{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:49:48Z","timestamp":1791978588414,"version":"4.4.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2019,10,28]],"date-time":"2019-10-28T00:00:00Z","timestamp":1572220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,10,28]],"date-time":"2019-10-28T00:00:00Z","timestamp":1572220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1007\/s10620-019-05881-3","type":"journal-article","created":{"date-parts":[[2019,10,28]],"date-time":"2019-10-28T11:40:29Z","timestamp":1572262829000},"page":"349-354","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Development and Pathophysiology of Oral Rehydration Therapy for the Treatment for Diarrhea"],"prefix":"10.1007","volume":"65","author":[{"given":"Henry J.","family":"Binder","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,10,28]]},"reference":[{"key":"5881_CR1","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1056\/NEJMcp031534","volume":"350","author":"NM Theilman","year":"2004","unstructured":"Theilman NM, Guerrant RL. Clinical practice: acute infectious diarrhea. N Engl J Med. 2004;350:38\u201347.","journal-title":"N Engl J Med"},{"key":"5881_CR2","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.ebiom.2016.07.030","volume":"10","author":"K Watanabe","year":"2016","unstructured":"Watanabe K, Petri WA. Environmental enteropathy: elusive but significant subclinical abnormalities in developing countries. J EbioMed. 2016;10:25\u201332.","journal-title":"J EbioMed"},{"key":"5881_CR3","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1172\/JCI106874","volume":"51","author":"M Field","year":"1972","unstructured":"Field M, Fromm D, al-Awqati Q, Greenough WB 3rd. Effect of cholera entertoxin on ion transport across isolated ileal muscosa. J Clin Invest. 1972;51:796\u2013804.","journal-title":"J Clin Invest"},{"key":"5881_CR4","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1152\/ajplegacy.1973.225.4.781","volume":"225","author":"DW Powell","year":"1973","unstructured":"Powell DW, Binder HJ, Curran PF. Active electrolyte secretion stimulated by choleragen in rabbit ileum in vitro. Am J Physiol. 1973;225:781\u2013787.","journal-title":"Am J Physiol"},{"key":"5881_CR5","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1172\/JCI200318326","volume":"111","author":"M Field","year":"2003","unstructured":"Field M. Intestinal ion transport and the pathophysiology of diarrhea. J Clin Invest. 2003;111:931\u2013943.","journal-title":"J Clin Invest"},{"key":"5881_CR6","first-page":"899","volume-title":"Medical Physiology","author":"HJ Binder","year":"2017","unstructured":"Binder HJ. Intestinal fluid and electrolyte movement. In: Boron E, Boulapaep EL, eds. Medical Physiology. 3rd ed. Philadelphia: Saunders; 2017:899\u2013913.","edition":"3"},{"key":"5881_CR7","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1085\/jgp.47.6.1043","volume":"47","author":"SG Schultz","year":"1964","unstructured":"Schultz SG, Zalusky R. Ion transport in isolated rabbit ileum. II. The interaction between active sodium and active sugar transport. J Gen Physiol. 1964;47:1043\u20131059.","journal-title":"J Gen Physiol"},{"key":"5881_CR8","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1152\/physrev.00055.2009","volume":"91","author":"EM Wright","year":"2011","unstructured":"Wright EM, Loo DD, Hirayama BA. Biology of human sodium glucose transporters. Physiol Rev. 2011;91:733\u2013794.","journal-title":"Physiol Rev"},{"key":"5881_CR9","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1016\/S0140-6736(68)90591-6","volume":"2","author":"DR Nalin","year":"1968","unstructured":"Nalin DR, Cash RA, Islam R, Molla M, Phillips RA. Oral maintenance therapy for cholera in adults. Lancet. 1968;2:370\u2013373.","journal-title":"Lancet"},{"key":"5881_CR10","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1056\/NEJM196807252790402","volume":"279","author":"N Hirschorn","year":"1968","unstructured":"Hirschorn N, Kinzie JL, Sachar DB, et al. Decrease in net stool output in cholera during intestinal perfusion with glucose-containing solutions. N Engl J Med. 1968;279:176\u2013181.","journal-title":"N Engl J Med"},{"key":"5881_CR11","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.7326\/0003-4819-70-6-1173","volume":"70","author":"NF Pierce","year":"1969","unstructured":"Pierce NF, Sack RB, Mitra RC, et al. Replacement of water and electrolyte losses in cholera by an oral glucose-electrolyte solution. Ann Intern Med. 1969;70:1173\u20131181.","journal-title":"Ann Intern Med"},{"key":"5881_CR12","first-page":"300","volume":"2","author":"Water with sugar and salt","year":"1978","unstructured":"Water with sugar and salt. Lancet. 1978;2:300\u2013306.","journal-title":"Lancet"},{"key":"5881_CR13","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1016\/S0140-6736(18)31488-0","volume":"392","author":"DR Nalin","year":"2018","unstructured":"Nalin DR, Cash RA. 50\u00a0years of oral rehydration therapy: the solution is still simple. Lancet. 2018;392:536\u2013538.","journal-title":"Lancet"},{"key":"5881_CR14","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/S0140-6736(89)90601-6","volume":"2","author":"AM Molla","year":"1989","unstructured":"Molla AM, Molla A, Nath SK, Khatun M. Food-based oral rehydration salt solution for acute childhood diarrhoea. Lancet. 1989;2:429\u2013431.","journal-title":"Lancet"},{"key":"5881_CR15","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/S0022-3476(96)70426-2","volume":"128","author":"M Santosham","year":"1996","unstructured":"Santosham M, Fayad I, Abu Zikri M, et al. A double-blind clinical trial comparing World Health Organization oral rehydration solution with a reduced osmolarity solution containing equal amounts of sodium and glucose. J Pedatr. 1996;128:45\u201351.","journal-title":"J Pedatr"},{"key":"5881_CR16","first-page":"113","volume":"12","author":"AM Molla","year":"1990","unstructured":"Molla AM, Molla A, Bari A. Role of glucose polymer (cereal) in oral rehydration therapy. Clin Ther. 1990;12:113\u2013120.","journal-title":"Clin Ther"},{"key":"5881_CR17","doi-asserted-by":"publisher","first-page":"2628","DOI":"10.1001\/jama.291.21.2628","volume":"291","author":"C Duggan","year":"2004","unstructured":"Duggan C, Fontaine O, Pierce NF, et al. Scientific rationale for a change in the composition of oral rehydration solution. JAMA. 2004;291:2628\u20132631.","journal-title":"JAMA"},{"key":"5881_CR18","first-page":"420","volume-title":"Yamada\u2019s Textbook of Gastroenterology","author":"KE Barrett","year":"2016","unstructured":"Barrett KE, Keely SJ. Electrolyte secretion and absorption in the small intestine and colon. In: Podolsky D, et al., eds. Yamada\u2019s Textbook of Gastroenterology. New York: Wiley; 2016:420\u2013449."},{"key":"5881_CR19","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1053\/j.gastro.2010.10.042","volume":"140","author":"R Lin","year":"2011","unstructured":"Lin R, Murtazina R, Cha B, et al. D-glucose acts via sodium\/glucose cotransporter 1 to increase NHE in mouse jejunal brush border by a Na+\/H+ exchange regulatory factor 2-dependent process. Gastroenterology. 2011;140:560\u2013571.","journal-title":"Gastroenterology"},{"key":"5881_CR20","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1146\/annurev-physiol-021909-135817","volume":"72","author":"HJ Binder","year":"2010","unstructured":"Binder HJ. Role of colonic short-chain fatty acid transport in diarrhea. Annu Rev Physiol. 2010;72:297\u2013313.","journal-title":"Annu Rev Physiol"},{"key":"5881_CR21","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1016\/0016-5085(89)91614-4","volume":"96","author":"HJ Binder","year":"1989","unstructured":"Binder HJ, Mehta P. Short-chain Fatty Acids stimulate active sodium and chloride absorption in vitro in the rat distal colon. Gastroenterology. 1989;96:989\u2013996.","journal-title":"Gastroenterology"},{"key":"5881_CR22","doi-asserted-by":"publisher","first-page":"G188","DOI":"10.1152\/ajpgi.00298.2014","volume":"308","author":"I Kaji","year":"2015","unstructured":"Kaji I, Iwanaga T, Watanabe M, et al. SCFA transport in rat duodenum. Am J Physiol Gastrointest Liver Physiol. 2015;308:G188\u2013G197.","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"5881_CR23","doi-asserted-by":"publisher","first-page":"G857","DOI":"10.1152\/ajpgi.00462.2006","volume":"293","author":"SB Subramanya","year":"2007","unstructured":"Subramanya SB, Rajendran VM, Srinivasan P, Nanda Kumar NS, Ramakrishna BS, Binder HJ. Differential regulation of cholera toxin-inhibited Na\u2013H exchange isoforms by butyrate in rat ileum. Am J Physiol Gastrointest Liver Physiol. 2007;293:G857\u2013G863.","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"5881_CR24","doi-asserted-by":"publisher","first-page":"C1246","DOI":"10.1152\/ajpcell.00598.2002","volume":"285","author":"S Krishnan","year":"2003","unstructured":"Krishnan S, Rajendran VM, Binder HJ. Apical NHE isoforms differentially regulate butyrate-stimulated Na absorption in rat distal colon. Am J Physiol Cell Physiol. 2003;285:C1246\u2013C1254.","journal-title":"Am J Physiol Cell Physiol"},{"key":"5881_CR25","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1056\/NEJM200002033420502","volume":"342","author":"BS Ramakrishna","year":"2000","unstructured":"Ramakrishna BS, Venkataraman S, Srinivasan P, Dash P, Young GP, Binder HJ. Amylase-resistant starch plus oral rehydration solution for cholera. N Engl J Med. 2000;342:308\u2013313.","journal-title":"N Engl J Med"},{"key":"5881_CR26","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1097\/01.mpg.0000214163.83316.41","volume":"42","author":"P Ragaputhy","year":"2006","unstructured":"Ragaputhy P, Ramakrishna BS, Oommen SP, et al. Amylase-resistant starch as an adjunct to oral rehydration therapy in children with diarrhea. J Pediatr Gastroenterol Nutr. 2006;42:362\u2013368.","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"5881_CR27","doi-asserted-by":"publisher","first-page":"e1587","DOI":"10.1371\/journal.pone.0001587","volume":"3","author":"BS Balakrishnan","year":"2008","unstructured":"Balakrishnan BS, Venkataraman S, Mohen V, et al. Amalase resistant starch in hypo-osmolar oral rehydration solution for the treatment of acute severe watery diarrhea in adults. PLoS ONE. 2008;3:e1587.","journal-title":"PLoS ONE"},{"key":"5881_CR28","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/S0140-6736(10)60356-X","volume":"376","author":"M Santosham","year":"2010","unstructured":"Santosham M, Chandran A, Fitzwater S, Fisher-Walker C, Baqui AH, Black R. Progress and barriers for the control of diarrheal disease. Lancet. 2010;376:63\u201367.","journal-title":"Lancet"},{"key":"5881_CR29","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1152\/ajpcell.00174.2013","volume":"306","author":"L Yin","year":"2014","unstructured":"Yin L, Vijaygopal P, MacGregor GG, et al. Glucose stimulates calcium-activated chloride secretion in small intestinal cells. Am J Physiol Cell Physiol. 2014;306:687\u2013696.","journal-title":"Am J Physiol Cell Physiol"},{"key":"5881_CR30","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1097\/HP.0000000000000117","volume":"106","author":"L Yin","year":"2014","unstructured":"Yin L, Vijaygoal P, Menon R, et al. An amino acid mixture mitigates radiation-induced gastrointestinal toxicity. Health Phys. 2014;106:734\u2013744.","journal-title":"Health Phys"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-019-05881-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10620-019-05881-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-019-05881-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T00:28:12Z","timestamp":1603758492000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10620-019-05881-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,28]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["5881"],"URL":"https:\/\/doi.org\/10.1007\/s10620-019-05881-3","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,28]]},"assertion":[{"value":"28 October 2019","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"Dr. Binder is a consultant for and has equity in Entrinsic Health Solutions, Inc.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}