{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T22:39:41Z","timestamp":1785364781965,"version":"3.55.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2020,2,15]],"date-time":"2020-02-15T00:00:00Z","timestamp":1581724800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,2,15]],"date-time":"2020-02-15T00:00:00Z","timestamp":1581724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1007\/s10620-020-06136-2","type":"journal-article","created":{"date-parts":[[2020,2,15]],"date-time":"2020-02-15T11:03:12Z","timestamp":1581764592000},"page":"3378-3388","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Inpatient Mortality Benefit with Transjugular Intrahepatic Portosystemic Shunt for Hospitalized Hepatorenal Syndrome Patients"],"prefix":"10.1007","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5512-4225","authenticated-orcid":false,"given":"Paris","family":"Charilaou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalpit","family":"Devani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romela","family":"Petrosyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chakradhar","family":"Reddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Pyrsopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,2,15]]},"reference":[{"key":"6136_CR1","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1038\/s41572-018-0022-7","volume":"4","author":"P Gines","year":"2018","unstructured":"Gines P, Sola E, Angeli P, Wong F, Nadim MK, Kamath PS. Hepatorenal syndrome. Nat Rev Dis Primers. 2018;4:23. https:\/\/doi.org\/10.1038\/s41572-018-0022-7.","journal-title":"Nat Rev Dis Primers"},{"key":"6136_CR2","first-page":"474","volume":"15","author":"AZ de Mattos","year":"2016","unstructured":"de Mattos AZ, de Mattos AA, Mendez-Sanchez N. Hepatorenal syndrome: current concepts related to diagnosis and management. Ann Hepatol. 2016;15:474\u2013481.","journal-title":"Ann Hepatol"},{"key":"6136_CR3","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1159\/000375346","volume":"33","author":"M Cavallin","year":"2015","unstructured":"Cavallin M, Fasolato S, Marenco S, Piano S, Tonon M, Angeli P. The treatment of hepatorenal syndrome. Dig Dis. 2015;33:548\u2013554. https:\/\/doi.org\/10.1159\/000375346.","journal-title":"Dig Dis"},{"key":"6136_CR4","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1007\/s12072-017-9815-0","volume":"12","author":"S Piano","year":"2018","unstructured":"Piano S, Tonon M, Angeli P. Management of ascites and hepatorenal syndrome. Hepatol Int. 2018;12:122\u2013134. https:\/\/doi.org\/10.1007\/s12072-017-9815-0.","journal-title":"Hepatol Int"},{"key":"6136_CR5","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.cld.2016.12.005","volume":"21","author":"F Fabrizi","year":"2017","unstructured":"Fabrizi F, Messa P. Challenges in renal failure treatment before liver transplant. Clin Liver Dis. 2017;21:303\u2013319. https:\/\/doi.org\/10.1016\/j.cld.2016.12.005.","journal-title":"Clin Liver Dis"},{"key":"6136_CR6","first-page":"1766","volume":"25","author":"JR Lake","year":"1993","unstructured":"Lake JR, Ring E, LaBerge J, Gordon R, Roberts J, Ascher N. Transjugular intrahepatic portacaval stent shunts in patients with renal insufficiency. Transplant Proc. 1993;25:1766\u20131767.","journal-title":"Transplant Proc"},{"key":"6136_CR7","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.1056\/NEJM199505043321803","volume":"332","author":"A Ochs","year":"1995","unstructured":"Ochs A, Rossle M, Haag K, et al. The transjugular intrahepatic portosystemic stent-shunt procedure for refractory ascites. N Engl J Med. 1995;332:1192\u20131197. https:\/\/doi.org\/10.1056\/NEJM199505043321803.","journal-title":"N Engl J Med"},{"key":"6136_CR8","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1016\/j.jvir.2010.05.009","volume":"21","author":"CL Anderson","year":"2010","unstructured":"Anderson CL, Saad WE, Kalagher SD, et al. Effect of transjugular intrahepatic portosystemic shunt placement on renal function: a 7-year, single-center experience. J Vasc Interv Radiol. 2010;21:1370\u20131376. https:\/\/doi.org\/10.1016\/j.jvir.2010.05.009.","journal-title":"J Vasc Interv Radiol"},{"key":"6136_CR9","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1002\/hep.510280219","volume":"28","author":"M Guevara","year":"1998","unstructured":"Guevara M, Gines P, Bandi JC, et al. Transjugular intrahepatic portosystemic shunt in hepatorenal syndrome: effects on renal function and vasoactive systems. Hepatology. 1998;28:416\u2013422. https:\/\/doi.org\/10.1002\/hep.510280219.","journal-title":"Hepatology"},{"key":"6136_CR10","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1136\/gut.47.2.288","volume":"47","author":"KA Brensing","year":"2000","unstructured":"Brensing KA, Textor J, Perz J, et al. Long term outcome after transjugular intrahepatic portosystemic stent-shunt in non-transplant cirrhotics with hepatorenal syndrome: a phase II study. Gut. 2000;47:288\u2013295.","journal-title":"Gut"},{"key":"6136_CR11","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1002\/hep.20262","volume":"40","author":"F Wong","year":"2004","unstructured":"Wong F, Pantea L, Sniderman K. Midodrine, octreotide, albumin, and TIPS in selected patients with cirrhosis and type 1 hepatorenal syndrome. Hepatology. 2004;40:55\u201364. https:\/\/doi.org\/10.1002\/hep.20262.","journal-title":"Hepatology"},{"key":"6136_CR12","first-page":"203","volume":"5","author":"G Testino","year":"2012","unstructured":"Testino G, Leone S, Ferro C, Borro P. Severe acute alcoholic hepatitis and hepatorenal syndrome: role of transjugular intrahepatic portosystemic stent shunt. J Med Life. 2012;5:203\u2013205.","journal-title":"J Med Life"},{"key":"6136_CR13","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1038\/nrneph.2011.96","volume":"7","author":"V Arroyo","year":"2011","unstructured":"Arroyo V, Fernandez J. Management of hepatorenal syndrome in patients with cirrhosis. Nat Rev Nephrol. 2011;7:517\u2013526. https:\/\/doi.org\/10.1038\/nrneph.2011.96.","journal-title":"Nat Rev Nephrol"},{"key":"6136_CR14","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1111\/jgh.12709","volume":"30","author":"M Egerod Israelsen","year":"2015","unstructured":"Egerod Israelsen M, Gluud LL, Krag A. Acute kidney injury and hepatorenal syndrome in cirrhosis. J Gastroenterol Hepatol. 2015;30:236\u2013243. https:\/\/doi.org\/10.1111\/jgh.12709.","journal-title":"J Gastroenterol Hepatol"},{"key":"6136_CR15","unstructured":"HCUP Databases. Healthcare Cost and Utilization Project (HCUP). Agency for Healthcare Research and Quality, Rockville, MD. 2016. https:\/\/www.hcup-us.ahrq.gov\/nisoverview.jsp. Accessed June 26, 2016."},{"key":"6136_CR16","unstructured":"HCUP NIS Database Documentation. Agency for Healthcare Research and Quality, Rockville, MD. 2016. http:\/\/www.hcup-us.ahrq.gov\/db\/nation\/nis\/nisdbdocumentation.jsp. Accessed June 26, 2016."},{"key":"6136_CR17","unstructured":"HCUP Methods Series 2012 HCUP National Inpatient Sample (NIS) Comparison Report. Agency for Healthcare Research and Quality. Rockville, MD. 2016. Available at: https:\/\/www.hcup-us.ahrq.gov\/db\/nation\/nis\/reports\/2012niscomparisonrpt.jsp."},{"key":"6136_CR18","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1111\/j.1365-2036.2007.03572.x","volume":"27","author":"JR Kramer","year":"2008","unstructured":"Kramer JR, Davila JA, Miller ED, Richardson P, Giordano TP, El-Serag HB. The validity of viral hepatitis and chronic liver disease diagnoses in Veterans Affairs administrative databases. Aliment Pharmacol Ther. 2008;27:274\u2013282. https:\/\/doi.org\/10.1111\/j.1365-2036.2007.03572.x.","journal-title":"Aliment Pharmacol Ther"},{"key":"6136_CR19","doi-asserted-by":"publisher","first-page":"e50","DOI":"10.1097\/MCG.0b013e3182688d2f","volume":"47","author":"MS Nehra","year":"2013","unstructured":"Nehra MS, Ma Y, Clark C, Amarasingham R, Rockey DC, Singal AG. Use of administrative claims data for identifying patients with cirrhosis. J Clin Gastroenterol. 2013;47:e50\u2013e54. https:\/\/doi.org\/10.1097\/MCG.0b013e3182688d2f.","journal-title":"J Clin Gastroenterol"},{"key":"6136_CR20","doi-asserted-by":"publisher","first-page":"e002739","DOI":"10.1161\/JAHA.115.002739","volume":"5","author":"JR Brown","year":"2016","unstructured":"Brown JR, Rezaee ME, Nichols EL, Marshall EJ, Siew ED, Matheny ME. Incidence and in-hospital mortality of Acute Kidney Injury (AKI) and dialysis-requiring AKI (AKI-D) after cardiac catheterization in the national inpatient sample. J Am Heart Assoc. 2016;5:e002739. https:\/\/doi.org\/10.1161\/JAHA.115.002739.","journal-title":"J Am Heart Assoc"},{"key":"6136_CR21","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1097\/01.CCM.0000261890.41311.E9","volume":"35","author":"VY Dombrovskiy","year":"2007","unstructured":"Dombrovskiy VY, Martin AA, Sunderram J, Paz HL. Rapid increase in hospitalization and mortality rates for severe sepsis in the United States: a trend analysis from 1993 to 2003. Crit Care Med. 2007;35:1244\u20131250. https:\/\/doi.org\/10.1097\/01.CCM.0000261890.41311.E9.","journal-title":"Crit Care Med"},{"key":"6136_CR22","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1681\/ASN.2012080800","volume":"24","author":"RK Hsu","year":"2013","unstructured":"Hsu RK, McCulloch CE, Dudley RA, Lo LJ, Hsu CY. Temporal changes in incidence of dialysis-requiring AKI. J Am Soc Nephrol. 2013;24:37\u201342. https:\/\/doi.org\/10.1681\/ASN.2012080800.","journal-title":"J Am Soc Nephrol"},{"key":"6136_CR23","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.athoracsur.2012.05.131","volume":"95","author":"CR Lenihan","year":"2013","unstructured":"Lenihan CR, Montez-Rath ME, Mora Mangano CT, Chertow GM, Winkelmayer WC. Trends in acute kidney injury, associated use of dialysis, and mortality after cardiac surgery, 1999\u20132008. Ann Thorac Surg. 2013;95:20\u201328. https:\/\/doi.org\/10.1016\/j.athoracsur.2012.05.131.","journal-title":"Ann Thorac Surg"},{"key":"6136_CR24","unstructured":"Gordon M. Calculates Comorbidity Indices Based on ICD-9\/10 (comorbidities.icd10). 0.6.1 ed. https:\/\/github.com\/gforge\/comorbidities.icd10. 2016."},{"key":"6136_CR25","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.1097\/01.mlr.0000182534.19832.83","volume":"43","author":"H Quan","year":"2005","unstructured":"Quan H, Sundararajan V, Halfon P, et al. Coding algorithms for defining comorbidities in ICD-9-CM and ICD-10 administrative data. Med Care. 2005;43:1130\u20131139.","journal-title":"Med Care"},{"key":"6136_CR26","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1002\/sim.5525","volume":"32","author":"P Paul","year":"2013","unstructured":"Paul P, Pennell ML, Lemeshow S. Standardizing the power of the Hosmer\u2013Lemeshow goodness of fit test in large data sets. Stat Med. 2013;32:67\u201380. https:\/\/doi.org\/10.1002\/sim.5525.","journal-title":"Stat Med"},{"key":"6136_CR27","unstructured":"Blackwell MIS, King G, Porro G. cem: Coarsened Exact Matching in Stata. 2010. http:\/\/gking.harvard.edu\/files\/gking\/files\/cem-stata.pdf. Accessed December 12, 2016."},{"key":"6136_CR28","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1002\/hep.29354","volume":"67","author":"A Sarwar","year":"2018","unstructured":"Sarwar A, Zhou L, Novack V, et al. Hospital volume and mortality after transjugular intrahepatic portosystemic shunt creation in the United States. Hepatology. 2018;67:690\u2013699. https:\/\/doi.org\/10.1002\/hep.29354.","journal-title":"Hepatology"},{"key":"6136_CR29","doi-asserted-by":"crossref","unstructured":"Barton RE, R\u00f6sch J, Saxon RR, Lakin PC, Petersen BD, Keller FS, eds. TIPS: Short-and Long-Term Results: A Survey of 1750 Patients. Copyright\u00a9 1995 by Thieme Medical Publishers, Inc.; 1995.","DOI":"10.1055\/s-0028-1082233"},{"key":"6136_CR30","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.1016\/j.jvir.2016.05.010","volume":"27","author":"AK Pillai","year":"2016","unstructured":"Pillai AK, Andring B, Faulconer N, et al. Utility of intravascular US-guided portal vein access during transjugular intrahepatic portosystemic shunt creation: retrospective comparison with conventional technique in 109 patients. J Vasc Interv Radiol. 2016;27:1154\u20131159. https:\/\/doi.org\/10.1016\/j.jvir.2016.05.010.","journal-title":"J Vasc Interv Radiol"},{"key":"6136_CR31","unstructured":"HCUP NIS Trend Weights. Healthcare Cost and Utilization Project (HCUP), Rockville, MD. 2015. https:\/\/www.hcup-us.ahrq.gov\/db\/nation\/nis\/trendwghts.jsp. Accessed June 26, 2016."},{"key":"6136_CR32","unstructured":"Houchens REA. Final Report on Calculating Nationwide Inpatient Sample (NIS) Variances for Data Years 2011 and Earlier. In: HCUP Method Series Report # 2003-02. U.S. Agency for Healthcare Research and Quality. 2015. https:\/\/www.hcup-us.ahrq.gov\/reports\/methods\/2003_02.jsp. Accessed June 26, 2016."},{"key":"6136_CR33","unstructured":"Houchens RRD, Elixhauser A. Final Report on Calculating National Inpatient Sample (NIS) Variances for Data Years 2012 and Later. In: HCUP Methods Series Report # 2015-09 ONLINE. U.S. Agency for Healthcare Research and Quality. 2015. https:\/\/www.hcup-us.ahrq.gov\/reports\/methods\/2015-09.pdf. Accessed February 26, 2017."},{"key":"6136_CR34","doi-asserted-by":"publisher","first-page":"S344","DOI":"10.1097\/MCG.0b013e318157e500","volume":"41","author":"L Colombato","year":"2007","unstructured":"Colombato L. The role of transjugular intrahepatic portosystemic shunt (TIPS) in the management of portal hypertension. J Clin Gastroenterol. 2007;41:S344\u2013S351. https:\/\/doi.org\/10.1097\/MCG.0b013e318157e500.","journal-title":"J Clin Gastroenterol"},{"key":"6136_CR35","doi-asserted-by":"publisher","first-page":"1839","DOI":"10.1053\/gast.2002.37073","volume":"123","author":"P Gines","year":"2002","unstructured":"Gines P, Uriz J, Calahorra B, et al. Transjugular intrahepatic portosystemic shunting versus paracentesis plus albumin for refractory ascites in cirrhosis. Gastroenterology. 2002;123:1839\u20131847. https:\/\/doi.org\/10.1053\/gast.2002.37073.","journal-title":"Gastroenterology"},{"key":"6136_CR36","first-page":"1753","volume":"50","author":"G Testino","year":"2003","unstructured":"Testino G, Ferro C, Sumberaz A, et al. Type-2 hepatorenal syndrome and refractory ascites: role of transjugular intrahepatic portosystemic stent-shunt in eighteen patients with advanced cirrhosis awaiting orthotopic liver transplantation. Hepatogastroenterology. 2003;50:1753\u20131755.","journal-title":"Hepatogastroenterology"},{"key":"6136_CR37","doi-asserted-by":"publisher","unstructured":"Late-Breaking Abstracts\u2014Presented at the 70th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting\u2122 2019. Hepatology. 2019;70:1477A\u20131501A. https:\/\/doi.org\/10.1002\/hep.31033.","DOI":"10.1002\/hep.31033"},{"key":"6136_CR38","doi-asserted-by":"publisher","first-page":"1651","DOI":"10.1002\/hep.26359","volume":"57","author":"BA Runyon","year":"2013","unstructured":"Runyon BA, Aasld. Introduction to the revised American Association for the Study of Liver Diseases Practice Guideline management of adult patients with ascites due to cirrhosis 2012. Hepatology. 2013;57:1651\u20131653. https:\/\/doi.org\/10.1002\/hep.26359.","journal-title":"Hepatology"},{"key":"6136_CR39","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacr.2019.08.020","author":"PS Trivedi","year":"2019","unstructured":"Trivedi PS, Brown MA, Rochon PJ, Ryu RK, Johnson DT. Gender disparity in inpatient mortality after transjugular intrahepatic portosystemic shunt creation in patients admitted with hepatorenal syndrome: a nationwide study. J Am Coll Radiol. 2019;. https:\/\/doi.org\/10.1016\/j.jacr.2019.08.020.","journal-title":"J Am Coll Radiol"},{"key":"6136_CR40","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1016\/S0168-8278(01)00309-9","volume":"36","author":"F Salerno","year":"2002","unstructured":"Salerno F, Merli M, Cazzaniga M, et al. MELD score is better than Child-Pugh score in predicting 3-month survival of patients undergoing transjugular intrahepatic portosystemic shunt. J Hepatol. 2002;36:494\u2013500.","journal-title":"J Hepatol"},{"key":"6136_CR41","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1148\/radiol.2311030967","volume":"231","author":"H Ferral","year":"2004","unstructured":"Ferral H, Gamboa P, Postoak DW, et al. Survival after elective transjugular intrahepatic portosystemic shunt creation: prediction with model for end-stage liver disease score. Radiology. 2004;231:231\u2013236. https:\/\/doi.org\/10.1148\/radiol.2311030967.","journal-title":"Radiology"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-020-06136-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10620-020-06136-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-020-06136-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,14]],"date-time":"2021-02-14T10:10:15Z","timestamp":1613297415000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10620-020-06136-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,15]]},"references-count":41,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["6136"],"URL":"https:\/\/doi.org\/10.1007\/s10620-020-06136-2","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,15]]},"assertion":[{"value":"28 October 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 February 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 February 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"Dr. Charilaou, Dr Devani, Dr Petrosyan, Dr Reddy have no conflict of interest to declare. Dr. Pyrsopoulos has the following affiliations with the following commercial entities: Grant\/Research Support\u2014Allergan, Bayer, BeiGene, Bristol-Myers Squibb, Confirm, Conatus, Intercept, Mallinckrodt, Novartis, Resusix, Saro, Valeant, Gilead, Exelixis, Hologic, Shire, Genfit and Prometheus. Consultant\u2014Bayer, Exelixis, Gilead, Novartis. There is no conflict of interest with any speakers\u2019 bureau, patent holder, stock shareholder and\/or other financial support.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}