{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T11:22:55Z","timestamp":1788952975143,"version":"build-2803163510"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,3,7]],"date-time":"2020-03-07T00:00:00Z","timestamp":1583539200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,3,7]],"date-time":"2020-03-07T00:00:00Z","timestamp":1583539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Italian Health Ministry","award":["Grant PE-2016- 02363692"],"award-info":[{"award-number":["Grant PE-2016- 02363692"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1007\/s10620-020-06184-8","type":"journal-article","created":{"date-parts":[[2020,3,7]],"date-time":"2020-03-07T09:02:57Z","timestamp":1583571777000},"page":"167-174","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Gynecological Disorders in Patients with Non-celiac Wheat Sensitivity"],"prefix":"10.1007","volume":"66","author":[{"given":"Maurizio","family":"Soresi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Incandela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Mansueto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Incandela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"La Blasca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Fayer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"D\u2019Alcamo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ada Maria","family":"Florena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Carroccio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,3,7]]},"reference":[{"key":"6184_CR1","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/1741-7015-10-13","volume":"10","author":"A Sapone","year":"2012","unstructured":"Sapone A, Bai JC, Ciacci C, et al. Spectrum of gluten-related disorders: consensus on new nomenclature and classification. BMC Med. 2012;10:13.","journal-title":"BMC Med"},{"key":"6184_CR2","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1053\/j.gastro.2013.08.061","volume":"146","author":"A Carroccio","year":"2014","unstructured":"Carroccio A, Rini G, Mansueto P. Non-celiac wheat sensitivity is a more appropriate label than non-celiac gluten sensitivity. Gastroenterology. 2014;146:320\u2013321.","journal-title":"Gastroenterology"},{"key":"6184_CR3","doi-asserted-by":"publisher","first-page":"4966","DOI":"10.3390\/nu7064966","volume":"7","author":"C Catassi","year":"2015","unstructured":"Catassi C, Elli L, Bonaz B, et al. Diagnosis of non-celiac gluten sensitivity (NCGS): the Salerno experts\u2019 criteria. Nutrients. 2015;7:4966\u20134977.","journal-title":"Nutrients"},{"key":"6184_CR4","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.3390\/nu9111268","volume":"9","author":"C Catassi","year":"2017","unstructured":"Catassi C, Alaedini A, Bojarski C, et al. The overlapping area of non-celiac gluten sensitivity (NCGS) and wheat-sensitive irritable bowel syndrome (IBS): an update. Nutrients. 2017;9:1268.","journal-title":"Nutrients"},{"key":"6184_CR5","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1038\/nrgastro.2015.107","volume":"12","author":"I Aziz","year":"2015","unstructured":"Aziz I, Hadjivassiliou M, Sanders DS. The spectrum of non-coeliac gluten sensitivity. Nat Rev Gastroenterol Hepatol. 2015;12:516\u2013526.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"6184_CR6","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1053\/j.gastro.2014.12.049","volume":"148","author":"A Fasano","year":"2015","unstructured":"Fasano A, Sapone A, Zevallos V, Schuppan D. Non-celiac gluten sensitivity. Gastroenterology. 2015;148:1195\u20131204.","journal-title":"Gastroenterology"},{"key":"6184_CR7","doi-asserted-by":"publisher","first-page":"1845","DOI":"10.1038\/ajg.2013.353","volume":"108","author":"A Carroccio","year":"2013","unstructured":"Carroccio A, Mansueto P, D\u2019Alcamo A, Iacono G. Non-celiac wheat sensitivity as an allergic condition: personal experience and narrative review. Am J Gastroenterol. 2013;108:1845\u20131852.","journal-title":"Am J Gastroenterol"},{"key":"6184_CR8","volume-title":"The Rome IV Committees. Rome IV functional gastrointestinal disorders\u2014disorders of gut\u2013brain interaction. I","author":"DA Drossman","year":"2016","unstructured":"Drossman DA, Chang L, Chey WD, Kellow J, Tack J, Whitehead WE. The Rome IV Committees. Rome IV functional gastrointestinal disorders\u2014disorders of gut\u2013brain interaction. I. Raleigh: The Rome Foundation; 2016."},{"key":"6184_CR9","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1053\/j.gastro.2016.03.035","volume":"150","author":"DA Drossman","year":"2016","unstructured":"Drossman DA, Hasler WL. Rome IV-functional GI disorders: disorders of gut\u2013brain interaction. Gastroenterology. 2016;150:1257\u20131261.","journal-title":"Gastroenterology"},{"key":"6184_CR10","doi-asserted-by":"publisher","first-page":"e178","DOI":"10.1038\/ctg.2016.35","volume":"7","author":"D Di Liberto","year":"2016","unstructured":"Di Liberto D, Mansueto P, D\u2019Alcamo A, et al. Predominance of type 1 innate lymphoid cells in the rectal mucosa of patients with non-celiac wheat sensitivity: reversal after a wheat-free diet. Clin Transl Gastroenterol. 2016;7:e178.","journal-title":"Clin Transl Gastroenterol"},{"key":"6184_CR11","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1016\/j.cgh.2018.08.043","volume":"17","author":"A Carroccio","year":"2019","unstructured":"Carroccio A, Giannone G, Mansueto P, et al. Duodenal and rectal mucosa inflammation in patients with non-celiac wheat sensitivity. Clin Gastroenterol Hepatol. 2019;17:682\u2013690.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"6184_CR12","doi-asserted-by":"publisher","first-page":"1898","DOI":"10.1038\/ajg.2012.236","volume":"107","author":"A Carroccio","year":"2012","unstructured":"Carroccio A, Mansueto P, Iacono G, et al. Non-celiac wheat sensitivity diagnosed by double-blind placebo-controlled challenge: exploring a new clinical entity. Am J Gastroenterol. 2012;107:1898\u20131906.","journal-title":"Am J Gastroenterol"},{"key":"6184_CR13","doi-asserted-by":"publisher","first-page":"1557","DOI":"10.1007\/s00415-018-9025-2","volume":"266","author":"T Julian","year":"2019","unstructured":"Julian T, Hadjivassiliou M, Zis P. Gluten sensitivity and epilepsy: a systematic review. J Neurol. 2019;266:1557\u20131565.","journal-title":"J Neurol"},{"key":"6184_CR14","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1038\/ajg.2015.434","volume":"111","author":"M Hadjivassiliou","year":"2016","unstructured":"Hadjivassiliou M, Rao DG, Grunewald R, et al. Neurological dysfunction in coeliac disease and non-celiac gluten sensitivity. Am J Gastroenterol. 2016;111:561\u2013567.","journal-title":"Am J Gastroenterol"},{"key":"6184_CR15","first-page":"294","volume":"8","author":"J Bold","year":"2015","unstructured":"Bold J, Rostami K. Non-coeliac gluten sensitivity and reproductive disorders. Gastroenterol Hepatol Bed Bench. 2015;8:294\u2013297.","journal-title":"Gastroenterol Hepatol Bed Bench"},{"key":"6184_CR16","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1136\/gut.30.7.996","volume":"30","author":"A Prior","year":"1989","unstructured":"Prior A, Whorwell PJ. Gynecological consultation in patients with irritable bowel syndrome. Gut. 1989;30:996\u2013998.","journal-title":"Gut"},{"key":"6184_CR17","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1097\/01.AOG.0000135275.63494.3d","volume":"104","author":"RE Williams","year":"2004","unstructured":"Williams RE, Hartmann KE, Sandler RS, Miller WC, Steege JF. Prevalence and characteristics of irritable bowel syndrome among women with chronic pelvic pain. Obstet Gynecol. 2004;104:452\u2013458.","journal-title":"Obstet Gynecol"},{"key":"6184_CR18","doi-asserted-by":"publisher","first-page":"3446","DOI":"10.3748\/wjg.v13.i25.3446","volume":"13","author":"A Matheis","year":"2007","unstructured":"Matheis A, Martens U, Kruse J, Enck P. Irritable bowel syndrome and chronic pelvic pain: a singular or two different clinical syndromes? World J Gastroenterol. 2007;13:3446\u20133455.","journal-title":"World J Gastroenterol"},{"key":"6184_CR19","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/0029-7844(95)00360-6","volume":"87","author":"DJ Jamieson","year":"1996","unstructured":"Jamieson DJ, Steege JF. The prevalence of dysmenorrhea, dyspareunia, pelvic pain, and irritable bowel syndrome in primary care practices. Obstet Gynecol. 1996;87:55\u201358.","journal-title":"Obstet Gynecol"},{"key":"6184_CR20","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1055\/s-0038-1676090","volume":"36","author":"CM Johnson","year":"2018","unstructured":"Johnson CM, Makai GEH. Fibromyalgia and irritable bowel syndrome in female pelvic pain. Semin Reprod Med. 2018;36:136\u2013142.","journal-title":"Semin Reprod Med"},{"key":"6184_CR21","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1046\/j.1365-2036.2003.01499.x","volume":"17","author":"WL Hasler","year":"2003","unstructured":"Hasler WL, Schoenfeld P. Systematic review: abdominal and pelvic surgery in patients with irritable bowel syndrome. Alim Pharmacol Ther. 2003;17:997\u20131005.","journal-title":"Alim Pharmacol Ther"},{"key":"6184_CR22","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1111\/apt.14612","volume":"47","author":"E Clevers","year":"2018","unstructured":"Clevers E, Vaes B, Henrard S, et al. Health problems associated with irritable bowel syndrome: analysis of a primary care registry. Aliment Pharmacol Ther. 2018;47:1349\u20131357.","journal-title":"Aliment Pharmacol Ther"},{"key":"6184_CR23","doi-asserted-by":"publisher","first-page":"15","DOI":"10.4081\/itjm.2019.1070","volume":"13","author":"P Mansueto","year":"2019","unstructured":"Mansueto P, Soresi M, Iacobucci R, et al. Non-celiac wheat sensitivity: a search for the pathogenesis of a self-reported condition. Ital J Med. 2019;13:15\u201323.","journal-title":"Ital J Med"},{"key":"6184_CR24","doi-asserted-by":"publisher","first-page":"7089","DOI":"10.3748\/wjg.v21.i23.7089","volume":"21","author":"P Mansueto","year":"2015","unstructured":"Mansueto P, D\u2019Alcamo A, Seidita A, Carroccio A. Food allergy in irritable bowel syndrome: the case of nonceliac wheat sensitivity. World J Gastroenterol. 2015;21:7089\u20137109.","journal-title":"World J Gastroenterol"},{"key":"6184_CR25","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1111\/j.1447-0756.2007.00578.x","volume":"33","author":"S Ozturk","year":"2007","unstructured":"Ozturk S, Caliskaner Z, Karaayvaz M, Dede M, Gulec M. Hypersensitivity to aeroallergens in patients with recurrent vulvovaginitis of undetermined etiology. J Obstet Gynaecol Res. 2007;33:496\u2013500.","journal-title":"J Obstet Gynaecol Res"},{"key":"6184_CR26","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/S1081-1206(10)62527-6","volume":"85","author":"PS Moraes","year":"2000","unstructured":"Moraes PS, Taketomi EA. Allergic vulvovaginitis. Ann Allergy Asthma Immunol. 2000;85:253\u2013265.","journal-title":"Ann Allergy Asthma Immunol"},{"key":"6184_CR27","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.urology.2006.08.1109","volume":"69","author":"GR Sant","year":"2007","unstructured":"Sant GR, Kempuraj D, Marchand JE, Theoharides TC. The Mast cell in interstitial cystitis: role in pathophysiology and pathogenesis. Urology. 2007;69:34\u201340.","journal-title":"Urology"},{"key":"6184_CR28","doi-asserted-by":"publisher","first-page":"F1478","DOI":"10.1152\/ajprenal.00395.2005","volume":"290","author":"E Ustinova","year":"2006","unstructured":"Ustinova E, Fraser MO, Pezzone MA. Colonic irritation in the rat sensitizes urinary bladder afferents to mechanical and chemical stimuli: an afferent origin of pelvic organ cross-sensitization. Am J Physiol Renal Physiol. 2006;290:F1478\u2013F1487.","journal-title":"Am J Physiol Renal Physiol"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-020-06184-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10620-020-06184-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-020-06184-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,7]],"date-time":"2021-03-07T00:57:56Z","timestamp":1615078676000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10620-020-06184-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,7]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["6184"],"URL":"https:\/\/doi.org\/10.1007\/s10620-020-06184-8","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,7]]},"assertion":[{"value":"12 October 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 February 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 March 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"None of the authors have conflict of interest to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study protocol conformed to the ethical guidelines of the Declaration of Helsinki. It was approved by the Human Research Committee of the University of Palermo and registered at clinicaltrials.gov (Registration Number: NCT03027492, \u201cGynecological Disorders in Not-celiac Wheat Sensitivity\u201d).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}