{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:21:31Z","timestamp":1792099291495,"version":"4.4.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1007\/s10620-017-4827-0","type":"journal-article","created":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T10:20:18Z","timestamp":1509531618000},"page":"403-410","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Proton Pump Inhibitors Independently Protect Against Early Allograft Injury or Chronic Rejection After Lung Transplantation"],"prefix":"10.1007","volume":"63","author":[{"given":"Wai-Kit","family":"Lo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilary J.","family":"Goldberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Boukedes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Burakoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter W.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,11,1]]},"reference":[{"key":"4827_CR1","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/j.healun.2014.08.004","volume":"33","author":"RD Yusen","year":"2014","unstructured":"Yusen RD, Edwards LB, Kucheryavya AY, et al. The registry of the international society for heart and lung transplantation: thirty-first adult lung and heart-lung transplant report\u20142014; focus theme: retransplantation. J Heart Lung Transplant. 2014;33:1009\u20131024.","journal-title":"J Heart Lung Transplant"},{"key":"4827_CR2","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1034\/j.1399-0012.2003.00060.x","volume":"17","author":"D Hadjiliadis","year":"2003","unstructured":"Hadjiliadis D, Davis RD, Steele MP, et al. Gastroesophageal reflux disease in lung transplant recipients. Clin Transplant. 2003;17:363\u2013368.","journal-title":"Clin Transplant"},{"key":"4827_CR3","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1378\/chest.124.5.1689","volume":"124","author":"LR Young","year":"2003","unstructured":"Young LR, Hadjiliadis D, Davis RD, Palmer SM. Lung transplantation exacerbates gastroesophageal reflux disease. Chest. 2003;124:1689\u20131693.","journal-title":"Chest"},{"key":"4827_CR4","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1183\/09031936.00064807","volume":"31","author":"K Blondeau","year":"2008","unstructured":"Blondeau K, Mertens V, Vanaudenaerde BA, et al. Gastro-oesophageal reflux and gastric aspiration in lung transplant patients with or without chronic rejection. Eur Respir J. 2008;31:707\u2013713.","journal-title":"Eur Respir J"},{"key":"4827_CR5","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1378\/chest.118.4.1214","volume":"118","author":"SM Palmer","year":"2000","unstructured":"Palmer SM, Miralles AP, Howell DN, Brazer SR, Tapson VF, Davis RD. Gastroesophageal reflux as a reversible cause of allograft dysfunction after lung transplantation. Chest. 2000;118:1214\u20131217.","journal-title":"Chest"},{"key":"4827_CR6","doi-asserted-by":"crossref","first-page":"e101","DOI":"10.1016\/j.jss.2013.06.011","volume":"185","author":"CS Davis","year":"2013","unstructured":"Davis CS, Mendez BM, Flint DV, et al. Pepsin concentrations are elevated in the bronchioalveolar lavage fluid of patients with idiopathic pulmonary fibrosis after lung transplantation. J Surg Res. 2013;185:e101\u2013e108.","journal-title":"J Surg Res"},{"key":"4827_CR7","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.jtcvs.2005.06.054","volume":"131","author":"MG Hartwig","year":"2006","unstructured":"Hartwig MG, Appel JZ, Li B, et al. Chronic aspiration of gastric fluid accelerates pulmonary allograft dysfunction in a rat model of lung transplantation. J Thorac Cardiovasc Surg. 2006;131:209\u2013217.","journal-title":"J Thorac Cardiovasc Surg"},{"key":"4827_CR8","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.jamcollsurg.2013.03.008","volume":"217","author":"PM Fisichella","year":"2013","unstructured":"Fisichella PM, Davis CS, Lowery E, Ramirez L, Gamelli RL, Kovacs EJ. Aspiration, localized pulmonary inflammation, and predictors of early-onset bronchiolitis obliterans syndrome after lung transplantation. J Am Coll Surg. 2013;217:90\u2013100.","journal-title":"J Am Coll Surg"},{"key":"4827_CR9","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.healun.2014.09.005","volume":"34","author":"W-K Lo","year":"2015","unstructured":"Lo W-K, Burakoff R, Goldberg H, Feldman N, Chan WW. Pre-transplant impedance measures of reflux are associated with early allograft injury after lung transplantation. J Heart Lung Transpl. 2015;34:26\u201335.","journal-title":"J Heart Lung Transpl"},{"key":"4827_CR10","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1513\/pats.200808-080GO","volume":"6","author":"T Martinu","year":"2009","unstructured":"Martinu T, Chen D-F, Palmer SM. Acute rejection and humoral sensitization in lung transplant recipients. Proc Am Thorac Soc. 2009;6:54\u201365.","journal-title":"Proc Am Thorac Soc"},{"key":"4827_CR11","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1164\/rccm.200706-951OC","volume":"177","author":"AR Glanville","year":"2008","unstructured":"Glanville AR, Aboyoun CL, Havryk A, Plit M, Rainer S, Malouf MA. Severity of lymphocytic bronchiolitis predicts long-term outcome after lung transplantation. Am J Respir Crit Care Med. 2008;177:1033\u20131040.","journal-title":"Am J Respir Crit Care Med"},{"key":"4827_CR12","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1016\/j.athoracsur.2004.04.044","volume":"78","author":"E Cantu","year":"2004","unstructured":"Cantu E, Appel JZ, Hartwig MG, et al. Early fundoplication prevents chronic allograft dysfunction in patients with gastroesophageal reflux disease. Ann Thorac Surg. 2004;78:1142\u20131151.","journal-title":"Ann Thorac Surg"},{"key":"4827_CR13","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s11605-015-2983-0","volume":"20","author":"W-K Lo","year":"2016","unstructured":"Lo W-K, Goldberg HJ, Wee J, Fisichella PM, Chan WW. Both pre-transplant and early post-transplant anti-reflux surgery prevent development of early allograft injury after lung transplantation. J Gastrointest Surg. 2016;20:111\u2013118.","journal-title":"J Gastrointest Surg"},{"key":"4827_CR14","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1001\/archsurg.2011.216","volume":"146","author":"T Hoppo","year":"2011","unstructured":"Hoppo T, Jarido V, Pannathur A, et al. Antireflux surgery preserves lung function in patients with gastroesophageal reflux disease and end-stage lung disease before and after lung transplantation. Arch Surg. 2011;146:1041\u20131047.","journal-title":"Arch Surg"},{"key":"4827_CR15","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1067\/mtc.2003.166","volume":"125","author":"RD Davis","year":"2003","unstructured":"Davis RD, Lau CL, Eubanks S, et al. Improved lung allograft function after fundoplication in patients with gastroesophageal reflux disease undergoing lung transplantation. J Thorac Cardiovasc Surg. 2003;125:533\u2013542.","journal-title":"J Thorac Cardiovasc Surg"},{"key":"4827_CR16","doi-asserted-by":"crossref","first-page":"e65","DOI":"10.1016\/j.jss.2012.03.066","volume":"177","author":"PM Fisichella","year":"2012","unstructured":"Fisichella PM, Davis CS, Lowery E, et al. Pulmonary immune changes early after laparoscopic antireflux surgery in lung transplant patients with gastroesophageal reflux disease. J Surg Res. 2012;177:e65\u2013e73.","journal-title":"J Surg Res"},{"key":"4827_CR17","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.surg.2011.07.053","volume":"150","author":"PM Fisichella","year":"2011","unstructured":"Fisichella PM, Davis CS, Lundberg PW, et al. The protective role of laparoscopic antireflux surgery against aspiration of pepsin after lung transplantation. Surgery. 2011;150:598\u2013606.","journal-title":"Surgery"},{"key":"4827_CR18","doi-asserted-by":"crossref","first-page":"4067","DOI":"10.3748\/wjg.v11.i26.4067","volume":"11","author":"W-H Wang","year":"2005","unstructured":"Wang W-H, Huang J-Q, Zheng G-F, et al. Head-to-head comparison of H2-receptor antagonists and proton pump inhibitors in the treatment of erosive esophagitis: a meta-analysis. World J Gastroenterol. 2005;11:4067\u20134077.","journal-title":"World J Gastroenterol"},{"key":"4827_CR19","doi-asserted-by":"publisher","first-page":"e0131558","DOI":"10.1371\/journal.pone.0131558","volume":"10","author":"C Mo","year":"2015","unstructured":"Mo C, Sun G, Wang YZ, Lu ML, Yang YS. PPI versus histamine H2 receptor antagonists for prevention of upper gastrointestinal injury associated with low-dose aspirin: systematic review and meta-analysis. PLoS ONE. 2015;10:e0131558. \n                        https:\/\/doi.org\/10.1371\/journal.pone.0131558\n                        \n                    .","journal-title":"PLoS ONE"},{"key":"4827_CR20","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1097\/CCM.0b013e3182758734","volume":"41","author":"W Alhazzani","year":"2013","unstructured":"Alhazzani W, Alenezi F, Jaeschke RZ, Moayyedi P, Cook DJ. Proton pump inhibitors versus histamine 2 receptor antagonists for stress ulcer prophylaxis in critically ill patients: a systematic review and meta-analysis. Crit Care Med. 2013;41:693\u2013705.","journal-title":"Crit Care Med"},{"key":"4827_CR21","first-page":"CD002095","volume":"11","author":"B Pinxteren van","year":"2010","unstructured":"van Pinxteren B, Sigterman KE, Bonis P, Lau J, Numans ME. Short-term treatment with proton pump inhibitors, H2-receptor antagonists and prokinetics for gastro-oesophageal reflux disease-like symptoms and endoscopy negative reflux disease. Cochrane Database Syst Rev. 2010;11:CD002095.","journal-title":"Cochrane Database Syst Rev"},{"key":"4827_CR22","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1111\/j.1365-2044.2008.05861.x","volume":"64","author":"K Clark","year":"2009","unstructured":"Clark K, Lam LT, Gibson S, Currow D. The effect of ranitidine versus proton pump inhibitors on gastric secretions: a meta-analysis of randomised control trials. Anaesthesia. 2009;64:652\u2013657.","journal-title":"Anaesthesia"},{"key":"4827_CR23","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.phrs.2012.01.005","volume":"65","author":"I Puig","year":"2012","unstructured":"Puig I, Calzado S, Suarez D, Sanchez-Delgado J, Lopez S, Calvet X. Meta-analysis: comparative efficacy of H2-receptor antagonists and proton pump inhibitors for reducing aspiration risk during anaesthesia depending on the administration route and schedule. Pharmacol Res. 2012;65:480\u2013490.","journal-title":"Pharmacol Res"},{"key":"4827_CR24","doi-asserted-by":"publisher","first-page":"2312","DOI":"10.1007\/s10620-009-0951-9","volume":"54","author":"RR Kedika","year":"2009","unstructured":"Kedika RR, Souza RF, Spechler SJ. Potential anti-inflammatory effects of proton pump inhibitors: a review and discussion of the clinical implications. Dig Dis Sci. 2009;54:2312\u20132317. \n                        https:\/\/doi.org\/10.1007\/s10620-009-0951-9\n                        \n                    .","journal-title":"Dig Dis Sci"},{"key":"4827_CR25","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1186\/s12967-015-0614-x","volume":"1","author":"YT Ghebremariam","year":"2015","unstructured":"Ghebremariam YT, Cooke JP, Gerhart W, et al. Pleiotropic effect of the proton pump inhibitor esomeprazole leading to suppression of lung inflammation and fibrosis. J Transl Med. 2015;1:249.","journal-title":"J Transl Med"},{"key":"4827_CR26","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1164\/rccm.201512-2316PP","volume":"193","author":"YT Ghebre","year":"2016","unstructured":"Ghebre YT, Raghu G. Idiopathic Pulmonary fibrosis: novel concepts of proton pump inhibitors as antifibrotic drugs. Am J Respir Crit Care Med. 2016;193:1345\u20131352.","journal-title":"Am J Respir Crit Care Med"},{"key":"4827_CR27","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1111\/j.1365-2036.2012.05201.x","volume":"36","author":"MW Hess","year":"2012","unstructured":"Hess MW, Hoenderop JG, Bindels RJ, Drenth JP. Systematic review: hypomagnesaemia induced by proton pump inhibition. Aliment Pharmacol Ther. 2012;36:405\u2013413.","journal-title":"Aliment Pharmacol Ther"},{"key":"4827_CR28","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.amjmed.2011.01.007","volume":"124","author":"EW Yu","year":"2011","unstructured":"Yu EW, Bauer SR, Bain PA, Bauer DC. Proton pump inhibitors and risk of fractures: a meta-analysis of 11 international studies. Am J Med. 2011;124:519\u2013526.","journal-title":"Am J Med"},{"key":"4827_CR29","doi-asserted-by":"crossref","first-page":"e372","DOI":"10.1136\/bmj.e372","volume":"344","author":"H Khalili","year":"2012","unstructured":"Khalili H, Huang ES, Jacobson BC, Camargo CA Jr, Feskanich D, Chan AT. Use of proton pump inhibitors and risk of hip fracture in relation to dietary and lifestyle factors: a prospective cohort study. BMJ. 2012;344:e372.","journal-title":"BMJ"},{"key":"4827_CR30","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1038\/ajg.2012.179","volume":"107","author":"S Janarthanan","year":"2012","unstructured":"Janarthanan S, Ditah I, Adler DG, Ehrinpreis MN. Clostridium difficile-associated diarrhea and proton pump inhibitor therapy: a meta-analysis. Am J Gastroenterol. 2012;107:1001\u20131010.","journal-title":"Am J Gastroenterol"},{"key":"4827_CR31","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.cgh.2012.12.011","volume":"11","author":"WK Lo","year":"2013","unstructured":"Lo WK, Chan WW. Proton pump inhibitor use and the risk of small intestinal bacterial overgrowth: a meta-analysis. Clin Gastroenterol Hepatol. 2013;11:483\u2013490.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"4827_CR32","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1111\/nmo.12627","volume":"27","author":"S Gavini","year":"2015","unstructured":"Gavini S, Finn RT, Lo WK, et al. Idiopathic pulmonary fibrosis is associated with increased impedance measures of reflux compared to non-fibrotic disease among pre-lung transplant patients. Neurogastroenterol Motil. 2015;27:1326\u20131332.","journal-title":"Neurogastroenterol Motil"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10620-017-4827-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-017-4827-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-017-4827-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,2,2]],"date-time":"2018-02-02T16:28:37Z","timestamp":1517588917000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10620-017-4827-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,1]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["4827"],"URL":"https:\/\/doi.org\/10.1007\/s10620-017-4827-0","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,1]]}}}