{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T13:11:33Z","timestamp":1786972293009,"version":"build-2736575974"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2018,4,27]],"date-time":"2018-04-27T00:00:00Z","timestamp":1524787200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81"],"award-info":[{"award-number":["81"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["570"],"award-info":[{"award-number":["570"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["596"],"award-info":[{"award-number":["596"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81"],"award-info":[{"award-number":["81"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["770"],"award-info":[{"award-number":["770"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["557"],"award-info":[{"award-number":["557"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"crossref","award":["2015B020229001"],"award-info":[{"award-number":["2015B020229001"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Major Projects and Emerging Interdisciplinary Cross-discipline Funding Project of Sun Yat-sen University","award":["17ykjc20"],"award-info":[{"award-number":["17ykjc20"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1007\/s10620-018-5082-8","type":"journal-article","created":{"date-parts":[[2018,4,27]],"date-time":"2018-04-27T00:09:54Z","timestamp":1524787794000},"page":"1821-1834","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Anti-fibrogenic Potential of Mesenchymal Stromal Cells in Treating Fibrosis in Crohn\u2019s Disease"],"prefix":"10.1007","volume":"63","author":[{"given":"Lei","family":"Lian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qunsheng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longjuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huabo","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaosheng","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Ke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghao","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,4,27]]},"reference":[{"key":"5082_CR1","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1016\/j.crohns.2014.03.008","volume":"8","author":"G Latella","year":"2014","unstructured":"Latella G, Rogler G, Bamias G, et al. Results of the 4th scientific workshop of the ECCO (I): pathophysiology of intestinal fibrosis in IBD. J Crohns Colitis. 2014;8:1147\u20131165.","journal-title":"J Crohns Colitis"},{"key":"5082_CR2","doi-asserted-by":"publisher","first-page":"1166","DOI":"10.1016\/j.crohns.2014.03.009","volume":"8","author":"F Rieder","year":"2014","unstructured":"Rieder F, de Bruyn JR, Pham BT, et al. Results of the 4th scientific workshop of the ECCO (group II): markers of intestinal fibrosis in inflammatory bowel disease. J Crohns Colitis. 2014;8:1166\u20131178.","journal-title":"J Crohns Colitis"},{"key":"5082_CR3","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1159\/000353364","volume":"31","author":"F Rieder","year":"2013","unstructured":"Rieder F, Fiocchi C. Mechanisms of tissue remodeling in inflammatory bowel disease. Dig Dis. 2013;31:186\u2013193.","journal-title":"Dig Dis"},{"key":"5082_CR4","doi-asserted-by":"publisher","first-page":"G786","DOI":"10.1152\/ajpgi.00059.2012","volume":"303","author":"F Rieder","year":"2012","unstructured":"Rieder F, Kessler S, Sans M, et al. Animal models of intestinal fibrosis: new tools for the understanding of pathogenesis and therapy of human disease. Am J Physiol Gastrointest Liver Physiol. 2012;303:G786\u2013G801.","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"5082_CR5","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1038\/nm.2807","volume":"18","author":"TA Wynn","year":"2012","unstructured":"Wynn TA, Ramalingam TR. Mechanisms of fibrosis: therapeutic translation for fibrotic disease. Nat Med. 2012;18:1028\u20131040.","journal-title":"Nat Med"},{"key":"5082_CR6","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1097\/MIB.0000000000000043","volume":"20","author":"C Li","year":"2014","unstructured":"Li C, Kuemmerle JF. Mechanisms that mediate the development of fibrosis in patients with Crohn\u2019s disease. Inflamm Bowel Dis. 2014;20:1250\u20131258.","journal-title":"Inflamm Bowel Dis"},{"key":"5082_CR7","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1136\/gut.49.6.777","volume":"49","author":"E Louis","year":"2001","unstructured":"Louis E, Collard A, Oger AF, et al. Behaviour of Crohn\u2019s disease according to the vienna classification: changing pattern over the course of the disease. Gut. 2001;49:777\u2013782.","journal-title":"Gut"},{"key":"5082_CR8","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1007\/s12272-012-0202-z","volume":"35","author":"T Yi","year":"2012","unstructured":"Yi T, Song SU. Immunomodulatory properties of mesenchymal stem cells and their therapeutic applications. Arch Pharm Res. 2012;35:213\u2013221.","journal-title":"Arch Pharm Res"},{"key":"5082_CR9","doi-asserted-by":"publisher","first-page":"742","DOI":"10.3748\/wjg.v21.i3.742","volume":"21","author":"S Berardis","year":"2015","unstructured":"Berardis S, Dwisthi Sattwika P, Najimi M, et al. Use of mesenchymal stem cells to treat liver fibrosis: current situation and future prospects. World J Gastroenterol. 2015;21:742\u2013758.","journal-title":"World J Gastroenterol"},{"key":"5082_CR10","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1177\/1479164114531300","volume":"11","author":"S Lv","year":"2014","unstructured":"Lv S, Liu G, Sun A, et al. Mesenchymal stem cells ameliorate diabetic glomerular fibrosis in vivo and in vitro by inhibiting TGF-beta signalling via secretion of bone morphogenetic protein 7. Diab Vasc Dis Res. 2014;11:251\u2013261.","journal-title":"Diab Vasc Dis Res"},{"key":"5082_CR11","doi-asserted-by":"publisher","first-page":"3136","DOI":"10.1007\/s10620-012-2290-5","volume":"57","author":"XW He","year":"2012","unstructured":"He XW, He XS, Lian L, et al. Systemic infusion of bone marrow-derived mesenchymal stem cells for treatment of experimental colitis in mice. Dig Dis Sci. 2012;57:3136\u20133144.","journal-title":"Dig Dis Sci"},{"key":"5082_CR12","doi-asserted-by":"publisher","first-page":"1662","DOI":"10.1136\/gut.2010.215152","volume":"59","author":"M Duijvestein","year":"2010","unstructured":"Duijvestein M, Vos AC, Roelofs H, et al. Autologous bone marrow-derived mesenchymal stromal cell treatment for refractory luminal Crohn\u2019s disease: results of a phase I study. Gut. 2010;59:1662\u20131669.","journal-title":"Gut"},{"key":"5082_CR13","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1053\/j.gastro.2016.09.047","volume":"152","author":"F Rieder","year":"2017","unstructured":"Rieder F, Fiocchi C, Rogler G. Mechanisms, management, and treatment of fibrosis in patients with inflammatory bowel diseases. Gastroenterology. 2017;152:340\u2013350 e346.","journal-title":"Gastroenterology"},{"key":"5082_CR14","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1007\/s10620-016-4166-6","volume":"62","author":"M Xie","year":"2017","unstructured":"Xie M, Qin H, Luo Q, et al. Comparison of adipose-derived and bone marrow mesenchymal stromal cells in a murine model of Crohn\u2019s disease. Dig Dis Sci. 2017;62:115\u2013123.","journal-title":"Dig Dis Sci"},{"key":"5082_CR15","doi-asserted-by":"publisher","first-page":"20202","DOI":"10.1074\/jbc.M110.102012","volume":"285","author":"SN Flier","year":"2010","unstructured":"Flier SN, Tanjore H, Kokkotou EG, et al. Identification of epithelial to mesenchymal transition as a novel source of fibroblasts in intestinal fibrosis. J Biol Chem. 2010;285:20202\u201320212.","journal-title":"J Biol Chem"},{"key":"5082_CR16","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1089\/scd.2012.0395","volume":"22","author":"T Li","year":"2013","unstructured":"Li T, Yan Y, Wang B, et al. Exosomes derived from human umbilical cord mesenchymal stem cells alleviate liver fibrosis. Stem Cells Dev. 2013;22:845\u2013854.","journal-title":"Stem Cells Dev"},{"key":"5082_CR17","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1038\/nprot.2008.221","volume":"4","author":"M Soleimani","year":"2009","unstructured":"Soleimani M, Nadri S. A protocol for isolation and culture of mesenchymal stem cells from mouse bone marrow. Nat Protoc. 2009;4:102\u2013106.","journal-title":"Nat Protoc"},{"key":"5082_CR18","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1186\/s12885-017-3291-8","volume":"17","author":"M Xie","year":"2017","unstructured":"Xie M, Qin H, Luo Q, et al. Microrna-30a regulates cell proliferation and tumor growth of colorectal cancer by targeting cd73. BMC Cancer. 2017;17:305.","journal-title":"BMC Cancer"},{"key":"5082_CR19","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1093\/ecco-jcc\/jjw055","volume":"10","author":"F Rieder","year":"2016","unstructured":"Rieder F, Latella G, Magro F, et al. European Crohn\u2019s and colitis organisation topical review on prediction, diagnosis and management of fibrostenosing Crohn\u2019s disease. J Crohns Colitis. 2016;10:873\u2013885.","journal-title":"J Crohns Colitis"},{"key":"5082_CR20","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1097\/MIB.0000000000000716","volume":"22","author":"R Meier","year":"2016","unstructured":"Meier R, Lutz C, Cosin-Roger J, et al. Decreased fibrogenesis after treatment with pirfenidone in a newly developed mouse model of intestinal fibrosis. Inflamm Bowel Dis. 2016;22:569\u2013582.","journal-title":"Inflamm Bowel Dis"},{"key":"5082_CR21","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1111\/j.1572-0241.2006.00330.x","volume":"101","author":"CN Bernstein","year":"2006","unstructured":"Bernstein CN, Nabalamba A. Hospitalization, surgery, and readmission rates of IBD in Canada: a population-based study. Am J Gastroenterol. 2006;101:110\u2013118.","journal-title":"Am J Gastroenterol"},{"key":"5082_CR22","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1136\/gutjnl-2012-302152","volume":"62","author":"P Anderson","year":"2013","unstructured":"Anderson P, Souza-Moreira L, Morell M, et al. Adipose-derived mesenchymal stromal cells induce immunomodulatory macrophages which protect from experimental colitis and sepsis. Gut. 2013;62:1131\u20131141.","journal-title":"Gut"},{"key":"5082_CR23","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1136\/gut.2010.214841","volume":"60","author":"R Ciccocioppo","year":"2011","unstructured":"Ciccocioppo R, Bernardo ME, Sgarella A, et al. Autologous bone marrow-derived mesenchymal stromal cells in the treatment of fistulising Crohn\u2019s disease. Gut. 2011;60:788\u2013798.","journal-title":"Gut"},{"key":"5082_CR24","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1053\/j.gastro.2008.11.041","volume":"136","author":"MA Gonzalez","year":"2009","unstructured":"Gonzalez MA, Gonzalez-Rey E, Rico L, et al. Adipose-derived mesenchymal stem cells alleviate experimental colitis by inhibiting inflammatory and autoimmune responses. Gastroenterology. 2009;136:978\u2013989.","journal-title":"Gastroenterology"},{"key":"5082_CR25","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1053\/j.gastro.2015.06.014","volume":"149","author":"I Molendijk","year":"2015","unstructured":"Molendijk I, Bonsing BA, Roelofs H, et al. Allogeneic bone marrow-derived mesenchymal stromal cells promote healing of refractory perianal fistulas in patients with Crohn\u2019s disease. Gastroenterology. 2015;149:918\u2013927 e916.","journal-title":"Gastroenterology"},{"key":"5082_CR26","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1016\/S0140-6736(16)31203-X","volume":"388","author":"J Panes","year":"2016","unstructured":"Panes J, Garcia-Olmo D, Van Assche G, et al. Expanded allogeneic adipose-derived mesenchymal stem cells (cx601) for complex perianal fistulas in Crohn\u2019s disease: a phase 3 randomised, double-blind controlled trial. Lancet. 2016;388:1281\u20131290.","journal-title":"Lancet"},{"key":"5082_CR27","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1053\/j.gastro.2015.03.013","volume":"149","author":"E Sala","year":"2015","unstructured":"Sala E, Genua M, Petti L, et al. Mesenchymal stem cells reduce colitis in mice via release of TSG6, independently of their localization to the intestine. Gastroenterology. 2015;149:163\u2013176 e120.","journal-title":"Gastroenterology"},{"key":"5082_CR28","first-page":"10555","volume":"8","author":"W Deng","year":"2015","unstructured":"Deng W, Chen QW, Li XS, et al. Bone marrow mesenchymal stromal cells with CD47 high expression via the signal transducer and activators of transcription signaling pathway preventing myocardial fibrosis. Int J Clin Exp Pathol. 2015;8:10555\u201310564.","journal-title":"Int J Clin Exp Pathol"},{"key":"5082_CR29","doi-asserted-by":"publisher","first-page":"3905","DOI":"10.1096\/fj.201600433R","volume":"30","author":"D Haldar","year":"2016","unstructured":"Haldar D, Henderson NC, Hirschfield G, et al. Mesenchymal stromal cells and liver fibrosis: a complicated relationship. FASEB J. 2016;30:3905\u20133928.","journal-title":"FASEB J"},{"key":"5082_CR30","doi-asserted-by":"publisher","first-page":"1500","DOI":"10.5966\/sctm.2015-0121","volume":"4","author":"N Srour","year":"2015","unstructured":"Srour N, Thebaud B. Mesenchymal stromal cells in animal bleomycin pulmonary fibrosis models: a systematic review. Stem Cells Transl Med. 2015;4:1500\u20131510.","journal-title":"Stem Cells Transl Med"},{"key":"5082_CR31","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1097\/MIB.0b013e3182802c32","volume":"19","author":"J Adler","year":"2013","unstructured":"Adler J, Rahal K, Swanson SD, et al. Anti-tumor necrosis factor alpha prevents bowel fibrosis assessed by messenger rna, histology, and magnetization transfer MRI in rats with Crohn\u2019s disease. Inflamm Bowel Dis. 2013;19:683\u2013690.","journal-title":"Inflamm Bowel Dis"},{"key":"5082_CR32","doi-asserted-by":"publisher","first-page":"617145","DOI":"10.1155\/2013\/617145","volume":"2013","author":"C Yuan","year":"2013","unstructured":"Yuan C, Chen WX, Zhu JS, et al. Il-10 treatment is associated with prohibitin expression in the Crohn\u2019s disease intestinal fibrosis mouse model. Mediat Inflamm. 2013;2013:617145.","journal-title":"Mediat Inflamm"},{"key":"5082_CR33","doi-asserted-by":"publisher","first-page":"1603","DOI":"10.1007\/s10620-015-3552-9","volume":"60","author":"AC Baird","year":"2015","unstructured":"Baird AC, Lloyd F, Lawrance IC. Prostaglandin e(2) and polyenylphosphatidylcholine protect against intestinal fibrosis and regulate myofibroblast function. Dig Dis Sci. 2015;60:1603\u20131616.","journal-title":"Dig Dis Sci"},{"key":"5082_CR34","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1007\/s10620-011-1879-4","volume":"57","author":"Y Abe","year":"2012","unstructured":"Abe Y, Murano M, Murano N, et al. Simvastatin attenuates intestinal fibrosis independent of the anti-inflammatory effect by promoting fibroblast\/myofibroblast apoptosis in the regeneration\/healing process from tnbs-induced colitis. Dig Dis Sci. 2012;57:335\u2013344.","journal-title":"Dig Dis Sci"},{"key":"5082_CR35","doi-asserted-by":"publisher","first-page":"G1076","DOI":"10.1152\/ajpgi.00229.2016","volume":"311","author":"MC Manresa","year":"2016","unstructured":"Manresa MC, Tambuwala MM, Radhakrishnan P, et al. Hydroxylase inhibition regulates inflammation-induced intestinal fibrosis through the suppression of erk-mediated TGF-beta1 signaling [corrected]. Am J Physiol Gastrointest Liver Physiol. 2016;311:G1076\u2013G1090.","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"5082_CR36","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1097\/MIB.0000000000000618","volume":"22","author":"S Speca","year":"2016","unstructured":"Speca S, Rousseaux C, Dubuquoy C, et al. Novel ppargamma modulator ged-0507-34 levo ameliorates inflammation-driven intestinal fibrosis. Inflamm Bowel Dis. 2016;22:279\u2013292.","journal-title":"Inflamm Bowel Dis"},{"key":"5082_CR37","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1053\/j.gastro.2017.06.013","volume":"153","author":"T Holvoet","year":"2017","unstructured":"Holvoet T, Devriese S, Castermans K, et al. Treatment of intestinal fibrosis in experimental inflammatory bowel disease by the pleiotropic actions of a local rho kinase inhibitor. Gastroenterology. 2017;153:1054\u20131067.","journal-title":"Gastroenterology"},{"key":"5082_CR38","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/j.bbrc.2010.12.006","volume":"404","author":"H Kitamura","year":"2011","unstructured":"Kitamura H, Yamamoto S, Nakase H, et al. Role of heat shock protein 47 in intestinal fibrosis of experimental colitis. Biochem Biophys Res Commun. 2011;404:599\u2013604.","journal-title":"Biochem Biophys Res Commun"},{"key":"5082_CR39","doi-asserted-by":"publisher","first-page":"2041","DOI":"10.1097\/MIB.0000000000000863","volume":"22","author":"L Goffin","year":"2016","unstructured":"Goffin L, Fagagnini S, Vicari A, et al. Anti-mmp-9 antibody: a promising therapeutic strategy for treatment of inflammatory bowel disease complications with fibrosis. Inflamm Bowel Dis. 2016;22:2041\u20132057.","journal-title":"Inflamm Bowel Dis"},{"key":"5082_CR40","first-page":"1283","volume":"17","author":"G Latella","year":"2013","unstructured":"Latella G, Sferra R, Speca S, et al. Can we prevent, reduce or reverse intestinal fibrosis in IBD? Eur Rev Med Pharmacol Sci. 2013;17:1283\u20131304.","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"5082_CR41","doi-asserted-by":"publisher","first-page":"3635","DOI":"10.3748\/wjg.v18.i28.3635","volume":"18","author":"S Speca","year":"2012","unstructured":"Speca S, Giusti I, Rieder F, et al. Cellular and molecular mechanisms of intestinal fibrosis. World J Gastroenterol. 2012;18:3635\u20133661.","journal-title":"World J Gastroenterol"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10620-018-5082-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-018-5082-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-018-5082-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,27]],"date-time":"2019-04-27T03:01:50Z","timestamp":1556334110000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10620-018-5082-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,27]]},"references-count":41,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["5082"],"URL":"https:\/\/doi.org\/10.1007\/s10620-018-5082-8","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,27]]},"assertion":[{"value":"4 February 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 April 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 April 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"All authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}