{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T02:56:26Z","timestamp":1778900186037,"version":"3.51.4"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2018,1,25]],"date-time":"2018-01-25T00:00:00Z","timestamp":1516838400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Virginia Mason Hospital Digestive Disease Institute"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1007\/s10620-018-4924-8","type":"journal-article","created":{"date-parts":[[2018,1,25]],"date-time":"2018-01-25T11:43:53Z","timestamp":1516880633000},"page":"2419-2429","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Identification of Candidate Biomarkers Associated with Response to Vedolizumab in Inflammatory Bowel Disease"],"prefix":"10.1007","volume":"63","author":[{"given":"Elisa K.","family":"Boden","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donna M.","family":"Shows","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael V.","family":"Chiorean","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James D.","family":"Lord","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,1,25]]},"reference":[{"key":"4924_CR1","doi-asserted-by":"crossref","first-page":"517","DOI":"10.4049\/jimmunol.153.2.517","volume":"15","author":"DJ Erle","year":"1994","unstructured":"Erle DJ, Briskin MJ, Butcher EC, Garcia-Pardo A, Lazarovits AI, Tidswell M. Expression and function of the MAdCAM-1 receptor, integrin alpha 4 beta 7, on human leukocytes. J Immunol. 1994;15:517\u2013528.","journal-title":"J Immunol"},{"key":"4924_CR2","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1046\/j.1365-2567.1996.d01-706.x","volume":"89","author":"JJ P\u00e9rez-Villar","year":"1996","unstructured":"P\u00e9rez-Villar JJ, Zapata JM, Melero I, Postigo A, S\u00e1nchez-Madrid E, L\u00f3pez-Botet M. Expression and function of alpha 4\/beta 7 integrin on human natural killer cells. Immunology. 1996;89:96\u2013104.","journal-title":"Immunology"},{"key":"4924_CR3","doi-asserted-by":"crossref","first-page":"3282","DOI":"10.4049\/jimmunol.152.7.3282","volume":"1","author":"A Hamann","year":"1994","unstructured":"Hamann A, Andrew DP, Jablonski-Westrich D, Holzmann B, Butcher EC. Role of alpha 4-integrins in lymphocyte homing to mucosal tissues in vivo. J Immunol. 1994;1:3282\u20133293.","journal-title":"J Immunol"},{"key":"4924_CR4","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1056\/NEJMoa1215734","volume":"22","author":"BG Feagan","year":"2013","unstructured":"Feagan BG, Rutgeerts P, Sands BE, et al. Vedolizumab as induction and maintenance therapy for ulcerative colitis. N Engl J Med. 2013;22:699\u2013710.","journal-title":"N Engl J Med"},{"key":"4924_CR5","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1056\/NEJMoa1215739","volume":"22","author":"WJ Sandborn","year":"2013","unstructured":"Sandborn WJ, Feagan BG, Rutgeerts P, et al. Vedolizumab as induction and maintenance therapy for Crohn\u2019s disease. N Engl J Med. 2013;22:711\u2013721.","journal-title":"N Engl J Med"},{"key":"4924_CR6","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1053\/j.gastro.2014.05.008","volume":"147","author":"BE Sands","year":"2014","unstructured":"Sands BE, Feagan BG, Rutgeerts P, et al. Effects of vedolizumab induction therapy for patients with Crohn\u2019s disease in whom tumor necrosis factor antagonist treatment failed. Gastroenterology. 2014;147:618\u2013627.e3.","journal-title":"Gastroenterology"},{"key":"4924_CR7","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-311079","author":"J-F Colombel","year":"2016","unstructured":"Colombel J-F, Sands BE, Rutgeerts P, et al. The safety of vedolizumab for ulcerative colitis and Crohn\u2019s disease. Gut. 2016. https:\/\/doi.org\/10.1136\/gutjnl-2015-311079 .","journal-title":"Gut"},{"key":"4924_CR8","doi-asserted-by":"publisher","first-page":"6352","DOI":"10.3748\/wjg.v21.i20.6352","volume":"28","author":"Y Jin","year":"2015","unstructured":"Jin Y, Lin Y, Lin L-J, Zheng C-Q. Meta-analysis of the effectiveness and safety of vedolizumab for ulcerative colitis. World J Gastroenterol. 2015;28:6352\u20136360.","journal-title":"World J Gastroenterol"},{"key":"4924_CR9","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1136\/gutjnl-2013-305279","volume":"63","author":"C Steenholdt","year":"2014","unstructured":"Steenholdt C, Brynskov J, Thomsen O\u00d8, et al. Individualised therapy is more cost-effective than dose intensification in patients with Crohn\u2019s disease who lose response to anti-TNF treatment: a randomised, controlled trial. Gut. 2014;63:919\u2013927.","journal-title":"Gut"},{"key":"4924_CR10","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1016\/j.cgh.2014.07.029","volume":"13","author":"H Yanai","year":"2015","unstructured":"Yanai H, Lichtenstein L, Assa A, et al. Levels of drug and antidrug antibodies are associated with outcome of interventions after loss of response to infliximab or adalimumab. Clin Gastroenterol Hepatol. 2015;13:522\u2013530.e2.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"4924_CR11","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.4049\/jimmunol.158.5.2099","volume":"1","author":"D Picarella","year":"1997","unstructured":"Picarella D, Hurlbut P, Rottman J, Shi X, Butcher E, Ringler DJ. Monoclonal antibodies specific for beta 7 integrin and mucosal addressin cell adhesion molecule-1 (MAdCAM-1) reduce inflammation in the colon of scid mice reconstituted with CD45RBhigh CD4+ T cells. J Immunol. 1997;1:2099\u20132106.","journal-title":"J Immunol"},{"key":"4924_CR12","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/nature01726","volume":"3","author":"JR Mora","year":"2003","unstructured":"Mora JR, Bono MR, Manjunath N, et al. Selective imprinting of gut-homing T cells by Peyer\u2019s patch dendritic cells. Nature. 2003;3:88\u201393.","journal-title":"Nature"},{"key":"4924_CR13","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1016\/j.immuni.2004.08.011","volume":"21","author":"M Iwata","year":"2004","unstructured":"Iwata M, Hirakiyama A, Eshima Y, Kagechika H, Kato C, Song S-Y. Retinoic acid imprints gut-homing specificity on T cells. Immunity. 2004;21:527\u2013538.","journal-title":"Immunity"},{"key":"4924_CR14","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/S0022-1759(03)00226-6","volume":"278","author":"CR Kreher","year":"2003","unstructured":"Kreher CR, Dittrich MT, Guerkov R, Boehm BO, Tary-Lehmann M. CD4+ and CD8+ cells in cryopreserved human PBMC maintain full functionality in cytokine ELISPOT assays. J Immunol Methods. 2003;278:79\u201393.","journal-title":"J Immunol Methods"},{"key":"4924_CR15","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1016\/S0140-6736(80)92767-1","volume":"8","author":"RF Harvey","year":"1980","unstructured":"Harvey RF, Bradshaw JM. A simple index of Crohn\u2019s-disease activity. Lancet. 1980;8:514.","journal-title":"Lancet"},{"key":"4924_CR16","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1136\/gut.43.1.29","volume":"43","author":"RS Walmsley","year":"1998","unstructured":"Walmsley RS, Ayres RC, Pounder RE, Allan RN. A simple clinical colitis activity index. Gut. 1998;43:29\u201332.","journal-title":"Gut"},{"key":"4924_CR17","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/1471-2172-5-13","volume":"5","author":"MW Rodriguez","year":"2004","unstructured":"Rodriguez MW, Paquet AC, Yang YH, Erle DJ. Differential gene expression by integrin beta 7+ and beta 7\u2212 memory T helper cells. BMC Immunol. 2004;5:5\u201313.","journal-title":"BMC Immunol"},{"key":"4924_CR18","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1165\/ajrcmb.10.3.7509610","volume":"10","author":"DJ Erle","year":"1994","unstructured":"Erle DJ, Brown T, Christian D, Aris R. Lung epithelial lining fluid T cell subsets defined by distinct patterns of beta 7 and beta 1 integrin expression. Am J Respir Cell Mol Biol. 1994;10:237\u2013244.","journal-title":"Am J Respir Cell Mol Biol"},{"key":"4924_CR19","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.1002\/ibd.21896","volume":"18","author":"A Parikh","year":"2012","unstructured":"Parikh A, Leach T, Wyant T, et al. Vedolizumab for the treatment of active ulcerative colitis: a randomized controlled phase 2 dose-ranging study. Inflamm Bowel Dis. 2012;18:1470\u20131479.","journal-title":"Inflamm Bowel Dis"},{"key":"4924_CR20","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1111\/apt.13243","volume":"20","author":"M Rosario","year":"2015","unstructured":"Rosario M, Dirks NL, Gastonguay MR, et al. Population pharmacokinetics-pharmacodynamics of vedolizumab in patients with ulcerative colitis and Crohn\u2019s disease. Aliment Pharmacol Ther. 2015;20:188\u2013202.","journal-title":"Aliment Pharmacol Ther"},{"key":"4924_CR21","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1038\/clpt.2011.328","volume":"91","author":"I Ord\u00e1s","year":"2012","unstructured":"Ord\u00e1s I, Mould DR, Feagan BG, Sandborn WJ. Anti-TNF monoclonal antibodies in inflammatory bowel disease: pharmacokinetics-based dosing paradigms. Clin Pharmacol Ther. 2012;91:635\u2013646.","journal-title":"Clin Pharmacol Ther"},{"key":"4924_CR22","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1016\/j.cgh.2006.06.025","volume":"4","author":"EA Maser","year":"2006","unstructured":"Maser EA, Villela R, Silverberg MS, Greenberg GR. Association of trough serum infliximab to clinical outcome after scheduled maintenance treatment for Crohn\u2019s disease. Clin Gastroenterol Hepatol. 2006;4:1248\u20131254.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"4924_CR23","first-page":"49","volume":"10","author":"CH Seow","year":"2009","unstructured":"Seow CH, Newman A, Irwin SP, Steinhart AH, Silverberg MS, Greenberg GR. Trough serum infliximab: a predictive factor of clinical outcome for infliximab treatment in acute ulcerative colitis. Gut. 2009;10:49\u201354.","journal-title":"Gut"},{"key":"4924_CR24","first-page":"S","volume":"138","author":"W Moerkercke Van","year":"2010","unstructured":"Van Moerkercke W, Ackaert C, Compernolle G, et al. 405 high infliximab trough levels are associated with mucosal healing in Crohn\u2019s disease. Gastroenterology. 2010;138:S\u201360.","journal-title":"Gastroenterology"},{"key":"4924_CR25","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1016\/j.cgh.2008.06.007","volume":"6","author":"BG Feagan","year":"2008","unstructured":"Feagan BG, Greenberg GR, Wild G, et al. Treatment of active Crohn\u2019s disease with MLN0002, a humanized antibody to the alpha4beta7 integrin. Clin Gastroenterol Hepatol. 2008;6:1370\u20131377.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"4924_CR26","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1007\/s40261-016-0437-4","volume":"36","author":"M Rosario","year":"2016","unstructured":"Rosario M, Wyant T, Leach T, et al. Vedolizumab pharmacokinetics, pharmacodynamics, safety, and tolerability following administration of a single, ascending, intravenous dose to healthy volunteers. Clin Drug Investig. 2016;36:913\u2013923.","journal-title":"Clin Drug Investig"},{"key":"4924_CR27","doi-asserted-by":"publisher","first-page":"S235","DOI":"10.1016\/S0016-5085(16)30859-9","volume":"150","author":"AHM Ladd","year":"2016","unstructured":"Ladd AHM, Scott FI, Grace R, Bownik H, Lichtenstein GR. Sa1086 dose escalation of vedolizumab from every 8\u00a0weeks to every 4 or 6\u00a0weeks enables patients with inflammatory bowel disease to recapture response. Gastroenterology. 2016;150:S235\u2013S236.","journal-title":"Gastroenterology"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10620-018-4924-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-018-4924-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-018-4924-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T18:04:30Z","timestamp":1693505070000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10620-018-4924-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,25]]},"references-count":27,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["4924"],"URL":"https:\/\/doi.org\/10.1007\/s10620-018-4924-8","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,25]]},"assertion":[{"value":"11 October 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 January 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 January 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"JDL has received research funding from Takeda Pharmaceuticals for an alternative investigator-initiated project. MVC is a site principal investigator, and JDL and EKB are site sub-investigators for Takeda-funded clinical trials.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosures"}},{"value":"JDL contributed to study concept. EKB and JDL helped in study design. EKB, MVC, and JDL participated in clinical care and subject recruitment. EKB contributed to clinical data acquisition. DMS and JDL contributed to scientific data acquisition. EKB, DMS, and JDL involved in data analysis and interpretation. EKB and JDL drafted the manuscript and made critical revision for important intellectual content. All authors contributed to the critical revision of the manuscript and have read and approved the final version of this manuscript.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Author\u2019s contribution"}}]}}