{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:48:47Z","timestamp":1791899327101,"version":"4.3.4"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,11,10]],"date-time":"2017-11-10T00:00:00Z","timestamp":1510272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2017,11,10]],"date-time":"2017-11-10T00:00:00Z","timestamp":1510272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"crossref","award":["R01AG034676"],"award-info":[{"award-number":["R01AG034676"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIH R01-DK57892"],"award-info":[{"award-number":["NIH R01-DK57892"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1007\/s10620-017-4835-0","type":"journal-article","created":{"date-parts":[[2017,11,10]],"date-time":"2017-11-10T09:34:13Z","timestamp":1510306453000},"page":"184-192","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Gender-Based Differences in a Population-Based Cohort with Celiac Disease: More Alike than Unalike"],"prefix":"10.1007","volume":"63","author":[{"given":"Claire L.","family":"Jansson-Knodell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine S.","family":"King","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph J.","family":"Larson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol T.","family":"Van Dyke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph A.","family":"Murray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Rubio-Tapia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,11,10]]},"reference":[{"key":"4835_CR1","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1136\/gutjnl-2011-301346","volume":"62","author":"JF Ludvigsson","year":"2013","unstructured":"Ludvigsson JF, Leffler DA, Bai J, et al. The Oslo definitions for coeliac disease and related terms. Gut. 2013;62:43\u201352.","journal-title":"Gut"},{"key":"4835_CR2","doi-asserted-by":"publisher","first-page":"1538","DOI":"10.1038\/ajg.2012.219","volume":"107","author":"A Rubio-Tapia","year":"2012","unstructured":"Rubio-Tapia A, Ludvigsson JF, Brantner TL, et al. The prevalence of celiac disease in the United States. Am J Gastroenterol. 2012;107:1538\u20131544.","journal-title":"Am J Gastroenterol"},{"key":"4835_CR3","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1155\/2006\/470273","volume":"20","author":"MJ Llorente-Alonso","year":"2006","unstructured":"Llorente-Alonso MJ, Fern\u00e1ndez-Acenero MJ, Sebasti\u00e1n M. Gluten intolerance: sex and age-related features. Can J Gastroenterol. 2006;20:719\u2013722.","journal-title":"Can J Gastroenterol"},{"key":"4835_CR4","doi-asserted-by":"publisher","first-page":"6036","DOI":"10.3748\/wjg.v18.i42.6036","volume":"18","author":"N Gujral","year":"2012","unstructured":"Gujral N, Freeman HJ, Thomson AB. Celiac disease: Prevalence, diagnosis, pathogenesis and treatment. World J Gastroenterol. 2012;18:6036\u20136059.","journal-title":"World J Gastroenterol"},{"key":"4835_CR5","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1046\/j.1365-2796.1999.00403.x","volume":"245","author":"A Ivarsson","year":"1999","unstructured":"Ivarsson A, Persson LA, Juto P, et al. High prevalence of undiagnosed coeliac disease in adults: a Swedish population-based study. J Intern Med. 1999;245:63\u201368.","journal-title":"J Intern Med"},{"key":"4835_CR6","doi-asserted-by":"publisher","first-page":"2700","DOI":"10.1111\/j.1572-0241.2001.04124.x","volume":"96","author":"JC Gomez","year":"2001","unstructured":"Gomez JC, Selvaggio GS, Viola M, et al. Prevalence of celiac disease in Argentina: screening of an adult population in the La Plata area. Am J Gastroenterol. 2001;96:2700\u20132704.","journal-title":"Am J Gastroenterol"},{"key":"4835_CR7","first-page":"43","volume":"132","author":"R Rutz","year":"2002","unstructured":"Rutz R, Ritzler E, Fierz W, et al. Prevalence of asymptomatic celiac disease in adolescents of eastern Switzerland. Swiss Med Wkly. 2002;132:43\u201347.","journal-title":"Swiss Med Wkly"},{"key":"4835_CR8","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.bone.2015.03.005","volume":"76","author":"MB Zanchetta","year":"2015","unstructured":"Zanchetta MB, Costa F, Longobardi G, et al. Significant bone microarchitecture impairment in premenopausal women with active celiac disease. Bone. 2015;76:149\u2013157.","journal-title":"Bone"},{"key":"4835_CR9","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1097\/MCG.0000000000000285","volume":"50","author":"P Singh","year":"2016","unstructured":"Singh P, Arora S, Lal S, et al. Celiac disease in women with infertility: a meta-analysis. J Clin Gastroenterol. 2016;50:33\u201339.","journal-title":"J Clin Gastroenterol"},{"key":"4835_CR10","first-page":"132","volume":"5","author":"M Cojocaru","year":"2010","unstructured":"Cojocaru M, Cojocaru I, Silosi I. Multiple autoimmune syndrome. Maedica. 2010;5:132\u2013134.","journal-title":"Maedica"},{"key":"4835_CR11","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1046\/j.1471-6712.2003.00228.x","volume":"17","author":"C Hallert","year":"2003","unstructured":"Hallert C, Sandlund O, Broqvist M. Perceptions of health-related quality of life of men and women living with coeliac disease. Scand J Caring Sci. 2003;17:301\u2013307.","journal-title":"Scand J Caring Sci"},{"key":"4835_CR12","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1080\/00365520510011498","volume":"40","author":"D Bai","year":"2005","unstructured":"Bai D, Brar P, Holleran S, et al. Effect of gender on the manifestations of celiac disease: evidence for greater malabsorption in men. Scand J Gastroenterol. 2005;40:183\u2013187.","journal-title":"Scand J Gastroenterol"},{"key":"4835_CR13","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.3109\/00365529509101610","volume":"30","author":"C Ciacci","year":"1995","unstructured":"Ciacci C, Cirillo M, Sollazzo R, et al. Gender and clinical presentation in adult celiac disease. Scand J Gastroenterol. 1995;30:1077\u20131081.","journal-title":"Scand J Gastroenterol"},{"issue":"Suppl 2","key":"4835_CR14","first-page":"38","volume":"152","author":"A Rubio-Tapia","year":"2016","unstructured":"Rubio-Tapia A, Jansson-Knodell CL, Rahim MW, et al. Influence of gender on the clinical presentation and associated diseases in adults with celiac disease. Gac Med Mex. 2016;152(Suppl 2):38\u201346. (Spanish).","journal-title":"Gac Med Mex"},{"key":"4835_CR15","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1080\/00365520410008169","volume":"40","author":"MT Bardella","year":"2005","unstructured":"Bardella MT, Fredella C, Saladino V, et al. Gluten intolerance: gender- and age-related differences in symptoms. Scand J Gastroenterol. 2005;40:15\u201319.","journal-title":"Scand J Gastroenterol"},{"key":"4835_CR16","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1053\/jcgh.2003.50004","volume":"1","author":"JA Murray","year":"2003","unstructured":"Murray JA, Van Dyke C, Plevak MF, et al. Trends in the identification and clinical features of celiac disease in a North American community, 1950-2001. Clin Gastroenterol Hepatol. 2003;1:19\u201327.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"4835_CR17","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1038\/ajg.2013.60","volume":"108","author":"JF Ludvigsson","year":"2013","unstructured":"Ludvigsson JF, Rubio-Tapia A, Van Dyke C, et al. Increasing incidence of celiac disease in a North American population. Am J Gastroenterol. 2013;108:818\u2013824.","journal-title":"Am J Gastroenterol"},{"key":"4835_CR18","doi-asserted-by":"publisher","first-page":"266","DOI":"10.4065\/71.3.266","volume":"71","author":"LJ Melton III","year":"1996","unstructured":"Melton LJ III. History of the Rochester epidemiology project. Mayo Clin Proc. 1996;71:266\u2013274.","journal-title":"Mayo Clin Proc"},{"key":"4835_CR19","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1016\/0016-5085(92)91819-P","volume":"102","author":"MN Marsh","year":"1992","unstructured":"Marsh MN. Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity (\u2018celiac sprue\u2019). Gastroenterology. 1992;102:330\u2013354.","journal-title":"Gastroenterology"},{"key":"4835_CR20","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1016\/S0753-3322(01)80003-2","volume":"54","author":"G Oberhuber","year":"2000","unstructured":"Oberhuber G. Histopathology of celiac disease. Biomed Pharmacother. 2000;54:368\u2013372.","journal-title":"Biomed Pharmacother"},{"key":"4835_CR21","volume-title":"Statistical methods for rates and proportions","author":"JL Fleiss","year":"1981","unstructured":"Fleiss JL. Statistical methods for rates and proportions. 2nd ed. New York, NY: Wiley; 1981.","edition":"2"},{"key":"4835_CR22","volume-title":"Practical statistics for medical research","author":"DG Altman","year":"1991","unstructured":"Altman DG. Practical statistics for medical research. London, England: Chapman and Hall; 1991."},{"key":"4835_CR23","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.2517-6161.1972.tb00899.x","volume":"34","author":"DR Cox","year":"1972","unstructured":"Cox DR. Regression models and life-tables. J R Stat Soc Ser B (Methodological). 1972;34:187\u2013220.","journal-title":"J R Stat Soc Ser B (Methodological)"},{"key":"4835_CR24","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1080\/01621459.1958.10501452","volume":"53","author":"EL Kaplan","year":"1958","unstructured":"Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc. 1958;53:457\u2013481.","journal-title":"J Am Stat Assoc"},{"key":"4835_CR25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12876-014-0194-x","volume":"14","author":"U Volta","year":"2014","unstructured":"Volta U, Caio G, Stanghellini V, et al. The changing clinical profile of celiac disease: a 15-year experience (1998\u20132012) in an Italian referral center. BMC Gastroenterol. 2014;14:1\u20138.","journal-title":"BMC Gastroenterol"},{"key":"4835_CR26","doi-asserted-by":"publisher","first-page":"S-444","DOI":"10.1053\/j.gastro.2010.09.039","volume":"140","author":"HJ Hwang","year":"2011","unstructured":"Hwang HJ, Facio L, Iantorno G, et al. Increased prevalence of celiac disease and positive markers of gluten sensitivity in patients with chronic constipation. Gastroeneterology. 2011;140:S-444.","journal-title":"Gastroeneterology"},{"key":"4835_CR27","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1590\/s0004-2803.201700000-22","volume":"54","author":"N Sadjadei","year":"2017","unstructured":"Sadjadei N, Hosseinmardy S, Hakimzadeh M, et al. Anti-TTG among children with chronic functional constipation unresponsive to 6\u00a0weeks of treatment of constipation. Arq Gastroenterol. 2017;54:197\u2013200.","journal-title":"Arq Gastroenterol"},{"key":"4835_CR28","first-page":"173","volume":"88","author":"RA Pelleboer","year":"2012","unstructured":"Pelleboer RA, Janssen RL, Deckers-Kocken JM, et al. Celiac disease is overrepresented in patients with constipation. J Pediatr (Rio J). 2012;88:173\u2013176.","journal-title":"J Pediatr (Rio J)"},{"key":"4835_CR29","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1111\/j.1572-0241.2001.03462.x","volume":"96","author":"PHR Green","year":"2001","unstructured":"Green PHR, Stavropoulos SN, Panagi SG, et al. Characteristics of adult celiac disease in the USA: results of a national survey. Am J Gastroenterol. 2001;96:126\u2013131.","journal-title":"Am J Gastroenterol"},{"key":"4835_CR30","first-page":"843","volume":"89","author":"NJ Talley","year":"1994","unstructured":"Talley NJ, Valdovinos M, Petterson TM, et al. Epidemiology of celiac sprue: a community-based study. Am J Gastroenterol. 1994;89:843\u2013846.","journal-title":"Am J Gastroenterol"},{"key":"4835_CR31","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1016\/j.cgh.2013.02.009","volume":"11","author":"JA Murray","year":"2013","unstructured":"Murray JA, McLachlan S, Adams PC, et al. Association between celiac disease and iron deficiency in Caucasians, but not non-Caucasians. Clin Gastroenterol Hepatol. 2013;11:808\u2013814.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"4835_CR32","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1016\/j.cgh.2007.12.022","volume":"6","author":"J Cosnes","year":"2008","unstructured":"Cosnes J, Cellier C, Viola S, et al. Incidence of autoimmune diseases in celiac disease: protective effect of the gluten-free diet. Clin Gastroenterol Hepatol. 2008;6:753\u2013758.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"4835_CR33","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1053\/gast.1999.0029900297","volume":"117","author":"A Ventura","year":"1999","unstructured":"Ventura A, Magazzu G, Greco L. Duration of exposure to gluten and risk for autoimmune disorders in patients with celiac disease. SIGEP Study Group for Autoimmune Disorders in Celiac Disease. Gastroenterology. 1999;117:297\u2013303.","journal-title":"Gastroenterology"},{"key":"4835_CR34","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1006\/clin.1997.4412","volume":"84","author":"DL Jacobson","year":"1997","unstructured":"Jacobson DL, Gange SJ, Rose NR, et al. Epidemiology and estimated population burden of selected autoimmune diseases in the United States. Clin Immunol Immunopathol. 1997;84:223\u2013243.","journal-title":"Clin Immunol Immunopathol"},{"key":"4835_CR35","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1016\/j.cgh.2008.03.017","volume":"6","author":"A Rubio-Tapia","year":"2008","unstructured":"Rubio-Tapia A, Murray JA. Celiac disease beyond the gut. Clin Gastroenterol Hepatol. 2008;6:722\u2013723.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"4835_CR36","unstructured":"Center for Behavioral Health Statistics and Quality. Behavioral health trends in the United States: Results from the 2014 National Survey on Drug Use and Health (HHS Publication No. SMA 15-4927, NSDUH Series H-50), 2015."},{"key":"4835_CR37","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.jad.2006.08.032","volume":"99","author":"JF Ludvigsson","year":"2007","unstructured":"Ludvigsson JF, Reutfors J, Osby U, et al. Coeliac disease and risk of mood disorders\u2014a general population-based cohort study. J Affect Disord. 2007;99:117\u2013126.","journal-title":"J Affect Disord"},{"key":"4835_CR38","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1080\/00365529850170801","volume":"33","author":"C Ciacci","year":"1998","unstructured":"Ciacci C, Iavarone A, Mazzacca G, et al. Depressive symptoms in adult coeliac disease. Scand J Gastroenterol. 1998;33:247\u2013250.","journal-title":"Scand J Gastroenterol"},{"key":"4835_CR39","first-page":"1","volume":"93","author":"AC Looker","year":"2012","unstructured":"Looker AC, Borrud LG, Dawson-Hughes B, et al. Osteoporosis or low bone mass at the femur neck or lumbar spine in older adults: United States, 2005\u20132008. NCHS Data Brief. 2012;93:1\u20138. (PMID: 22617299).","journal-title":"NCHS Data Brief"},{"key":"4835_CR40","doi-asserted-by":"publisher","first-page":"1566","DOI":"10.1001\/archinte.163.13.1566","volume":"163","author":"U Peters","year":"2003","unstructured":"Peters U, Askling J, Gridley G, et al. Causes of death in patients with celiac disease in a population-based Swedish cohort. Arch Intern Med. 2003;163:1566\u20131572.","journal-title":"Arch Intern Med"},{"key":"4835_CR41","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1001\/jama.2009.1320","volume":"302","author":"JF Ludvigsson","year":"2009","unstructured":"Ludvigsson JF, Montgomery SM, Ekbom A, et al. Small-intestinal histopathology and mortality risk in celiac disease. JAMA. 2009;302:1171\u20131178.","journal-title":"JAMA"},{"key":"4835_CR42","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.1136\/gutjnl-2014-308285","volume":"64","author":"A Abdul Sultan","year":"2015","unstructured":"Abdul Sultan A, Crooks CJ, West J, et al. Causes of death in people with coeliac disease in England compared with the general population: a competing risk analysis. Gut. 2015;64:1220\u20131226.","journal-title":"Gut"},{"key":"4835_CR43","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1016\/S0140-6736(01)05554-4","volume":"358","author":"G Corrao","year":"2001","unstructured":"Corrao G, Corazza GR, et al. Mortality in patients with celiac disease and their relatives: a cohort study. Lancet. 2001;358:356\u2013361.","journal-title":"Lancet"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10620-017-4835-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-017-4835-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-017-4835-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T23:35:22Z","timestamp":1750980922000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10620-017-4835-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,10]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["4835"],"URL":"https:\/\/doi.org\/10.1007\/s10620-017-4835-0","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,10]]},"assertion":[{"value":"6 July 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 November 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 November 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Joseph A. Murray (JAM) received grant support from National Institutes of Health, Alvine Pharmaceuticals, and Alba Therapeutics; received ongoing support from Oberkotter Foundation and Broad Medical Research Program at CCFA; serves on advisory board of Celimmune, LLC; was previous consultant to BioLineRx, GlaxoSmithKline (GSK), Genentech, and Glenmark Pharmaceuticals Ltd.; and is current consultant to ImunnosanT, Institute for Protein Design (PvP Biologics), Takeda Pharmaceutical Company, Ltd., Innovate Biopharmaceuticals, Inc., and Intrexon. Other authors have no disclosures.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}