008.01977.x","volume":"103","author":"S Vivas","year":"2008","unstructured":"Vivas S, Ruiz de Morales JM, Fernandez M, et al. Age-related clinical, serological, and histopathological features of celiac disease. Am J Gastroenterol. 2008;103:2360\u20132365. doi:\n                        10.1111\/j.1572-0241.2008.01977.x\n                        \n                    . (quiz 2366).","journal-title":"Am J Gastroenterol"},{"key":"4672_CR16","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1097\/MPG.0b013e31817d80f4","volume":"47","author":"C Lagerqvist","year":"2008","unstructured":"Lagerqvist C, Dahlbom I, Hansson T, et al. Antigliadin immunoglobulin A best in finding celiac disease in children younger than 18\u00a0months of age. J Pediatr Gastroenterol Nutr. 2008;47:428\u2013435. doi:\n                        10.1097\/MPG.0b013e31817d80f4\n                        \n                    .","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"4672_CR17","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1111\/j.1651-2227.2010.01740.x","volume":"99","author":"E Savilahti","year":"2010","unstructured":"Savilahti E, Kolho KL, Westerholm-Ormio M, Verkasalo M. Clinics of coeliac disease in children in the 2000s. Acta Paediatr. 2010;99:1026\u20131030. doi:\n                        10.1111\/j.1651-2227.2010.01740.x\n                        \n                    .","journal-title":"Acta Paediatr"},{"key":"4672_CR18","doi-asserted-by":"crossref","first-page":"238","DOI":"10.4321\/S1130-01082011000700003","volume":"103","author":"L Rodrigo-S\u00e1ez","year":"2011","unstructured":"Rodrigo-S\u00e1ez L, Fuentes-\u00c1lvarez D, P\u00e9rez-Mart\u00ednez I, et al. Differences between pediatric and adult celiac disease. Rev Esp Enferm Dig. 2011;103:238\u2013244.","journal-title":"Rev Esp Enferm Dig"},{"key":"4672_CR19","doi-asserted-by":"publisher","first-page":"121","DOI":"10.14309\/crj.2015.25","volume":"2","author":"N Rawal","year":"2015","unstructured":"Rawal N, Twaddell W, Fasano A, Blanchard S, Safta A. Remission of refractory celiac disease with infliximab in a pediatric patient. ACG Case Rep J. 2015;2:121\u2013123. doi:\n                        10.14309\/crj.2015.25\n                        \n                    .","journal-title":"ACG Case Rep J"},{"key":"4672_CR20","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1016\/j.clnu.2015.04.014","volume":"35","author":"NJ Wierdsma","year":"2016","unstructured":"Wierdsma NJ, Nijeboer P, de van der Schueren MA, Berkenpas M, van Bodegraven AA, Mulder CJ. Refractory celiac disease and EATL patients show severe malnutrition and malabsorption at diagnosis. Clin Nutr. 2016;35:685\u2013691. doi:\n                        10.1016\/j.clnu.2015.04.014\n                        \n                    .","journal-title":"Clin Nutr"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10620-017-4672-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-017-4672-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-017-4672-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,8,16]],"date-time":"2017-08-16T11:57:49Z","timestamp":1502884669000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10620-017-4672-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,17]]},"references-count":20,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["4672"],"URL":"https:\/\/doi.org\/10.1007\/s10620-017-4672-1","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,17]]}}}