{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T05:10:52Z","timestamp":1787634652356,"version":"build-2736575974"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2018,8,6]],"date-time":"2018-08-06T00:00:00Z","timestamp":1533513600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Fapesp","doi-asserted-by":"crossref","award":["(2008\/02678-6"],"award-info":[{"award-number":["(2008\/02678-6"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001807","name":"Fapesp","doi-asserted-by":"crossref","award":["2011\/11224-1"],"award-info":[{"award-number":["2011\/11224-1"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1007\/s10620-018-5223-0","type":"journal-article","created":{"date-parts":[[2018,8,6]],"date-time":"2018-08-06T14:59:01Z","timestamp":1533567541000},"page":"2889-2897","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Effect of Helicobacter pylori Infection on GATA-5 and TFF1 Regulation, Comparison Between Pediatric and Adult Patients"],"prefix":"10.1007","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5804-1962","authenticated-orcid":false,"given":"Marisa Claudia","family":"Alvarez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Michel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliette","family":"Touati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo Lima","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,8,6]]},"reference":[{"key":"5223_CR1","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0889-8553(21)00270-3","volume":"22","author":"B Drumm","year":"1993","unstructured":"Drumm B. Helicobacter pylori in the pediatric patient. Gastroenterol Clin N Am. 1993;22:169\u2013182.","journal-title":"Gastroenterol Clin N Am"},{"key":"5223_CR2","doi-asserted-by":"publisher","first-page":"S626","DOI":"10.1097\/00005176-200406002-00008","volume":"39","author":"B Drumm","year":"2004","unstructured":"Drumm B, Day AS, Gold B, et al. Helicobacter pylori and peptic ulcer. Working group report of the second world congress of pediatric gastroenterology, hepatology and nutrition. J Pediatr Gastroenterol Nutr. 2004;39:S626\u2013S631.","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"5223_CR3","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1177\/0022034510378683","volume":"1","author":"D Bayarsaihan","year":"2011","unstructured":"Bayarsaihan D. Epigenetic mechanisms in inflammation. J Dent Res. 2011;1:9\u201317.","journal-title":"J Dent Res"},{"key":"5223_CR4","doi-asserted-by":"publisher","first-page":"851","DOI":"10.2217\/fon.10.37","volume":"6","author":"SZ Ding","year":"2010","unstructured":"Ding SZ, Goldberg JB, Hatekeyama M. Helicobacter pylori infection, oncogenic pathways and epigenetics mechanism in gastric carcinogenesis. Future Oncol. 2010;6:851\u2013862.","journal-title":"Future Oncol"},{"key":"5223_CR5","first-page":"451","volume":"136","author":"JCS Roa","year":"2008","unstructured":"Roa JCS, Garc\u00eda P, Melo A, et al. Gene methylation patterns in digestive tumors. Rev M\u00e9d Chile. 2008;136:451\u2013458.","journal-title":"Rev M\u00e9d Chile"},{"key":"5223_CR6","doi-asserted-by":"publisher","first-page":"5427","DOI":"10.1038\/sj.onc.1205600","volume":"21","author":"M Esteller","year":"2002","unstructured":"Esteller M. CpG island hypermethylation and tumor suppressor genes: a booming present, a brighter future. Oncogene. 2002;21:5427\u20135440.","journal-title":"Oncogene"},{"key":"5223_CR7","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1007\/3-540-37633-X_7","volume":"57","author":"M Esteller","year":"2006","unstructured":"Esteller M. CpG island methylation and histone modifications: biology and significance. ErnstSchering Res Found Workshop. 2006;57:115\u2013126.","journal-title":"ErnstSchering Res Found Workshop"},{"key":"5223_CR8","first-page":"2847","volume":"61","author":"GH Kang","year":"2001","unstructured":"Kang GH, Shim YH, Jung HY, et al. CpG island methylation in premalignant stages of gastric carcinoma. Cancer Res. 2001;61:2847\u20132851.","journal-title":"Cancer Res"},{"key":"5223_CR9","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/S0002-9440(10)64195-8","volume":"161","author":"T Waki","year":"2002","unstructured":"Waki T, Tamura G, Tsuchiya T, et al. Promoter methylation status of E-cadherin, hMLH1, and p16 genes in nonneoplastic gastric epithelia. Am J Pathol. 2002;161:399\u2013403.","journal-title":"Am J Pathol"},{"key":"5223_CR10","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1136\/gut.52.4.502","volume":"52","author":"AO Chan","year":"2003","unstructured":"Chan AO, Lam SK, Wong BC, et al. Promoter methylation of E-cadherin gene in gastric mucosa associated with Helicobacter pylori infection and in gastric cancer. Gut. 2003;52:502\u2013506.","journal-title":"Gut"},{"key":"5223_CR11","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1158\/1078-0432.CCR-05-2096","volume":"12","author":"T Maekita","year":"2006","unstructured":"Maekita T, Nakazawa K, Mihara M, et al. High levels of aberrant DNA methylation in Helicobacter pylori-infected gastric mucosae and its possible association with gastric cancer risk. Clin Cancer Res. 2006;12:989\u2013995.","journal-title":"Clin Cancer Res"},{"key":"5223_CR12","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1002\/ijc.24018","volume":"124","author":"T Nakajima","year":"2009","unstructured":"Nakajima T, Yamashita S, Maekita T, et al. The presence of a methylation fingerprint of Helicobacter infection in human gastric mucosae. Int J Cancer. 2009;124:905\u2013910.","journal-title":"Int J Cancer"},{"key":"5223_CR13","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1111\/j.1462-5822.2010.01457.x","volume":"12","author":"F Bussi\u00e8re","year":"2010","unstructured":"Bussi\u00e8re F, Michel V, M\u00e9met S, et al. H. pylori-induced promoter hypermethylation downregulates USF1 and USF2 transcription factor gene expression. Cell Microbiol. 2010;12:1124\u20131133.","journal-title":"Cell Microbiol"},{"key":"5223_CR14","doi-asserted-by":"publisher","first-page":"3043","DOI":"10.3748\/wjg.v19.i20.3043","volume":"19","author":"MC Alvarez","year":"2013","unstructured":"Alvarez MC, Santos JC, Maniezzo N, et al. MGMT and MLH1 methylation in Helicobacter pylori-infected children and adults. World J Gastroenterol. 2013;19:3043\u20133051.","journal-title":"World J Gastroenterol"},{"key":"5223_CR15","doi-asserted-by":"publisher","first-page":"2850","DOI":"10.1007\/s10620-013-2742-6","volume":"58","author":"MC Alvarez","year":"2013","unstructured":"Alvarez MC, Ladeira MS, Scaletsky IC, Pedrazzoli J Jr, Ribeiro ML. Methylation pattern of THBS1, GATA-4, and HIC1 in pediatric and adult patients infected with Helicobacter pylori. Dig Dis Sci. 2013;58:2850\u20132857. https:\/\/doi.org\/10.1007\/s10620-013-2742-6 .","journal-title":"Dig Dis Sci"},{"key":"5223_CR16","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1177\/1947601911404223","volume":"12","author":"R Zheng","year":"2010","unstructured":"Zheng R, Blobel GA. GATA transcription factors and cancer. Genes Cancer. 2010;12:1178\u20131188.","journal-title":"Genes Cancer"},{"key":"5223_CR17","doi-asserted-by":"crossref","first-page":"23177","DOI":"10.1016\/S0021-9258(17)31636-8","volume":"269","author":"A Laverriere","year":"1994","unstructured":"Laverriere A, MacNeill C, Mueller C, et al. GATA-4\/5\/6, a subfamily of three transcription factors transcribed in the developing heart and gut. J Biol Chem. 1994;269:23177\u201323184.","journal-title":"J Biol Chem"},{"key":"5223_CR18","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.3748\/wjg.v16.i10.1201","volume":"16","author":"X Wen","year":"2010","unstructured":"Wen X, Akiyama Y, Pan KF, et al. Methylation of GATA-4 and GATA-5 and development of sporadic gastric carcinomas. World J Gastroenterol. 2010;16:1201\u20131208.","journal-title":"World J Gastroenterol"},{"key":"5223_CR19","doi-asserted-by":"publisher","first-page":"8429","DOI":"10.1128\/MCB.23.23.8429-8439.2003","volume":"23","author":"Y Akiyama","year":"2003","unstructured":"Akiyama Y, Watkins N, Suzuki H, et al. GATA-4 and GATA-5 transcription factor genes and potential dowstream antitumor target genes are epigenetically silenced in colorectal and gastric cancer. Mol Cell Biol. 2003;23:8429\u20138439.","journal-title":"Mol Cell Biol"},{"key":"5223_CR20","doi-asserted-by":"publisher","first-page":"7917","DOI":"10.1158\/1078-0432.CCR-04-1140","volume":"10","author":"M Guo","year":"2004","unstructured":"Guo M, Akiyama Y, House MG, et al. Hypermethylation of the GATA genes in lung cancer. Clin Cancer Res. 2004;10:7917\u20137924.","journal-title":"Clin Cancer Res"},{"key":"5223_CR21","doi-asserted-by":"publisher","first-page":"2078","DOI":"10.1002\/ijc.22092","volume":"119","author":"M Guo","year":"2006","unstructured":"Guo M, House MG, Akiyama Y, et al. Hypermethylation of the GATA gene family in esophageal cancer. Int J Cancer. 2006;119:2078\u20132083.","journal-title":"Int J Cancer"},{"key":"5223_CR22","first-page":"278","volume":"89","author":"MS Wu","year":"1998","unstructured":"Wu MS, Shun CT, Wang HP, et al. Loss of pS2 protein expression is an early event of intestinal-type gastric cancer. J Cancer Res. 1998;89:278\u2013282.","journal-title":"J Cancer Res"},{"key":"5223_CR23","doi-asserted-by":"publisher","first-page":"1408","DOI":"10.1016\/S0016-5085(03)00266-X","volume":"124","author":"E Touati","year":"2003","unstructured":"Touati E, Michel V, Thiberge JM, et al. Chronic Helicobacter pylori infections induce gastric mutations in mice. Gastroenterology. 2003;124:1408\u20131419.","journal-title":"Gastroenterology"},{"key":"5223_CR24","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212\u2206\u2206(CT)) method. Methods. 2001;25:402\u2013408.","journal-title":"Methods"},{"key":"5223_CR25","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1038\/nrg816","volume":"3","author":"PA Jones","year":"2002","unstructured":"Jones PA, Baylin SB. The fundamental role of epigenetics events in cancer. Nat Rev Genet. 2002;3:415\u2013428.","journal-title":"Nat Rev Genet"},{"key":"5223_CR26","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1126\/science.274.5285.259","volume":"274","author":"O Lefebvre","year":"1996","unstructured":"Lefebvre O, Chenard MP, Masson R, et al. Gastric mucosa abnormalities and tumorigenesis in mice lacking the pS2 trefoil protein. Science. 1996;274:259\u2013262.","journal-title":"Science"},{"key":"5223_CR27","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1126\/science.274.5285.262","volume":"274","author":"H Mashimo","year":"1996","unstructured":"Mashimo H, Wu DC, Podolsky DK, et al. Impaired defense of intestinal mucosa in mice lacking intestinal trefoil factor. Science. 1996;274:262\u2013265.","journal-title":"Science"},{"key":"5223_CR28","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1038\/labinvest.3780260","volume":"81","author":"H Lassus","year":"2001","unstructured":"Lassus H, Laitinen MP, Anttonen M, et al. Comparison of serous and mucinous ovarian carcinomas: distinct pattern of allelic loss at distal 8p and expression of transcription factor GATA-4. Lab Invest. 2001;81:517\u2013526.","journal-title":"Lab Invest"},{"key":"5223_CR29","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/0016-5085(91)90205-Y","volume":"100","author":"MC Rio","year":"1991","unstructured":"Rio MC, Chenard MP, Wolf C, et al. Induction of pS2 and hSP genes as markers of mucosal ulceration of the digestive tract. Gastroenterology. 1991;100:375\u2013379.","journal-title":"Gastroenterology"},{"key":"5223_CR30","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1038\/nrc1799","volume":"6","author":"S Baylin","year":"2006","unstructured":"Baylin S, Ohm JE. Epigenetic gene silencing in cancer\u2014a mechanism for early oncogenic pathway addiction? Nat Rev Cancer. 2006;6:107\u2013116.","journal-title":"Nat Rev Cancer"},{"key":"5223_CR31","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1586\/17474124.2.2.243","volume":"2","author":"G Nardone","year":"2008","unstructured":"Nardone G, Compare D. Epigenetic alterations due to diet and Helicobacter pylori infection in gastric carcinogenesis. Expert Rev Gastroenterol Hepatol. 2008;2:243\u2013248.","journal-title":"Expert Rev Gastroenterol Hepatol"},{"key":"5223_CR32","doi-asserted-by":"publisher","first-page":"3834","DOI":"10.3748\/wjg.v11.i25.3834","volume":"25","author":"HM Nan","year":"2005","unstructured":"Nan HM, Song YJ, Yun HY, et al. Effects of dietary intake and genetic factors on hypermethylation of the hMLH1 gene promoter in gastric cancer. World J Gastroenterol. 2005;25:3834\u20133841.","journal-title":"World J Gastroenterol"},{"key":"5223_CR33","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1038\/nrc2191","volume":"8","author":"HK Seitz","year":"2007","unstructured":"Seitz HK, Stickel F. Molecular mechanisms of alcohol-mediated carcinogenesis. Nat Rev Cancer. 2007;8:599\u2013612.","journal-title":"Nat Rev Cancer"},{"key":"5223_CR34","doi-asserted-by":"publisher","first-page":"563","DOI":"10.3892\/ijmm_00000266","volume":"24","author":"T Tahara","year":"2009","unstructured":"Tahara T, Hibata T, Nakamura M, et al. Effect of polymorphisms of IL-17A, -17F and MIF genes on CpG island hyper-methylation (CIHM) in the human gastric mucosa. Int J Mol Med. 2009;24:563\u2013569.","journal-title":"Int J Mol Med"},{"key":"5223_CR35","doi-asserted-by":"publisher","first-page":"2901","DOI":"10.1128\/MCB.18.5.2901","volume":"18","author":"X Gao","year":"1998","unstructured":"Gao X, Sedgwick T, Shi YB, et al. Distinct functions are implicated for the GATA-4, -5, and -6 transcription factors in the regulation of intestine epithelial cell differentiation. Mol Cell Biol. 1998;18:2901\u20132911.","journal-title":"Mol Cell Biol"},{"key":"5223_CR36","doi-asserted-by":"publisher","first-page":"1753","DOI":"10.1172\/JCI43922","volume":"121","author":"M Soutto","year":"2011","unstructured":"Soutto M, Belkhiri A, Piazuelo MB, et al. Loss of TFF1 is associated with activation of NF-\u03baB-mediated inflammation and gastric neoplasia in mice and humans. J Clin Invest. 2011;121:1753\u20131767.","journal-title":"J Clin Invest"},{"key":"5223_CR37","doi-asserted-by":"publisher","first-page":"4348","DOI":"10.1002\/cncr.29644","volume":"121","author":"M Soutto","year":"2015","unstructured":"Soutto M, Chen Z, Katsha AM, et al. Trefoil factor 1 expression suppresses Helicobacter pylori-induced inflammation in gastric carcinogenesis. Cancer. 2015;121:4348\u20134358.","journal-title":"Cancer"},{"key":"5223_CR38","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1007\/s00439-016-1687-1","volume":"135","author":"RS Sobota","year":"2016","unstructured":"Sobota RS, Kodaman N, Mera R, et al. Epigenetic and genetic variation in GATA5 is associated with gastric disease risk. Hum Genet. 2016;135:895\u2013906.","journal-title":"Hum Genet"},{"key":"5223_CR39","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/1471-2164-10-3","volume":"10","author":"M McClain","year":"2009","unstructured":"McClain M, Shaffer CL, Israel DA, et al. Genome sequence analysis of Helicobacter pylori strains associated with gastric ulceration and gastric cancer. BMC Genom. 2009;10:3.","journal-title":"BMC Genom"},{"key":"5223_CR40","doi-asserted-by":"publisher","first-page":"1166","DOI":"10.1038\/ni1131","volume":"5","author":"J Viala","year":"2004","unstructured":"Viala J, Chaput C, Boneca IG, et al. Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island. Nat Immunol. 2004;5:1166\u20131174.","journal-title":"Nat Immunol"},{"key":"5223_CR41","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1016\/S0016-5085(97)70155-0","volume":"112","author":"A Lee","year":"1997","unstructured":"Lee A, Rourke J, De Ungria MC, Robertson B, et al. A standardized mouse model of Helicobacter pylori infection: introducing the Sydney strain. Gastroenterology. 1997;112:1386\u20131397.","journal-title":"Gastroenterology"},{"key":"5223_CR42","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1177\/039463200802100305","volume":"21","author":"JR Vivas","year":"2008","unstructured":"Vivas JR, Regnault B, Michel V, et al. Interferon gamma-signature transcript profiling and IL-23 upregulation in response to Helicobacter pylori infection. Int J Immunopathol Pharmacol. 2008;21:515\u2013526.","journal-title":"Int J Immunopathol Pharmacol"},{"key":"5223_CR43","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1097\/00000478-199610000-00001","volume":"20","author":"M Dixon","year":"1996","unstructured":"Dixon M, Genta RM, Yardley JH, et al. Classification and grading of gastritis. The updated Sydney System. International Workshop on the Histopathology of Gastritis, Houston 1994. Am J Surg Pathol. 1996;20:1161\u20131181.","journal-title":"Am J Surg Pathol"},{"key":"5223_CR44","first-page":"53","volume":"15","author":"LGV Coelho","year":"1996","unstructured":"Coelho LGV, Barros CA, Lima DCA. National consensus on \u2018\u2018H. pylori\u2019\u2019. GED. 1996;15:53\u201358.","journal-title":"GED"},{"key":"5223_CR45","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/S0167-7012(03)00166-0","volume":"55","author":"M Mikula","year":"2003","unstructured":"Mikula M, Dzwonek A, Jagusztyn-Krynicka K, et al. Quantitative detection for low levels of Helicobacter pylori infection in experimentally infected mice by real-time PCR. J Microbiol Methods. 2003;55:351\u2013359.","journal-title":"J Microbiol Methods"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10620-018-5223-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-018-5223-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-018-5223-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,28]],"date-time":"2022-08-28T20:24:28Z","timestamp":1661718268000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10620-018-5223-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,6]]},"references-count":45,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["5223"],"URL":"https:\/\/doi.org\/10.1007\/s10620-018-5223-0","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,6]]},"assertion":[{"value":"26 September 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 July 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 August 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}