{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T14:27:52Z","timestamp":1790605672797,"version":"4.1.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2020,1,2]],"date-time":"2020-01-02T00:00:00Z","timestamp":1577923200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,1,2]],"date-time":"2020-01-02T00:00:00Z","timestamp":1577923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1007\/s10620-019-06005-7","type":"journal-article","created":{"date-parts":[[2020,1,2]],"date-time":"2020-01-02T16:02:38Z","timestamp":1577980958000},"page":"2719-2729","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Acute-on-Chronic Liver Failure in Budd\u2013Chiari Syndrome: Profile and Predictors of Outcome"],"prefix":"10.1007","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1247-437X","authenticated-orcid":false,"family":"Shalimar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanchit","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivanand R.","family":"Gamanagatti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Chauhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudheer Kumar","family":"Vuyyuru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anshuman","family":"Elhence","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyanranjan","family":"Rout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anoop","family":"Saraya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak","family":"Gunjan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baibaswata","family":"Nayak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramesh","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subrat Kumar","family":"Acharya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,1,2]]},"reference":[{"key":"6005_CR1","doi-asserted-by":"publisher","first-page":"1729","DOI":"10.1002\/hep.22772","volume":"49","author":"LD DeLeve","year":"2009","unstructured":"DeLeve LD, Valla D-C, Garcia-Tsao G. American Association for the study liver diseases. Vascular disorders of the liver. Hepatology. 2009;49:1729\u20131764.","journal-title":"Hepatology"},{"key":"6005_CR2","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1053\/j.gastro.2008.05.051","volume":"135","author":"JC Garcia-Pag\u00e1n","year":"2008","unstructured":"Garcia-Pag\u00e1n JC, Heydtmann M, Raffa S, et al. TIPS for Budd\u2013Chiari syndrome: long-term results and prognostics factors in 124 patients. Gastroenterology. 2008;135:808\u2013815.","journal-title":"Gastroenterology"},{"key":"6005_CR3","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.1111\/apt.13604","volume":"43","author":"Shalimar","year":"2016","unstructured":"Shalimar, Kumar A, Kedia S, et al. Hepatic venous outflow tract obstruction: treatment outcomes and development of a new prognostic score. Aliment Pharmacol Ther. 2016;43:1154\u20131167.","journal-title":"Aliment Pharmacol Ther"},{"key":"6005_CR4","doi-asserted-by":"publisher","first-page":"1962","DOI":"10.1002\/hep.26306","volume":"57","author":"S Seijo","year":"2013","unstructured":"Seijo S, Plessier A, Hoekstra J, et al. Good long-term outcome of Budd\u2013Chiari syndrome with a step-wise management. Hepatology. 2013;57:1962\u20131968.","journal-title":"Hepatology"},{"key":"6005_CR5","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1002\/lt.24643","volume":"23","author":"J Parekh","year":"2017","unstructured":"Parekh J, Matei VM, Canas-Coto A, Friedman D, Lee WM. Budd\u2013Chiari syndrome causing acute liver failure: a multicenter case series. Liver Transpl. 2017;23:135\u2013142.","journal-title":"Liver Transpl"},{"key":"6005_CR6","doi-asserted-by":"publisher","first-page":"1870","DOI":"10.1136\/gutjnl-2017-314240","volume":"67","author":"J Fern\u00e1ndez","year":"2018","unstructured":"Fern\u00e1ndez J, Acevedo J, Wiest R, et al. Bacterial and fungal infections in acute-on-chronic liver failure: prevalence, characteristics and impact on prognosis. Gut. 2018;67:1870\u20131880.","journal-title":"Gut"},{"key":"6005_CR7","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1111\/liv.13568","volume":"38","author":"MM M\u00fccke","year":"2018","unstructured":"M\u00fccke MM, Rumyantseva T, M\u00fccke VT, et al. Bacterial infection-triggered acute-on-chronic liver failure is associated with increased mortality. Liver Int. 2018;38:645\u2013653.","journal-title":"Liver Int"},{"key":"6005_CR8","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1016\/j.dld.2018.05.013","volume":"50","author":"Shalimar","year":"2018","unstructured":"Shalimar, Rout G, Jadaun SS, et al. Prevalence, predictors and impact of bacterial infection in acute on chronic liver failure patients. Dig Liver Dis. 2018;50:1225\u20131231.","journal-title":"Dig Liver Dis"},{"key":"6005_CR9","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1007\/s12072-014-9580-2","volume":"8","author":"SK Sarin","year":"2014","unstructured":"Sarin SK, Kedarisetty CK, Abbas Z, Amarapurkar D, Bihari C, et al. Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL) 2014. Hepatol Int. 2014;8:453\u2013471.","journal-title":"Hepatol Int"},{"key":"6005_CR10","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/S0168-8278(02)00434-8","volume":"38","author":"HLA Janssen","year":"2003","unstructured":"Janssen HLA, Garcia-Pagan J-C, Elias E, et al. Budd\u2013Chiari syndrome: a review by an expert panel. J Hepatol. 2003;38:364\u2013371.","journal-title":"J Hepatol"},{"key":"6005_CR11","doi-asserted-by":"publisher","first-page":"1437.e1","DOI":"10.1053\/j.gastro.2013.02.042","volume":"144","author":"R Moreau","year":"2013","unstructured":"Moreau R, Jalan R, Gines P, et al. Acute-on-chronic liver failure is a distinct syndrome that develops in patients with acute decompensation of cirrhosis. Gastroenterology. 2013;144:1437.e1\u20131437.e9.","journal-title":"Gastroenterology"},{"key":"6005_CR12","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1016\/j.jhep.2014.06.012","volume":"61","author":"R Jalan","year":"2014","unstructured":"Jalan R, Saliba F, Pavesi M, et al. Development and validation of a prognostic score to predict mortality in patients with acute-on-chronic liver failure. J Hepatol. 2014;61:1038\u20131047.","journal-title":"J Hepatol"},{"key":"6005_CR13","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1002\/hep.27210","volume":"60","author":"H Vilstrup","year":"2014","unstructured":"Vilstrup H, Amodio P, Bajaj J, et al. Hepatic encephalopathy in chronic liver disease: 2014 Practice Guideline by the American Association for the Study of Liver Diseases and the European Association for the Study of the Liver. Hepatology. 2014;60:715\u2013735.","journal-title":"Hepatology"},{"key":"6005_CR14","doi-asserted-by":"publisher","first-page":"W168","DOI":"10.2214\/AJR.05.0168","volume":"188","author":"G Brancatelli","year":"2007","unstructured":"Brancatelli G, Vilgrain V, Federle MP, et al. Budd\u2013Chiari syndrome: spectrum of imaging findings. Am J Roentgenol. 2007;188:W168\u2013W176.","journal-title":"Am J Roentgenol"},{"key":"6005_CR15","doi-asserted-by":"publisher","first-page":"29","DOI":"10.4103\/2156-7514.186510","volume":"6","author":"JM Owen","year":"2016","unstructured":"Owen JM, Gaba RC. Transjugular intrahepatic portosystemic shunt dysfunction: concordance of clinical findings, doppler ultrasound examination, and shunt venography. J Clin Imaging Sci. 2016;6:29.","journal-title":"J Clin Imaging Sci"},{"key":"6005_CR16","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1002\/bjs.1800600817","volume":"60","author":"RN Pugh","year":"1973","unstructured":"Pugh RN, Murray-Lyon IM, Dawson JL, Pietroni MC, Williams R. Transection of the oesophagus for bleeding oesophageal varices. Br J Surg. 1973;60:646\u2013649.","journal-title":"Br J Surg"},{"key":"6005_CR17","doi-asserted-by":"publisher","first-page":"1649","DOI":"10.1097\/CCM.0b013e31819def97","volume":"37","author":"AE Jones","year":"2009","unstructured":"Jones AE, Trzeciak S, Kline JA. The Sequential Organ Failure Assessment score for predicting outcome in patients with severe sepsis and evidence of hypoperfusion at the time of emergency department presentation. Crit Care Med. 2009;37:1649\u20131654.","journal-title":"Crit Care Med"},{"key":"6005_CR18","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1002\/hep.21563","volume":"45","author":"PS Kamath","year":"2007","unstructured":"Kamath PS, Kim WR. The model for end-stage liver disease (MELD). Hepatology. 2007;45:797\u2013805.","journal-title":"Hepatology"},{"key":"6005_CR19","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1111\/j.1365-2036.2009.04134.x","volume":"30","author":"AJ Montano-Loza","year":"2009","unstructured":"Montano-Loza AJ, Tandon P, Kneteman N, Bailey R, Bain VG. Rotterdam score predicts early mortality in Budd\u2013Chiari syndrome, and surgical shunting prolongs transplant-free survival. Aliment Pharmacol Ther. 2009;30:1060\u20131069.","journal-title":"Aliment Pharmacol Ther"},{"key":"6005_CR20","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.1016\/j.jhep.2014.01.024","volume":"60","author":"R Jalan","year":"2014","unstructured":"Jalan R, Fernandez J, Wiest R, et al. Bacterial infections in cirrhosis: a position statement based on the EASL Special Conference 2013. J Hepatol. 2014;60:1310\u20131324.","journal-title":"J Hepatol"},{"key":"6005_CR21","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.jhep.2008.10.007","volume":"50","author":"D-C Valla","year":"2009","unstructured":"Valla D-C. Primary Budd\u2013Chiari syndrome. J Hepatol. 2009;50:195\u2013203.","journal-title":"J Hepatol"},{"key":"6005_CR22","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1016\/0016-5085(94)90765-X","volume":"106","author":"A Hadengue","year":"1994","unstructured":"Hadengue A, Poliquin M, Vilgrain V, et al. The changing scene of hepatic vein thrombosis: recognition of asymptomatic cases. Gastroenterology. 1994;106:1042\u20131047.","journal-title":"Gastroenterology"},{"key":"6005_CR23","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1056\/NEJMra020282","volume":"350","author":"KVN Menon","year":"2004","unstructured":"Menon KVN, Shah V, Kamath PS. The Budd\u2013Chiari syndrome. N Engl J Med. 2004;350:578\u2013585.","journal-title":"N Engl J Med"},{"key":"6005_CR24","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1111\/jgh.13213","volume":"31","author":"Shalimar","year":"2016","unstructured":"Shalimar, Kumar D, Vadiraja PK, et al. Acute on chronic liver failure because of acute hepatic insults: etiologies, course, extrahepatic organ failure and predictors of mortality. J Gastroenterol Hepatol. 2016;31:856\u2013864.","journal-title":"J Gastroenterol Hepatol"},{"key":"6005_CR25","doi-asserted-by":"publisher","first-page":"1742","DOI":"10.1111\/jgh.13340","volume":"31","author":"Shalimar","year":"2016","unstructured":"Shalimar, Saraswat V, Singh SP, et al. Acute-on-chronic liver failure in India: the Indian National Association for study of the liver consortium experience. J Gastroenterol Hepatol. 2016;31:1742\u20131749.","journal-title":"J Gastroenterol Hepatol"},{"key":"6005_CR26","doi-asserted-by":"publisher","first-page":"2367","DOI":"10.1002\/hep.29773","volume":"67","author":"JG O\u2019Leary","year":"2018","unstructured":"O\u2019Leary JG, Reddy KR, Garcia-Tsao G, et al. NACSELD acute-on-chronic liver failure (NACSELD-ACLF) score predicts 30-day survival in hospitalized patients with cirrhosis. Hepatology. 2018;67:2367\u20132374.","journal-title":"Hepatology"},{"key":"6005_CR27","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1002\/hep.27077","volume":"60","author":"JS Bajaj","year":"2014","unstructured":"Bajaj JS, O\u2019Leary JG, Reddy KR, et al. Survival in infection-related acute-on-chronic liver failure is defined by extrahepatic organ failures. Hepatology. 2014;60:250\u2013256.","journal-title":"Hepatology"},{"key":"6005_CR28","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1186\/s13054-018-2156-0","volume":"22","author":"C Engelmann","year":"2018","unstructured":"Engelmann C, Thomsen KL, Zakeri N, et al. Validation of CLIF-C ACLF score to define a threshold for futility of intensive care support for patients with acute-on-chronic liver failure. Crit Care. 2018;22:254.","journal-title":"Crit Care"},{"key":"6005_CR29","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1016\/j.jhep.2015.05.022","volume":"63","author":"R de Franchis","year":"2015","unstructured":"de Franchis R. Expanding consensus in portal hypertension. J Hepatol. 2015;63:743\u2013752.","journal-title":"J Hepatol"},{"key":"6005_CR30","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1111\/liv.12355","volume":"34","author":"X Qi","year":"2014","unstructured":"Qi X, Guo W, He C, et al. Transjugular intrahepatic portosystemic shunt for Budd\u2013Chiari syndrome: techniques, indications and results on 51 Chinese patients from a single centre. Liver Int. 2014;34:1164\u20131175.","journal-title":"Liver Int"},{"key":"6005_CR31","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1097\/MCG.0000000000000823","volume":"51","author":"Shalimar","year":"2017","unstructured":"Shalimar, Kedia S, Mahapatra SJ, et al. Severity and outcome of acute-on-chronic liver failure is dependent on the etiology of acute hepatic insults: analysis of 368 patients. J Clin Gastroenterol. 2017;51:734\u2013741.","journal-title":"J Clin Gastroenterol"},{"key":"6005_CR32","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1586\/17474124.2015.1024224","volume":"9","author":"X Qi","year":"2015","unstructured":"Qi X, Ren W, Wang Y, Guo X, Fan D. Survival and prognostic indicators of Budd\u2013Chiari syndrome: a systematic review of 79 studies. Expert Rev Gastroenterol Hepatol. 2015;9:865\u2013875.","journal-title":"Expert Rev Gastroenterol Hepatol"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-019-06005-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10620-019-06005-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-019-06005-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T01:03:24Z","timestamp":1609463004000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10620-019-06005-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,2]]},"references-count":32,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["6005"],"URL":"https:\/\/doi.org\/10.1007\/s10620-019-06005-7","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,2]]},"assertion":[{"value":"14 October 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 December 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 January 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}