{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T00:46:50Z","timestamp":1793234810512,"version":"4.5.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2019,5,10]],"date-time":"2019-05-10T00:00:00Z","timestamp":1557446400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,5,10]],"date-time":"2019-05-10T00:00:00Z","timestamp":1557446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AA020703"],"award-info":[{"award-number":["R01 AA020703"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AA24726"],"award-info":[{"award-number":["AA24726"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 AA021856"],"award-info":[{"award-number":["U01 AA021856"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 AA026939"],"award-info":[{"award-number":["U01 AA026939"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007496","name":"Biomedical Laboratory Research and Development, VA Office of Research and Development","doi-asserted-by":"publisher","award":["BX004594"],"award-info":[{"award-number":["BX004594"]}],"id":[{"id":"10.13039\/100007496","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002661","name":"Fonds De La Recherche Scientifique - FNRS","doi-asserted-by":"publisher","award":["CDR J.0146.17"],"award-info":[{"award-number":["CDR J.0146.17"]}],"id":[{"id":"10.13039\/501100002661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002661","name":"Fonds De La Recherche Scientifique - FNRS","doi-asserted-by":"publisher","award":["PDR T.0217.18"],"award-info":[{"award-number":["PDR T.0217.18"]}],"id":[{"id":"10.13039\/501100002661","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1007\/s10620-019-05638-y","type":"journal-article","created":{"date-parts":[[2019,5,10]],"date-time":"2019-05-10T17:07:31Z","timestamp":1557508051000},"page":"1878-1892","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Serum and Fecal Oxylipins in Patients with Alcohol-Related Liver Disease"],"prefix":"10.1007","volume":"64","author":[{"given":"Bei","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Lang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debbie L.","family":"Shawcross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Louvet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Mathurin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel B.","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"St\u00e4rkel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Schnabl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,5,10]]},"reference":[{"key":"5638_CR1","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1038\/ajg.2016.517","volume":"112","author":"PY Kwo","year":"2017","unstructured":"Kwo PY, Cohen SM, Lim JK. ACG clinical guideline: evaluation of abnormal liver chemistries. Am J Gastroenterol. 2017;112:18.","journal-title":"Am J Gastroenterol"},{"key":"5638_CR2","doi-asserted-by":"publisher","first-page":"1572","DOI":"10.1053\/j.gastro.2011.09.002","volume":"141","author":"B Gao","year":"2011","unstructured":"Gao B, Bataller R. Alcoholic liver disease: pathogenesis and new therapeutic targets. Gastroenterology. 2011;141:1572\u20131585.","journal-title":"Gastroenterology"},{"key":"5638_CR3","doi-asserted-by":"publisher","first-page":"513","DOI":"10.3945\/an.114.007732","volume":"6","author":"M Gabbs","year":"2015","unstructured":"Gabbs M, Leng S, Devassy JG, Monirujjaman M, Aukema HM. Advances in our understanding of oxylipins derived from dietary PUFAs. Adv Nutr (Bethesda, Md.). 2015;6:513\u2013540.","journal-title":"Adv Nutr (Bethesda, Md.)"},{"key":"5638_CR4","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1194\/jlr.R900004-JLR200","volume":"50","author":"MW Buczynski","year":"2009","unstructured":"Buczynski MW, Dumlao DS, Dennis EA. Thematic review series: proteomics. An integrated omics analysis of eicosanoid biology. J Lipid Res. 2009;50:1015\u20131038.","journal-title":"J Lipid Res"},{"key":"5638_CR5","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1016\/S1734-1140(10)70311-X","volume":"62","author":"C Arnold","year":"2010","unstructured":"Arnold C, Konkel A, Fischer R, Schunck W-H. Cytochrome P450\u2013dependent metabolism of \u03c9-6 and \u03c9-3 long-chain polyunsaturated fatty acids. Pharmacol Rep. 2010;62:536\u2013547.","journal-title":"Pharmacol Rep"},{"key":"5638_CR6","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.biochi.2016.12.012","volume":"136","author":"V Barquissau","year":"2017","unstructured":"Barquissau V, Ghandour RA, Ailhaud G, et al. Control of adipogenesis by oxylipins, GPCRs and PPARs. Biochimie. 2017;136:3\u201311.","journal-title":"Biochimie"},{"key":"5638_CR7","doi-asserted-by":"publisher","first-page":"H903","DOI":"10.1152\/ajpheart.00201.2017","volume":"313","author":"SPB Caligiuri","year":"2017","unstructured":"Caligiuri SPB, Parikh M, Stamenkovic A, Pierce GN, Aukema HM. Dietary modulation of oxylipins in cardiovascular disease and aging. Am J Physiol Heart Circ Physiol. 2017;313:H903\u2013H918.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"5638_CR8","doi-asserted-by":"publisher","first-page":"176","DOI":"10.3389\/fphar.2013.00176","volume":"4","author":"BE Tourdot","year":"2014","unstructured":"Tourdot BE, Ahmed I, Holinstat M. The emerging role of oxylipins in thrombosis and diabetes. Front Pharmacol. 2014;4:176.","journal-title":"Front Pharmacol"},{"key":"5638_CR9","doi-asserted-by":"publisher","first-page":"1871","DOI":"10.1126\/science.294.5548.1871","volume":"294","author":"CD Funk","year":"2001","unstructured":"Funk CD. Prostaglandins and leukotrienes: advances in eicosanoid biology. Science. 2001;294:1871.","journal-title":"Science"},{"key":"5638_CR10","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1007\/s00109-017-1542-4","volume":"95","author":"J Yeung","year":"2017","unstructured":"Yeung J, Hawley M, Holinstat M. The expansive role of oxylipins on platelet biology. J Mol Med (Berlin, Germany). 2017;95:575\u2013588.","journal-title":"J Mol Med (Berlin, Germany)"},{"key":"5638_CR11","doi-asserted-by":"publisher","first-page":"S211","DOI":"10.1086\/317517","volume":"31","author":"D Wagner","year":"2000","unstructured":"Wagner D, Westover K, Simmons DL. Nonsteroidal anti-inflammatory drugs, acetaminophen, cyclooxygenase 2, and fever. Clin Infect Dis. 2000;31:S211\u2013S218.","journal-title":"Clin Infect Dis"},{"key":"5638_CR12","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1016\/S0091-6749(96)80002-9","volume":"98","author":"MC Liu","year":"1996","unstructured":"Liu MC, Dub\u00e9 LM, Lancaster J. Acute and chronic effects of a 5-lipoxygenase inhibitor in asthma: A 6-month randomized multicenter trial. J Allergy Clin Immunol. 1996;98:859\u2013871.","journal-title":"J Allergy Clin Immunol"},{"key":"5638_CR13","doi-asserted-by":"publisher","first-page":"8976","DOI":"10.1038\/s41598-017-02759-0","volume":"7","author":"W Zhang","year":"2017","unstructured":"Zhang W, Zhong W, Sun Q, Sun X, Zhou Z. Hepatic overproduction of 13-HODE due to ALOX15 upregulation contributes to alcohol-induced liver injury in mice. Sci Rep. 2017;7:8976.","journal-title":"Sci Rep"},{"key":"5638_CR14","doi-asserted-by":"publisher","first-page":"3046","DOI":"10.1194\/jlr.M007096","volume":"51","author":"AE Feldstein","year":"2010","unstructured":"Feldstein AE, Lopez R, Tamimi TA-R, et al. Mass spectrometric profiling of oxidized lipid products in human nonalcoholic fatty liver disease and nonalcoholic steatohepatitis. J Lipid Res. 2010;51:3046\u20133054.","journal-title":"J Lipid Res"},{"key":"5638_CR15","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1037\/0021-843X.106.4.545","volume":"106","author":"SA Ball","year":"1997","unstructured":"Ball SA, Tennen H, Poling JC, Kranzler HR, Rounsaville BJ. Personality, temperament, and character dimensions and the DSM-IV personality disorders in substance abusers. J Abnorm Psychol. 1997;106:545\u2013553.","journal-title":"J Abnorm Psychol"},{"key":"5638_CR16","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1016\/j.jhep.2018.03.031","volume":"69","author":"K Brandl","year":"2018","unstructured":"Brandl K, Hartmann P, Jih LJ, et al. Dysregulation of serum bile acids and FGF19 in alcoholic hepatitis. J Hepatol. 2018;69:396\u2013405.","journal-title":"J Hepatol"},{"key":"5638_CR17","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1016\/S2468-1253(18)30124-9","volume":"3","author":"E Nguyen-Khac","year":"2018","unstructured":"Nguyen-Khac E, Thiele M, Voican C, et al. Non-invasive diagnosis of liver fibrosis in patients with alcohol-related liver disease by transient elastography: an individual patient data meta-analysis. Lancet Gastroenterol Hepatol. 2018;3:614\u2013625.","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"5638_CR18","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000001119","author":"M Salavrakos","year":"2018","unstructured":"Salavrakos M, Piessevaux H, Komuta M, Lanthier N, Starkel P. Fibroscan reliably rules out advanced liver fibrosis and significant portal hypertension in alcoholic patients. J Clin Gastroenterol. 2018. \n                    https:\/\/doi.org\/10.1097\/MCG.0000000000001119\n                    \n                  .","journal-title":"J Clin Gastroenterol"},{"key":"5638_CR19","doi-asserted-by":"publisher","first-page":"343828","DOI":"10.1155\/2015\/343828","volume":"2015","author":"E Buzzetti","year":"2015","unstructured":"Buzzetti E, Lombardi R, De Luca L, Tsochatzis EA. Noninvasive assessment of fibrosis in patients with nonalcoholic fatty liver disease. Int J Endocrinol. 2015;2015:343828.","journal-title":"Int J Endocrinol"},{"key":"5638_CR20","doi-asserted-by":"publisher","first-page":"1717","DOI":"10.1053\/j.gastro.2019.01.042","volume":"156","author":"PJ Eddowes","year":"2019","unstructured":"Eddowes PJ, Sasso M, Allison M, et al. Accuracy of FibroScan controlled attenuation parameter and liver stiffness measurement in assessing steatosis and fibrosis in patients with non-alcoholic fatty liver disease. Gastroenterology. 2019;\u200b156:1717\u20131730.","journal-title":"Gastroenterology"},{"key":"5638_CR21","doi-asserted-by":"publisher","first-page":"1348","DOI":"10.1002\/hep.29639","volume":"67","author":"C Caussy","year":"2018","unstructured":"Caussy C, Alquiraish MH, Nguyen P, et al. Optimal threshold of controlled attenuation parameter with MRI-PDFF as the gold standard for the detection of hepatic steatosis. Hepatology. 2018;67:1348\u20131359.","journal-title":"Hepatology"},{"key":"5638_CR22","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1016\/j.jhep.2016.12.022","volume":"66","author":"T Karlas","year":"2017","unstructured":"Karlas T, Petroff D, Sasso M, et al. Individual patient data meta-analysis of controlled attenuation parameter (CAP) technology for assessing steatosis. J Hepatol. 2017;66:1022\u20131030.","journal-title":"J Hepatol"},{"key":"5638_CR23","doi-asserted-by":"publisher","first-page":"E4485","DOI":"10.1073\/pnas.1415174111","volume":"111","author":"S Leclercq","year":"2014","unstructured":"Leclercq S, Matamoros S, Cani PD, et al. Intestinal permeability, gut-bacterial dysbiosis, and behavioral markers of alcohol-dependence severity. Proc Natl Acad Sci USA. 2014;111:E4485\u2013E4493.","journal-title":"Proc Natl Acad Sci USA"},{"key":"5638_CR24","doi-asserted-by":"publisher","first-page":"2074","DOI":"10.1194\/jlr.M900193-JLR200","volume":"51","author":"GC Shearer","year":"2010","unstructured":"Shearer GC, Harris WS, Pedersen TL, Newman JW. Detection of omega-3 oxylipins in human plasma and response to treatment with omega-3 acid ethyl esters. J Lipid Res. 2010;51:2074\u20132081.","journal-title":"J Lipid Res"},{"key":"5638_CR25","doi-asserted-by":"publisher","first-page":"2891","DOI":"10.1074\/jbc.M608057200","volume":"282","author":"A Luria","year":"2007","unstructured":"Luria A, Weldon SM, Kabcenell AK, et al. Compensatory mechanism for homeostatic blood pressure regulation in Ephx2 gene-disrupted mice. J Biol Chem. 2007;282:2891\u20132898.","journal-title":"J Biol Chem"},{"key":"5638_CR26","doi-asserted-by":"publisher","first-page":"14567","DOI":"10.1038\/s41598-017-15231-w","volume":"7","author":"DK Barupal","year":"2017","unstructured":"Barupal DK, Fiehn O. Chemical similarity enrichment analysis (ChemRICH) as alternative to biochemical pathway mapping for metabolomic datasets. Sci Rep. 2017;7:14567.","journal-title":"Sci Rep"},{"key":"5638_CR27","doi-asserted-by":"publisher","first-page":"e0204119","DOI":"10.1371\/journal.pone.0204119","volume":"13","author":"DR Warner","year":"2018","unstructured":"Warner DR, Liu H, Ghosh Dastidar S, et al. Ethanol and unsaturated dietary fat induce unique patterns of hepatic \u03c9-6 and \u03c9-3 PUFA oxylipins in a mouse model of alcoholic liver disease. PloS One. 2018;13:e0204119.","journal-title":"PloS One"},{"key":"5638_CR28","doi-asserted-by":"publisher","first-page":"e107658","DOI":"10.1371\/journal.pone.0107658","volume":"9","author":"M Lazic","year":"2014","unstructured":"Lazic M, Inzaugarat ME, Povero D, et al. Reduced dietary omega-6 to omega-3 fatty acid ratio and 12\/15-lipoxygenase deficiency are protective against chronic high fat diet-induced steatohepatitis. PloS one. 2014;9:e107658.","journal-title":"PloS one"},{"key":"5638_CR29","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1194\/jlr.M066175","volume":"57","author":"P Puri","year":"2016","unstructured":"Puri P, Xu J, Vihervaara T, et al. Alcohol produces distinct hepatic lipidome and eicosanoid signature in lean and obese. J Lipid Res. 2016;57:1017\u20131028.","journal-title":"J Lipid Res"},{"key":"5638_CR30","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.1002\/hep.23229","volume":"50","author":"P Puri","year":"2009","unstructured":"Puri P, Wiest MM, Cheung O, et al. The plasma lipidomic signature of nonalcoholic steatohepatitis. Hepatology (Baltimore, Md.). 2009;50:1827\u20131838.","journal-title":"Hepatology (Baltimore, Md.)"},{"key":"5638_CR31","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1002\/hep.25778","volume":"56","author":"CO Zein","year":"2012","unstructured":"Zein CO, Lopez R, Fu X, et al. Pentoxifylline decreases oxidized lipid products in nonalcoholic steatohepatitis: new evidence on the potential therapeutic mechanism. Hepatology (Baltimore, Md.). 2012;56:1291\u20131299.","journal-title":"Hepatology (Baltimore, Md.)"},{"key":"5638_CR32","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1111\/j.1530-0277.2011.01673.x","volume":"36","author":"IA Kirpich","year":"2012","unstructured":"Kirpich IA, Feng W, Wang Y, et al. The type of dietary fat modulates intestinal tight junction integrity, gut permeability, and hepatic toll-like receptor expression in a mouse model of alcoholic liver disease. Alcohol Clin Exp Res. 2012;36:835\u2013846.","journal-title":"Alcohol Clin Exp Res"},{"key":"5638_CR33","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1128\/CMR.16.3.517-533.2003","volume":"16","author":"MC Noverr","year":"2003","unstructured":"Noverr MC, Erb-Downward JR, Huffnagle GB. Production of eicosanoids and other oxylipins by pathogenic eukaryotic microbes. Clin Microbiol Rev. 2003;16:517\u2013533.","journal-title":"Clin Microbiol Rev"},{"key":"5638_CR34","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.tim.2007.01.005","volume":"15","author":"DI Tsitsigiannis","year":"2007","unstructured":"Tsitsigiannis DI, Keller NP. Oxylipins as developmental and host\u2013fungal communication signals. Trends Microbiol. 2007;15:109\u2013118.","journal-title":"Trends Microbiol"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-019-05638-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10620-019-05638-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-019-05638-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T14:20:44Z","timestamp":1589725244000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10620-019-05638-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,10]]},"references-count":34,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["5638"],"URL":"https:\/\/doi.org\/10.1007\/s10620-019-05638-y","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,10]]},"assertion":[{"value":"27 March 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 April 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 May 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"B.S. is consulting for Ferring Research Institute.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}